Precision in Imaging Multivariate Optical Computing

Multivariate optical computing (MOC) is a method of performing chemical analysis using a multilayer thin-film structure known as a multivariate optical element (MOE). Recently we have been advancing MOC for imaging problems by using an imaging MOE (IMOE) in a normal-incidence geometry and employing normalization by the 1-norm. There are several important differences between the previously described 45° and the normal-incidence imaging, one of which is the measurement precision due to photon counting. We compare this precision to 45° MOC. We also discuss how MOE models with similar values of standard errors of calibration and prediction and similar gain values may vary in precision because of the sign or offset of the regression vector encoded in the IMOE spectrum. Experimental verification of a key result is provided by near-infrared imaging of slides coated with a dye-doped polymer film

Energy poverty and indoor cooling: an overlooked issue in Europe

Conceptually, many energy poverty studies to date have been narrowly focused on inadequate indoor heating, paying little attention to other domestic energy services. Yet there are indications that a growing number of households in Europe are struggling to achieve adequate levels of indoor cooling, with adverse consequences for their health, well-being and productivity. This situation is exacerbated by changing global weather patterns, with many countries facing increases in the frequency and intensity of extreme heatwaves. There is limited understanding of the ways in which households respond to extreme heat, and consequently how this might create greater demand for indoor space cooling and air conditioning, and the consequences for increased stress on power grids and conflicts with carbon reduction goals. Using custom-built survey data collected from 2,337 households in Gdańsk (Poland), Prague (Czech Republic), Budapest (Hungary) and Skopje (FYR Macedonia), along with in-depth qualitative fieldwork with 55 households in the same cities, this paper presents novel evidence on the issue of summertime energy poverty and space cooling difficulties. We identify the driving forces of household vulnerability to excessive indoor heat, in terms of risk of exposure, adaptive capacity, and sensitivity, and explore the implications for addressing energy poverty

A cure-all for energy poverty? Thinking critically about energy advice

Dramatic increases in global energy prices in 2022 have sharpened focus on the suffering experienced by people living in energy poverty – a situation where they are unable to afford the energy required to meet their basic needs. In many countries, providing energy advice to householders is part of a wider strategy to assist those who are experiencing such hardship. However, little research scrutinises whether and how energy advice can be useful in reducing vulnerability to energy poverty. It is this research gap we address here. Drawing on an extensive qualitative dataset, we find that efforts to provide tailored, in-person advice can help to partially ameliorate energy poverty, but its impacts are limited by structural factors that are beyond the immediate influence of advisors or individual citizens. Energy advice should be seen as a supplement to, not a replacement for, more ambitious and transformative political action that addresses the structural and institutional drivers of inequality

Fuel poverty in the cost of living crisis

Access to energy is being severely restricted by the cost of living crisis, with almost a quarter of households experiencing fuel poverty, despite existing interventions. Here we draw on a large body of evidence on fuel poverty to summarise likely effects on households this winter. We find there is urgent need for further bill support, energy efficiency and targeted advice for vulnerable households

Phase 2 Study of Pomalidomide (CC-4047) Monotherapy for Children and Young Adults With Recurrent or Progressive Primary Brain Tumors

INTRODUCTION: Treatment of recurrent primary pediatric brain tumors remains a major challenge, with most children succumbing to their disease. We conducted a prospective phase 2 study investigating the safety and efficacy of pomalidomide (POM) in children and young adults with recurrent and progressive primary brain tumors. BACKGROUND: METHODS: Patients with recurrent and progressive high-grade glioma (HGG), diffuse intrinsic pontine glioma (DIPG), ependymoma, or medulloblastoma received POM 2.6 mg/m2/day (the recommended phase 2 dose [RP2D]) on days 1-21 of a 28-day cycle. A Simon’s Optimal 2-stage design was used to determine efficacy. Primary endpoints included objective response (OR) and long-term stable disease (LTSD) rates. Secondary endpoints included duration of response, progression-free survival (PFS), overall survival (OS), and safety. RESULTS: 46 patients were evaluable for response (HGG, n = 19; DIPG, ependymoma, and medulloblastoma, n = 9 each). Two patients with HGG achieved OR or LTSD (10.5% [95% CI, 1.3%-33.1%]; 1 partial response and 1 LTSD) and 1 patient with ependymoma had LTSD (11.1% [95% CI, 0.3%-48.2%]). There were no ORs or LTSD in the DIPG or medulloblastoma cohorts. The median PFS for patients with HGG, DIPG, ependymoma, and medulloblastoma was 7.86, 11.29, 8.43, and 8.43 weeks, respectively. Median OS was 5.06, 3.78, 12.02, and 11.60 months, respectively. Neutropenia was the most common grade 3/4 adverse event. CONCLUSIONS: Treatment with POM monotherapy did not meet the primary measure of success in any cohort. Future studies are needed to evaluate if POM would show efficacy in tumors with specific molecular signatures or in combination with other anticancer agents. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, identifier NCT03257631; EudraCT, identifier 2016-002903-25

An International Expert Delphi Consensus to Develop Dedicated Geriatric Radiation Oncology Curriculum Learning Outcomes.

PURPOSE: The management of older adults with cancer is rapidly becoming a significant challenge in radiation oncology (RO) practice. The education of future radiation oncologists in geriatric oncology is fundamental to ensuring that older adults receive high-quality care. Currently RO trainees receive little training and education in geriatric oncology. The objective of this study was to define core geriatric RO curriculum learning outcomes relevant to RO trainees worldwide. METHODS AND MATERIALS: A 2-stage modified Delphi consensus was conducted. Stage 1 involved the formation of an expert reference panel (ERP) of multiprofessional experts in geriatric oncology and/or RO and the compilation of a potential geriatric RO learning outcomes set. Stage 2 involved 3 iterative rounds: round 1 and round 2 (both online surveys), and an intervening ERP round. These aimed at identifying and refining ideal geriatric RO learning outcomes. Invited participants for round 1 and 2 included oncology health care professionals with expertise across RO, geriatric oncology, and/or education and consumers. Predefined Delphi consensus definitions were applied to the results of rounds 1 and 2. RESULTS: An ERP of 11 experts in geriatric oncology and/or RO was formed. Seventy potential knowledge- and skill-based learning outcomes were identified. In round 1, 103 of 179 invited eligible Delphi participants completed the survey (58% response rate). The ERP round was conducted, resulting in the exclusion of 28 learning outcomes. In round 2, 54 of 103 completed the survey (52% response rate). This identified a final total of 33 geriatric RO learning outcomes. CONCLUSIONS: The geriatric RO learning outcomes described in this study form an international consensus that can inform RO training bodies worldwide. This represents the first fundamental step in developing a global educational framework aimed at improving RO trainee knowledge and skills in geriatric oncology