1,123 research outputs found
The transition between hole-pairs and four-hole clusters in four-leg tJ ladders
Holes weakly doped into a four-leg \tj ladder bind in pairs. At dopings
exceeding a critical doping of four hole clusters are
observed to form in DMRG calculations. The symmetry of the ground state
wavefunction does not change and we are able to reproduce this behavior
qualitatively with an effective bosonic model in which the four-leg ladder is
represented as two coupled two-leg ladders and hole-pairs are mapped on hard
core bosons moving along and between these ladders. At lower dopings,
, a one dimensional bosonic representation for hole-pairs
works and allows us to calculate accurately the Luttinger liquid parameter
\krho, which takes the universal value \krho=1 as half-filling is
approached
Feed rate modeling in circular–circular interpolation discontinuity for high-speed milling
In this paper, a modeling approach is presented in order to evaluate feed rate during a circular interpolation in high-speed milling. The developed model depends on the type of discontinuity and the kinematic performance of the machine tool. To begin with, a feed rate modeling for circular interpolation with continuity in tangency is developed. After, the discontinuity in tangency between two circular interpolations is replaced by discontinuity in curvature by adding a fillet which is in relation to the functional tolerance ε imposed in the part design. An experimental study has been carried out to validate the models
Calcium channel blockers reduce the antiplatelet effect of clopidogrel
ObjectivesBecause of the known CYP3A4 inhibition by calcium-channel blockers (CCBs), we hypothesized that there might be a drug-drug interaction between clopidogrel and dihydropyridines in patients with coronary artery disease.BackgroundClopidogrel is activated by CYP3A4, which also metabolizes CCBs of the dihydropyridine class.MethodsResponsiveness to clopidogrel was assessed by the vasodilator-stimulated phosphoprotein (VASP) phosphorylation assay and aggregometry in 200 patients with coronary artery disease undergoing percutaneous coronary intervention.ResultsThe platelet reactivity index (PRI) (in the VASP assay, normal range 69% to 100%) was higher in patients receiving both clopidogrel and CCBs (61%) as compared with patients receiving clopidogrel without CCBs (48%). The absolute difference was 13% (95% confidence interval: 6% to 20%; p = 0.001), and the relative difference approached 21%. A decreased platelet inhibition by clopidogrel (PRI >69%) was seen in 40% of patients with concomitant CCB treatment and in 20% of patients without concomitant treatment (chi-square test, p = 0.008). Intake of CCB remained an independent predictor of reduced platelet inhibition by clopidogrel after adjustment for cardiovascular risk factors. Adenosine diphosphate-induced platelet aggregation was 30% higher in patients on concomitant CCB treatment compared with patients without CCBs (p = 0.046). Moreover, intake of CCBs was associated with adverse clinical outcome. In vitro incubation with CCBs (nimodipine, verapamil, amlodipine, and diltiazem) did not alter the PRI or the adenosine diphosphate–induced platelet aggregation of patients taking clopidogrel. This finding indicates that the negative effect occurs in vivo, conceivably at the level of the CYP3A4 cytochrome.ConclusionsCoadministration of CCBs is associated with decreased platelet inhibition by clopidogrel
Optimal duration and combination of antiplatelet therapies following percutaneous coronary intervention: a meta-analysis.
Abstract Introduction The ideal duration of dual antiplatelet therapy (DAPT) following percutaneous coronary intervention (PCI) is still unknown. In this meta-analysis, we aimed to compare very short-term (1–3 months), short-term (6 months), standard-term (12 months) and long-term (>12 months) DAPT durations for efficacy and safety. Methods Overall DAPT comparisons were classified as "any shorter-term"/"any longer-term" DAPT. The primary outcome was a composite of major adverse cardiovascular events (MACE: non-fatal myocardial infarction, non-fatal stroke and cardiovascular death). The primary safety outcome was major bleeding. Results Twenty-six studies comprising 103.394 patients were included. Compared with standard-term DAPT duration, very short-term DAPT duration with subsequent drop of aspirin (RR 1.06, 95% CI, 0.95–1.18, p = 0.26) or drop of the P2Y12 inhibitor (RR 0.92, 95% CI, 0.72-1.16, p = 0.47) was not associated with a higher risk of MACE. Any longer-term compared with any shorter-term DAPT durations led to a significantly lower risk of MACE (RR 0.88, 95% CI, 0.81–0.96, p = 0.002), but a significantly higher risk of BARC 3-5 major bleeding events (RR 1.63, 95% CI, 1.22–2.17, p = 0.001). In the ACS subgroup receiving prasugrel or ticagrelor but not clopidogrel, any longer-term DAPT duration was associated with a significantly lower risk of MACE compared to any shorter-term DAPT duration (RR 0.84, 95% CI, 0.77–0.92, p = 0.0001). Conclusion DAPT may be shortened to 1-3 months in patients with low ischemic but high bleeding risk followed by aspirin or P2Y12 monotherapy. Prasugrel or ticagrelor based DAPT may be extended to >12 months in case of high ischemic and low bleeding risk. PROSPERO registration no CRD42020163719
Development of a rapid screen for the endodermal differentiation potential of human pluripotent stem cell lines.
A challenge facing the human pluripotent stem cell (hPSC) field is the variability observed in differentiation potential of hPSCs. Variability can lead to time consuming and costly optimisation to yield the cell type of interest. This is especially relevant for the differentiation of hPSCs towards the endodermal lineages. Endodermal cells have the potential to yield promising new knowledge and therapies for diseases affecting multiple organ systems, including lung, thymus, intestine, pancreas and liver, as well as applications in regenerative medicine and toxicology. Providing a means to rapidly, cheaply and efficiently assess the differentiation potential of multiple hPSCs is of great interest. To this end, we have developed a rapid small molecule based screen to assess the endodermal potential (EP) of hPSCs, based solely on definitive endoderm (DE) morphology. This drastically reduces the cost and time to identify lines suitable for use in deriving endodermal lineages. We demonstrate the efficacy of this screen using 10 different hPSCs, including 4 human embryonic stem cell lines (hESCs) and 6 human induced pluripotent stem cell lines (hiPSCs). The screen clearly revealed lines amenable to endodermal differentiation, and only lines that passed our morphological assessment were capable of further differentiation to hepatocyte like cells (HLCs)
Charge density correlations in t-J ladders investigated by the CORE method
Using 4-site plaquette or rung basis decomposition, the CORE method is
applied to 2-leg and 4-leg t-J ladders and cylinders. Resulting range-2
effective hamiltonians are studied numerically on periodic rings taking full
advantage of the translation symmetry as well as the drastic reduction of the
Hilbert space. We investigate the role of magnetic and fermionic degrees of
freedom to obtain the most reliable representation of the underlying model.
Spin gaps, pair binding energies and charge correlations are computed and
compared to available ED and DMRG data for the full Hamiltonian. Strong
evidences for short-range diagonal stripe correlations are found in periodic
4-leg t-J ladders.Comment: Computation of Luttinger liquid parameters (charge velocity and
charge correlation exponent) adde
The Wisconsin Plasma Astrophysics Laboratory
The Wisconsin Plasma Astrophysics Laboratory (WiPAL) is a flexible user
facility designed to study a range of astrophysically relevant plasma processes
as well as novel geometries that mimic astrophysical systems. A multi-cusp
magnetic bucket constructed from strong samarium cobalt permanent magnets now
confines a 10 m, fully ionized, magnetic-field free plasma in a spherical
geometry. Plasma parameters of to eV and
to cm provide an ideal testbed
for a range of astrophysical experiments including self-exciting dynamos,
collisionless magnetic reconnection, jet stability, stellar winds, and more.
This article describes the capabilities of WiPAL along with several
experiments, in both operating and planning stages, that illustrate the range
of possibilities for future users.Comment: 21 pages, 12 figures, 2 table
A Bosonic Model of Hole Pairs
We numerically investigate a bosonic representation for hole pairs on a
two-leg t-J ladder where hard core bosons on a chain represent the hole pairs
on the ladder. The interaction between hole pairs is obtained by fitting the
density profile obtained with the effective model to the one obtained with the
\tj model, taking into account the inner structure of the hole pair given by
the hole-hole correlation function. For these interactions we calculate the
Luttinger liquid parameter, which takes the universal value as
half filling is approached, for values of the rung exchange between strong
coupling and the isotropic case. The long distance behavior of the hole-hole
correlation function is also investigated. Starting from large , the
correlation length first increases as expected, but diminishes significantly as
is reduced and bound holes sit mainly on adjacent rungs. As the isotropic
case is approached, the correlation length increases again. This effect is
related to the different kind of bonds in the region between the two holes of a
hole pair when they move apart.Comment: 11 page
Friedel Oscillations and Charge Density Waves in Chains and Ladders
The density matrix renormalization group method for ladders works much more
efficiently with open boundary conditions. One consequence of these boundary
conditions is groundstate charge density oscillations that often appear to be
nearly constant in magnitude or to decay only slightly away from the
boundaries. We analyse these using bosonization techniques, relating their
detailed form to the correlation exponent and distinguishing boundary induced
generalized Friedel oscillations from true charge density waves. We also
discuss a different approach to extracting the correlation exponent from the
finite size spectrum which uses exclusively open boundary conditions and can
therefore take advantage of data for much larger system sizes. A general
discussion of the Friedel oscillation wave-vectors is given, and a convenient
Fourier transform technique is used to determine it. DMRG results are analysed
on Hubbard and t-J chains and 2 leg t-J ladders. We present evidence for the
existence of a long-ranged charge density wave state in the t-J ladder at a
filling of n=0.75 and near J/t \approx 0.25.Comment: Revtex, 15 pages, 15 postscript figure
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