1,378 research outputs found
Complex networks created by aggregation
We study aggregation as a mechanism for the creation of complex networks. In
this evolution process vertices merge together, which increases the number of
highly connected hubs. We study a range of complex network architectures
produced by the aggregation. Fat-tailed (in particular, scale-free)
distributions of connections are obtained both for networks with a finite
number of vertices and growing networks. We observe a strong variation of a
network structure with growing density of connections and find the phase
transition of the condensation of edges. Finally, we demonstrate the importance
of structural correlations in these networks.Comment: 12 pages, 13 figure
A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation
Like Bcl-2, Mcl-1 is an important survival factor for many cancers, its expression contributing to chemoresistance and disease relapse. However, unlike other prosurvival Bcl-2âlike proteins, Mcl-1 stability is acutely regulated. For example, the Bcl-2 homology 3 (BH3)âonly protein Noxa, which preferentially binds to Mcl-1, also targets it for proteasomal degradation. In this paper, we describe the discovery and characterization of a novel BH3-like ligand derived from Bim, BimS2A, which is highly selective for Mcl-1. Unlike Noxa, BimS2A is unable to trigger Mcl-1 degradation, yet, like Noxa, BimS2A promotes cell killing only when Bcl-xL is absent or neutralized. Furthermore, killing by endogenous Bim is not associated with Mcl-1 degradation. Thus, functional inactivation of Mcl-1 does not always require its elimination. Rather, it can be efficiently antagonized by a BH3-like ligand tightly engaging its binding groove, which is confirmed here with a structural study. Our data have important implications for the discovery of compounds that might kill cells whose survival depends on Mcl-1
Anti-Nirvana: crime, culture and instrumentalism in the age of insecurity
âAnti-Nirvanaâ explores the relationship between consumer culture, media and criminal motivations. It has appeared consistently on the list of the top-ten most-read articles in this award-winning international journal, and it mounts a serious neo-Freudian challenge to the predominant naturalistic notion of âresistanceâ at the heart of liberal criminology and media studies. It is also cited in the Oxford Handbook of Criminology and other criminology texts as a persuasive argument in support of the theory that criminality amongst young people is strongly linked to the acquisitive values of consumerism and the images of possessive individualism that dominate mass media
Autoantibodies Produced at the Site of Tissue Damage Provide Evidence of Humoral Autoimmunity in Inclusion Body Myositis
Inclusion body myositis (IBM) belongs to a group of muscle diseases known as the inflammatory myopathies. The presence of antibody-secreting plasma cells in IBM muscle implicates the humoral immune response in this disease. However, whether the humoral immune response actively contributes to IBM pathology has not been established. We sought to investigate whether the humoral immune response in IBM both in the periphery and at the site of tissue damage was directed towards self-antigens. Peripheral autoantibodies present in IBM serum but not control serum recognized self-antigens in both muscle tissue and human-derived cell lines. To study the humoral immune response at the site of tissue damage in IBM patients, we isolated single plasma cells directly from IBM-derived muscle tissue sections and from these cells, reconstructed a series of recombinant immunoglobulins (rIgG). These rIgG, each representing a single muscle-associated plasma cell, were examined for reactivity to self-antigens. Both, flow cytometry and immunoblotting revealed that these rIgG recognized antigens expressed by cell lines and in muscle tissue homogenates. Using a mass spectrometry-based approach, Desmin, a major intermediate filament protein, expressed abundantly in muscle tissue, was identified as the target of one IBM muscle-derived rIgG. Collectively, these data support the view that IBM includes a humoral immune response in both the periphery and at the site of tissue damage that is directed towards self-antigens
Two-Proton Correlations near Midrapidity in p+Pb and S+Pb Collisions at the CERN SPS
Correlations of two protons emitted near midrapidity in p+Pb collisions at
450 GeV/c and S+Pb collisions at 200A GeV/c are presented, as measured by the
NA44 Experiment. The correlation effect, which arises as a result of final
state interactions and Fermi-Dirac statistics, is related to the space-time
characteristics of proton emission. The measured source sizes are smaller than
the size of the target lead nucleus but larger than the sizes of the
projectiles. A dependence on the collision centrality is observed; the source
size increases with decreasing impact parameter. Proton source sizes near
midrapidity appear to be smaller than those of pions in the same interactions.
Quantitative agreement with the results of RQMD (v1.08) simulations is found
for p+Pb collisions. For S+Pb collisions the measured correlation effect is
somewhat weaker than that predicted by the model simulations, implying either a
larger source size or larger contribution of protons from long-lived particle
decays.Comment: 10 pages (LaTeX) text, 4 (EPS) figures; accepted for publication in
Phys. Lett.
Strange Meson Enhancement in PbPb Collisions
The NA44 Collaboration has measured yields and differential distributions of
K+, K-, pi+, pi- in transverse kinetic energy and rapidity, around the
center-of-mass rapidity in 158 A GeV/c Pb+Pb collisions at the CERN SPS. A
considerable enhancement of K+ production per pi is observed, as compared to
p+p collisions at this energy. To illustrate the importance of secondary hadron
rescattering as an enhancement mechanism, we compare strangeness production at
the SPS and AGS with predictions of the transport model RQMD.Comment: 11 pages, including 4 figures, LATE
Living for the weekend: youth identities in northeast England
Consumption and consumerism are now accepted as key contexts for the construction of youth identities in de-industrialized Britain. This article uses empirical evidence from interviews with young people to suggest that claims of `new community' are overstated, traditional forms of friendship are receding, and increasingly atomized and instrumental youth identities are now being culturally constituted and reproduced by the pressures and anxieties created by enforced adaptation to consumer capitalism. Analysis of the data opens up the possibility of a critical rather than a celebratory exploration of the wider theoretical implications of this process
One and two dimensional analysis of 3pi correlations measured in Pb+Pb interactions
3pi- correlations from Pb+Pb collisions at 158 GeV/c per nucleon are
presented as measured by the focusing spectrometer of the NA44 experiment at
CERN. The three-body effect is found to be stronger for PbPb than for SPb. The
two-dimensional three-particle correlation function is also measured and the
longitudinal extension of the source is larger than the transverse extension
Use of conventional and alternative treatment strategies for a case of low back pain in a F/A-18 aviator
BACKGROUND: Low back pain can diminish jet pilot concentration and function during flight and be severe enough to ground pilots or cause decreased flying time. The objective of this case report is to present an example of the integration of chiropractic care with conventional treatments for the management of low back pain in a F/A-18 aviator. CASE PRESENTATION: The patient had insidious severe low back pain without radiation or neurological deficit, resulting in 24 hours of hospitalization. Spinal degeneration was discovered upon imaging. Four months later, it still took up to 10 minutes for him to get out of bed and several minutes to exit the jet due to stiffness and pain. He had discontinued his regular Marine Corps fitness training due to pain avoidance. Pain severity ranged from 1.5â7.1 cm on a visual analog scale. His Roland Morris Disability Questionnaire score was 5 out of 24. The pilot's pain was managed with the coordinated efforts of the flight surgeon, physiatrist, physical therapist, and doctor of chiropractic. Following this regimen he had no pain and no functional disability; he was able to fly multiple training missions per week and exercise to Marine Corps standards. CONCLUSION: A course of care integrating flight medicine, chiropractic, physical therapy, and physiatry appeared to alleviate pain and restore function to this F/A-18 aviator with low back pain
Two-kaon correlations in central Pb + Pb collisions at 158 A GeV/c
Two-particle interferometry of positive kaons is studied in Pb + Pb
collisions at mean transverse momenta and 0.91 GeV/c. A
three-dimensional analysis was applied to the lower data, while a
two-dimensional analysis was used for the higher data. We find that the
source size parameters are consistent with the scaling curve observed in
pion correlation measurements in the same collisions, and that the duration
time of kaon emission is consistent with zero within the experimental
sensitivity.Comment: 4 pages incl. 1 table and 3 fig's; RevTeX; accepted for publication
in PR
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