2,387 research outputs found

    Magnetic buoyancy instabilities in the presence of magnetic flux pumping at the base of the solar convection zone

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    We perform idealized numerical simulations of magnetic buoyancy instabilities in three dimensions, solving the equations of compressible magnetohydrodynamics in a model of the solar tachocline. In particular, we study the effects of including a highly simplified model of magnetic flux pumping in an upper layer (‘the convection zone’) on magnetic buoyancy instabilities in a lower layer (‘the upper parts of the radiative interior – including the tachocline’), to study these competing flux transport mechanisms at the base of the convection zone. The results of the inclusion of this effect in numerical simulations of the buoyancy instability of both a preconceived magnetic slab and a shear-generated magnetic layer are presented. In the former, we find that if we are in the regime that the downward pumping velocity is comparable with the AlfvĂ©n speed of the magnetic layer, magnetic flux pumping is able to hold back the bulk of the magnetic field, with only small pockets of strong field able to rise into the upper layer. In simulations in which the magnetic layer is generated by shear, we find that the shear velocity is not necessarily required to exceed that of the pumping (therefore the kinetic energy of the shear is not required to exceed that of the overlying convection) for strong localized pockets of magnetic field to be produced which can rise into the upper layer. This is because magnetic flux pumping acts to store the field below the interface, allowing it to be amplified both by the shear and by vortical fluid motions, until pockets of field can achieve sufficient strength to rise into the upper layer. In addition, we find that the interface between the two layers is a natural location for the production of strong vertical gradients in the magnetic field. If these gradients are sufficiently strong to allow the development of magnetic buoyancy instabilities, strong shear is not necessarily required to drive them (cf. previous work by Vasil & Brummell). We find that the addition of magnetic flux pumping appears to be able to assist shear-driven magnetic buoyancy in producing strong flux concentrations that can rise up into the convection zone from the radiative interior

    Collisional depolarization of state selected (J,M J ) BaO A 1Σ+ measured by optical–optical double resonance

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    The optical–optical double resonance (OODR) technique is used to investigate the change in magnetic quantum number (M) a state selected molecule undergoes on collision with other molecules. A first linearly polarized dye laser prepares A  1ÎŁ+BaO(v = 1) in the J = 1, M = 0 sublevel. The extent of collisional transfer to other M sublevels of both J = 1 and J = 2 is then probed by a second polarized dye laser which induces fluorescence from the C  1ÎŁ+ state. Elastic collisions (ΔJ = 0) between BaO (A  1ÎŁ+) and CO2 are observed to change M from 0 to ±1 leaving J unchanged. The total elasticM‐changing cross section is σΔM CO2 = 8.4±2.4 Å2. Inelastic collisions (ΔJ = +1’ which transfer molecules to j = 2 also cause M changes. with both Ar and CO2 as collision partners. M, the s p a c e‐f i x e d projection of J, is found to be neither conserved nor randomized. Quantum atom–diatom collision models with quantization axis along the relative velocity vector are considered. Transition amplitudes in this system are evaluated using the l‐dominant and CS approximations

    Age-related differences in emotional reactivity, regulation, and rejection sensitivity in adolescence

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    Although adolescents’ emotional lives are thought to be more turbulent than those of adults, it is unknown whether this difference is attributable to developmental changes in emotional reactivity or emotion regulation. Study 1 addressed this question by presenting healthy individuals aged 10–23 with negative and neutral pictures and asking them to respond naturally or use cognitive reappraisal to down-regulate their responses on a trial-by-trial basis. Results indicated that age exerted both linear and quadratic effects on regulation success but was unrelated to emotional reactivity. Study 2 replicated and extended these findings using a different reappraisal task and further showed that situational (i.e., social vs. nonsocial stimuli) and dispositional (i.e., level of rejection sensitivity) social factors interacted with age to predict regulation success: young adolescents were less successful at regulating responses to social than to nonsocial stimuli, particularly if the adolescents were high in rejection sensitivity. Taken together, these results have important implications for the inclusion of emotion regulation in models of emotional and cognitive development.National Science Foundation (U.S.) (Award BCS-0224342)National Institutes of Health (U.S.) (Award MH076137)National Institutes of Health (U.S.) (Award HD069178)National Institutes of Health (U.S.) (Award MH094056

    The 25th Anniversary of the Baby Doe Rules: Perspectives from the Fields of Law, Health Care, Ethics, and Disability Policy

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    A highly publicized and controversial case involving the withholding of medical treatment from a “Baby Doe” with Down syndrome gave rise in 1984 to the federal law known as the Baby Doe Rules, which went into effect the following year. The law conditions the grant of federal funds for any state’s child protective services program on the state’s assurance that it can respond to reports of medical neglect, which may include the withholding of medical treatment from disabled infants with life-threatening conditions. Leading scholars and practitioners from the fields of health care, law, ethics, and disability policy who are experts in the field of neonatal medicine and decision-making involving very premature and other medically at-risk infants gathered to provide thoughtful commentary and debate on the occasion of the 25th Anniversary of the Baby Doe Rules. The Georgia State University Law Review will publish a symposium volume on the topic in Fall 2009

    The 25th Anniversary of the Baby Doe Rules: Perspectives from the Fields of Law, Health Care, Ethics, and Disability Policy

    Get PDF
    A highly publicized and controversial case involving the withholding of medical treatment from a “Baby Doe” with Down syndrome gave rise in 1984 to the federal law known as the Baby Doe Rules, which went into effect the following year. The law conditions the grant of federal funds for any state’s child protective services program on the state’s assurance that it can respond to reports of medical neglect, which may include the withholding of medical treatment from disabled infants with life-threatening conditions. Leading scholars and practitioners from the fields of health care, law, ethics, and disability policy who are experts in the field of neonatal medicine and decision-making involving very premature and other medically at-risk infants gathered to provide thoughtful commentary and debate on the occasion of the 25th Anniversary of the Baby Doe Rules. The Georgia State University Law Review will publish a symposium volume on the topic in Fall 2009

    “What if There's Something Wrong with Her?”‐How Biomedical Technologies Contribute to Epistemic Injustice in Healthcare

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    While there is a steadily growing literature on epistemic injustice in healthcare, there are few discussions of the role that biomedical technologies play in harming patients in their capacity as knowers. Through an analysis of newborn and pediatric genetic and genomic sequencing technologies (GSTs), I argue that biomedical technologies can lead to epistemic injustice through two primary pathways: epistemic capture and value partitioning. I close by discussing the larger ethical and political context of critical analyses of GSTs and their broader implications for just and equitable healthcare delivery

    Phenotypic and functional characteristics of highly differentiated CD57 +NKG2C + NK cells in HIV-1- infected individuals

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    Natural killer (NK) cells are important anti-viral effector cells. The function and phenotype of the NK cells that constitute an individual’s NK cell repertoire can be influenced by ongoing and/or previous viral infections. Indeed, infection with human cytomegalovirus (HCMV) drives the expansion of a highly differentiated NK cell population characterized by expression of CD57 and the activating NKG2C receptor. This NK cell population has also been noted to occur in HIV-1-infected individuals. We evaluated the NK cells of HIV-1-infected and –uninfected individuals to determine the relative frequency of highly differentiated CD57 +NKG2C + NK cells and characterize these cells for their receptor expression and responsiveness to diverse stimuli. Highly differentiated CD57 +NKG2C + NK cells occurred at higher frequencies in HCMV-infected donors relative to HCMV-uninfected donors and were dramatically expanded in HIV-1/HCMV co-infected donors. The expanded CD57 +NKG2C + NK cell population in HIV-1-infected donors remained stable following antiretroviral therapy. CD57 +NKG2C + NK cells derived from HIV-1-infected individuals were robustly activated by antibody-dependent stimuli that contained anti-HIV-1 antibodies or therapeutic anti-CD20 antibody, and these NK cells mediated cytolysis through NKG2C. Lastly, CD57 +NKG2C + NK cells from HIV-1-infected donors were characterized by reduced expression of the inhibitory NKG2A receptor. The abundance of highly functional CD57 +NKG2C + NK cells in HIV-1-infected individuals raises the possibility that these NK cells could play a role in HIV-1 pathogenesis or serve as effector cells for therapeutic/cure strategies
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