Sociological analysis of remote work as a new format of current population employment in Russia

The article discusses remote work as a subject of scientific research, describes the factors stimulating the development of distance employment and substantiates the need for a sociological study of this phenomenon in view of the high potential for the impact of changes in forms of employment not only on the labor market, but also on other social structures. Sociologists extremely rarely consider the remote work, despite the increased relevance in recent years, as a subject of study. Scientific publications devoted to remote work as the main type of employment, as a rule, relate to personnel management issues. However, it should be noted that changes in the structure of employment can also affect other social institutions, processes and relationships: the institution of the family, domestic relations, social and professional communications, social mobility, and the very relationship of a person to work. The authors have conducted preliminary monitoring of the media and blogosphere in the Tyumen region and come to the conclusion that, as of today, the applied research methods do not allow to fully reveal the impact of remote employment on all spheres of social life and describe the trends. Therefore, an in-depth sociological analysis of telecommuting with the help of in-depth interviews, interviews with experts, questionnaires to specialists employed in the labor market and representatives of the authorities is required to identify trends, prospects and social consequences

UROGENITAL TRACT MICROFLORA IN SEXUAL PARTNERS WITH CHRONIC GENITOURINARY TRICHOMONIASIS

Trichomonas infection is a scientific and clinical problem in dermatology, urology, obstetrics and gynecology. This infection in men and women is often causes to urethritis, cystitis, prostatitis, post-abortion infection, premature labor and other diseases. This literature review has shown that in spite of a lot of numbers of scientific data concerning the impact of trichomoniasis to urogenital bioceonosis of both men and women, there is no enough data about influence of trichomoniasis to urinary microecology in sexual partners. Meanwhile, this question is in the field of scientific and applied interest and need to be studied

Modelling of conditions of development of network structures

The present stage of development of the economy is characterized by fast changes in the external environment, an increase in processes of globalization, growing competition, uncertainty and chance in the field of administrative decision making. Under such conditions, traditional forms of organization are replaced with network forms as the most effective and adaptive ones. The development of inter-firm relations, an increase in the number and variety of forms of network organizations cause the necessity of searching and assessing factors influencing this process. One of the most attractive forms of network interaction is the cluster. Regional and interregional clusters are considered as priority interindustry complexes which define the development of the economy at the national and regional level. Their formation is connected with the processes of integration of production and other organizations within one uniform territory for creating an effective industrial structure of the economy. Manufacturing enterprises and other organizations, combined in a cluster, hold a steady position amid market volatility thanks to a flexible cluster structure, synergetic effect, saving on transaction expenses, to an effective exchange of knowledge and information. In the article, the mechanisms of formation of cluster structures are considered; conditions of their effective functioning are analyzed. Special attention is paid to external factors of the successful development and formation of frame conditions of the development of clusters. On the basis of international statistics on the development of cluster structures in different countries of the world and using tools of statistical research, dependence between the development of cluster structures and a number of external conditions promoting it is shown. In this work, the importance of such factors as the development of an institutional environment, infrastructure, financial market, education, technological readiness for economy clustering is noted. On the basis of the obtained results recommendations about the development of clusters are made.Современный этап развития экономики характеризуется быстрыми изменениями во внешней среде, нарастанием процессов глобализации, повышением уровня конкуренции, неопределенности и случайности в области принятия управленческих решений. В таких условиях традиционные формы организации замещаются сетевыми формами, как наиболее эффективными и адаптивными. Развитие межфирменных отношений, увеличение числа и разнообразия форм сетевых организаций вызывают необходимость поиска и оценки факторов, влияющих на этот процесс. Одной из наиболее привлекательных форм сетевого взаимодействия на сегодняшний момент является кластер. Региональные и межрегиональные кластеры рассматриваются как приоритетные межотраслевые комплексы, которые определяют развитие экономики на национальном и региональном уровне. Их формирование связывают с процессами интеграции производственных и иных организаций в рамках единой территории для получения эффективной промышленной структуры экономики. Объединенные в кластер производственные предприятия и другие организации занимают устойчивое положение в условиях волатильной рыночной конъюнктуры за счет гибкой кластерной структуры, синергетического эффекта, экономии на трансакционных издержках, эффективному обмену знаниями и информацией. В статье рассматриваются механизмы формирования кластерных структур, анализируются условия их эффективного функционирования. Особое внимание уделяется внешним факторам успешного развития, формированию рамочных условий развития кластеров. На основе данных международной статистики по развитию кластерных структур в разных странах мира и используя инструментарий статистических исследований, показана зависимость между развитием кластерных структур и способствующих этому ряда внешних условий. В работе отмечается важность таких факторов, как развитие институциональной среды, инфраструктуры, финансового рынка, образования, технологическая готовность для кластеризации экономики. На основе полученных результатов даются рекомендации по развитию кластеров.Исследование выполнено при финансовой поддержке Российского гуманитарного научного фонда, грант № 15-02-000158

Approaches to monitoring of competences and qualifications

The relevance of the analyzed issue is caused by the need to assess the state of competences and qualifications in the labor market in the region. The purpose of the article is the substantiation of approaches to the integrated monitoring training status, conditions of formation and use of labor, the results of which will complement the statistics. The leading approach to the study of this issue is the development of a new monitoring methodology to identify the qualitative characteristics of the labor force in the quantitative parameters. Results: the authors have developed conceptual approaches and structural elements of quality monitoring of labor at regional level. The identified shortcomings of existing competences and qualifications of monitoring techniques necessitated the search for other approaches to the assessment of the real state of the qualitative characteristics of the labor force in the labor market, as collected data can significantly affect the results of the personnel forecast and formation of labor potential management strategies. The study was proposed to focus on improving the quality of personnel management departments of large and medium-sized organizations in the region to solve the problem of the interaction between the education system and employers. The data of the article may be useful for research organizations and regional governance structures in the development of medium- and long-term development programs of labor potential. © 2016 Simonova et al

Xenobiotic-induced activation of human aryl hydrocarbon receptor target genes in Drosophila is mediated by the epigenetic chromatin modifiers

Aryl hydrocarbon receptor (AHR) is the key transcription factor that controls animal development and various adaptive processes. The AHR\u27s target genes are involved in biodegradation of endogenous and exogenous toxins, regulation of immune response, organogenesis, and neurogenesis. Ligand binding is important for the activation of the AHR signaling pathway. Invertebrate AHR homologs are activated by endogenous ligands whereas vertebrate AHR can be activated by both endogenous and exogenous ligands (xenobiotics). Several studies using mammalian cultured cells have demonstrated that transcription of the AHR target genes can be activated by exogenous AHR ligands, but little is known about the effects of AHR in a living organism. Here, we examined the effects of human AHR and its ligands using transgenic Drosophila lines with an inducible human AhR gene. We found that exogenous AHR ligands can increase as well as decrease the transcription levels of the AHR target genes, including genes that control proliferation, motility, polarization, and programmed cell death. This suggests that AHR activation may affect the expression of gene networks that could be critical for cancer progression and metastasis. Importantly, we found that AHR target genes are also controlled by the enzymes that modify chromatin structure, in particular components of the epigenetic Polycomb Repressive complexes 1 and 2. Since exogenous AHR ligands (alternatively - xenobiotics) and small molecule inhibitors of epigenetic modifiers are often used as pharmaceutical anticancer drugs, our findings may have significant implications in designing new combinations of therapeutic treatments for oncological diseases. © Akishina et al

Combination of hypomorphic mutations of the Drosophila homologues of aryl hydrocarbon receptor and nucleosome assembly protein family genes disrupts morphogenesis, memory and detoxification

Aryl hydrocarbon receptor is essential for biological responses to endogenous and exogenous toxins in mammals. Its Drosophila homolog spineless plays an important role in fly morphogenesis. We have previously shown that during morphogenesis spineless genetically interacts with CG5017 gene, which encodes a nucleosome assembly factor and may affect cognitive function of the fly. We now demonstrate synergistic interactions of spineless and CG5017 in pathways controlling oxidative stress response and long-term memory formation in Drosophila melanogaster. Oxidative stress was induced by low doses of X-ray irradiation of flies carrying hypomorphic mutation of spineless, mutation of CG5017, and their combination. To determine the sensitivity of these mutants to pharmacological modifiers of the irradiation effect, we irradiated flies growing on standard medium supplemented by radiosensitizer furazidin and radioprotector serotonin. The effects of irradiation were investigated by analyzing leg and antenna morphological structures and by using real-time PCR to measure mRNA expression levels for spineless, Cyp6g1 and Gst-theta genes. We also examined long-term memory in these mutants using conditioned courtship suppression paradigm. Our results show that the interaction of spineless and CG5017 is important for regulation of morphogenesis, long-term memory formation, and detoxification during oxidative stress. Since spineless and CG5017 are evolutionary conserved, these results must be considered when evaluating the risk of combining similar mutations in other organisms, including humans

Heterogeneity of population of microorganisms grown in presence of iron oxide maghemite nanoparticles

In this work γ-Fe2O3 MNPs were obtained by laser target evaporation and water based suspensions were prepared. Maximum permissive dose of iron in water (MPD) is 0.3 mg/L. It was found that 100 MPD dose of iron induces formation of non-typical colonies after 72 or 96 hours exposition: against a background of small black colonies large white colonies appeared due to a disruption in tyrosine synthesis. Multiple re-cloning of the white colonies grown with MNPs showed that they retained their properties both under standard conditions (temperature of 24 °C) and at the temperatures up to 37o C. E.nigrum grown with MNPs demonstrated very scant extension of small colonies at the cultivation temperature of 24o C, their growth was completely blocked at 37°C. Significant changes in the structure of the population were noted. First of all, large cells with pronounced aggregation were observed among the black colonies. These aggregates consisted of large cells connected to each other by matrix. In the white colonies the appearance of very long threadlike cells connecting different groups of the cells establishing an intercellular communication was evident. Fe2O3 MNPs induce an increase in the heterogeneity of the population, expressed as a change in morpho-physiological states. © 2018 The Authors, published by EDP Sciences.The work was supported by the Ministry of Education and Science of the Russian Federation (project No. 3.6121.210 )7 and R FFI №16-34-015 92 grant s. e tW hank R ndrA ade, Iu. Novoselova and I.V. Beketov for special support. Selected measurements were made at ISG KER services UPV/EHU

Inflammatory markers in cystic fibrosis patients with lung Pseudomonas aeruginosa infection.

Chronic endobronchial inflammation and bacterial infection are the main causes of morbidity and mortality in cystic fibrosis (CF), an autosomal recessive genetic disorder associated with improper function of chloride channels. Inflammation in CF lung is greatly amplified after Pseudomonas aeruginosa infection. In this study the relationship between P. aeruginosa status and inflammatory markers has been investigated. Seventeen CF children in acute lung exacerbation were examined. CF patients without P. aeruginosa infection were characterized by elevated activity of sputum elastase, reduced response of peripheral blood lymphocytes to PHA and significant resistance to the antiproliferative action of glucocorticoids. These parameters were normalized after antibiotic treatment. The patients with prolonged P. aeruginosa infection demonstrated extremely high levels of elastase activity and elevated amounts of sputum IL-8 and TNF-alpha. Although antibiotic treatment resulted in clinical improvement, it failed to suppress excessive immune response in the lung. The data indicate that CF patients with prolonged P. aeruginosa need the modified treatment, which should include immunomodulating drugs and protease inhibitors as well as antibacterial therapy

OLYMPIC SPORT AS A SOFT POWER INSTRUMENT IN POLITICS

Статья посвящена влиянию допинговых скандалов на политические процессы. Они рассмотрены как инструмент политического давления на примере олимпийских игр в Сочи, Рио-де-Жанейро, Пченчхане и Пекине.The article is devoted to the impact of doping scandals on political processes. They are considered as an instrument of political pressure on the example of the Olympic Games in Sochi, Rio de Janeiro, Pyeongchang and Beijing