Bronchiectasis as long-term complication of acute fire smoke inhalation?

In this letter to editor, we discuss the occurrence of radiological and clinical evidence of bronchiectasis syndrome three years after acute exposure to fire smoke in a Caucasian non-smoker asthmatic patient

DMTs and Covid-19 severity in MS: a pooled analysis from Italy and France

We evaluated the effect of DMTs on Covid-19 severity in patients with MS, with a pooled-analysis of two large cohorts from Italy and France. The association of baseline characteristics and DMTs with Covid-19 severity was assessed by multivariate ordinal-logistic models and pooled by a fixed-effect meta-analysis. 1066 patients with MS from Italy and 721 from France were included. In the multivariate model, anti-CD20 therapies were significantly associated (OR = 2.05, 95%CI = 1.39–3.02, p < 0.001) with Covid-19 severity, whereas interferon indicated a decreased risk (OR = 0.42, 95%CI = 0.18–0.99, p = 0.047). This pooled-analysis confirms an increased risk of severe Covid-19 in patients on anti-CD20 therapies and supports the protective role of interferon

Trends in sexual orientation in Brazil = Tendências da orientação sexual no Brasil = Tendencias de orientación sexual en Brasil

Avaliou-se a prevalência de identidades sexuais em homens e mulheres de diferentes gerações com base em cinco categorias (heterossexuais, predominantemente heterossexuais, bissexuais, predominantemente homossexuais e homossexuais) e aferiu-se a ideação e comportamentos homoeróticos em heterossexuais. A coleta de dados foi realizada por meio de questionários de autorrelato disponibilizados em um sitio de pesquisa na Internet. Dados de 41. 873 Brasileiros foram colhidos e analisados. Do total, 78. 2% dos homens e 89. 8% das mulheres se declaram heterossexuais, a minoria sexual mais prevalente foi a de homossexuais (4. 6%) e de predominantemente heterossexuais (4. 1%). Ideação e comportamentos homoeróticos em heterossexuais foram frequentes e diferenças entre homens e mulheres foram robustas. Não heterossexualidades foram mais prevalentes em gerações mais joven

Trends in sexual orientation in Brazil

The current study aimed to evaluate the prevalence of sexual identities in Brazil across age and sex based on five categories (heterosexuals, mostly heterosexuals, bisexual, mostly homosexuals, and homosexuals) and to assess homoerotic ideation and behavior in heterosexuals. The data were collected using self-report questionnaires in a research website. Data from 41,873 participants were collected and analyzed. From total sample, 78.2% of males and 89.8% of females self-declared to be heterosexuals. The most prevalent minorities were homosexuals (4.6%) and mostly heterosexuals (4.1%). Same-sex ideation and behavior among heterosexuals was frequent and gender differences were robust. Orientation identities other than substantial heterosexuals seem to be more prevalent in the younger generations.Avaliou-se a prevalência de identidades sexuais em homens e mulheres de diferentes gerações com base em cinco categorias (heterossexuais, predominantemente heterossexuais, bissexuais, predominantemente homossexuais e homossexuais) e aferiu-se a ideação e comportamentos homoeróticos em heterossexuais. A coletada de dados foi realizada por meio de questionários de autorrelato disponibilizados em um sitio de pesquisa na Internet. Dados de 41.873 Brasileiros foram colhidos e analisados. Do total, 78.2% dos homens e 89.8% das mulheres se declaram heterossexuais, a minoria sexual mais prevalente foi a de homossexuais (4.6%) e de predominantemente heterossexuais (4.1%). Ideação e comportamentos homoeróticos em heterossexuais foram frequentes e diferenças entre homens e mulheres foram robustas. Não heterossexualidades foram mais prevalentes em gerações mais jovens.Se evaluó la prevalencia de las identidades sexuales en hombres y mujeres de diferentes generaciones sobre la base de las cinco categorías (heterosexuales, predominantemente heterosexuales, bisexuales, predominantemente homosexuales y homosexuales) y la ideación y conductas homoeróticas fueran evaluadas en heterosexuales. Los datos fueron recolectados a través de cuestionarios de autorrelato en un sitio de pesquisa en la Internet. Se recogieron y analizaron datos de 41.873 brasileños. Del total, el 78,2% de hombres y 89,8% de las mujeres dicen que son heterosexuales, la minoría sexual más prevalente era homosexual (4,6%) y predominantemente heterosexual (4,1%). Ideación y conductas homoeróticas en heterosexuales fueran comunes y las diferencias entre hombres y mujeres fueran robustas. Identidades non heterosexuales fueron más prevalentes en las generaciones más jóvenes

Arterial blood gas analysis in breath-hold divers at depth

The present study aimed to evaluate the partial pressure of arterial blood gases in breath-hold divers performing a submersion at 40 m. Eight breath-hold divers were enrolled for the trials held at "Y-40 THE DEEP JOY" pool (Montegrotto Terme, Padova, Italy). Prior to submersion, an arterial cannula in the radial artery of the non-dominant limb was positioned. All divers performed a sled-assisted breath-hold dive to 40 m. Three blood samplings occurred: at 10 min prior to submersion, at 40 m depth, and within 2 min after diver's surfacing and after resuming normal ventilation. Blood samples were analyzed immediately on site. Six subjects completed the experiment, without diving-related problems. The theoretically predicted hyperoxia at the bottom was observed in 4 divers out of 6, while the other 2 experienced a reduction in the partial pressure of oxygen (paO2) at the bottom. There were no significant increases in arterial partial pressure of carbon dioxide (paCO2) at the end of descent in 4 of 6 divers, while in 2 divers paCO2 decreased. Arterial mean pH and mean bicarbonate (HCO3-) levels exhibited minor changes. There was a statistically significant increase in mean arterial lactate level after the exercise. Ours was the first attempt to verify real changes in blood gases at a depth of 40 m during a breath-hold descent in free-divers. We demonstrated that, at depth, relative hypoxemia can occur, presumably caused by lung compression. Also, hypercapnia exists at depth, to a lesser degree than would be expected from calculations, presumably because of pre-dive hyperventilation and carbon dioxide distribution in blood and tissues