The Barcan formula in metaphysics

La fórmula Barcan (FB) se considera por lo general una amenaza al realismo. Muestro de qué modo FB puede verse libre de esta imputación si se construye como un principio puente que conecte la modalidad "de dicto" y la modalidad "de re" al mismo tiempo que retiene un sentido russelliano robusto de realidad en cuestiones modales

Synthese von bicyclischen Lactonen aus Aldehyden und 2,5-Bis(trimethylsiloxy)thiophen

By reaction of 2,5-Bis(trimethylsiloxy)thiophene (3) with aldehydes (4) in presence of trimethylsilyl trifluoromethanesulfonate (1) 3,4-disubstituted thiosuccinic anhydrides (5) were obtained. Hydrolysis of the products 5 yields the bislactones 6, 7

Synthese von Trimethylsilylpropinsäure-trimethylsilylester

A new type of reaction, the «silylating decarboxylation», generates for example the polyfunctional derivative 1 from the silyl ester of α,β-unsaturated carboxylic acid 2

Rules and Self-Citation

I discuss a neglected solution to the skeptical problem introduced by Lewis Carroll’s “What the Tortoise Said to Achilles” (1895) in terms of a self-citational inferential license. I then consider some responses to this solution. The most significant response on behalf of the skeptic utilizes the familiar distinction between two ways of accepting a rule: as action-guiding and as a mere truth. I argue that this is ultimately unsatisfactory and conclude by opting for an alternative conception of rules as representations of behavior deployed for various purposes, some theoretical and others practical. This alternative conception does not allow the skeptical problem to get off the ground

Fregean Metasemantics

How the semantic significance of numerical discourse gets determined is a metasemantic issue par excellence. At the sub-sentential level, the issue is riddled with difficulties on account of the contested metaphysical status of the subject matter of numerical discourse, i.e. numbers and numerical properties and relations. Setting those difficulties aside, I focus instead on the sentential level, specifically, on obvious affinities between whole numerical and non-numerical sentences and how their significance is determined. From such a perspective, Frege's 1884 construction of number, while famously mathematically untenable, fares better metasemantically than extant alternatives in the philosophy of mathematics

Spore germination in Saccharomyces cerevisiae: global gene expression patterns and cell cycle landmarks

Genome-wide expression profiling of spore germination in Saccharomyces cerevisiae reveals two major stages and identifies germination-specific regulation of cell cycle machinery