443 research outputs found
Classification of Singular Fibres on Rational Elliptic Surfaces in Characteristic Three
We determine and list all possible configurations of singular fibres on
rational elliptic surfaces in characteristic three. In total, we find that 267
distinct configurations exist. This result complements Miranda and Persson's
classification in characteristic zero, and Lang's classification in
characteristic two.Comment: 40 Pages. Minor typos correcte
Results of a Second Year of Therapy with the 12-Month Histrelin Implant for the Treatment of Central Precocious Puberty
Background. Gonadotropin releasing hormone analogs (GnRHas) are standard of care for central precocious puberty (CPP). The histrelin subcutaneous implant is safe and effective in the treatment of CPP for one year.
Objective. The study evaluates a second year of therapy in children with CPP who received a new implant after one year of treatment.
Methods. A prospective one-year study following an initial 12-month treatment period was conducted.
Results. Thirty-one patients (29 girls) aged 7.7 ± 1.5 years received a second implant. Eighteen were naïve to GnRHa therapy at first implantation. Peak LH declined from 0.92 ± 0.58 mIU/mL at 12 months to 0.51 ± 0.33 mIU/mL at 24 months (P < .0001) in naïve subjects, and from 0.74 ± 0.50 mIU/mL at 12 months to 0.45 ± 0.35 mIU/mL at 24 months (P = .0081) in previously treated subjects. Predicted adult height increased by 5.1 cm at 24 months (P = .0001). Minor implant site reactions occurred in 61%, while minor difficulties with explantation occurred in 32.2% of subjects.
Conclusion. The histrelin implant demonstrates profound hypothalamic-pituitary-gonadal axis suppression when a new implant is placed for a second year of treatment. Prospective follow-up of this therapeutic modality for the treatment of CPP is needed
Parent and child agreement for acute stress disorder, post-traumatic stress disorder and other psychopathology in a prospective study of children and adolescents exposed to single-event trauma
Examining parent-child agreement for Acute Stress Disorder (ASD) and Post-Traumatic Stress Disorder (PTSD) in children and adolescents is essential for informing the assessment of trauma-exposed children, yet no studies have examined this relationship using appropriate statistical techniques. Parent-child agreement for these disorders was examined by structured interview in a prospective study of assault and motor vehicle accident (MVA) child survivors, assessed at 2-4 weeks and 6 months post-trauma. Children were significantly more likely to meet criteria for ASD, as well as other ASD and PTSD symptom clusters, based on their own report than on their parent's report. Parent-child agreement for ASD was poor (Cohen's κ = -.04), but fair for PTSD (Cohen's κ = .21). Agreement ranged widely for other emotional disorders (Cohen's κ = -.07-.64), with generalised anxiety disorder found to have superior parent-child agreement (when assessed by phi coefficients) relative to ASD and PTSD. The findings support the need to directly interview children and adolescents, particularly for the early screening of posttraumatic stress, and suggest that other anxiety disorders may have a clearer presentation post-trauma
Episodic Star Formation Coupled to Reignition of Radio Activity in 3C 236
We present Hubble Space Telescope UV and optical imaging of the radio galaxy
3C 236, whose relic 4 Mpc radio jet lobes and inner 2 kpc CSS radio source are
evidence of multiple epochs of AGN activity. Our data confirm the presence of
four bright knots of FUV emission in an arc along the edge of the inner
circumnuclear dust disk in the galaxy's nucleus, as well as FUV emission
cospatial with the nucleus itself. We interpret these to be sites of recent or
ongoing star formation. We present photometry of these knots, as well as an
estimate for the internal extinction in the source using the Balmer decrement
from SDSS spectroscopy. We estimate the ages of the knots by comparing our
extinction-corrected photometry with stellar population synthesis models. We
find the four knots cospatial with the dusty disk to be young, of order 10^7 yr
old. The FUV emission in the nucleus is likely due to an episode of star
formation triggered ~10^9 yr ago. We argue that the young 10^7 yr old knots
stem from an episode of star formation that was roughly coeval with the event
resulting in reignition of radio activity, creating the CSS source. The 10^9 yr
old stars in the nucleus may be associated with the previous epoch of activity
that generated the 4 Mpc relic source, before it was cut off by exhaustion or
interruption. The ages of the knots, considered in context with the disturbed
morphology of the nuclear dust and the double-double morphology of the "old"
and "young" radio sources, present evidence for an episodic AGN/starburst
connection. We suggest that the AGN fuel supply was interrupted for ~10^7 yr
due to a minor merger event and has now been restored, and the resultant
non-steady flow of gas toward the nucleus is likely responsible for both the
new episode of infall-induced star formation and also the multiple epochs of
radio activity.Comment: 15 pages, 7 figures. Accepted for publication in ApJ
HST/ACS Emission Line Imaging of Low Redshift 3CR Radio Galaxies I: The Data
We present 19 nearby (z<0.3) 3CR radio galaxies imaged at low- and
high-excitation as part of a Cycle 15 Hubble Space Telescope snapshot survey
with the Advanced Camera for Surveys. These images consist of exposures of the
H-alpha (6563 \AA, plus [NII] contamination) and [OIII] 5007 \AA emission lines
using narrow-band linear ramp filters adjusted according to the redshift of the
target. To facilitate continuum subtraction, a single-pointing 60 s line-free
exposure was taken with a medium-band filter appropriate for the target's
redshift. We discuss the steps taken to reduce these images independently of
the automated recalibration pipeline so as to use more recent ACS flat-field
data as well as to better reject cosmic rays. We describe the method used to
produce continuum-free (pure line-emission) images, and present these images
along with qualitative descriptions of the narrow-line region morphologies we
observe. We present H-alpha+[NII] and [OIII] line fluxes from aperture
photometry, finding the values to fall expectedly on the redshift-luminosity
trend from a past HST/WFPC2 emission line study of a larger, generally higher
redshift subset of the 3CR. We also find expected trends between emission line
luminosity and total radio power, as well as a positive correlation between the
size of the emission line region and redshift. We discuss the associated
interpretation of these results, and conclude with a summary of future work
enabled by this dataset.Comment: 18 pages, 12 figures, accepted for publication in ApJ
A single vertebrate DNA virus protein disarms invertebrate immunity to RNA virus infection
Virus-host interactions drive a remarkable diversity of immune responses and countermeasures. We found that two RNA viruses with broad host ranges, vesicular stomatitis virus (VSV) and Sindbis virus (SINV), are completely restricted in their replication after entry into Lepidopteran cells. This restriction is overcome when cells are co-infected with vaccinia virus (VACV), a vertebrate DNA virus. Using RNAi screening, we show that Lepidopteran RNAi, Nuclear Factor-kappaB, and ubiquitin-proteasome pathways restrict RNA virus infection. Surprisingly, a highly conserved, uncharacterized VACV protein, A51R, can partially overcome this virus restriction. We show that A51R is also critical for VACV replication in vertebrate cells and for pathogenesis in mice. Interestingly, A51R colocalizes with, and stabilizes, host microtubules and also associates with ubiquitin. We show that A51R promotes viral protein stability, possibly by preventing ubiquitin-dependent targeting of viral proteins for destruction. Importantly, our studies reveal exciting new opportunities to study virus-host interactions in experimentally-tractable Lepidopteran systems
Risk Factors for Post-ERCP Pancreatitis: A Prospective Multicenter Study
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75082/1/j.1572-0241.2006.00380.x.pd
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