Outcome analysis in patients with multi vessel coronary artery disease and left ventricular ejection fraction after percutaneous coronary intervention: single center experience

Background: The present study evaluated the changes in baseline left ventricular function and clinical symptoms in multi-vessel coronary artery disease patients after multi-vessel percutaneous coronary intervention.Methods: This was a prospective, observational study conducted at Medical Super-speciality Hospital, Kolkata, India, between August 2017 and August 2019. The study included 48 patients who were diagnosed with ≥2 coronary artery stenosis of ≥50% in native coronary arteries with left ventricular ejection fraction (LVEF) <40%. Echocardiography was performed before and after 3 months of the procedure to observe LVEF. Canadian Cardiovascular Society (CCS) score was calculated before and after 3 months after PCI.Results: Mean age of the patients was 61.89±9.96 years and 89.6% patients were male. Mean LVEF before and after angioplasty was 34.9±4.95% and 42.06±8.78%, respectively (p=0.001). CCS score before and after angioplasty was 2.89 and 1.83, respectively (p=0.001).Conclusions: The results displayed significant improvement in clinical symptoms as well as LVEF after PCI in patients with multi-vessel disease with LVEF <40%. These results will be helpful to conduct larger randomized trials with long term follow-up in order to prove the safety and effectiveness of PCI in such patients over coronary artery bypass grafting

Structural and functional characterisation of animal adenovirus capsid proteins

Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Ciencias, Departamento de Biología Molecular. Fecha de lectura: 24-10-2014Adenoviruses are disease-causing agents, but are also explored as a model system to decipher mechanisms of molecular biology and used as vectors for gene and cancer therapy trials. Vectors wholly or partially based on animal adenoviruses may be interesting in this respect, both for avoiding pre-existing immunity in humans and the possibility of having novel cell-targeting properties. The capsid of the icosahedral, double-stranded DNA-containing adenovirus maintains the integrity of virus particle, but also has proteins involved in virus entry. The fibre is one such protein and is responsible for primary virus-host interaction. Hence, the homo-trimeric fibre protein is an important factor in adenoviral biology and to successfully exploit these viruses for medical applications. In this thesis work, X-ray crystallographic structures of four animal adenovirus fibre heads have been determined, three of which belong to recently established genera of Adenoviridae, namely Siadenovirus and Atadenovirus. Despite being members of distinct genera and targeting various organisms, the structures revealed overall conserved topology of the central beta-sandwich in their head domains. However, other features of these fibre heads, such as their size, shape and the length of connecting loops show more diversity, which may, in turn, have an impact on their tropism. Structures determined from two atadenoviruses have established their fibre heads as the smallest among all known adenovirus fibre head structures. Both the snake adenovirus 1 fibre head and the lizard adenovirus 2 short fibre heads are compact, with relatively short loops connecting their beta-strands. The presence of a prominent alpha-helix in their structures is also interesting. Turkey adenovirus-3, which exists in avirulent and virulent forms, has a fibre head more similar to reovirus fibre heads than to those of other adenoviruses. The presence of a betahairpin insertion is unique to the structure. Moreover, the striking similarity of turkey adenovirus-3 fibre head with reovirus attachment proteins has strengthened the theory of an evolutionary link between adenoviruses and reoviruses. Sialic acid-containing carbohydrates were identified as in vitro ligands by NMR spectroscopy and calorimetry and co-crystal structures were successfully determined. The structure of ligand-bound turkey adenovirus 3 fibre head revealed the sialic acid binding site located on the side of the trimer. Murine adenovirus 2, like most mammalian adenoviruses and all known human adenoviruses, belongs to the Mastadenovirus genus and could potentially be developed into a model system to study adenovirus pathogenicity. I have determined the high-resolution crystal XVI structure of the fibre head domain of murine adenovirus 2, along with the two directly preceding shaft domain repeats, which shows an overall resemblance to other adenovirus fibre heads of Mastadenovirus genus. Structural comparison with other fibre head structures, however, clearly shows variations that may have functional implications. Nacetylglucosamine, which is common component of glycosaminoglycans such as heparan sulfate and has a wide tissue distribution, has been identified as a ligand for murine adenovirus 2 fibre head in this thesis. In summary, I present new structural and functional findings on distinct adenovirus fibre heads that will be useful in elucidating their tropism and biology. The new structures may also be useful in the design and development of animal adenovirus-based applications

A case of three year child with uncorrected tetralogy of Fallot for drainage of fronto-parietal abscess

The Tetralogy Fallot was one of the commonest Right to Left shunting disease in the children. TOF is most common in association with brain abscess (13-70%). This case is of a 3 year old child who had tetralogy of Fallot (uncorrected) and was to be taken for drainage of Fronto-Parietal sub dural abscess via Burr hole. The abscess was drained and patient was shifted with inotropes and ventilator support. In next 24 hours patient improved and supports were gradually withdrawn

Research Productivity and Visualization of the All India Institute of Medical Sciences (AIIMS) Bhubaneswar during 2012-2019: A Scientometric Approach

The purpose of the present study is to evaluate the productivity of research at the Indian Institute of Medical Sciences (AIIMS), Bhubaneswar, in the first eight years (2012-2019) of its establishment. In this study, the authors used a number of Scientometric indices to assess research productivity. The results of the study showed that in the selected period of 2019, most research publications appear with an average growth rate of 46.43%. Most of the comments were written by five or more authors. In addition, R.R. Das is recognized as the most prolific author, and the Journal of Clinical and Diagnostic Research is one of the most popular sources of publications, with the largest number of publications with the help of scientists from AIIMS. The UK and AIIMS New Delhi are the countries and institutions that work best together. In addition, the study also found that the Indian Medical Research Council is the leading research institution with AIIMS Bhubaneswar. The title of Maiti R Metronomic Chemotherapy , published in the Journal of Pharmacology and Pharmacotherapeutics, received the most citations. this sentence is long and somewhat complicated. This study is useful for policymakers and stakeholders in medical institutions to improve their research prospects

Domain of Existence and Uniqueness for Nonlinear Hammerstein Integral Equations

[EN] In this work, we performed an study about the domain of existence and uniqueness for an efficient fifth order iterative method for solving nonlinear problems treated in their infinite dimensional form. The hypotheses for the operator and starting guess are weaker than in the previous studies. We assume omega continuity condition on second order Frechet derivative. This fact it is motivated by showing different problems where the nonlinear operators that define the equation do not verify Lipschitz and Holder condition; however, these operators verify the omega condition established. Then, the semilocal convergence balls are obtained and the R-order of convergence and error bounds can be obtained by following thee main theorem. Finally, we perform a numerical experience by solving a nonlinear Hammerstein integral equations in order to show the applicability of the theoretical results by obtaining the existence and uniqueness balls.This research was partially supported by Ministerio de Economia y Competitividad under grant PGC2018-095896-B-C22.Singh, S.; Martínez Molada, E.; Kumar, A.; Gupta, DK. (2020). Domain of Existence and Uniqueness for Nonlinear Hammerstein Integral Equations. Mathematics. 8(3):1-11. https://doi.org/10.3390/math8030384S11183Hernández, M. A. (2001). Chebyshev’s approximation algorithms and applications. Computers & Mathematics with Applications, 41(3-4), 433-445. doi:10.1016/s0898-1221(00)00286-8Amat, S., Hernández, M. A., & Romero, N. (2008). A modified Chebyshev’s iterative method with at least sixth order of convergence. Applied Mathematics and Computation, 206(1), 164-174. doi:10.1016/j.amc.2008.08.050Argyros, I. K., Ezquerro, J. A., Gutiérrez, J. M., Hernández, M. A., & Hilout, S. (2011). On the semilocal convergence of efficient Chebyshev–Secant-type methods. Journal of Computational and Applied Mathematics, 235(10), 3195-3206. doi:10.1016/j.cam.2011.01.005Hueso, J. L., & Martínez, E. (2013). Semilocal convergence of a family of iterative methods in Banach spaces. Numerical Algorithms, 67(2), 365-384. doi:10.1007/s11075-013-9795-7Zhao, Y., & Wu, Q. (2008). Newton–Kantorovich theorem for a family of modified Halley’s method under Hölder continuity conditions in Banach space. Applied Mathematics and Computation, 202(1), 243-251. doi:10.1016/j.amc.2008.02.004Parida, P. K., & Gupta, D. K. (2007). Recurrence relations for a Newton-like method in Banach spaces. Journal of Computational and Applied Mathematics, 206(2), 873-887. doi:10.1016/j.cam.2006.08.027Parida, P. K., & Gupta, D. K. (2008). Recurrence relations for semilocal convergence of a Newton-like method in Banach spaces. Journal of Mathematical Analysis and Applications, 345(1), 350-361. doi:10.1016/j.jmaa.2008.03.064Cordero, A., Ezquerro, J. A., Hernández-Verón, M. A., & Torregrosa, J. R. (2015). On the local convergence of a fifth-order iterative method in Banach spaces. Applied Mathematics and Computation, 251, 396-403. doi:10.1016/j.amc.2014.11.084Argyros, I. K., & Hilout, S. (2013). On the local convergence of fast two-step Newton-like methods for solving nonlinear equations. Journal of Computational and Applied Mathematics, 245, 1-9. doi:10.1016/j.cam.2012.12.002Argyros, I. K., George, S., & Magreñán, Á. A. (2015). Local convergence for multi-point-parametric Chebyshev–Halley-type methods of high convergence order. Journal of Computational and Applied Mathematics, 282, 215-224. doi:10.1016/j.cam.2014.12.023Wang, X., Kou, J., & Gu, C. (2012). Semilocal Convergence of a Class of Modified Super-Halley Methods in Banach Spaces. Journal of Optimization Theory and Applications, 153(3), 779-793. doi:10.1007/s10957-012-9985-9Argyros, I. K., & Magreñán, Á. A. (2015). A study on the local convergence and the dynamics of Chebyshev–Halley–type methods free from second derivative. Numerical Algorithms, 71(1), 1-23. doi:10.1007/s11075-015-9981-xWu, Q., & Zhao, Y. (2007). Newton–Kantorovich type convergence theorem for a family of new deformed Chebyshev method. Applied Mathematics and Computation, 192(2), 405-412. doi:10.1016/j.amc.2007.03.018Martínez, E., Singh, S., Hueso, J. L., & Gupta, D. K. (2016). Enlarging the convergence domain in local convergence studies for iterative methods in Banach spaces. Applied Mathematics and Computation, 281, 252-265. doi:10.1016/j.amc.2016.01.036Kumar, A., Gupta, D. K., Martínez, E., & Singh, S. (2018). Semilocal convergence of a Secant-type method under weak Lipschitz conditions in Banach spaces. Journal of Computational and Applied Mathematics, 330, 732-741. doi:10.1016/j.cam.2017.02.042Singh, S., Gupta, D. K., Martínez, E., & Hueso, J. L. (2016). Semilocal Convergence Analysis of an Iteration of Order Five Using Recurrence Relations in Banach Spaces. Mediterranean Journal of Mathematics, 13(6), 4219-4235. doi:10.1007/s00009-016-0741-

Nanomechanical inhomogeneities in CVA-deposited titanium nitride thin films: Nanoindentation and Finite Element Method Investigations

Refractory metals that can withstand at high temperatures and harsh conditions are of utmost importance for solar-thermal and energy storage applications. Thin films of TiN have been deposited using cathodic vacuum arc deposition (CVA) at relatively low temperatures ~ 300 oC using the substrate bias ~ -60V. The nanomechanical properties of these films were investigated using nanoindentation and the spatial fluctuations were observed. The nanoindentation results were simulated using finite element method (FEM) through Johnson-Cook model. We have found the local nitridation plays an important role on nanomechanical properties of TiN thin films and confirms that the nitrogen deficient regions are ductile with low yield stress and hardening modulus. This study further opens the opportunities of modelling the nanoscale system using FEM analysis

Research Productivity and Visualization of the All India Institute of Medical Sciences (AIIMS) Bhubaneswar during 2012-2019: A Scientometric Approach

Scientometric analysis of research results enable individuals and institutions to understand their current status and improve their performance. The present study evaluate the productivity of research at the Indian Institute of Medical Sciences (AIIMS), Bhubaneswar using scientometric parameters. Study revealed that most research publications appeared with an average growth rate of 46.43%. and R.R. Das was the most prolific author. Journal of Clinical and Diagnostic Research was found to be the most popular source of publications and AIIMS Bhubaneswar the leading research institution. The title of Maiti R 'Metronomic Chemotherapy' published in the Journal of Pharmacology and Pharmacotherapeutics, received the highest citations. The findings of the study will be of use to the policy makers to improve research in the the area