A Model for Building Projects on Knowledge Base in Organizations, Supported by Collaborative Tools

A utilização de ferramentas de colaboração para o gerenciamento de bases de conhecimento permite que as organizações possam armazenar e disseminar o conhecimento produzido nos projetos de maneira efetiva Aliar modernas soluções de tecnologia de informação a conceitos de gestão do conhecimento e gerenciamento de projetos, beneficiando com a manutenção e utilização da memória organizacional através da utilização de modelos especificados possibilitaa obtenção de vantagens competitivas.Este artigo tem por objetivo apresentar um modelo para a construção de uma base de conhecimentos, com basenas lições aprendidas no gerenciamento de projetos baseado no guia PMBOK (Um Guia do Conhecimento em Gerenciamento de Projetos), suportado por ferramentas colaborativas e fundamentos de gestão do conhecimento.DOI:10.5585/gep.v3i3.128The use of collaboration tools for managing knowledge bases, allows organizations to store and disseminate the knowledge generated in projects effectively, combining modern information technology solutions to the concepts of knowledge management and project management, benefiting the maintenance and use of organizational memory through the use of specified models and thus enabling the achievement of competitive advantages. Thus, this paper aims to present a model for building a knowledge base, lessons learned in project management based on PMBOK (A Guide to Knowledge in Project Management), supported by collaborative tools and fundamentals of management knowledge

Content of basil essential oil on a loam texture soil under water regimes and different harvest stages

The essential oil of basil (Ocimum basilicum L.) has high economic value and is produced in the plant by secondary metabolism. Its quantity and composition tend to vary as a response of the plant to stress situations due to changes in the environment and phenological phase. This work aimed to evaluate the development, the chemical composition, content, and the yield of essential oil of basil rich in Linalool, as a function of the soil water tensions and the harvest stages, in a loam texture soil. The experiment was carried out in a greenhouse and consisted of three harvest times (BF - beginning of flowering,  FF - full flowering,  and EF - end of flowering) and five values of soil water tension to define when to irrigate (20, 30, 40, 50, and 60 kPa), totalizing 15 treatments. The irrigation in the soil water tension of 60 kPa generated a reduction in the content and the yield of essential oils compared with 20 kPa, only in the FF harvest stage. However, it did not modify the composition of the essential oil. Regardless of the soil water tension to define irrigation, the highest levels and yields of essential oil were found in the EF harvest stage. Harvest stages did not change the composition of the essential oil or the content of Linalool. In turn, the contents of the components Cineol, Camphor, ∝-Terpeneol, and Isobornyl acetate increased with the harvesting period from BF to EF. Eugenol had the opposite trend, reducing the content from BF to EF. Linalool, a component in greater proportion in essential oil, showed a higher content in soil water tensions up to 50 kPa, decreasing only by 60 kPa. In loam textured soils, it is recommended that basil producers, who aim to extract Linalool, irrigate when the soil water tension reaches up to 50 kPa, with the harvest at any stage of flowering

Turnera subulata Anti-Inflammatory Properties in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages

In South America, particularly in the Northeastern regions of Brazil, Turnera subulata leaf extract is used as an alternative traditional medicine approach for several types of chronic diseases, such as diabetes, hypertension, chronic pain, and general inflammation. Despite its widespread use, little is known about the medicinal properties of the plants of this genus. In this study, we evaluate the antioxidant and anti-inflammatory of T. subulata leaf extract in an in vitro model of inflammation, using lipopolysaccharide-stimulated RAW-264.7 macrophage cell line. We observed that cotreatment with T. subulata leaf extract was able to reduce the oxidative stress in cells due to inflammatory response. More importantly, we observed that the leaf extract was able to directly modulate inflammatory response by altering activity of members of the mitogen-activated protein kinase pathways. Our results demonstrate for the first time that T. subulata have antioxidant and anti-inflammatory properties, which warrant further investigation of the medicinal potential of this species.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140112/1/jmf.2016.0047.pd

NOVAS TECNOLOGIAS ALIADAS AO DESENVOLVIMENTO SUSTENTÁVEL: CRIAÇÃO DE APP PARA MONITORAMENTO DE PONTOS INADEQUADOS DE DESCARTES DE RESÍDUOS

A gestão correta dos resíduos sólidos é um fator de grande relevância socioambiental, impondo ao poder público e a coletividade uma maior atenção, com vistas à manutenção da qualidade de vida da população. Neste sentido, o estudo objetivou avaliar os pontos de disposição irregular de resíduos sólidos no município de Soledade/RS como orientação para a análise da gestão municipal. Alinhado a esta temática, propõem-se o desenvolvimento de um aplicativo para ser usado em smartphone como uma ferramenta para gestão dos resíduos. Além disto, o projeto visa o despertar da população soledadense uma visão crítica sobre a proteção do meio ambiente, usando um meio tecnológico comum e acessível por muitas pessoas como os smartphone. Nesta perspectiva, a metodologia foi pesquisa-ação. Através do desenvolvimento do aplicativo observou-se 37 pontos de descarte irregular de materiais. As denúncias foram computadas no aplicativo e observou-se que os principais materiais gerados foram resíduos de construção civil, resíduos verdes, resíduos volumosos, resíduos domiciliares e resíduos de serviços de saúde. Os bairros que mais possuíam descartes irregulares foram o Centro com 10 pontos, bairro Fontes com 8 pontos, bairro Missões com 6 pontos, bairro Expedicionário com 4 pontos e, empatados com 3 pontos, os bairros Ipiranga, Farroupilha e Botucaraí. Com o desenvolvimento e a execução deste projeto, concedeu o sentido de uma universidade junto as ações de inovação, de pesquisa e do desenvolvimento de novas tecnologias, atendendo as demandas locais e regionais, de forma a apoiar e assessorar as potenciais transformações sociais, econômicas e culturais do município onde está inserida

Antioxidant and Anti-Inflammatory Properties of Anacardium occidentale

In tropical America, principally in Northeastern Brazil, the leaf extract of Anacardium occidentale is traditionally used for treatment of different diseases. However, chemical and biological properties and activities of Anacardium occidentale are poorly investigated and known. Here, we evaluated the antioxidant and anti-inflammatory activities “in vitro” of leaf extract from Anacardium occidentale. Our results show that leaf extract exhibits antioxidant activity when used to treat RAW 264.7 macrophage cells. Antioxidant effects were observed by decrease in oxidative damage in macrophage cells treated with 0.5 µg/mL and 5 µg/mL of leaf extract. Moreover, leaf extract reversed oxidative damage and inflammatory parameters induced in LPS-stimulated RAW 264.7 macrophage cells. Leaf extract at 0.5 µg/mL and 5 µg/mL was able to inhibit release of TNF-α and IL-1β in LPS-stimulated cells. Taken together, our results indicate antioxidant and anti-inflammatory effects of leaf extract from Anacardium occidentale and reveal the positive effects that intake of these products can mediate in biological system

Efficacy and safety of glecaprevir/pibrentasvir in treatment-naïve adults with chronic hepatitis C virus genotypes 1–6 in Brazil

Introduction and objectives: Glecaprevir/pibrentasvir is a highly effective and well tolerated treatment for hepatitis C infection. Brazilian patients were not included in the original development studies for glecaprevir/pibrentasvir. This study aimed to assess safety and efficacy of glecaprevir/pibrentasvir in treatment-naïve Brazilian adults without cirrhosis or with compensated cirrhosis. Patients and methods: EXPEDITION-3 was a Phase 3, open-label, multicenter study in treatment-naïve Brazilian adults with hepatitis C infection genotype 1–6. Patients without cirrhosis (F2 or F3) or with compensated cirrhosis (F4) received 8 or 12 weeks of glecaprevir/pibrentasvir, respectively. The primary efficacy endpoint was the rate of sustained virologic response at post-treatment Week 12. Secondary endpoints were on-treatment virologic failure and relapse rates. Baseline polymorphisms were assessed in NS3 and NS5A. Adverse events and laboratory abnormalities were monitored. Results: 100 patients were enrolled, 75 received 8 weeks of treatment and 25 received 12 weeks; all patients completed treatment. Overall sustained virologic response at post-treatment Week 12 rate was high (98.0%; 98/100; 95% confidence interval: 93.0–99.4) and remained high regardless of baseline viral or host factors, including demographics, hepatitis C virus RNA levels, polymorphisms in NS3 and/or NS5A, genotype, and relevant comorbidities. 55% of patients reported ≥1 adverse event, the most common beingheadache (18.0%). Four patients reported serious adverse events; none were considered drug related orled to study drug discontinuation. No hepatic decompensations were observed.Conclusions: Glecaprevir/pibrentasvir was effective and well tolerated in treatment-naïve Brazilianpatients with hepatitis C infection without cirrhosis and with compensated cirrhosis

Structural and productive features of Panicum cultivars submitted to different rest periods in the irrigated semiarid region of Brazil

The objective of this study was to evaluate the structural and productive features of Panicum maximum cultivars (Tanzânia, Mombaça, Massai, and Zuri) in three rest periods (30, 45 and 60 days), in the semiarid region of Brazil. The experiment was carried out in a completely randomized design with three replicates. The length of the leaf blade and the diameter of the stem increased as a function of the cut intervals. Leaf blade width and number of live leaves (3.86 leaves tiller-1) were not affected by cut intervals. The height of the canopy increased with the ages, with effect in the mass of forage, being the cv. Zuri the most productive with 148,75 cm e 18.297,49 kg ha-1 DM at 60 days. The highest masses of leaves and stems were obtained in the longest rest period, while the leaf/stem ratio decreased. In the cut-off interval of 45 days, the cultivars of Panicum maximum have shown satisfactory yield, and the smaller cut interval provides a reduction in canopy height and stem thickness

Complicações cardiovasculares decorrentes do uso abusivo de esteroides anabolizantes: uma revisão

Este trabalho tem por objetivo examinar e evidenciar as principais complicações cardiovasculares sucedidas do uso abusivo de esteroides anabolizantes. Sendo o presente estudo uma revisão integrativa, realizado a partir da busca dos seguintes Descritores em Ciências da Saúde (DeCS): cardiovascular; anabolic; steroid. Destes, foram escolhidos apenas artigos publicados de 2021 a 2023, até a data de 24/10/2023, sendo selecionados 14 artigos, em que 5 foram excluídos e somente 9 foram examinados para a produção deste estudo. As complicações cardiovasculares associadas ao uso de esteroide anabolizantes são de grande relevância levando em consideração sua morbidade e mortalidade, uma vez que podem possuir desfechos graves como infarto agudo do miocárdio, acidente vascular cerebral isquêmico e eventos trombóticos. A partir do conhecimento destas informações, necessita-se de um apanhado dos principais estudos acerca desta temática para que seja feita a conscientização dos usuários e da população no geral além de auxiliar no diagnóstico diferencial das etiologias para as referidas complicações cardiovasculares.  &nbsp

Modelo para Construção de Base de Conhecimentos sobre Projetos Suportado por Ferramentas Colaborativas

The use of collaboration tools for managing knowledge bases, allows organizations to store and disseminate the knowledge generated in projects effectively, combining modern information technology solutions to the concepts of knowledge management and project management, benefiting the maintenance and use of organizational memory through the use of specified models and thus enabling the achievement of competitive advantages. Thus, this paper aims to present a model for building a knowledge base, lessons learned in project management based on PMBOK (A Guide to Knowledge in Project Management), supported by collaborative tools and fundamentals of management knowledge.A utilização de ferramentas de colaboração para o gerenciamento de bases de conhecimento permite que as organizações possam armazenar e disseminar o conhecimento produzido nos projetos de maneira efetiva Aliar modernas soluções de tecnologia de informação a conceitos de gestão do conhecimento e gerenciamento de projetos, beneficiando com a manutenção e utilização da memória organizacional através da utilização de modelos especificados possibilitaa obtenção de vantagens competitivas.Este artigo tem por objetivo apresentar um modelo para a construção de uma base de conhecimentos, com basenas lições aprendidas no gerenciamento de projetos baseado no guia PMBOK (Um Guia do Conhecimento em Gerenciamento de Projetos), suportado por ferramentas colaborativas e fundamentos de gestão do conhecimento.DOI:10.5585/gep.v3i3.12