Análise do desempenho econômico-financeiro de três empresas de capital aberto do setor de construção civil (2009-2018)

This study aims to analyze the evolution of the economic and financial performance of three largest publicly listed companies in the field of incorporations, through liquidity indicators; debt and capital composition; operational profitability and rentability, from 2009 to 2018, assessing the impact of the economic recession period (2014-2018), in relation to the previous period. As for the methodological aspects, it is a descriptive, documentary and quantitative research. The companies selected were the first three in the ranking of Construction Business Intelligence in 2016: MRV Engenharia & Participacoes SA, Direcional Engenharia SA and Cyrela Brazil Realty AS. The data were collected at [B]3 – Brasil, Bolsa e Balcão and treated by the software Stata, with the application of Wilcoxon tests (to compare the results before and after the economic recession) and the Kruskal-Wallis test (to compare the performance between companies). The results revealed a statistically significant influence of the economic recession, with reduction in the short-term debt ratio (MRV and Direcional); increased fundraising for third parties (Direcional and Cyrela); reduction in the Ebitda´s Margin (MRV) and profitability (Cyrela). It also found significant differences between companies’ liquidity and debt indicators.Este artigo tem por objetivo analisar o desempenho econômico-financeiro das três maiores empresas de capital aberto do segmento de Incorporações, mediante os indicadores de liquidez (imediata e corrente), endividamento (curto prazo e participação de capital de terceiros), lucratividade (Margem Ebitda) e rentabilidade (Retorno sobre o Patrimônio Líquido), em dois períodos (2009 a 2013 e 2014 a 2018), avaliando o impacto da recessão econômica a partir de 2014. Quanto aos aspectos metodológicos, trata-se de pesquisa quantitativa, descritiva e documental. As empresas escolhidas foram as três primeiras do ranking da Inteligência Empresarial da Construção (2016): MRV Engenharia, Direcional Engenharia e Cyrela Brazil Realty. Os dados foram coletados na [B]3 – Brasil, Bolsa e Balcão tratados pelo software Stata, com aplicação dos testes de Wilcoxon (comparação dos resultados antes e após a recessão econômica) e Kruskal-Wallis (comparação do desempenho entre as empresas). Os resultados revelaram influência significativa do período de recessão econômica, com redução do índice endividamento em curto prazo (MRV e Direcional), aumento da captação de recursos de terceiros (Direcional e Cyrela), redução da Margem Ebitda (MRV) e rentabilidade (Cyrela). Ainda, constataram-se diferenças significativas entre as empresas para os indicadores de liquidez e endividamento

Qualidade de vida de indivíduos com HIV: revisão integrativa / Quality of living of individuals with HIV integration review

 A qualidade de  vida de pacientes vivendo com HIV/AIDS é essencial, tendo em vista o caso específico dos adolescentes é ainda mais importante porque o jovem além de lidar com a resistência e a aceitação da doença, deve também enfrentar os conflitos da puberdade.O presente trabalho tem como objetivo realizar uma revisão integrativa em relação a qualidade de vida dos pacientes com HIV. Trata-se de um estudo de revisão integrativa realizado no período de 2016 a 2017, utilizando-se o banco de dados Medline e Lilacs. Apesar do impacto da infecção pelo HIV/AIDS na saúde psicológica e nas relações sociais dos indivíduos infectados, assim como no domínio físico, o uso da TARV provocou consequências positivas na saúde psicológica, proporcionando a desconstrução da ideia de morte advinda ao diagnóstico de portador do HIV/AIDS e a construção de melhores perspectivas de vida. A adesão ao tratamento em HIV/AIDS está relacionada a um aumento da sobrevida e de sua qualidade. Porém deve-se respeitar a posição pessoal do portador para fazer ou não o tratamento

Consequências da deriva de clomazone e sulfentrazone em clones de E. grandis x E. urophylla

Este trabalho teve por objetivo estudar os efeitos de deriva simulada dos herbicidas clomazone e sulfentrazone em dois clones comerciais de E. grandis x E. urophylla, da Votorantim Celulose e Papel (VCP1 e VCP2). Na simulação, as doses do herbicida clomazone variaram de 0 a 2.000 mL ha-1 e no sulfentrazone, de 0 a 1.500 mL ha-1. As mudas dos dois clones, previamente selecionadas, foram plantadas em vasos com capacidade para 5,0 L. O solo utilizado foi o Neossolo Quartzarênico, sendo a aplicação dos herbicidas realizada 80 dias após o plantio. O delineamento experimental utilizado em cada herbicida foi o de blocos casualizados, com os tratamentos dispostos em esquema fatorial 2 x 8, com três repetições. O efeito do clomazone resultou em folhas novas rosadas, amareladas e, em alguns casos, esbranquiçadas, como um todo ou em parte dela, enquanto as nervuras se mantiveram verdes. Observou-se, também, que as folhas velhas se tornaram mais verdes e grossas. Ocorreu redução nas características de crescimento, variando de 13 a 57%, e as doses consideradas críticas do herbicida clomazone foram de 800 e 1.200 ml ha-1 nos clones VCP1 e VCP2, respectivamente. Com o sulfentrazone, os sintomas da deriva foram necroses generalizadas nas folhas novas e velhas; ao redor da necrose, formaram-se região arroxeada e deformação intensa nas folhas novas e regular nas folhas velhas, bem como houve perda de dominância apical. As características de crescimento indicaram redução de 9 a 66%. A dose crítica desse herbicida foi de 75 ml ha-1 no clone VCP1 e 1.200 ml ha-1 no VCP2. Conclui-se que uma possível deriva dos herbicidas estudados e utilizados em cana-de-açúcar poderá causar prejuízos ao crescimento dos clones avaliados.This research aimed to develop accurate information about the effects of two simulated herbicide drift (clomazone and sulfentrazone) on the growth of Votorantim Celulose e Papel Eucalyptus grandis x E. urohylla comercial clones (VCP1 and VCP2). This research imposed doses to clomazone ranging between 0 and 2000 mL ha-1 and 0 to 1500 mL ha-1 to sulfentrazone. One cutting of each clone was planted in 5.0 liter plastic pots filled with sandy soil. 80 days after the planting, the herbicide applications were carried out. The treatments were applied to plots with completely randomized blocks with a 2x8 factorial design and replicated three times. The clomazone effects resulted in yellowish, pinkish young leaves and, in some cases, a whitening effect between leaf veins and strongly green and thicker older leaves. The growth parameters were reduced between 13 and 57% and the critical doses of clomazone were from 800 to 1200 ml ha-1, for the clones VCP1 and VCP2, respectively. For sulfentrazone, the drift symptoms included speckling and spotting of younger and older leaves, and purple rings around the spots. High deformation of younger leaves, regular deformation of older leaves, and apical dominance also occurred. The growth parameters indicated a reduction between 9 and 66%. The critical doses to sulfentrazone were 75 - 1200 ml ha-1, for the clones VCP1 and VCP2, respectively. We may conclude from this research that clomazone and sulfentrazone drift could affect the development of the clones evaluated.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq

Data_Sheet_1_First generation of multifunctional peptides derived from latarcin-3a from Lachesana tarabaevi spider toxin.DOCX

The need for discovering new compounds that can act selectively on pathogens is becoming increasingly evident, given the number of deaths worldwide due to bacterial infections or tumor cells. New multifunctional biotechnological tools are being sought, including compounds present in spider venoms, which have high biotechnological potential. The present work aims to perform the rational design and functional evaluation of synthetic peptides derived from Lachesana tarabaevi spider toxin, known as latarcin-3a. The antimicrobial activity was tested against Gram-positive and -negative bacteria, with minimum inhibitory concentrations (MIC) between 4 and 128 μg.ml−1. Anti-biofilm tests were then performed to obtain MICs, where the peptides demonstrated activity from 4 to 128 μg.ml−1. In vitro cell cytotoxicity assays were carried out from tumor cell lines, lineages C1498, Kasumi-1, K-562, Jurkat, MOLT4, and Raji. Erythrocyte integrity was evaluated in the presence of synthetic peptides analog, which did not promote hemolysis at 128 μg.ml−1. The peptide that showed the best antibacterial activity was Lt-MAP3 and the best antitumor was Lt-MAP2. In conclusion, rational design of multifunctional antimicrobial peptides may be promising alternative tools in the treatment of emerging diseases such as bacterial infections and tumor cells.</p

Image_5_First generation of multifunctional peptides derived from latarcin-3a from Lachesana tarabaevi spider toxin.TIF

The need for discovering new compounds that can act selectively on pathogens is becoming increasingly evident, given the number of deaths worldwide due to bacterial infections or tumor cells. New multifunctional biotechnological tools are being sought, including compounds present in spider venoms, which have high biotechnological potential. The present work aims to perform the rational design and functional evaluation of synthetic peptides derived from Lachesana tarabaevi spider toxin, known as latarcin-3a. The antimicrobial activity was tested against Gram-positive and -negative bacteria, with minimum inhibitory concentrations (MIC) between 4 and 128 μg.ml−1. Anti-biofilm tests were then performed to obtain MICs, where the peptides demonstrated activity from 4 to 128 μg.ml−1. In vitro cell cytotoxicity assays were carried out from tumor cell lines, lineages C1498, Kasumi-1, K-562, Jurkat, MOLT4, and Raji. Erythrocyte integrity was evaluated in the presence of synthetic peptides analog, which did not promote hemolysis at 128 μg.ml−1. The peptide that showed the best antibacterial activity was Lt-MAP3 and the best antitumor was Lt-MAP2. In conclusion, rational design of multifunctional antimicrobial peptides may be promising alternative tools in the treatment of emerging diseases such as bacterial infections and tumor cells.</p

Image_2_First generation of multifunctional peptides derived from latarcin-3a from Lachesana tarabaevi spider toxin.TIF

The need for discovering new compounds that can act selectively on pathogens is becoming increasingly evident, given the number of deaths worldwide due to bacterial infections or tumor cells. New multifunctional biotechnological tools are being sought, including compounds present in spider venoms, which have high biotechnological potential. The present work aims to perform the rational design and functional evaluation of synthetic peptides derived from Lachesana tarabaevi spider toxin, known as latarcin-3a. The antimicrobial activity was tested against Gram-positive and -negative bacteria, with minimum inhibitory concentrations (MIC) between 4 and 128 μg.ml−1. Anti-biofilm tests were then performed to obtain MICs, where the peptides demonstrated activity from 4 to 128 μg.ml−1. In vitro cell cytotoxicity assays were carried out from tumor cell lines, lineages C1498, Kasumi-1, K-562, Jurkat, MOLT4, and Raji. Erythrocyte integrity was evaluated in the presence of synthetic peptides analog, which did not promote hemolysis at 128 μg.ml−1. The peptide that showed the best antibacterial activity was Lt-MAP3 and the best antitumor was Lt-MAP2. In conclusion, rational design of multifunctional antimicrobial peptides may be promising alternative tools in the treatment of emerging diseases such as bacterial infections and tumor cells.</p