15 research outputs found
Repositioning analysis of mucopolysaccharidoses-related drugs based on transcriptional signatures
MPSBase : comprehensive repository of differentially expressed genes for mucopolysaccharidoses
Avaliação do perfil de metilação do promotor do gene btd em indivíduos com diferentes níveis de atividade da biotinidase
Drug Repositioning Applied to Cardiovascular Disease in Mucopolysaccharidosis
Mucopolysaccharidoses (MPS) are genetic metabolic diseases characterized by defects in the activity of lysosomal hydrolases. In MPS, secondary cell disturbance affects pathways related to cardiovascular disorders. Hence, the study aimed to identify MPS-related drugs targeting cardiovascular disease and select a list of drugs for repositioning. We obtained a list of differentially expressed genes and pathways. To identify drug perturbation-driven gene expression and drug pathways interactions, we used the CMAP and LINCS databases. For molecular docking, we used the DockThor web server. Our results suggest that pirfenidone and colchicine are promising drugs to treat cardiovascular disease in MPS patients. We also provide a brief description of good practices for the repositioning analysis. Furthermore, the list of drugs and related MPS-enriched genes could be helpful to new treatments and considered for pathophysiological studies
Gerda Cristal Villalba Silva's Quick Files
The Quick Files feature was discontinued and it’s files were migrated into this Project on March 11, 2022. The file URL’s will still resolve properly, and the Quick Files logs are available in the Project’s Recent Activity
Caracterização da região 3'UTR e de elementos regulatórios do gene BTD em indivíduos com diferentes níveis de atividade da biotinidase
Resumo não disponíve