Nyilvános diplomácia = Public diplomacy

A kutatás újszerűsége magának a témának is köszönhető, hiszen a modern nyilvános diplomácia tematikájával magyar szakirodalomban elvétve találkozhatunk. Tehát egyrészt a komplex elméleti-gyakorlati eredményeknek az összességét tekinthetjük tudományos eredménynek, másrészt pedig a kutatás újszerű produktumát, nevezetesen egy hatékony magyar nyilvános diplomácia kialakításához szükséges módszertan kidolgozását. A kutatás elméleti jelentősége azon kommunikációs szegmens meghatározása, mely a magyar nyilvános diplomácia sarokköve lehet, illetve annak bemutatása, hogy a nyilvános diplomáciában fontos a belföldre és külföldre szóló üzenetek összehangolása, hiszen ezek nem választhatók szét, együttesen alakítják az országról kialakult képet. Gyakorlati jelentősége a nyilvános diplomácia tematikájának megjelenése a magyar szakirodalomban és felsőoktatásban, mely a szerző reményei szerint a magyar szakembereket, illetve a nemzetközi kapcsolatok képzésben résztvevő hallgatókat további kutatásokra ösztönözheti

AMP-activated kinase (AMPK) activation by AICAR in human white adipocytes derived from pericardial white adipose tissue stem cells induces a partial beige-like phenotype

Beige adipocytes are special cells situated in the white adipose tissue. Beige adipocytes, lacking thermogenic cues, morphologically look quite similar to regular white adipocytes, but with a markedly different response to adrenalin. White adipocytes respond to adrenergic stimuli by enhancing lipolysis, while in beige adipocytes adrenalin induces mitochondrial biogenesis too. A key step in the differentiation and function of beige adipocytes is the deacetylation of peroxisome proliferator-activated receptor (PPARγ) by SIRT1 and the consequent mitochondrial biogenesis. AMP-activated protein kinase (AMPK) is an upstream activator of SIRT1, therefore we set out to investigate the role of AMPK in beige adipocyte differentiation using human adipose-derived mesenchymal stem cells (hADMSCs) from pericardial adipose tissue. hADMSCs were differentiated to white and beige adipocytes and the differentiation medium of the white adipocytes was supplemented with 100 μM [(2R,3S,4R,5R)-5-(4-Carbamoyl-5-aminoimidazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate (AICAR), a known activator of AMPK. The activation of AMPK with AICAR led to the appearance of beige-like morphological properties in differentiated white adipocytes. Namely, smaller lipid droplets appeared in AICAR-treated white adipocytes in a similar fashion as in beige cells. Moreover, in AICAR-treated white adipocytes the mitochondrial network was more fused than in white adipocytes; a fused mitochondrial system was characteristic to beige adipocytes. Despite the morphological similarities between AICAR-treated white adipocytes and beige cells, functionally AICAR-treated white adipocytes were similar to white adipocytes. We were unable to detect increases in basal or cAMP-induced oxygen consumption rate (a marker of mitochondrial biogenesis) when comparing control and AICAR-treated white adipocytes. Similarly, markers of beige adipocytes such as TBX1, UCP1, CIDEA, PRDM16 and TMEM26 remained the same when comparing control and AICAR-treated white adipocytes. Our data point out that in human pericardial hADMSCs the role of AMPK activation in controlling beige differentiation is restricted to morphological features, but not to actual metabolic changes

Impact of safety-related dose reductions or discontinuations on sustained virologic response in HCV-infected patients: Results from the GUARD-C Cohort

BACKGROUND: Despite the introduction of direct-acting antiviral agents for chronic hepatitis C virus (HCV) infection, peginterferon alfa/ribavirin remains relevant in many resource-constrained settings. The non-randomized GUARD-C cohort investigated baseline predictors of safety-related dose reductions or discontinuations (sr-RD) and their impact on sustained virologic response (SVR) in patients receiving peginterferon alfa/ribavirin in routine practice. METHODS: A total of 3181 HCV-mono-infected treatment-naive patients were assigned to 24 or 48 weeks of peginterferon alfa/ribavirin by their physician. Patients were categorized by time-to-first sr-RD (Week 4/12). Detailed analyses of the impact of sr-RD on SVR24 (HCV RNA <50 IU/mL) were conducted in 951 Caucasian, noncirrhotic genotype (G)1 patients assigned to peginterferon alfa-2a/ribavirin for 48 weeks. The probability of SVR24 was identified by a baseline scoring system (range: 0-9 points) on which scores of 5 to 9 and <5 represent high and low probability of SVR24, respectively. RESULTS: SVR24 rates were 46.1% (754/1634), 77.1% (279/362), 68.0% (514/756), and 51.3% (203/396), respectively, in G1, 2, 3, and 4 patients. Overall, 16.9% and 21.8% patients experienced 651 sr-RD for peginterferon alfa and ribavirin, respectively. Among Caucasian noncirrhotic G1 patients: female sex, lower body mass index, pre-existing cardiovascular/pulmonary disease, and low hematological indices were prognostic factors of sr-RD; SVR24 was lower in patients with 651 vs. no sr-RD by Week 4 (37.9% vs. 54.4%; P = 0.0046) and Week 12 (41.7% vs. 55.3%; P = 0.0016); sr-RD by Week 4/12 significantly reduced SVR24 in patients with scores <5 but not 655. CONCLUSIONS: In conclusion, sr-RD to peginterferon alfa-2a/ribavirin significantly impacts on SVR24 rates in treatment-naive G1 noncirrhotic Caucasian patients. Baseline characteristics can help select patients with a high probability of SVR24 and a low probability of sr-RD with peginterferon alfa-2a/ribavirin

Expression Patterns of Coagulation Factor XIII Subunit A on Leukemic Lymphoblasts Correlate with Clinical Outcome and Genetic Subtypes in Childhood B-cell Progenitor Acute Lymphoblastic Leukemia

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The effects of TNF-alpha inhibitor therapy on the incidence of infection in JIA children

Juvenile Idiopathic arthritis (JIA) is the most common chronic rheumatic disease in childhood. The diagnosis is based on the underlying symptoms of arthritis with an exclusion of other diseases Biologic agents are increasingly used on the side of disease-modifying anti-rheumatic drugs (DMARD) in JIA treatment.The aim of this meta-analysis was to investigate the observed infections in JIA children during tumor necrosis factor (TNF)-alpha inhibitor therapy. A systematic search of three databases (Medline via PubMed, Embase, Cochrane Library) was carried out up to May 2018. Published trials that evaluated the infectious adverse events in patients receiving TNF-alpha inhibitor vs. a control group were included in the analysis. Full-text data extraction was carried out independently by the investigators from ten relevant publications. 1434 patients received TNF-alpha inhibitor therapy; the control group consisted of 696 subjects. The analysis presented the risk of infection in the active treatment group (OR = 1.13; 95% CI: 0.76-1.69; p = 0.543). The majority of infections were upper respiratory tract infections (URTIs). Furthermore, the subgroup analysis demonstrated a higher infection rate in the observed localization.Anti-TNF therapy slightly but not significantly increases the incidence of infection in JIA children compared to other therapies (GRADE: moderate evidence). The most common infections reported were mild URTIs. Further studies with larger patients number with a strong evidence level are crucially needed to finalize the answer whether anti-TNF therapy elevates and if yes on what extent the incidence of infection in JIA children.Prospero: CRD42017067873

Evaluation of a Partial Genome Screening of Two Asthma Susceptibility Regions Using Bayesian Network Based Bayesian Multilevel Analysis of Relevance

Genetic studies indicate high number of potential factors related to asthma. Based on earlier linkage analyses we selected the 11q13 and 14q22 asthma susceptibility regions, for which we designed a partial genome screening study using 145 SNPs in 1201 individuals (436 asthmatic children and 765 controls). The results were evaluated with traditional frequentist methods and we applied a new statistical method, called Bayesian network based Bayesian multilevel analysis of relevance (BN-BMLA). This method uses Bayesian network representation to provide detailed characterization of the relevance of factors, such as joint significance, the type of dependency, and multi-target aspects. We estimated posteriors for these relations within the Bayesian statistical framework, in order to estimate the posteriors whether a variable is directly relevant or its association is only mediated. With frequentist methods one SNP (rs3751464 in the FRMD6 gene) provided evidence for an association with asthma (OR = 1.43(1.2–1.8); p = 3×10−4). The possible role of the FRMD6 gene in asthma was also confirmed in an animal model and human asthmatics. In the BN-BMLA analysis altogether 5 SNPs in 4 genes were found relevant in connection with asthma phenotype: PRPF19 on chromosome 11, and FRMD6, PTGER2 and PTGDR on chromosome 14. In a subsequent step a partial dataset containing rhinitis and further clinical parameters was used, which allowed the analysis of relevance of SNPs for asthma and multiple targets. These analyses suggested that SNPs in the AHNAK and MS4A2 genes were indirectly associated with asthma. This paper indicates that BN-BMLA explores the relevant factors more comprehensively than traditional statistical methods and extends the scope of strong relevance based methods to include partial relevance, global characterization of relevance and multi-target relevance

How introduction of deposit-refund system (DRS) changes recycling of non-drinking bottle PET wastes

Under the era of circular economy, the deposit-refund system (DRS) for e.g. polyethylene terephthalate (PET) is thought to be a good choice to achieve a more structured plastic recycling. The present research has the aim to make a comprehensive description and a practical guideline in order to evaluate how collection and separation system influence the quality and efficiency of mechanical recycling of PET. The DRS has been symbolized by manually collected bottles with (BCL) and without (B) caps and labels. Samples have been given from the selective income (SI) and the sorting residue (SR) of a manual selective waste sorting plant and PET fraction of refuse derived fuel (RDF). Based on preliminary qualification results such as melt flow indices (MFI), PET bottles are worth selecting into the main colours like water clear, blue, and all the others together, referred to as PET-A, PET-B, and PET-D fractions of the sorting plant. The SR seemed to be a beneficial raw material for PET recycling as both mechanical and rheological properties were proper enough. PET separated from the Mechanical Biological Treatment (MBT) plant as RDF showed the worst processing and mechanical properties, but both can be improved with deeper precleaning. X-ray tomography (CT) scans have shown a correlation between the source of waste and the gas void structure which influence the macroscopic mechanical properties

A 2018. évi országos kompetenciamérés eredményei Magyarországon - az SNI-vel és BTM-mel diagnosztizált 6., 8., 10. évfolyamos gyermekek körében

A tanulmány egyik célja a 2018-es Országos kompetenciamérés eredményeinek ismertetése, a beilleszkedési tanulási és magatartás zavaros (BTM) tanulók és a sajátos nevelésű tanulók (SNI) egy csoportjának szempontjából, másik kiemelten fontos célja pedig a BTM kóddal rendelkező gyerekek előfordulási arányának elemzése megyei bontásban. A szerzők először röviden vázolják az alapfogalmakat, azzal a megjegyzéssel, hogy a részletes definíciók a témában 2017-ben keletkezett tanulmányban találhatóak meg. Ezután az előző munkapublikálása óta megjelent idevágó közleményeket ismertetik. Ezt követően bemutatják a 2018-as mintában a BTM alcsoportok előfordulásai arányait megyei bontásban. A megyei bontás csak részbenhozta a várt eredményeket, hiszen valóban vannak különbözőségek, de ezek nem a várt mintázatot mutatják. A diszkusszióban ennek tárgyalása, illetve a BTM-s és SNI-s gyerekek iskolai lemaradásának csökkentést szolgáló stratégiák tárgyalása található. Hosszú távú célunk elindítani egy több írásból álló sorozatot, melynek elméleti alapját jelen tanulmányban vezettünk fel azzal, hogy elemeztük a BTM-es országos adatokat. A következő írásban az SNI-s adatok, majd az ADHD-s adatok regionális bemutatását tervezzük. A szerzők a tanulmány alapjául szolgáló kutatást az Országoskompetenciaméréskutatócsoport 20642B800 témaszámú, a Károli Gáspár Református Egyetem Bölcsészet-és Társadalomtudományi Kara által finanszírozott pályázat keretében végezték.Dolgozatunk mellékleteként angol nyelven is közöljük tanulmányunkat