2,467 research outputs found

    Building public-private partnerships for agricultural innovation:

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    Public-private partnerships are a new way of carrying out research and development (R&D) in Latin America's agricultural sector. These partnerships spur innovation for agricultural development and have various advantages over other institutional arrangements fostering R&D. This report summarizes the experiences of a research project that analyzed 125 public-private research partnerships (PPPs) in 12 Latin American countries. The analysis indicates that several types of partnerships have emerged in response to the various needs of the different partners. Nevertheless, public-private partnerships are not always the most appropriate mechanism by which to carry out R&D and foster innovation in agriculture. Sometimes, it is more efficient to organize research via participatory projects or through research contracts.Public-private partnerships, Agricultural innovations, Capacity strengthening, Agricultural research,

    Distance perception in a natural outdoor setting: is there a developmental trend to overconstancy?

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    The main purpose of the present study was to investigate whether in natural environment, using very large physical distances, there is a trend to overconstancy for distance estimates during development. One hundred and twenty-nine children aged 5 to 13 years old and twenty-one adults (in a control group), participated as observers. The observer’s task was to bisect egocentric distances, ranging from 1.0 to 296.0 m, presented in a large open field. The analyses focused on two parameters, constant errors and variable errors, such as measuring accuracy and precision, respectively. A third analysis focused on the developmental pattern of shifts in constancy as a function of age and range of distances. Constant error analysis showed that there are two relevant parameters for accuracy, age, and range of distances. For short distances, there are three developmental stages: 5-7 years, when children have unstable responses, 7-11, underconstancy, and 13 to adulthood, when accuracy is reached. For large distances, there is a two-stage development: 5-11 years, with severe underconstancy, and beyond this age, with mild underconstancy. Variable errors analyses indicate that precision is noted for 7 year-old children, independently of the range of distances. The constancy analyses indicated that there is a shift from constancy (or slightly overconstancy) to underconstancy as a function of physical distance for all age groups. The age difference is noted in the magnitude of underconstancy that occurs in larger distances, where adults presented lower levels of underconstancy than children. The present data were interpreted as due to a developmental change in cognitive processing rather than to changes in visual space perception.El principal objetivo de este estudio fue investigar si en un medio natural, empleando distancias físicas muy grandes, hay una tendencia a sobre-constancia para las estimaciones de distancias durante el desarrollo evolutivo. Participaron como observadores 129 niños de edades entre 5 y 13 años y 21 adultos (en un grupo control). La tarea de los observadores consistió en biseccionar unas distancias egocéntricas, que variaban entre 1,0 y 296,0 m, presentadas en un gran campo abierto. El análisis se centró en dos parámetros, error constante y error variable, de la exactitud y precisión de medida, respectivamente. Un tercer análisis se centró en el patrón evolutivo de cambios en la constancia en función de la edad y el rango de distancias. El análisis de los errores constantes mostró que hay dos parámetros relevantes para la precisión, edad y rango de distancias. Para distancias cortas, hay tres fases evolutivas: 5-7 años, cuando los niños dan respuestas inestables, 7-11, infra-constancia, y 13 años hasta la adultez, cuando alcanzan la exactitud (constancia). Para las distancias largas, hay un desarrollo de dos fases: 5-11 años, con infra-constancia severa, y más allá de esta edad, con ligera infraconstancia. El análisis del error variable indica que se alcanza precisión a partir de 7 años, con independencia del rango de distancias. En análisis de la constancia indica que existe un cambio desde la constancia (o una ligera sobre-constancia) a infra-constancia en función de la distancia física para todos los grupos de edad. La diferencia de edad se nota en la magnitud de la infra-constancia que ocurre en las distancias más largas, donde los adultos presentaban niveles menores de infra-constancia que los niños. Estos datos se interpretan como debidos a un cambio evolutivo en el procesamiento cognitivo más que a cambios en la percepción visual del espacio

    TRAF1/C5 but Not PTPRC Variants Are Potential Predictors of Rheumatoid Arthritis Response to Anti-Tumor Necrosis Factor Therapy

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    Background. The aim of our work was to replicate, in a Southern European population, the association reported in Northern populations between PTPRC locus and response to anti-tumor necrosis factor (anti-TNF) treatment in rheumatoid arthritis (RA). We also looked at associations between five RA risk alleles and treatment response. Methods. We evaluated associations between anti-TNF treatment responses assessed by DAS28 change and by EULAR response at six months in 383 Portuguese patients. Univariate and multivariate linear and logistic regression analyses were performed. In a second step to confirm our findings, we pooled our population with 265 Spanish patients. Results. No association was found between PTPRC rs10919563 allele and anti-TNF treatment response, neither in Portuguese modeling for several clinical variables nor in the overall population combining Portuguese and Spanish patients. The minor allele for RA susceptibility, rs3761847 SNP in TRAF1/C5 region, was associated with a poor response in linear and logistic univariate and multivariate regression analyses. No association was observed with the other allellic variants. Results were confirmed in the pooled analysis. Conclusion. This study did not replicate the association between PTPRC and the response to anti-TNF treatment in our Southern European population. We found that TRAF1/C5 risk RA variants potentially influence anti-TNF treatment response.This work was supported by a grant from Harvard-Portugal Program HMSP-ICS/SAU-ICT/0002/2010. Daniel H. Solomon received support for this work from the NIH (K24-AR-055989). Elizabeth W. Karlson received support for this work from NIH (K24-AR-AR0524). Reuma.pt received unrestricted grants from Abbott, Bristol-Myers Squibb, Merck Sharp and Dohme, Pfizer, Roche, and UCB Pharma

    Comparison of Three-Phase Active Rectifiers For Aircraft Application

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    In aircraft applications, there has been an increasing trend related with the More Electric Aircraft (MEA), which results in rapid rise in the electrical power demand on-board. One of its goals lies in minimizing weight and volume of the electrical subsystem while maintaining good power quality and efficiency. The main purpose of this paper is to present and analyze an electrical design of three-phase Boost rectifier, three-phase Buck rectifier and three-phase Vienna rectifier for 10 kW active rectifiers and compare them in terms of weight, volume, efficiency etc. Moreover, the design is obliged to comply with DO-160 standard for avionic equipment with 230 V AC, 360-800 Hz grid conditions. Even though all proposed solutions satisfy the standard requirements, it will be shown that the Vienna rectifier has the lowest volume and therefore, the better solution overall. However, due to increased number of semiconductors and additional circuitry required for soft start-up, the Buck rectifier would prove to be the safest solution failure-wise
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