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È nostra convinzione che gli argomenti della dissoluzione del luogo contribuiscono a ideare una città che va aggiungendo architetture atopici, architetture dove si può manifestare più facilmente la spettacolarità delle sue forme, e dove la rottura spaziale della città diventa più evidente. D'altra parte, la difesa dell’anti-storicità del processo creativo architettonico, nel confronto con la città e la sua architettura in nome del progresso e del futuro, crea le forme di rottura e di disagio e dà forza ad una nuova visione puramente funzionalista. Oggi l'architettura appare come controllata d’altre aree del sapere, manifestandosi, tuttavia, esuberante nelle sue forme, in un’autonomia illusoria, e prigioniera di presupposti che le superano e svalutano. L'architettura contemporanea deve chiamare di nuovo a sé il concetto di continuità e permanenza, della prospettiva di creare nuove memorie e di contribuire alla definizione di riferimenti collettivi che possano edificare le forme della nostra storia attuale, e le forme di una città in crescita che oggi è già difficile da identificare. Siamo preoccupati, tuttavia, in un altro ordine, l'ordine che possiamo trovare attraverso esempi che mostrano una sequenza 'genomica', una struttura che stabilisca la continuità dei fatti che hanno determinato la città e che la hanno configurato in molti modi, nel corso della sua storia. In un processo dicotomico di causa ed effetto, la città contemporanea può anche vedere la sua forma descritta con la precisazione della forma dei suoi spazi pubblici (Il suo design e la sua posizione – una grammatica operativa), ma anche con il rapporto e i legami tra loro, (un ordine – una sintassi efficiente).We are convinced that the arguments surrounding the dissolution of place tend toward the materialization of a city which continues to amass atopic architectures, architectures that facilitate the spectacularism of their forms and where the spatial rupture of the city becomes more discernible. On the other hand, the vindication of the architectural creative process as anti-historical creates forms of rupture and discomfort, and empowers a new, merely functionalist, vision. Today architecture is seen as subsidiary to other branches of knowledge, and, despite its exuberant forms, it retains an illusory autonomy, confined by assumptions that surpass and depreciate it. Contemporary architecture must reclaim the notion of perpetuity and permanence, so as to create new memories and contribute to the maintenance of collective references that solidify our current history’s forms and the forms of a growing city increasingly difficult to identify. We are interested in the order that we can find by way of examples that feature a ‘genomic’ sequence, a structure capable of establishing the continuity of facts that throughout history have determined and configured the city in so many ways. By means of a dichotomous cause and effect process, we may also describe the contemporary city’s form by clarifying the form of public spaces (their design and position – an operative grammar) and the relation and articulation between public spaces (an order – an efficient syntax).Peer Reviewe

Online jobseeking platforms

Online jobseeking platforms are now widespread, but little research has been done so far on what drives them, what they are required for and what their success depends on, as well as how they influence the success of individual jobseekers. This dissertation includes a study on various aspects that potentially affect jobseeking success and pertain to online jobseeking platforms. This dissertation aims to investigate how the use of jobseeking platforms impacts the success of a job search, as well as how the success of that job search is affected by a site’s usability. These aspects were investigated through a jobseeking habits survey answered by 73 participants and analysed to draw conclusions on the sample and wider world. Due to the nature of the sample, a more qualitative approach was also taken, with individual respondents’ answers to an open-ended question also taken into account. The survey respondents were classified into three types: generalist users, specific users and youthful users, and further analysed to obtain a more accurate idea of their jobseeking habits and subsequent success. It was concluded that a higher educational level can be a strong precursor to job search success. Moreover, the use of jobseeking platforms does, in fact, impact the success of a job search, in this case positively.utilização de plataformas de procura de emprego "online" são uma prática corrente. No entanto, pouca investigação foi realizada até ao momento sobre o que as impulsiona, para que são necessárias, assim como qual a maneira que influenciam o sucesso de indivíduos que se encontram à procura de emprego. Esta dissertação inclui um estudo sobre os vários aspetos que podem afetar o sucesso na procura de emprego e que dizem respeito às plataformas de procura de emprego "online", tendo como objetivo investigar como a utilização de plataformas de procura de emprego "online" influencia o sucesso dessa procura de emprego, assim como a maneira que esse sucesso é influenciado pela facilidade de utilização dos sites. Estes aspetos foram investigados através de um questionário sobre hábitos de procura de emprego, preenchido por 73 participantes, e analisado para se poder apurar conclusões sobre a amostra e sobre o mundo em geral. Devido à natureza da amostra, foi também adotada uma abordagem mais qualitativa, em que foram consideradas respostas fornecidas a uma pergunta aberta. Os participantes do questionário foram classificados em três tipos: generalistas, específicos e jovens. De seguida, estes participantes foram analisados mais a fundo para obter uma ideia mais precisa dos seus hábitos no que diz respeito à procura de emprego e respetivo sucesso. Foi concluído que um nível de formação mais elevado pode levar ao sucesso na procura de emprego. A utilização de plataformas de procura de emprego "online" também influencia o sucesso de uma procura, neste caso de forma positiva

New Chalcone–Triazole Hybrids with Promising Antimicrobial Activity in Multidrug Resistance Strains

Resistance to antibiotics is an emerging problem worldwide, which leads to an increase in morbidity and mortality rates. Several mechanisms are attributed to bacterial resistance, overexpression of efflux pumps being one of the most prominent. As an attempt to develop new effective antimicrobial drugs, which could be able to act against resistant bacterial strains and considering the antimicrobial potential of flavonoids and triazolyl flavonoid derivatives, in particular chalcones, a small library of chalcone derivatives was synthesized and evaluated for its potential to act as antimicrobials and/or adjuvants in combination with antibiotics towards resistant bacteria. Although only compound 7 was able to act as antibacterial, compounds 1, 2, 4, 5, 7, and 9 revealed to be able to potentiate the activity of antibiotics in resistant bacteria. Moreover, five compounds (3, 5–8) demonstrated to be effective inhibitors of efflux pumps in Salmonella enterica serovar Typhimurium SL1344, and four compounds (1, 3, 7, and 10) showed higher ability than reserpine to inhibit biofilm formation of resistant Staphylococcus aureus 272123. Together, our results showed the potential of these compounds regarding reversion of bacterial resistance

Key initiatives to successfully manage collaborative university-industry R&D: IC-HMI case study

This paper describes the results of a qualitative study to identify the key management initiatives in a successful university-industry (UI) collaborative funded program between the University of Minho (UMinho) and Bosch Car Multimedia Portugal (Bosch), named IC-HMI. The IC-HMI program embraced an overall investment of 54.7 M€ and involved around 500 people throughout the Program's duration (2015-2018). While the literature provides some advice on managing programs and projects, the specific context of UI R&D collaboration is being scarcely reported, demanding a strong research effort to produce effective guidelines. The IC-HMI is considered a successful program for several reasons, as evidenced by the decision of UMinho and Bosch partners to develop a subsequent R&D collaborative program from 2018 to 2021, doubling its investment. The success attained with the IC-HMI program could be somehow explained by key management initiatives adopted, such as the: creation of Program and Project Management Office, definition and communication of a Governance Model, creation of Project Charters, promotion of Alignment Stakeholders Workshops, Project Progress Meetings and creation of Project Transition Plans, among other key initiatives reported in this paper.This research is sponsored by the Fundação para a Ciência e a Tecnologia FCT (SFRH/BPD/111033/2015), and by the Portugal Incentive System for R&D. Project in co-promotion nº 039479/2018 (FoF 2018-2021)

Sulfated small molecules targeting EBV in Burkitt lymphoma: from in silico screening to the evidence of in vitro effect on viral episomal DNA

Epstein–Barr virus (EBV) infects more than 90% of the world population. Following primary infection, Epstein– Barr virus persists in an asymptomatic latent state. Occasionally, it may switch to lytic infection. Latent EBV infection has been associated with several diseases, such as Burkitt lymphoma (BL). To date, there are no available drugs to target latent EBV, and the existing broad-spec trum antiviral drugs are mainly active against lytic viral infection. Thus, using computational molecular docking, a virtual screen of a library of small molecules, including xanthones and flavonoids (described with potential for antiviral activity against EBV), was carried out targeting EBV proteins. The more interesting molecules were selected for further computational analysis, and sub sequently, the compounds were tested in the Raji (BL) cell line, to evaluate their activity against latent EBV. This work identified three novel sulfated small molecules capable of decreasing EBV levels in a BL. Therefore, the in silico screening presents a good approach for the development of new anti-EBV agents.info:eu-repo/semantics/publishedVersio

The MOVE.TE Falls Prevention and Management Program: lessons learnt in the Portuguese context

MOVE.TE is a non-profit participatory physiotherapy platform that aims at translating knowledge in the field of physiotherapy and developing freely available evidence-based physiotherapy programmes targeting the primary care services of the Portuguese National Health service. A group of volunteer academics and clinicians collaborated at different stages and time points to create the first ever falls prevention and management programme and guidance for Physiotherapy in primary care, in Portugal. This report describes this seven-step process. In spite of many challenges, this project constitutes an example of advocacy in physiotherapy for the promotion of better healthcare for older adults.info:eu-repo/semantics/publishedVersio