The aim of this work was to develop clozapine tablets that can be classified as a pharmaceutical
equivalent to a reference brand product. Tablets were produced by direct compression and dissolution
tests were realized in order to evaluate the dissolution profiles. The results show that the tablets can
be classified as immediate release dosage forms due to clozapine fast release, and such release was dependent
on the amount of sodium croscarmelose in the formulation. Analysis of f1 and f2 factors was frustrated
due to the fast drug release; the tablets were analyzed by the dissolution efficiency and the dissolution
curve shape. The dissolution efficiency was higher than 98 % and the analysis of the dissolution shape
curve showed that the tablets from one batch of the developed formulations were similar to the reference
brand product. The clozapine tablets obtained in this study can be considered as pharmaceutically equivalent
to the reference brand product.Colegio de Farmacéuticos de la Provincia de Buenos Aire
