Connotation Frames: A Data-Driven Investigation

Through a particular choice of a predicate (e.g., "x violated y"), a writer can subtly connote a range of implied sentiments and presupposed facts about the entities x and y: (1) writer's perspective: projecting x as an "antagonist"and y as a "victim", (2) entities' perspective: y probably dislikes x, (3) effect: something bad happened to y, (4) value: y is something valuable, and (5) mental state: y is distressed by the event. We introduce connotation frames as a representation formalism to organize these rich dimensions of connotation using typed relations. First, we investigate the feasibility of obtaining connotative labels through crowdsourcing experiments. We then present models for predicting the connotation frames of verb predicates based on their distributional word representations and the interplay between different types of connotative relations. Empirical results confirm that connotation frames can be induced from various data sources that reflect how people use language and give rise to the connotative meanings. We conclude with analytical results that show the potential use of connotation frames for analyzing subtle biases in online news media.Comment: 11 pages, published in Proceedings of ACL 201

A Voice for the Voiceless:Through the lens of lived experience: No Recourse to Public Funds, the violation of human rights, and resilience to it.

In a 2012 newspaper interview, Theresa May announced a commitment to reducing immigration figures by creating a ‘hostile environment’ for undocumented migrants (1). This ‘hostile environment’ has been perpetuated by the state in the form of a restriction of access to basic social services, social security, work and education

Investigating Content Planning for Navigating Trade-offs in Knowledge-Grounded Dialogue

Knowledge-grounded dialogue generation is a challenging task because it requires satisfying two fundamental yet often competing constraints: being responsive in a manner that is specific to what the conversation partner has said while also being attributable to an underlying source document. In this work, we bring this trade-off between these two objectives (specificity and attribution) to light and ask the question: Can explicit content planning before the response generation help the model to address this challenge? To answer this question, we design a framework called PLEDGE, which allows us to experiment with various plan variables explored in prior work, supporting both metric-agnostic and metric-aware approaches. While content planning shows promise, our results on whether it can actually help to navigate this trade-off are mixed -- planning mechanisms that are metric-aware (use automatic metrics during training) are better at automatic evaluations but underperform in human judgment compared to metric-agnostic mechanisms. We discuss how this may be caused by over-fitting to automatic metrics and the need for future work to better calibrate these metrics towards human judgment. We hope the observations from our analysis will inform future work that aims to apply content planning in this context.Comment: Accepted at EACL 2024 Main Conference (Long

MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation.

MicroRNAs (miRNAs) exert powerful effects on immunity through coordinate regulation of multiple target genes in a wide variety of cells. Type 2 innate lymphoid cells (ILC2s) are tissue sentinel mediators of allergic inflammation. We established the physiological requirements for miRNAs in ILC2 homeostasis and immune function and compared the global miRNA repertoire of resting and activated ILC2s and T helper type 2 (TH2) cells. After exposure to the natural allergen papain, mice selectively lacking the miR-17∼92 cluster in ILC2s displayed reduced lung inflammation. Moreover, miR-17∼92-deficient ILC2s exhibited defective growth and cytokine expression in response to IL-33 and thymic stromal lymphopoietin in vitro. The miR-17∼92 cluster member miR-19a promoted IL-13 and IL-5 production and inhibited expression of several targets, including SOCS1 and A20, signaling inhibitors that limit IL-13 and IL-5 production. These findings establish miRNAs as important regulators of ILC2 biology, reveal overlapping but nonidentical miRNA-regulated gene expression networks in ILC2s and TH2 cells, and reinforce the therapeutic potential of targeting miR-19 to alleviate pathogenic allergic responses

Open is not enough: design considerations for a networked data commons

Recently, researchers within the Networked Learning (NL) community have tried to (re)claim NL’s roots in critical pedagogy and (re)assert its commitment to social justice (Networked Learning Editorial Collective, 2021; 2021a). However, despite these avowed intentions, NL has also been criticised from within for “fail[ing] to take account of emancipatory struggles and political imperatives in society more broadly” (Networked Learning Editorial Collective, 2021a, p. 328). The suggestion is made to put NL “to work … to allow the concept of NL itself to become ‘networked’: to make connections, to interrelate, to transform, mutate, and hybridise in response to the pressing issues of our time” (Networked Learning Editorial Collective, 2021a, p. 359). In this paper, we take concepts from NL and put them “to work” in relation to the design of an informal digital learning environment – that is, a digital environment that lies outside of formal education provision, but that is intended to be a place where knowledge can be shared and circulated and where people encounter knowledge in ways that enable them to think, understand or act differently. The work was carried out in the context of a project aiming to develop design principles for an internet-based platform through people would be able to openly access, learn about and share publicly available data, using Scotland’s waste and re-use data as a case study. In this context, we plug NL into a theoretical and methodological design assemblage that connects concepts of openness, data literacy, (de)coloniality, and participatory design into new formations that we hope will allow these concepts to mutate and hybridise into something closer to the social justice ideals that NL claims

Transcriptional Pausing Factor m1bp Regulates Cellular Homeostasis by Suppressing Autophagy and Apoptosis in \u3cem\u3eDrosophila \u3c/em\u3eEye

During organogenesis cellular homeostasis plays a crucial role in patterning and growth. The role of promoter proximal pausing of RNA polymerase II, which regulates transcription of several developmental genes by GAGA factor or Motif 1 Binding Protein (M1BP), has not been fully understood in cellular homeostasis. Earlier, we reported that M1BP, a functional homolog of ZKSCAN3, regulates wingless (wg) and caspase-dependent cell death (apoptosis) in the Drosophila eye. Further, blocking apoptosis does not fully rescue the M1BPRNAi phenotype of reduced eye. Therefore, we looked for other possible mechanism(s). In a forward genetic screen, members of the Jun-amino-terminal-(NH2)-Kinase (JNK) pathway were identified. Downregulation of M1BP ectopically induces JNK, a pro-death pathway, known to activate both apoptosis and caspase-independent (autophagy) cell death. Activation of JNK pathway components can enhance M1BPRNAi phenotype and vice-versa. Downregulation of M1BP ectopically induced JNK signaling, which leads to apoptosis and autophagy. Apoptosis and autophagy are regulated independently by their genetic circuitry. Here, we found that blocking either apoptosis or autophagy alone rescues the reduced eye phenotype of M1BP downregulation; whereas, blocking both apoptosis and autophagy together significantly rescues the M1BP reduced eye phenotype to near wild-type in nearly 85% progeny. This data suggests that the cellular homeostasis response demonstrated by two independent cell death mechanisms, apoptosis and autophagy, can be regulated by a common transcriptional pausing mechanism orchestrated by M1BP. Since these fundamental processes are conserved in higher organisms, this novel functional link between M1BP and regulation of both apoptosis and autophagy can be extrapolated to humans

Clinical evaluation of the MPS 9000 Macular Pigment Screener

Background/aims The MPS 9000 uses a psychophysical technique known as heterochromatic flicker photometry to measure macular pigment optical density (MPOD). Our aim was to determine the measurement variability (noise) of the MPS 9000. Methods Forty normally sighted participants who ranged in age from 18 to 50 years (25.4±8.2 years) were recruited from staff and students of Aston University (Birmingham, UK). Data were collected by two operators in two sessions separated by 1 week in order to assess test repeatability and reproducibility. Results The overall mean MPOD for the cohort was 0.35±0.14. There was no significant negative correlation between MPS 9000 MPOD readings and age (r=-0.192, p=0.236). Coefficients were 0.33 and 0.28 for repeatability, and 0.25 and 0.26 for reproducibility. There was no significant correlation between mean and difference MPOD values for any of the four pairs of results. Conclusions When MPOD is being monitored over time then any change less than 0.33 units should not be considered clinically significant as it is very likely to be due to measurement noise. The size of the coefficient appears to be positively correlated with MPOD

Potential animal reservoir of Mycobacterium ulcerans: a systematic review

Mycobacterium ulcerans is the causative agent of Buruli ulcer, also known in Australia as Daintree ulcer or Bairnsdale ulcer. This destructive skin disease is characterized by extensive and painless necrosis of the skin and soft tissue with the formation of large ulcers, commonly on the leg or arm. To date, 33 countries with tropical, subtropical and temperate climates in Africa, the Americas, Asia and the Western Pacific have reported cases of Buruli ulcer. The disease is rarely fatal, although it may lead to permanent disability and/or disfigurement if not treated appropriately or in time. It is the third most common mycobacterial infection in the world after tuberculosis and leprosy. The precise mode of transmission of M. ulcerans is yet to be elucidated. Nevertheless, it is possible that the mode of transmission varies with different geographical areas and epidemiological settings. The knowledge about the possible routes of transmission and potential animal reservoirs of M. ulcerans is poorly understood and still remains patchy. Infectious diseases arise from the interaction of agent, host and environment. The majority of emerging or remerging infectious disease in human populations is spread by animals: either wildlife, livestock or pets. Animals may act as hosts or reservoirs and subsequently spread the organism to the environment or directly to the human population. The reservoirs may or may not be the direct source of infection for the hosts; however, they play a major role in maintenance of the organism in the environment, and in the mode of transmission. This remains valid for M. ulcerans. Possums have been suggested as one of the reservoir of M. ulcerans in south-eastern Australia, where possums ingest M. ulcerans from the environment, amplify them and shed the organism through their faeces. We conducted a systematic review with selected key words on PubMed and INFORMIT databases to aggregate available published data on animal reservoirs of M. ulcerans around the world. After certain inclusion and exclusion criteria were implemented, a total of 17 studies was included in the review. A variety of animals around the world e.g., rodents, shrews, possums (ringtail and brushtail), horses, dogs, alpacas, koalas and Indian flap-shelled turtles have been recorded as being infected with M. ulcerans. The majority of studies included in this review identified animal reservoirs as predisposing to the emergence and reemergence of M. ulcerans infection. Taken together, from the selected studies in this systematic review, it is clear that exotic wildlife and native mammals play a significant role as reservoirs for M. ulceran

Subsurface hydrogen storage controlled by small-scale rock heterogeneities

Subsurface porous rocks have the potential to store large volumes of hydrogen (H$_2$) required for transitioning towards a H$_2$-based energy future. Understanding the flow and trapping behavior of H$_2$ in subsurface storage systems, which is influenced by pore-scale heterogeneities inherent to subsurface rocks, is crucial to reliably evaluate the storage efficiency of a geological formation. In this work, we performed 3D X-ray imaging and flow experiments to investigate the impact of pore-scale heterogeneity on H$_2$ distribution after its cyclic injection (drainage) and withdrawal (imbibition) from a layered rock sample, characterized by varying pore and throat sizes. Our findings reveal that even subtle variations in rock structure and properties significantly influence H$_2$ displacement and storage efficiency. During drainage, H$_2$ follows a path consisting of large pores and throats, bypassing the majority of the low permeability rock layer consisting of smaller pores and throats. This bypassing substantially reduces the H$_2$ storage capacity. Moreover, due to the varying pore and throat sizes in the layered sample, depending on the experimental flow strategy, we observe a higher H$_2$ saturation after imbibition compared to drainage, which is counterintuitive and opposite to that observed in homogeneous rocks. These findings emphasize that small-scale rock heterogeneity, which is often unaccounted for in reservoir-scale models, can play a vital role in the displacement and trapping of H$_2$ in subsurface porous media