Polichromatic image sensor with microlenses for stereoscopic acquisition

This paper presents the fabrication of microlenses for integration on a stereoscopic image sensor in CMOS technology and a low-cost technology for fabricating optical filters arrays tuned for the primary colors. The material selected for fabricating the microlens was the AZ4562 positive photoresist and the fabrication process explained. Moreover, the fabrication process presented in this paper is for directly printing the optical filters into a transparent flexible substrate (acetate).This work was fully supported by the Portuguese Foundation for Science and Technology under the project FCT/PTDC/EEA-ELC/109936/2009 and R. P. Rocha is supported by the Foundation for Science and Technology financial grant SFRH/BD/33733/2009

Photonic sensors based on flexible materials with FBGs for use on biomedical applications

This chapter is intended for presenting biomedical applications of FBGs embedded into flexible carriers for enhancing the sensitivity and to provide interference-free instrumentation.This work was fully supported by the Algoritmi’s Strategic Project UI 319-2011-2012, under the Portuguese Foundation for Science and Technology grant Pest C/EEI/UI0319/2011

Development of clozapine tablets by direct compression - analysis of pharmaceutical equivalence by dissolution profiles

The aim of this work was to develop clozapine tablets that can be classified as a pharmaceutical equivalent to a reference brand product. Tablets were produced by direct compression and dissolution tests were realized in order to evaluate the dissolution profiles. The results show that the tablets can be classified as immediate release dosage forms due to clozapine fast release, and such release was dependent on the amount of sodium croscarmelose in the formulation. Analysis of f1 and f2 factors was frustrated due to the fast drug release; the tablets were analyzed by the dissolution efficiency and the dissolution curve shape. The dissolution efficiency was higher than 98 % and the analysis of the dissolution shape curve showed that the tablets from one batch of the developed formulations were similar to the reference brand product. The clozapine tablets obtained in this study can be considered as pharmaceutically equivalent to the reference brand product.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Development of clozapine tablets by direct compression - analysis of pharmaceutical equivalence by dissolution profiles

The aim of this work was to develop clozapine tablets that can be classified as a pharmaceutical equivalent to a reference brand product. Tablets were produced by direct compression and dissolution tests were realized in order to evaluate the dissolution profiles. The results show that the tablets can be classified as immediate release dosage forms due to clozapine fast release, and such release was dependent on the amount of sodium croscarmelose in the formulation. Analysis of f1 and f2 factors was frustrated due to the fast drug release; the tablets were analyzed by the dissolution efficiency and the dissolution curve shape. The dissolution efficiency was higher than 98 % and the analysis of the dissolution shape curve showed that the tablets from one batch of the developed formulations were similar to the reference brand product. The clozapine tablets obtained in this study can be considered as pharmaceutically equivalent to the reference brand product.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Polyvinylpyrrolidone Nanofibers Incorporating Mesoporous Bioactive Glass for Bone Tissue Engineering

Publisher Copyright: © 2023 by the authors.Composite biomaterials that combine osteoconductive and osteoinductive properties are a promising approach for bone tissue engineering (BTE) since they stimulate osteogenesis while mimicking extracellular matrix (ECM) morphology. In this context, the aim of the present research was to produce polyvinylpyrrolidone (PVP) nanofibers containing mesoporous bioactive glass (MBG) 80S15 nanoparticles. These composite materials were produced by the electrospinning technique. Design of experiments (DOE) was used to estimate the optimal electrospinning parameters to reduce average fiber diameter. The polymeric matrices were thermally crosslinked under different conditions, and the fibers’ morphology was studied using scanning electron microscopy (SEM). Evaluation of the mechanical properties of nanofibrous mats revealed a dependence on thermal crosslinking parameters and on the presence of MBG 80S15 particles inside the polymeric fibers. Degradation tests indicated that the presence of MBG led to a faster degradation of nanofibrous mats and to a higher swelling capacity. The assessment of in vitro bioactivity in simulated body fluid (SBF) was performed using MBG pellets and PVP/MBG (1:1) composites to assess if the bioactive properties of MBG 80S15 were kept when it was incorporated into PVP nanofibers. FTIR and XRD analysis along with SEM–EDS results indicated that a hydroxy-carbonate apatite (HCA) layer formed on the surface of MBG pellets and nanofibrous webs after soaking in SBF over different time periods. In general, the materials revealed no cytotoxic effects on the Saos-2 cell line. The overall results for the materials produced show the potential of the composites to be used in BTE.publishersversionpublishe

Promoting a compassionate motivation in detained youth: A secondary analysis of a controlled trial with the PSYCHOPATHY.COMP program

This study aims to assess the efficacy of the PSYCHOPATHY.COMP in promoting a compassionate motivation among male detained youth, also testing its role as a potential mechanism of change on the reduction of psychopathic traits. A treatment group (n = 58) and a control group (n = 61) answered a set of self-report measures on psychopathic traits, shame, fears of compassion, social safeness, self-compassion, and compassion for others at three timepoints: baseline, posttreatment, and 6 months’ follow-up. Treatment participants attended the PSYCHOPATHY.COMP. Controls received the treatment as usual delivered at juvenile detention facilities. The treatment effects were tested with latent growth curve models. At baseline, no significant differences between groups were found. Results from latent growth curve models showed that condition was a significant predictor of change over time observed in all outcome measures, even after controlling for psychopathic traits scores. When compared with the control group, the treatment group showed a significant decrease on shame and fears of compassion and a significant increase on social safeness, self-compassion, and compassion for others over time (medium-to-large effect sizes; growth modeling analysis d ranging from .57 to .96). It was also observed that increases in self-compassion and, in some cases, decreases in fears of receiving compassion, were crucial to the decrease of psychopathic traits. These findings suggest that the PSYCHOPATHY.COMP is a promising approach to promote a compassionate motivation in these youth, strengthening their rehabilitation odds. Increasing self-compassion and decreasing fears of receiving compassion should be considered when designing intervention programs for detained youth.

Montagem do sistema para dosimetria de nêutrons com detectores de bolhas

São descritos a montagem e o procedimento desenvolvido para a aquisição e analise de imagens obtidas com os novos detectores de bolha BDS, para dosimetria de nêutrons ou nas medições de fluência e distribuição de energia de nêutrons de uma instalação nuclear