A Quantitative Approach to Investigating the Hypothesis of Prokaryotic Intron Loss

Using a novel method, we show that ordered triplets of motifs usually associated with spliceosomal intron recognition are underrepresented in the protein coding sequence of complete Thermotogae, archaeal and bacterial genomes. The underrepresentation observed does not extend to the noncoding strand, suggesting that the cause of the asymmetry is related to mRNA rather than DNA. Our data do not suggest that the underrepresentation is due to gene transfer from eukaryotes. We speculate that one possible explanation for these observations is that the protein coding sequence of Thermotogae, Archaea and Bacteria was at some time in the past subjected to selection against certain motifs appearing in an order which might initiate splicing in environments harboring a functional spliceosome. This is consistent with, but certainly does not prove, a hypothetical scenario in which at least some prokaryote lineages once possessed a functional spliceosome. Thus, we present a new quantitative method, observations obtained using the method, and a speculative discussion of a possible explanation of the observations

Quantization and simulation of Born-Infeld non-linear electrodynamics on a lattice

Born-Infeld non-linear electrodynamics arises naturally as a field theory description of the dynamics of strings and branes. Most analyses of this theory have been limited to studying it as a classical field theory. We quantize this theory on a Euclidean 4-dimensional space-time lattice and determine its properties using Monte-Carlo simulations. The electromagnetic field around a static point charge is measured using Luscher-Weisz methods to overcome the sign problem associated with the introduction of this charge. The D field appears identical to that of Maxwell QED. However, the E field is enhanced by quantum fluctuations, while still showing the short distance screening observed in the classical theory. In addition, whereas for the classical theory, the screening increases without bound as the non-linearity increases, the quantum theory approaches a limiting conformal field theory.Comment: 24 pages, 10 figures. Latex with postscript figure

The effects of shoe temperature on the kinetics and kinematics of running

The aim of the current investigation was to examine the effects of cooled footwear on the kinetics and kinematics of running in comparison to footwear at normal temperature. Twelve participants ran at 4.0 m/s ± 5% in both cooled and normal temperature footwear conditions over a force platform. Two identical footwear were worn, one of which was cooled for 30 min. Lower extremity kinematics were obtained using a motion capture system and tibial accelerations were measured using a triaxial accelerometer. Differences between cooled and normal footwear temperatures were contrasted using paired samples t-tests. The results showed that midsole temperature (cooled = 4.21 °C and normal = 23.25 °C) and maximal midsole deformation during stance (cooled = 12.85 mm and normal = 14.52 mm) were significantly reduced in the cooled footwear. In addition, instantaneous loading rate (cooled = 186.21 B.W/s and normal = 167.08 B W/s), peak tibial acceleration (cooled = 12.75 g and normal = 10.70 g) and tibial acceleration slope (cooled = 478.69 g/s and normal = 327.48 g/s) were significantly greater in the cooled footwear. Finally, peak eversion (cooled = −10.57 ° and normal = −7.83°) and tibial internal rotation (cooled = 10.67 ° and normal = 7.77°) were also shown to be significantly larger in the cooled footwear condition. This study indicates that running in cooled footwear may place runners at increased risk from the biomechanical parameters linked to the aetiology of injuries

Cut loci and conjugate loci on Liouville surfaces

In the earlier paper (Itoh and Kiyohara, Manuscr Math 114:247–264, 2004), we showed that the cut locus of a general point on two-dimensional ellipsoid is a segment of a curvature line and proved "Jacobi’s last geometric statement" on the singularities of the conjugate locus. In the present paper,we showthat a wider class of Liouville surfaces possess such simple cut loci and conjugate loci. The results include the determination of cut loci and the set of poles on two-sheeted hyperboloids and elliptic paraboloids

Developing Scenarios for Product Longevity and Sufficiency

This paper explores the narrative of peoples’ relationships with products as a window on understanding the types of innovation that may inform a culture of sufficiency. The work forms part of the 'Business as Unusual: Designing Products with Consumers in the Loop' [BaU] project, funded as part of the UK EPSRC-ESRC RECODE network (RECODE, 2016) that aims to explore the potential of re-distributed manufacturing (RdM) in a context of sustainability. This element of the project employed interviews, mapping and workshops as methods to investigate the relationship between people and products across the product lifecycle. A focus on product longevity and specifically the people-product interactions is captured in conversations around product maintenance and repair. In exploring ideas of ‘broken’ we found different characteristics of, and motivations for, repair. Mapping these and other product-people interactions across the product lifecycle indicated where current activity is, who owns such activity (i.e. organisation or individual) and where gaps in interactions occur. These issues were explored further in a workshop which grouped participants to look at products from the perspective of one of four scenarios; each scenario represented either short or long product lifespans and different types of people engagement in the design process. The findings help give shape to new scenarios for designing sufficiency-based social models of material flows

Social innovation without social justice: Disbanding the victim market

This paper argues that social innovation requires dispensing with social justice as a goal. Why? Despite the best of intentions of advocates of social justice, the outcomes of social justice initiatives are axiomatically perverse. I argue that advocates of social justice, rather than the ostensible target populations they champion, are the primary beneficiaries of social justice initiatives (Sinclair, 2000; Sinclair, 2002). This seemingly counter-intuitive effect is caused by the field of social justice activity itself, which has become a market in victim circumstances

Can the Fed Predict the State of the Economy?

Recent research has documented that the Federal Reserve produces systematic errors in forecasting inflation, real GDP growth, and the unemployment rate, even though these forecasts are unbiased. We show that these systematic errors reveal that the Fed is “surprised” by real and inflationary cycles. Using a modified Mincer-Zarnowitz regression, we show that the Fed knows the state of the economy for the current quarter, but cannot predict it one quarter ahead.Forecast Evaluation; Federal Reserve; Systematic Errors; Recessions

Are 'unbiased' forecasts really unbiased? Another look at the Fed forecasts

This paper reconciles contradictory findings obtained from forecast evaluations: the existence of systematic errors and the failure to reject rationality in the presence of such errors. Systematic errors in one economic state may offset the opposite types of errors in the other state such that the null of rationality is not rejected. A modified test applied to the Fed forecasts shows that the forecasts were ex post biased.Greenbook Forecasts, forecast evaluation, systematic errors