7 research outputs found
Rapid Development of Salivary Gland Carcinomas upon Conditional Expression of K-ras Driven by the Cytokeratin 5 Promoter
We have used a recently described model in which a ras oncogene is expressed in cytokeratin 5 (K5)-expressing cells on doxycycline administration to explore the effects of this oncogene in salivary glands of adult mice. Inducible expression of a mutated K-ras gene under the control of the K5 promoter led to the development of hyperplastic and dysplastic epithelial lesions and carcinomas, with an incidence of 100% and a minimum latency of a week. All major salivary glands were affected, as well as a set of previously undescribed buccal accessory salivary glands located on the apex of the masseter muscle, close to the oral angle. The tumors appear to arise from the cytokeratin 5-positive basal cell compartment. Myoepithelial cells participated in the hyperplasias but not in carcinomas, because the tumors are negative for smooth muscle actin. Carcinomas did not accumulate immunoreactive p53 but are positive for p63, as assayed by immunohistochemistry using an antibody against the N terminus of ΔN p63, a splice variant of p63 that can inhibit p53 transcriptional activity. In this study, we provide evidence that the ras oncogene, targeted to a specifically sensitive cell compartment within the salivary glands, can trigger a series of event that are sufficient for full carcinogenesis
Measurement of D-s(+) and D-s(*+) production in B meson decays and from continuum e(+)e(-) annihilation at root s=10.6 GeV
New measurements of D-s(+) and D-s(*+) meson production rates from B decays and from q(q) over bar continuum events near the Y(4S) resonance are presented. Using 20.8 fb(-1) of data on the Y(4S) resonance and 2.6 fb(-1) off-resonance, we find the inclusive branching fractions B(B-->Ds+X) = (10.93+/-0.19+/-0.58+/-2.73)% and B(B-->Ds*+X) = (7.9+/-0.8+/-0.7+/-2.0)%, where the first error is statistical, the second is systematic, and the third is due to the D-s(+)-->phipi(+) branching fraction uncertainty. The production cross sections sigma(e(+)e(-)-->Ds+X)xB(D-s(+)-->phipi(+)) = 7.55+/-0.20+/-0.34 pb and sigma(e(+)e(-)-->Ds*+/-X)xB(D-s(+)-->phipi(+)) = 5.8+/-0.7+/-0.5 pb are measured at center-of-mass energies about 40 MeV below the Y(4S) mass. The branching fractions SigmaB(B-->D-s((*)+)(D) over bar ((*))) = (5.07+/-0.14+/-0.30+/-1.27)% and SigmaB(B-->D-s(*+)(D) over bar ((*))) = (4.1+/-0.2+/-0.4+/-1.0)% are determined from the D-s((*)+) momentum spectra. The mass difference m(D-s(+)) -m(D+) = 98.4+/-0.1+/-0.3 MeV/c(2) is also measured
Measurement of Ds+ and Ds*+ production in B meson decays and from continuum e+e- annihilation at √s=10.6 GeV
New measurements of Ds+ and Ds*+ meson production rates from B decays and from qq̅ continuum events near the Υ(4S) resonance are presented. Using 20.8 fb-1 of data on the Υ(4S) resonance and 2.6 fb-1 off-resonance, we find the inclusive branching fractions B(B⃗Ds+X)=(10.93±0.19±0.58±2.73)% and B(B⃗Ds*+X)=(7.9±0.8±0.7±2.0)%, where the first error is statistical, the second is systematic, and the third is due to the Ds+→φπ+ branching fraction uncertainty. The production cross sections σ(e+e-→Ds+X)×B(Ds+→φπ+)=7.55±0.20±0.34pb and σ(e+e-→Ds*±X)×B(Ds+→φπ+)=5.8±0.7±0.5pb are measured at center-of-mass energies about 40 MeV below the Υ(4S) mass. The branching fractions ΣB(B⃗Ds(*)+D(*))=(5.07±0.14±0.30±1.27)% and ΣB(B⃗Ds*+D(*))=(4.1±0.2±0.4±1.0)% are determined from the Ds(*)+ momentum spectra. The mass difference m(Ds+)-m(D+)=98.4±0.1±0.3MeV/c2 is also measured
Measurement of D+(s) and D*+(s) production in B meson decays and from continuum e+ e- annihilations at s**(1/2) = 10.6-GeV.
none622Bernard Aubert; D. Boutigny; J.M. Gaillard; A. Hicheur; Y. Karyotakis; J.P. Lees; P. Robbe; V. Tisserand; A. Palano; G.P. Chen; J.C. Chen; N.D. Qi; G. Rong; P. Wang; Y.S. Hz; G. Eigen; P.L. Reinertsen; B. Stugu; B. Abbott; G.S. Abrams; A.W. Borgland; A.B. Breon; David Nathan Brown; Janice Button-Shafer; R.N. Cahn; A.R. Clark; M.S. Gill; A.V. Gritsan; Y. Groysman; R.G. Jacobsen; R.W. Kadel; J. Kadyk; L.T. Kerth; S. Kluth; Yu.G. Kolomensky; J.F. Kral; C. LeClerc; M.E. Levi; T. Liu; G. Lynch; A.B. Meyer; M. Momayezi; P.J. Oddone; A. Perazzo; M. Pripstein; N.A. Roe; A. Romosan; M.T. Ronan; V.G. Shelkov; A.V. Telnov; W.A. Wenzel; P.G. Bright-Thomas; T.J. Harrison; C.M. Hawkes; D.J. Knowles; S.W. O'Neale; R.C. Penny; A.T. Watson; N.K Watson; T. Deppermann; K. Goetzen; H. Koch; J. Krug; M. Kunze; B. Lewandowski; K. Peters; H. Schmuecker; M. Steinke; J.C. Andress; N.R. Barlow; W. Bhimji; N. Chevalier; P.J. Clark; W.N. Cottingham; N. De Groot; N. Dyce; B. Foster; J.D. McFall; D. Wallom; F.F. Wilson; K. Abe; C. Hearty; T.S. Mattison; J.A. McKenna; D. Thiessen; S. Jolly; A.K. McKemey; Jane S. Tinslay; V.E. Blinov; A.D. Bukin; D.A. Bukin; A.R. Buzykaev; V.B. Golubev; V.N. Ivanchenko; A.A. Korol; E.A. Kravchenko; A.P. Onuchin; A.A. Salnikov; S.I. Serednyakov; Yu.I. Skovpen; Valery I. Telnov; A.N. Yushkov; D. Best; A.J. Lankford; M. Mandelkern; S. McMahon; D.P. Stoker; A. Ahsan; K. Arisaka; C. Buchanan; S. Chun; J.G. Branson; D.B. MacFarlane; Soeren A. Prell; S. Rahatlou; G. Raven; V. Sharma; C. Campagnari; B. Dahmes; P.A. Hart; N. Kuznetsova; S.L. Levy; O. Long; A. Lu; J.D. Richman; W. Verkerke; Michael S. Witherell; S. Yellin; J. Beringer; D.E. Dorfan; A.M. Eisner; A. Frey; A.A. Grillo; M. Grothe; C.A. Heusch; R.P. Johnson; W. Kroeger; William S. Lockman; T. Pulliam; H. Sadrozinski; T. Schalk; R.E. Schmitz; B.A. Schumm; A. Seiden; M. Turri; W. Walkowiak; D.C. Williams; M.G. Wison; E. Chen; G.P. Dubois-Felsmann; A. Dvoretskii; D.G. Hitlin; S. Metzler; J. Oyang; F.C. Porter; A. Ryd; A. Samuel; M. Weaver; S. Yang; R.Y. Zhu; S. Devmal; T.L. Geld; S. Jayatilleke; G. Mancinelli; B.T. Meadows; M.D. Sokoloff; T. Barillari; P. Bloom; M.O. Dima; S. Fahey; William T. Ford; D.R. Johnson; U. Nauenberg; A. Olivas; H. Park; P. Rankin; J. Roy; S. Sen; James G. Smith; W.C. van Hoek; D.L. Wagner; J. Blouw; John L. Harton; M. Krishnamurthy; A. Soffer; W.H. Toki; R.J. Wilson; J. Zhang; T. Brandt; J. Brose; T. Colberg; G. Dahlinger; M. Dickopp; R.S. Dubitzky; A. Hauke; E. Maly; R. Muller-Pfefferkorn; S. Otto; Klaus R. Schubert; R. Schwierz; B. Spaan; L. Wilden; L. Behr; Denis Bernard; 1; G.R. Bonneaud; F. Brochard; J. Cohen-Tanugi; S. Ferrag; E. Roussot; S. T'Jampens; C. Thiebaux; G. Vasileiadis; M. Verderi; A. Anjomshoaa; R. Bernet; A. Khan; D. Lavin; F. Muheim; S. Playfer; J.E. Swain; M. Falbo; C. Borean; C. Bozzi; S. Dittongo; M. Folegani; L. Piemontese; E. Treadwell; F. Anulli; R. Baldini-Ferroli; A. Calcaterra; R. de Sangro; D. Falciai; G. Finocchiaro; P. Patteri; I.M. Peruzzi; M. Piccolo; Y. Xie; A. Zallo; S. Bagnasco; A. Buzzo; R. Contri; G. Crosetti; P. Fabbricatore; S. Farinon; M. Lo Vetere; M. Macri; M.R. Monge; R. Musenich; M. Pallavicini; R. Parodi; S. Passaggio; F.C. Pastore; C. Patrignani; M.G. Pia; C. Priano; E. Robutti; A. Santroni; M. Morii; R. Bartoldus; T. Dignan; R. Hamilton; U. Mallik; J. Cochran; H.B. Crawley; P.A. Fischer; J. Lamsa; W.T. Meyer; E.I. Rosenberg; M. Benkebil; G. Grosdidier; C. Hast; Andreas Hocker; H.M. Lacker; S. Laplace; V. Lepeltier; A.M. Lutz; S. Plaszczynski; M.H. Schune; S. Trincaz-Duvoid; A. Valassi; G. Wormser; R.M. Bionta; V. Brigljevic; D.J. Lange; M. Mugge; X. Shi; K. van Bibber; T.J. Wenaus; D.M. Wright; C.R. Wuest; M. Carroll; J.R. Fry; E. Gabathuler; R. Gamet; M. George; M. Kay; D.J. Payne; R.J. Sloane; C. Touramanis; M.L. Aspinwall; D.A. Bowerman; Paul D. Dauncey; U. Egede; Ivo M. Gough Eschrich; N.J.W. Gunawardane; J.A. Nash; P. Sanders; D. Smith; D.E. Azzopardi; J.J. Back; P. Dixon; P.F. Harrison; R.J.L. Potter; H.W. Shorthouse; P. Strother; P.B. Vidal; M.I. Williams; G. Cowan; S. George; M.G. Green; A. Kurup; C.E. Marker; P. McGrath; T.R. McMahon; S. Ricciardi; F. Salvatore; I. Scott; G. Vaitsas; David Norvil Brown; C.L. Davis; John Allison; Roger J. Barlow; J.T. Boyd; A.C. Forti; J. Fullwood; F. Jackson; G.D. Lafferty; N. Savvas; E.T. Simopoulos; J.H. Weatherall; A. Farbin; A. Jawahery; V. Lillard; J. Olsen; D.A. Roberts; J.R. Schieck; G. Blaylock; C. Dallapiccola; K.T. Flood; Stanley S. Hertzbach; R. Kofler; T.B. Moore; H. Staengle; Stephane Willocq; B. Brau; R. Cowan; G. Sciolla; F. Taylor; R.K. Yamamoto; M. Milek; P.M. Patel; J. Trischuk; F. Lanni; F. Palombo; J.M. Bauer; M. Booke; L. Cremaldi; V. Eschenburg; R. Kroeger; J. Reidy; D.A. Sanders; D.J. Summers; J.P. Martin; J.Y. Nief; R. Seitz; P. Taras; A. Woch; V. Zacek; H. Nicholson; C.S. Sutton; C. Cartaro; N. Cavallo; G. De Nardo; F. Fabozzi; C. Gatto; L. Lista; P. Paolucci; D. Piccolo; C. Sciacca; J.M. LoSecco; J.R.G. Alsmiller; T.A. Gabriel; T. Handler; J. Brau; R. Frey; M. Iwasaki; N.B. Sinev; David M. Strom; F. Colecchia; F. Dal Corso; A. Dorigo; F. Galeazzi; M. Margoni; G. Michelon; M. Morandin; M. Posocco; M. Rotondo; F. Simonetto; R. Stroili; E. Torassa; C. Voci; Maurice Benayoun; H. Briand; J. Chauveau; P. David; C. de la Vaissiere; L. Del Buono; O. Hamon; F. Le Diberder; P Leruste; J. Lory; L. Roos; J. Stark; S. Versille; P. Manfredi; V. Re; V. Speziali; E.D. Frank; Larry D. Gladney; Q.H. Guo; J.H. Panetta; C. Angelini; G. Batignani; S. Bettarini; M. Bondioli; M. Carpinelli; F. Forti; M.A. Giorgi; A. Lusiani; F. Martinez-Vidal; M. Morganti; N. Neri; E. Paoloni; M. Rama; G. Rizzo; F. Sandrelli; G. Simi; G. Triggiani; J. Walsh; M. Haire; D. Judd; K. Paick; L. Turnbull; D.E. Wagoner; J. Albert; C. Bula; P. Elmer; C. Lu; K.T. McDonald; V. Miftakov; S.F. Schaffner; A.J.S. Smith; A. Tumanov; E.W. Varnes; G. Cavoto; D. del Re; R. Faccini; F. Ferrarotto; F. Ferroni; K. Fratini; E. Lamanna; Emanuele Leonardi; M.A. Mazzoni; Silvio Morganti; G. Piredda; F. Safai Tehrani; M. Serra; C. Voena; S. Christ; R. Waldi; P.F. Jacques; M. Kalelkar; R.J. Plano; T. Adye; B. Franek; N.I. Geddes; G.P. Gopal; S.M. Xella; R. Aleksan; G. De Domenico; S. Emery; A. Gaidot; S.F. Ganzhur; P.F. Giraud; W. Kozanecki; M. Langer; G.W. London; B. Mayer; B. Serfass; G. Vasseur; C. Yeche; M. Zito; N. Copty; M.V. Purohit; H. Singh; F.X. Yumiceva; I. Adam; P.L. Anthony; D. Aston; K. Baird; J.P. Berger; Elliott D. Bloom; A.M. Boyarski; F. Bulos; G. Calderini; R. Claus; M.R. Convery; D.P. Coupal; D.H. Coward; J. Dorfan; M. Doser; W. Dunwoodie; R.C. Field; T. Glanzman; G.L. Godfrey; S.J. Gowdy; P. Grosso; T. Himel; Tetiana Berger-Hryn'ova; M.E. Huffer; Walter R. Innes; C.P. Jessop; M.H. Kelsey; P. Kim; M.L. Kocian; Urs Langenegger; David W.G.S. Leith; S. Luitz; V. Luth; H.L. Lynch; H. Marsiske; S. Menke; R. Messner; K.C. Moffeit; R. Mount; D.R. Muller; C.P. O'Grady; M. Perl; S. Petrak; Helen R. Quinn; B.N. Ratcliff; S.H. Robertson; L.S. Rochester; A. Roodman; T. Schietinger; R.H. Schindler; J. Schwiening; V.V. Serbo; A. Snyder; A. Soha; S.M. Spanier; J. Stelzer; D. Su; M.K. Sullivan; H.A. Tanaka; J. Va'vra; S.R. Wagner; A.J.R. Weinstein; William J. Wisniewski; D.H. Wright; C.C. Young; P.R. Burchat; C.H. Cheng; David P. Kirkby; T.I. Meyer; C. Roat; R. Henderson; W. Bugg; H. Cohn; A.W. Weidemann; J.M. Izen; I. Kitayama; X.C. Lou; m. Turcotte; F. Bianchi; Marcella Bona; B. Di Girolamo; D. Gamba; A. Smol; D. Zanin; L. Bosisio; G. Della Ricca; L. Lanceri; A. Pompili; P. Poropat; M. Prest; E. Vallazza; G. Vuagnin; R.S. Panvini; C. Brown; Asoka S. De Silva; Robert V. Kowalewski; J.M. Roney; H.R. Band; E. Charles; S. Dasu; F. Di Lodovico; A.M. Eichenbaum; H. Hu; J.R. Johnson; R. Liu; J. Nielsen; Y. Pan; R. Prepost; I.J. Scott; J.H. von Wimmersperg-Toeller; S.L. Wu; Z. Yu; H. Zobernig; T.M.B. Kordich; H. NealBernard, Aubert; D., Boutigny; J. 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P., Johnson; W., Kroeger; William S., Lockman; T., Pulliam; H., Sadrozinski; T., Schalk; R. E., Schmitz; B. A., Schumm; A., Seiden; M., Turri; W., Walkowiak; D. C., Williams; M. G., Wison; E., Chen; G. P., Dubois Felsmann; A., Dvoretskii; D. G., Hitlin; S., Metzler; J., Oyang; F. C., Porter; A., Ryd; A., Samuel; M., Weaver; S., Yang; R. Y., Zhu; S., Devmal; T. L., Geld; S., Jayatilleke; G., Mancinelli; B. T., Meadows; M. D., Sokoloff; T., Barillari; P., Bloom; M. O., Dima; S., Fahey; William T., Ford; D. R., Johnson; U., Nauenberg; A., Olivas; H., Park; P., Rankin; J., Roy; S., Sen; James G., Smith; W. C., van Hoek; D. L., Wagner; J., Blouw; John L., Harton; M., Krishnamurthy; A., Soffer; W. H., Toki; R. J., Wilson; J., Zhang; T., Brandt; J., Brose; T., Colberg; G., Dahlinger; M., Dickopp; R. S., Dubitzky; A., Hauke; E., Maly; R., Muller Pfefferkorn; S., Otto; Klaus R., Schubert; R., Schwierz; B., Spaan; L., Wilden; L., Behr; Denis, Bernard; 1, ; G. 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Identification of Membrane-Associated Proteins Regulated by the Arbuscular Mycorrhizal Symbiosis
Measurement of the CP violating asymmetry amplitude sin 2beta
We present results on time-dependent CP-violating asymmetries in neutral B
decays to several CP eigenstates. The measurements use a data sample of about
88 million Y(4S) --> B Bbar decays collected between 1999 and 2002 with the
BABAR detector at the PEP-II asymmetric-energy B Factory at SLAC. We study
events in which one neutral B meson is fully reconstructed in a final state
containing a charmonium meson and the other B meson is determined to be either
a B0 or B0bar from its decay products. The amplitude of the CP-violating
asymmetry, which in the Standard Model is proportional to sin2beta, is derived
from the decay-time distributions in such events. We measure sin2beta = 0.741
+/- 0.067 (stat) +/- 0.034 (syst) and |lambda| = 0.948 +/- 0.051 (stat) +/-
0.030 (syst). The magnitude of lambda is consistent with unity, in agreement
with the Standard Model expectation of no direct CP violation in these modes.Comment: 7 pages, 2 postscript figures, submitted to PR