Por uma cidade educadora — IV Seminário Teorias e Práticas Sociais com Crianças e Adolescentes

The IV Seminary of Social Theories and Practices with Children and Adolescents was held in 2007, at the Sports Center of the University of São Paulo, being an initiative of the Sport Talent Project (a social project of education through sports developed for the University of São Paulo in partnership with the Ayrton Senna Institute) and having the support of the Pro-Rectory of Culture and Extension.The subject of reference for practical and the dialogues was For an Educator City and the event had two great stages: the the Child and the Adolescent’s Week, where a series of workshops were developed for children, adolescents and adults in public spaces at the Butanta neighborhood during one week and; the seminary properly said, that involved more than one hundred people and included on an opening cerimony, four wheels of dialogue and the presentation of nineteen personal experiences.As a register of the event, a DVD with the main moments of the two cited phases was made. Each institution that proposed a workshop or presented a story received this product.The subject of the event anticipated and stimulated, mainly in the region of the Butanta, the discussions of the “X International Congress of the Educational Cities”, held in April of 2008 in the city of São Paulo.O IV Seminário Teorias e Práticas Sociais com Crianças e Adolescentes foi realizado em 2007, no Centro de Práticas Esportivas da Universidade de São Paulo, sendo uma iniciativa do Projeto Esporte Talento (projeto social de educação pelo esporte desenvolvido pela Universidade de São Paulo em parceria com o Instituto Ayrton Senna) e tendo o apoio da Pró-Reitoria de Cultura e Extensão Universitária.O tema de referência para as práticas e diálogos foi Por uma Cidade Educadora e o evento teve duas grandes etapas: a Semana da Criança e do Adolescente, que compreendeu uma série de ofi cinas desenvolvidas para crianças, adolescentes e adultos em espaços públicos da região do Butantã durante uma semana, e o seminário propriamente dito, que envolveu mais de cem pessoas e contou com uma mesa de abertura, quatro rodas de diálogo e a apresentação de dezenove relatos.Como registro do evento, foi feito um DVD com os principais momentos das duas fases citadas. Cada instituição que propôs uma ofi cina ou apresentou um relato recebeu esse produto.O tema do evento antecipou e estimulou, principalmente na região do Butantã, as discussões do “X Congresso Internacional de Cidades Educadoras”, realizado em abril de 2008, na cidade de São Paulo

A 46,XX testicular disorder of sex development caused by a Wilms’ tumour Factorâ 1 (WT1) pathogenic variant

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146930/1/cge13459_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/146930/2/cge13459.pd

MLST-Based Population Genetic Analysis in a Global Context Reveals Clonality amongst Cryptococcus neoformans var. grubii VNI Isolates from HIV Patients in Southeastern Brazil

Cryptococcosis is an important fungal infection in immunocompromised individuals, especially those infected with HIV. In Brazil, despite the free availability of antiretroviral therapy (ART) in the public health system, the mortality rate due to Cryptococcus neoformans meningitis is still high. To obtain a more detailed picture of the population genetic structure of this species in southeast Brazil, we studied 108 clinical isolates from 101 patients and 35 environmental isolates. Among the patients, 59% had a fatal outcome mainly in HIV-positive male patients. All the isolates were found to be C. neoformans var. grubii major molecular type VNI and mating type locus alpha. Twelve were identified as diploid by flow cytometry, being homozygous (AαAα) for the mating type and by PCR screening of the STE20, GPA1, and PAK1 genes. Using the ISHAM consensus multilocus sequence typing (MLST) scheme, 13 sequence types (ST) were identified, with one being newly described. ST93 was identified from 81 (75%) of the clinical isolates, while ST77 and ST93 were identified from 19 (54%) and 10 (29%) environmental isolates, respectively. The southeastern Brazilian isolates had an overwhelming clonal population structure. When compared with populations from different continents based on data extracted from the ISHAM-MLST database (mlst.mycologylab.org) they showed less genetic variability. Two main clusters within C. neoformans var. grubii VNI were identified that diverged from VNB around 0.58 to 4.8 million years ago

MLST-Based Population Genetic Analysis in a Global Context Reveals Clonality amongst <i>Cryptococcus neoformans</i> var. <i>grubii</i> VNI Isolates from HIV Patients in Southeastern Brazil

<div><p>Cryptococcosis is an important fungal infection in immunocompromised individuals, especially those infected with HIV. In Brazil, despite the free availability of antiretroviral therapy (ART) in the public health system, the mortality rate due to <i>Cryptococcus neoformans</i> meningitis is still high. To obtain a more detailed picture of the population genetic structure of this species in southeast Brazil, we studied 108 clinical isolates from 101 patients and 35 environmental isolates. Among the patients, 59% had a fatal outcome mainly in HIV-positive male patients. All the isolates were found to be <i>C</i>. <i>neoformans</i> var. <i>grubii</i> major molecular type VNI and mating type locus alpha. Twelve were identified as diploid by flow cytometry, being homozygous (AαAα) for the mating type and by PCR screening of the <i>STE20</i>, <i>GPA1</i>, and <i>PAK1</i> genes. Using the ISHAM consensus multilocus sequence typing (MLST) scheme, 13 sequence types (ST) were identified, with one being newly described. ST93 was identified from 81 (75%) of the clinical isolates, while ST77 and ST93 were identified from 19 (54%) and 10 (29%) environmental isolates, respectively. The southeastern Brazilian isolates had an overwhelming clonal population structure. When compared with populations from different continents based on data extracted from the ISHAM-MLST database (mlst.mycologylab.org) they showed less genetic variability. Two main clusters within <i>C</i>. <i>neoformans</i> var. <i>grubii</i> VNI were identified that diverged from VNB around 0.58 to 4.8 million years ago.</p></div

Quality of life in women with breast cancer, after surgical intervention, in a city in the zona da mata region in Minas Gerais, Brazil

Objectives: To evaluate health-related quality of life (HRQoL) in women with breast cancer, after surgical intervention, attended at the regional Oncology Referral Hospital in Juiz de Fora (MG). Methods: 121 women were evaluated and the European Organization for Research and Treatment of Cancer, Breast Cancer-Specific Quality of Life Questionnaire (EORTC QLC 30 BR23) was applied. After the descriptive analysis, a multiple linear regression model was created. The SPSS 14 was used to build the database and to conduct the analysis. Results: the mean values of the EORTC QLC 30 BR23 showed a tendency for good HRQoL, thus, the functional scale showed the most impairment with the worst mean scores observed. There was statistical significance among the symptoms scale and obese women who underwent adjuvant radiotherapy and those who had a greater number of dissected lymph nodes. The subjective perceptions influenced all the EORTC QLC 30 BR23domains. Conclusions: after controlling the variable by functional hand, and time of surgery, the BMI variables, breast reconstruction, heavy feeling in the arm, range of motion (ROM) reduction of the shoulder, and the tight shirt-sleeve sensation proven capable of explaining HRQoL. HRQoL appears to be relatively good, but negatively influenced by subjective perceptions, in addition to treatment factors.

Representative flow cytometry curves of selected southeastern Brazilian <i>Cryptococcus neoformans</i> var. <i>grubii</i> VNI isolates.

<p>Out of 143 isolates, 12 were identified as diploid. The haploid strains H99 <i>C</i>. <i>neoformans</i> var. <i>grubii</i> VNI and CDCR265 <i>C</i>. <i>gattii</i> VGII and the diploid hybrid strain WM 09.184 <i>C</i>. <i>neoformans</i> VNII/VNIV were included in each flow run as controls.</p

Multilocus linkage disequilibrium and recombination analyses amongst <i>Cryptococcus neoformans</i> var. <i>grubii</i> VNI continental populations.

<p>Multilocus linkage disequilibrium and recombination analyses amongst <i>Cryptococcus neoformans</i> var. <i>grubii</i> VNI continental populations.</p

Characteristics associated with deaths of the Brazilian patients.

<p>Characteristics associated with deaths of the Brazilian patients.</p