13 research outputs found
Genetic Diversity and Population Structure in South African, French and Argentinian Angora Goats from Genome-Wide SNP Data.
The Angora goat populations in Argentina (AR), France (FR) and South Africa (SA) have been kept geographically and genetically distinct. Due to country-specific selection and breeding strategies, there is a need to characterize the populations on a genetic level. In this study we analysed genetic variability of Angora goats from three distinct geographical regions using the standardized 50k Goat SNP Chip. A total of 104 goats (AR: 30; FR: 26; SA: 48) were genotyped. Heterozygosity values as well as inbreeding coefficients across all autosomes per population were calculated. Diversity, as measured by expected heterozygosity (HE) ranged from 0.371 in the SA population to 0.397 in the AR population. The SA goats were the only population with a positive average inbreeding coefficient value of 0.009. After merging the three datasets, standard QC and LD-pruning, 15 105 SNPs remained for further analyses. Principal component and clustering analyses were used to visualize individual relationships within and between populations. All SA Angora goats were separated from the others and formed a well-defined, unique cluster, while outliers were identified in the FR and AR breeds. Apparent admixture between the AR and FR populations was observed, while both these populations showed signs of having some common ancestry with the SA goats. LD averaged over adjacent loci within the three populations per chromosome were calculated. The highest LD values estimated across populations were observed in the shorter intervals across populations. The Ne for the Angora breed was estimated to be 149 animals ten generations ago indicating a declining trend. Results confirmed that geographic isolation and different selection strategies caused genetic distinctiveness between the populations
angora_plos
Genotyping data of 104 angora goats (30 from Argentina, 26 from France and 48 from South Africa) genotyped with the standardized 50k Goat SNP Chip. Date file is made of 5 colums: 1st Column -> country code (AR -> Argentina, FR -> France, ZA -> South Africa); 2nd column -> Individual ID; 3rd column -> snp name; 4th column ->: allel 1 ; 5th column -> allel 2
Population structure plot for K = 3 (Green: SA Angora, Blue: Argentinian Angora, Red: French Angora).
<p>Population structure plot for K = 3 (Green: SA Angora, Blue: Argentinian Angora, Red: French Angora).</p
Trends in historic effective population size (N<sub>e</sub>).
<p>Trends in historic effective population size (N<sub>e</sub>).</p
Summary statistics for the three separate Angora sub-populations and the merged Angora population.
<p>Summary statistics for the three separate Angora sub-populations and the merged Angora population.</p
A cross-validation plot, indicating the choice of the appropriate K-value.
<p>A cross-validation plot, indicating the choice of the appropriate K-value.</p
Mean pairwise linkage disequilibrium (LD) estimates for different inter-SNP distance intervals.
<p>Mean pairwise linkage disequilibrium (LD) estimates for different inter-SNP distance intervals.</p
Linkage disequilibrium (LD) statistics per chromosome.
<p>Linkage disequilibrium (LD) statistics per chromosome.</p