11,114 research outputs found

    On the positive mass theorem for manifolds with corners

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    We study the positive mass theorem for certain non-smooth metrics following P. Miao's work. Our approach is to smooth the metric using the Ricci flow. As well as improving some previous results on the behaviour of the ADM mass under the Ricci flow, we extend the analysis of the zero mass case to higher dimensions.Comment: 21 pages, incorporated referee's comment

    Flux-flow in d-wave superconductors: Low temperature universality and scaling

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    We demonstrate that superclean d-wave superconductors display a novel type of vortex dynamics: At low temperatures, both dissipative and transverse components of the flux-flow conductivity are found to approach universal values even in the limit of infinite relaxation time. A finite dissipation in the superclean limit is explained in terms of the Landau damping on zero-frequency vortex modes which appear due to minigap nodes in the bound-state spectrum in the vortex core. In the moderately clean regime the scaling law at low T and low field is obtained.Comment: RevTex file, 4 pages, no figures, submitted to Phys. Rev. Lett., revised after referee report

    Theoretical and Experimental Studies of Schottky Diodes That Use Aligned Arrays of Single Walled Carbon Nanotubes

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    We present theoretical and experimental studies of Schottky diodes that use aligned arrays of single walled carbon nanotubes. A simple physical model, taking into account the basic physics of current rectification, can adequately describe the single-tube and array devices. We show that for as grown array diodes, the rectification ratio, defined by the maximum-to-minimum-current-ratio, is low due to the presence of m-SWNT shunts. These tubes can be eliminated in a single voltage sweep resulting in a high rectification array device. Further analysis also shows that the channel resistance, and not the intrinsic nanotube diode properties, limits the rectification in devices with channel length up to ten micrometer.Comment: Nano Research, 2010, accepte

    Absence of toll-like receptor 4 (TLR4) extends survival in the hSOD1<sup>G93A</sup> mouse model of amyotrophic lateral sclerosis

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    Background: Amyotrophic lateral sclerosis (ALS) is a devastating late onset neurodegenerative disorder that is characterised by the progressive loss of upper and lower motor neurons. The mechanisms underlying ALS pathogenesis are unclear; however, there is emerging evidence the innate immune system, including components of the toll-like receptor (TLR) system, may drive disease progression. For example, toll-like receptor 4 (TLR4) antagonism in a spontaneous 'wobbler mouse' model of ALS increased motor function, associated with a decrease in microglial activation. This study therefore aimed to extend from these findings and determine the expression and function of TLR4 signalling in hSOD1(G93A) mice, the most widely established preclinical model of ALS

    BHDPC Is a Novel Neuroprotectant That Provides Anti-neuroinflammatory and Neuroprotective Effects by Inactivating NF-κB and Activating PKA/CREB.

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    Microglia-mediated neuroinflammatory responses are inevitable and important pathological processes in several kinds of disorder of the central nervous system (CNS). Therefore, alleviating activated microglia-induced inflammatory process might be a valuable therapeutic approach to neuroinflammation-related diseases. In the present study, we investigated BHDPC, a novel neuroprotectant discovered in our previous study that had anti-inflammatory effects under neuroinflammatory conditions. First, we found that BHDPC could inhibit neuroinflammatory responses and promote microglial M2 phenotype polarization in both lipopolysaccharide (LPS)-activated BV-2 microglia l cells. Furthermore, BHDPC provided protective actions against neuroinflammation-induced neurotoxicity in HT22 mouse hippocampal cells co-cultured with activated BV-2 microglia. Further experiments demonstrated that BHDPC could suppress LPS-induced activation of transcription factor nuclear factor kappa B (NF-κB) via interfering with the degradation of the inhibitor of kappa B (IκB) and phosphorylation of IκB, the IκB kinase (IKK). Moreover, we also found that BHDPC could induce phosphorylation of cAMP-dependent protein kinase A (PKA) and cAMP-response element-binding protein (CREB) in BV-2 microglial cells. Also, using the PKA-specific inhibitor, we found that BHDPC-induced CREB phosphorylation was dependent on PKA, which also contributed to BHDPC-mediated anti-inflammation and neuroprotection

    Observation of Collective Excitations of the Dilute 2D Electron System

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    We report inelastic light scattering measurements of dispersive spin and charge density excitations in dilute 2D electron systems reaching densities less than 10^{10} cm^{-2}. In the quantum Hall state at nu=2, roton critical points in the spin inter--Landau level mode show a pronounced softening as r_s is increased. Instead of a soft mode instability predicted by Hartree--Fock calculations for r_s ~ 3.3, we find evidence of multiple rotons in the dispersion of the softening spin excitations. Extrapolation of the data indicates the possibility of an instability for r_s >~ 11.Comment: Submitted to Physical Review Letter

    A Wide Field Survey of Satellite Galaxies around the Spiral Galaxy M106

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    We present a wide field survey of satellite galaxies in M106 (NGC 4258) covering a 1.7\degr \times 2\degr field around M106 using Canada-France-Hawaii Telescope/MegaCam. We find 16 satellite galaxy candidates of M106. Eight of these galaxies are found to be dwarf galaxies that are much smaller and fainter than the remaining galaxies. Four of these galaxies are new findings. Surface brightness profiles of 15 out of 16 satellite galaxies can be represented well by an exponential disk profile with varying scale length. We derive the surface number density distribution of these satellite galaxies. The central number density profile (d <100<100 kpc) is well fitted by a power-law with a power index of −2.1±0.5-2.1\pm0.5, similar to the expected power index of isothermal distribution. The luminosity function of these satellites is represented well by the Schechter function with a faint end slope of −1.19−0.06+0.03-1.19^{+0.03}_{-0.06}. Integrated photometric properties (total luminosity, total colour, and disk scale length) and the spatial distribution of these satellite galaxies are found to be roughly similar to those of the Milky Way and M31.Comment: Accepted by MNRA

    Topological Nature of Anomalous Hall Effect in Ferromagnet

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    The anomalous Hall effect in two-dimensional ferromagnets is discussed to be the physical realization of the parity anomaly in (2+1)D, and the band crossing points behave as the topological singularity in the Brillouin zone. This appears as the sharp peaks and the sign changes of the transverse conductance σxy\sigma_{xy} as a function of the Fermi energy and/or the magnetization. The relevance to the experiments including the three dimensional systems is also discussed.Comment: LaTeX 13 pages, 3 figure

    Risk stratification for progression of IgA nephropathy using a decision tree induction algorithm

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    Background. Immunoglobulin A nephropathy (IgAN) is the most common form of glomerulonephritis, and many patients are at risk of at least slow progression. However, prediction of the renal outcome in individual patients remains difficult
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