747 research outputs found

    Complementarity and the resource curse

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    This paper discusses how the economic structure and asset ownership shape economic and political outcomes. Using a simple model of the productive sector, I provide theoretical evidence that complementarities between productive assets reduce the stakes of political competition, and therefore reduce the intensity of the conflict over political power. In particular, these results provide a theoretical explanation for the frequent conflicts associated with abundant mineral resources. They are valid in a democratic setting, where this competition is electoral, but also in any other setting, where competition may be of a more violent nature. I then extend this analysis to show that complementarity of productive assets positively influences the willingness of elite groups to invest in property rights institutions, thus providing an economic explanation for why some countries have endogenously developed a context more favorable to business than others

    From Leadership to Partnership

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    The present United States Security Strategy for Europe appears to be based on the assumption that only the United States has the vision and strength to consolidate the gains of the last few years and to build an even better wo rld. It is a fact that without the United States those gains would probably require much longer to consolidate. However, even the United States may fail if its policy remains too strongly defined by the heritage of the Cold War. Neglecting to clarify what is meant by the terms partnership and leadership, so frequently used in U.S. foreign policy, may ultimately foster confrontation with its partners and leave the United States weaker

    Laser forming and creative metalwork

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    Laser forming and creative metalwor

    Dysplasies osseuses héréditaires et voies de signalisation associées aux récepteurs FGFR3 et PTHR1

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    La croissance des os longs se fait selon un processus complexe impliquant la migration et la condensation de cellules mĂ©senchymateuses en cellules chondrogĂ©niques qui se diffĂ©rencient en chondrocytes produisant la matrice cartilagineuse pour former la plaque de croissance. De nombreux facteurs protĂ©iques sont impliquĂ©s dans la rĂ©gulation de ces phĂ©nomĂšnes parmi lesquels des facteurs transcriptionnels, des facteurs de signalisation et des protĂ©ines de la matrice extracellulaire dont le rĂŽle a Ă©tĂ© rĂ©vĂ©lĂ© grĂące aux Ă©tudes de gĂ©nĂ©tique molĂ©culaire sur des dysplasies osseuses humaines et Ă  la crĂ©ation de modĂšles animaux reproduisant certaines de ces maladies. Cet article se focalise sur deux rĂ©cepteurs, FGFR3 et PTHR1, dont l’importance dans la croissance des os longs est illustrĂ©e par le groupe de dysplasies osseuses qui leurs sont associĂ©es. Des rĂ©sultats rĂ©cents indiquent que prolifĂ©ration et diffĂ©renciation chondrocytaires sont Ă©troitement liĂ©es et que la croissance harmonieuse des os longs repose sur un Ă©quilibre strict entre diffĂ©rentes voies de signalisation dont celles contrĂŽlĂ©es par ces facteurs.Skeletal development is a highly sophisticated process involving, as a first step, migration and condensation of mesenchymal cells into osteoprogenitor cells. These cells further differentiate into chondrocytes and osteoblasts through multiple differentiation stages requiring a set of specific transcriptional factors. Defective endochondral ossification in human is associated with a large number of inherited skeletal dysplasias caused by mutations in genes encoding extracellular matrix components, growth factors and their receptors, signaling molecules and transcription factors. This review summarizes some of the recent findings on a series of chondrodysplasias caused by mutations in FGFR3 and PTHR1, two receptors expressed in the cartilage growth plate and mediating two main signaling pathways. Data from human diseases and relevant animal models provide new clues for understanding how signaling molecules and their interaction with key transcription factors control and regulate the development and growth of long bones

    Ollier disease

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    Enchondromas are common intraosseous, usually benign cartilaginous tumors, that develop in close proximity to growth plate cartilage. When multiple enchondromas are present, the condition is called enchondromatosis also known as Ollier disease (WHO terminology). The estimated prevalence of Ollier disease is 1/100,000. Clinical manifestations often appear in the first decade of life. Ollier disease is characterized by an asymmetric distribution of cartilage lesions and these can be extremely variable (in terms of size, number, location, evolution of enchondromas, age of onset and of diagnosis, requirement for surgery). Clinical problems caused by enchondromas include skeletal deformities, limb-length discrepancy, and the potential risk for malignant change to chondrosarcoma. The condition in which multiple enchondromatosis is associated with soft tissue hemangiomas is known as Maffucci syndrome. Until now both Ollier disease and Maffucci syndrome have only occurred in isolated patients and not familial. It remains uncertain whether the disorder is caused by a single gene defect or by combinations of (germ-line and/or somatic) mutations. The diagnosis is based on clinical and conventional radiological evaluations. Histological analysis has a limited role and is mainly used if malignancy is suspected. There is no medical treatment for enchondromatosis. Surgery is indicated in case of complications (pathological fractures, growth defect, malignant transformation). The prognosis for Ollier disease is difficult to assess. As is generally the case, forms with an early onset appear more severe. Enchondromas in Ollier disease present a risk of malignant transformation of enchondromas into chondrosarcomas

    Open design: non‐professional user‐designers creating products for citizen science, a case study of beekeepers.

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    Affiliated technologies have opened up opportunities for people, no matter what their design competency or expertise, to engage in the design of the products they use. The notion of “Open Design” or the open sharing of information relating to the design and manufacture of products, services or objects, can be seen as part of a much more encompassing phenomenon whereby users are the innovators and fabricators of their own products. Digital fabrication can enable the remote fabrication of objects tailoring artefacts to specific users or environmental needs. Open fabrication makes manufacturing processes accessible and can respond to niche needs with bespoke production. Citizen science uses non‐professionals to conduct research in their own environment or location, extending the impact of research. This process of “amateur scientist” and community monitoring has positive and negative aspects that design can help to address. The workshop conducted as part of this research involved 15 amateur bee‐ keepers and led to a probe study involving 150 participants in the UK, testing a new approach to co‐collaboration yielding positive outcomes. The bee population is currently under threat from environmental change, pollution, disease and they are users with a specific interest, bespoke needs and a knowledge base outside of their profession. The decline in bees is a scientific issue as they are seen as a barometer for the health of the environment. Through analysis of observations and insights gained through active design‐led workshops, this paper examines the potential barriers, opportunities, benefits and pitfalls of user‐designers engaging with citizen science using open design and open fabrication tools. Workshop results included: methods, motivations, designer and manufacturer opportunities and insights into repeatable processes forming the start of a citizen science toolkit. The objective was to ascertain the possible pitfalls of a group of user‐designers creating their own citizen science tools enabled by technologists and designers

    Making Instructions for Others: Exploring Mental Models Through a Simple Exercise

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    Investigating how people understand the systems around them—from technology to democracy to our own bodies—is a common research goal across many disciplines. One of the practical aims is uncovering differences between how people think systems work and how they actually work (particularly where differences can cause problems) and then addressing them, either by trying to change people’s understanding or by changing the way people inter- act with systems so that this better matches people’s understanding [1]. Being able to say that you under- stand a system is essentially saying that you have a model of the system [2]. In HCI and other people-centered design fields, attempting to characterize people’s mental models of technology in which their behavior plays a role can be a significant part of user research. Users’ mental models will perhaps only rarely accord exactly with designers’ conceptual models of a system [3], but this is not necessarily a problem in itself: “[A]ll models are wrong, but some are useful” [4]. Mental models should not be assumed to be static constructs covering the whole of a system; multiple models working at different levels of abstraction can be relevant in different circumstances, from complex work domains to simple everyday interactions [5]
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