Cancer treating nanothread

Medicine doesn't stand still; scientists from all over the world are working to create new medicines and ways of treatment of different diseases. New openings and technologies give them a chance to combat those illnesses which earlier seemed to be incurable

Planck early results XV : Spectral energy distributions and radio continuum spectra of northern extragalactic radio sources

Peer reviewe

Quantitative Response of IMS Detector for Mixtures Containing Two Active Components

This study describes the relationship between the output signal of the ion mobility spectrometry (IMS) detector and the concentrations of two compounds being simultaneously introduced into the reaction section. Investigations were performed for three pairs of compounds, that is, dimethyl methylphosphonate (DMMP) and acetone, methyl <i>tert</i>-butyl ether (MTBE), and acetone, as well as trimethylamine (TMA) and <i>n</i>-nonylamine (NA). Vapors of the investigated compounds were produced in a two-channel generator with permeation sources and a dilution system based on mass-flow controllers. The generator design and the method of concentration determination are discussed in this paper. It was found that admixture can differently influence detection of an analyte. The presence of acetone does not effect the signal corresponding to dimer ions of DMMP. For pairs MTBE + acetone and TMA + NA characteristic peaks of analyte ions diminish with growing concentration of admixture, however, the detection based on the peak of the asymmetric dimer containing proton-bound molecules of both compounds is effective. For the detection of TMA in the presence of NA, the signal generated by the asymmetric dimer ions is meaningfully higher than the signals of monomer or dimer TMA ions measured without the NA admixture. The course of calibration dependencies was analyzed on the basis of a simple mathematical model of the reaction region. This model provided an estimation of the intensity of the signal for a given ionic species for definite concentration of analyte

Diphenoxo-Bridged Ni^IILn^III Dinuclear Complexes as Platforms for Heterotrimetallic (Ln^IIINi^II)₂Ru^III Systems with a High-Magnetic-Moment Ground State: Synthesis, Structure, and Magnetic Properties

The first examples of pentanuclear heterotrimetallic [(LnNi)₂Ru] [Ln³⁺ = Gd (<b>1</b>) and Dy (<b>2</b>)] complexes were prepared and magnetostructurally characterized. They exhibit ferromagnetic interactions, leading to a high-magnetic-moment ground state

Genetics of hypospadias: are single-nucleotide polymorphisms in SRD5A2, ESR1, ESR2, and ATF3 really associated with the malformation?

Contains fulltext : 88536.pdf (publisher's version ) (Open Access)CONTEXT: Hypospadias is a common congenital malformation of the male external genitalia with a multifactorial etiology. Little is known about the genes involved in hypospadias. A few genetic associations have been reported but mainly in studies of small sample size. Most of these associations have not been replicated. OBJECTIVE: The aim of this study was to investigate whether previously reported associations for four single-nucleotide polymorphisms (SNPs) in genes involved in hormonal pathways could be replicated in a large Dutch hypospadias sample. The SNPs investigated are rs523349 in steroid-5 alpha-reductase (SRD5A2), rs6932902 in estrogen receptor 1 (ESR1), rs2987983 in ESR2, and rs11119982 in activating transcription factor 3 (ATF3). DESIGN, PARTICIPANTS, AND METHODS: We genotyped 620 Caucasian hypospadias cases and 596 controls for these SNPs using TaqMan-based genotyping. RESULTS: We did not replicate the associations of the SNPs in SRD5A2 and ESR1 with hypospadias. The SNPs in ESR2 and ATF3 were borderline associated with hypospadias [odds ratios 0.9 (95% confidence interval 0.7-1.0) and 1.2 (95% confidence interval 1.0-1.4), respectively] but in the opposite direction compared with earlier publications. Stratification according to localization of the urethral opening produced comparable results in the subgroups. CONCLUSIONS: The lack of consistency between our and previously performed studies might represent spurious results or chance findings in our or the earlier studies, differences in criteria used to select the study populations, or a real difference between populations, i.e. different genes contributing to disease risk. These results once again confirm the importance of replication in genetic association approaches.1 mei 201

Science with the Cherenkov Telescope Array

The Cherenkov Telescope Array, CTA, will be the major global observatory for very high energy gamma-ray astronomy over the next decade and beyond. The scientific potential of CTA is extremely broad: from understanding the role of relativistic cosmic particles to the search for dark matter. CTA is an explorer of the extreme universe, probing environments from the immediate neighbourhood of black holes to cosmic voids on the largest scales. Covering a huge range in photon energy from 20 GeV to 300 TeV, CTA will improve on all aspects of performance with respect to current instruments. The observatory will operate arrays on sites in both hemispheres to provide full sky coverage and will hence maximize the potential for the rarest phenomena such as very nearby supernovae, gamma-ray bursts or gravitational wave transients. With 99 telescopes on the southern site and 19 telescopes on the northern site, flexible operation will be possible, with sub-arrays available for specific tasks. CTA will have important synergies with many of the new generation of major astronomical and astroparticle observatories. Multi-wavelength and multi-messenger approaches combining CTA data with those from other instruments will lead to a deeper understanding of the broad-band non-thermal properties of target sources. The CTA Observatory will be operated as an open, proposal-driven observatory, with all data available on a public archive after a pre-defined proprietary period. Scientists from institutions worldwide have combined together to form the CTA Consortium. This Consortium has prepared a proposal for a Core Programme of highly motivated observations. The programme, encompassing approximately 40% of the available observing time over the first ten years of CTA operation, is made up of individual Key Science Projects (KSPs), which are presented in this document

Science with the Cherenkov Telescope Array

The Cherenkov Telescope Array, CTA, will be the major global observatory for very high energy gamma-ray astronomy over the next decade and beyond. The scientific potential of CTA is extremely broad: from understanding the role of relativistic cosmic particles to the search for dark matter. CTA is an explorer of the extreme universe, probing environments from the immediate neighbourhood of black holes to cosmic voids on the largest scales. Covering a huge range in photon energy from 20 GeV to 300 TeV, CTA will improve on all aspects of performance with respect to current instruments. The observatory will operate arrays on sites in both hemispheres to provide full sky coverage and will hence maximize the potential for the rarest phenomena such as very nearby supernovae, gamma-ray bursts or gravitational wave transients. With 99 telescopes on the southern site and 19 telescopes on the northern site, flexible operation will be possible, with sub-arrays available for specific tasks. CTA will have important synergies with many of the new generation of major astronomical and astroparticle observatories. Multi-wavelength and multi-messenger approaches combining CTA data with those from other instruments will lead to a deeper understanding of the broad-band non-thermal properties of target sources. The CTA Observatory will be operated as an open, proposal-driven observatory, with all data available on a public archive after a pre-defined proprietary period. Scientists from institutions worldwide have combined together to form the CTA Consortium. This Consortium has prepared a proposal for a Core Programme of highly motivated observations. The programme, encompassing approximately 40% of the available observing time over the first ten years of CTA operation, is made up of individual Key Science Projects (KSPs), which are presented in this document