175 research outputs found
Π‘ΠΈΠ½ΡΠ΅Π· ΡΠ° Π±ΡΠΎΠ»ΠΎΠ³ΡΡΠ½Π° ΠΎΡΡΠ½ΠΊΠ° [[1,2,4]ΡΡΠΈΠ°Π·ΠΎΠ»ΠΎ[4,3-Π°]ΠΏΡΡΠΈΠ΄ΠΈΠ½-3-ΡΠ»]Π°ΡΠ΅ΡΠ°ΠΌΡΠ΄ΡΠ² Π· 1,2,4-ΠΎΠΊΡΠ°Π΄ΡΠ°Π·ΠΎΠ»ΡΠ½ΠΈΠΌ ΡΠΈΠΊΠ»ΠΎΠΌ Ρ 6, 7 ΡΠ° 8 ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½Π½Ρ
Fused heterocyclic 1,2,4-triazoles have provided much attention due to variety of their interesting biological properties.Aim. To develop the method for the synthesis of novel 2-[(1,2,4-oxadiazol-5-yl)-[1,2,4]triazolo[4,3-a]pyridine-3-yl]acetamides and conduct the biological assessment of the compounds synthesized.Results and discussion. A diverse set of acetamides newly synthesized consists of 32 analogs bearing an 1,2,4-oxadiazole cycle in positions 6, 7 and 8. A convenient scheme of the synthesis starts from commercially available 2-chloropyridine-3-, 2-chloropyridine-4-, 2-chloropyridine-5-carboxylic acids with amidoximes to form the corresponding 2-chloro-[3-R1-1,2,4-oxadiazol-5-yl]pyridines, then follows the reaction ofΒ hydrazinolysis with an excess of hydrazine hydrate. The process continues via the ester formation with the pyridine ring closure, then the amide formations of the end products are obtained by hydrolysis into acetic acid.Experimental part. A series of new 2-[6-(1,2,4-oxadiazol-5-yl)-, 2-[7-(1,2,4-oxadiazol-5-yl)-, 2-[8-(1,2,4-oxadiazol-5-yl)-[1,2,4]triazolo[4,3-a]pyridine-3-yl]acetamides were obtained in good yields, and their structures were proven by the method of 1H NMR spectroscopy. The prognosis and study of their pharmacological activity were also conducted.Conclusions. The synthetic approach of obtaining the representatives of 2-[(1,2,4-oxadiazol-5-yl)-[1,2,4]triazolo[4,3-a]pyridine-3-yl]acetamides previously unknown can be used as an applicable method for the synthesis of diverse functionalized [1,2,4]triazolo[4,3-a]pyridine derivatives.ΠΠΎΠ½Π΄Π΅Π½ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ Π³Π΅ΡΠ΅ΡΠΎΡΠΈΠΊΠ»ΠΈΡΠ΅ΡΠΊΠΈΠ΅ 1,2,4-ΡΡΠΈΠ°Π·ΠΎΠ»Ρ ΠΏΡΠΈΠ²Π»Π΅ΠΊΠ°ΡΡ Π±ΠΎΠ»ΡΡΠΎΠ΅ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΡΠ°Π·Π½ΠΎΠΎΠ±ΡΠ°Π·ΠΈΠ΅ΠΌ ΠΈΠ½ΡΠ΅ΡΠ΅ΡΠ½ΡΡ
Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ²ΠΎΠΉΡΡΠ².Π¦Π΅Π»Ρ ΡΠ°Π±ΠΎΡΡ. Π Π°Π·ΡΠ°Π±ΠΎΡΠ°ΡΡ ΠΌΠ΅ΡΠΎΠ΄ ΡΠΈΠ½ΡΠ΅Π·Π° Π½ΠΎΠ²ΡΡ
2-[(1,2,4-ΠΎΠΊΡΠ°Π΄ΠΈΠ°Π·ΠΎΠ»-5-ΠΈΠ»)- [1,2,4]ΡΡΠΈΠ°Π·ΠΎΠ»ΠΎ[4,3-a]ΠΏΠΈΡΠΈΠ΄ΠΈΠ½-3-ΠΈΠ»]Π°ΡΠ΅ΡΠ°ΠΌΠΈΠ΄ΠΎΠ² ΠΈ ΠΏΡΠΎΠ²Π΅ΡΡΠΈ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΡΡ ΠΎΡΠ΅Π½ΠΊΡ ΡΠΈΠ½ΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈ ΠΈΡ
ΠΎΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΠ΅. Π‘ΠΈΠ½ΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½ ΡΡΠ΄ Π½ΠΎΠ²ΡΡ
ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΡ
Π°ΡΠ΅ΡΠ°ΠΌΠΈΠ΄ΠΎΠ², ΠΊΠΎΡΠΎΡΡΠΉ ΡΠΎΡΡΠΎΠΈΡ ΠΈΠ· 32 Π°Π½Π°Π»ΠΎΠ³ΠΎΠ², ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΡ
1,2,4-ΠΎΠΊΡΠ°Π΄ΠΈΠ°Π·ΠΎΠ»ΡΠ½ΡΠΉ ΡΠΈΠΊΠ» Π² 6, 7 ΠΈ 8 ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΡΡ
. Π£Π΄ΠΎΠ±Π½Π°Ρ ΡΡ
Π΅ΠΌΠ° ΡΠΈΠ½ΡΠ΅Π·Π° Π½Π°ΡΠΈΠ½Π°Π΅ΡΡΡ Ρ ΠΊΠΎΠΌΠΌΠ΅ΡΡΠ΅ΡΠΊΠΈ Π΄ΠΎΡΡΡΠΏΠ½ΡΡ
2-Ρ
Π»ΠΎΡΠΏΠΈΡΠΈΠ΄ΠΈΠ½-3, 2-Ρ
Π»ΠΎΡΠΏΠΈΡΠΈΠ΄ΠΈΠ½-4, 2-Ρ
Π»ΠΎΡΠΏΠΈΡΠΈΠ΄ΠΈΠ½-5-ΠΊΠ°ΡΠ±ΠΎΠ½ΠΎΠ²ΡΡ
ΠΊΠΈΡΠ»ΠΎΡ Ρ Π°ΠΌΠΈΠ΄ΠΎΠΊΡΠΈΠΌΠ°ΠΌΠΈ Ρ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΡΡΠΈΡ
2-Ρ
Π»ΠΎΡ-[3-R1-1,2,4-ΠΎΠΊΡΠ°Π΄ΠΈΠ°Π·ΠΎΠ»-5-ΠΈΠ»]ΠΏΠΈΡΠΈΠ΄ΠΈΠ½ΠΎΠ², ΠΏΠΎΡΠ»Π΅ ΡΠ΅Π³ΠΎ ΡΠ»Π΅Π΄ΡΠ΅Ρ ΡΠ΅Π°ΠΊΡΠΈΡ Π³ΠΈΠ΄ΡΠ°Π·ΠΈΠ½ΠΎΠ»ΠΈΠ·Π° Ρ ΠΈΠ·Π±ΡΡΠΊΠΎΠΌ Π³ΠΈΠ΄ΡΠ°Π·ΠΈΠ½ Π³ΠΈΠ΄ΡΠ°ΡΠ°. ΠΡΠΎΡΠ΅ΡΡ ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠ°Π΅ΡΡΡ ΠΏΡΡΠ΅ΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ ΡΡΠΈΡΠ° Ρ Π·Π°ΠΊΡΡΡΠΈΠ΅ΠΌ ΠΏΠΈΡΠΈΠ΄ΠΈΠ½ΠΎΠ²ΠΎΠ³ΠΎ ΠΊΠΎΠ»ΡΡΠ°, Π·Π°ΡΠ΅ΠΌ ΡΠ΅ΡΠ΅Π· Π³ΠΈΠ΄ΡΠΎΠ»ΠΈΠ· ΠΊ ΡΠΊΡΡΡΠ½ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΠ΅ ΠΌΡ ΠΏΠΎΠ»ΡΡΠ°Π΅ΠΌ Π°ΠΌΠΈΠ΄Π½ΡΠ΅ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ ΠΊΠΎΠ½Π΅ΡΠ½ΡΡ
ΠΏΡΠΎΠ΄ΡΠΊΡΠΎΠ².ΠΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½Π°Ρ ΡΠ°ΡΡΡ. Π ΡΠ΄ Π½ΠΎΠ²ΡΡ
2-[6-(1,2,4-ΠΎΠΊΡΠ°Π΄ΠΈΠ°Π·ΠΎΠ»-5-ΠΈΠ»)-, 2-[7-(1,2,4-ΠΎΠΊΡΠ°Π΄ΠΈΠ°Π·ΠΎΠ»-5-ΠΈΠ»)-, 2-[8-(1,2,4-ΠΎΠΊΡΠ°Π΄ΠΈΠ°Π·ΠΎΠ»-5-ΠΈΠ»)-[1,2,4]ΡΡΠΈΠ°Π·ΠΎΠ»ΠΎ[4,3-Π°] ΠΏΠΈΡΠΈΠ΄ΠΈΠ½-3-ΠΈΠ»]Π°ΡΠ΅ΡΠ°ΠΌΠΈΠ΄ΠΎΠ² Π±ΡΠ» ΠΏΠΎΠ»ΡΡΠ΅Π½ Ρ Ρ
ΠΎΡΠΎΡΠΈΠΌΠΈ Π²ΡΡ
ΠΎΠ΄Π°ΠΌΠΈ, Π° ΠΈΡ
ΡΡΡΡΠΊΡΡΡΡ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π΅Π½Ρ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π―ΠΠ 1H-ΡΠΏΠ΅ΠΊΡΡΠΎΡΠΊΠΎΠΏΠΈΠΈ. Π’Π°ΠΊΠΆΠ΅ Π±ΡΠ» ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ ΠΏΡΠΎΠ³Π½ΠΎΠ· ΠΈ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΈΡ
ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ.ΠΡΠ²ΠΎΠ΄Ρ. Π‘ΠΈΠ½ΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ ΡΠ°Π½Π΅Π΅ Π½Π΅ΠΈΠ·Π²Π΅ΡΡΠ½ΡΡ
ΠΏΡΠ΅Π΄ΡΡΠ°Π²ΠΈΡΠ΅Π»Π΅ΠΉ 2-[(1,2,4-ΠΎΠΊΡΠ°Π΄ΠΈΠ°Π·ΠΎΠ»-5-ΠΈΠ»)-[1,2,4]ΡΡΠΈΠ°Π·ΠΎΠ»ΠΎ4,3-Π°]ΠΏΠΈΡΠΈΠ΄ΠΈΠ½-3-ΠΈΠ»]Π°ΡΠ΅ΡΠ°ΠΌΠΈΠ΄ΠΎΠ² ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ Π΄Π»Ρ ΡΠΈΠ½ΡΠ΅Π·Π° ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
[1,2,4]ΡΡΠΈΠ°Π·ΠΎΠ»ΠΎ[4,3-Π°]ΠΏΠΈΡΠΈΠ΄ΠΈΠ½ΠΎΠ²ΡΡ
ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΡ
.ΠΠΎΠ½Π΄Π΅Π½ΡΠΎΠ²Π°Π½Ρ Π³Π΅ΡΠ΅ΡΠΎΡΠΈΠΊΠ»ΡΡΠ½Ρ 1,2,4-ΡΡΠΈΠ°Π·ΠΎΠ»ΠΈ ΠΏΡΠΈΠ²Π΅ΡΡΠ°ΡΡΡ Π²Π΅Π»ΠΈΠΊΡ ΡΠ²Π°Π³Ρ Π΄ΠΎ ΡΠ΅Π±Π΅ ΡΡΠ·Π½ΠΎΠΌΠ°Π½ΡΡΠ½ΡΡΡΡ ΡΡΠΊΠ°Π²ΠΈΡ
Π±ΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΈΡ
Π²Π»Π°ΡΡΠΈΠ²ΠΎΡΡΠ΅ΠΉ.ΠΠ΅ΡΠ° ΡΠΎΠ±ΠΎΡΠΈ. Π ΠΎΠ·ΡΠΎΠ±ΠΈΡΠΈ ΠΌΠ΅ΡΠΎΠ΄ ΡΠΈΠ½ΡΠ΅Π·Ρ Π½ΠΎΠ²ΠΈΡ
2-[(1,2,4-ΠΎΠΊΡΠ°Π΄ΡΠ°Π·ΠΎΠ»-5-ΡΠ»)-[1,2,4]ΡΡΠΈΠ°Π·ΠΎΠ»ΠΎ[4,3-Π°]ΠΏΡΡΠΈΠ΄ΠΈΠ½-3-ΡΠ»]Π°ΡΠ΅ΡΠ°ΠΌΡΠ΄ΡΠ² ΡΠ° ΠΏΡΠΎΠ²Π΅ΡΡΠΈ Π±ΡΠΎΠ»ΠΎΠ³ΡΡΠ½Ρ ΠΎΡΡΠ½ΠΊΡ ΡΠΈΠ½ΡΠ΅Π·ΠΎΠ²Π°Π½ΠΈΡ
ΡΠΏΠΎΠ»ΡΠΊ.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΠΈ ΡΠ° ΡΡ
ΠΎΠ±Π³ΠΎΠ²ΠΎΡΠ΅Π½Π½Ρ. Π‘ΠΈΠ½ΡΠ΅Π·ΠΎΠ²Π°Π½ΠΎ Π½ΠΈΠ·ΠΊΡ Π½ΠΎΠ²ΠΈΡ
ΠΏΠΎΡ
ΡΠ΄Π½ΠΈΡ
Π°ΡΠ΅ΡΠ°ΠΌΡΠ΄ΡΠ², ΡΠΊΠ° ΡΠΊΠ»Π°Π΄Π°ΡΡΡΡΡ Π· 32 Π°Π½Π°Π»ΠΎΠ³ΡΠ², ΡΠΎ ΠΌΡΡΡΡΡΡ 1,2,4-ΠΎΠΊΡΠ°Π΄ΡΠ°Π·ΠΎΠ»ΡΠ½ΠΈΠΉ ΡΠΈΠΊΠ» Ρ 6, 7 ΡΠ° 8 ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½Π½ΡΡ
. ΠΡΡΡΠ½Π° ΡΡ
Π΅ΠΌΠ° ΡΠΈΠ½ΡΠ΅Π·Ρ ΠΏΠΎΡΠΈΠ½Π°ΡΡΡΡΡ Π· ΠΊΠΎΠΌΠ΅ΡΡΡΠΉΠ½ΠΎ Π΄ΠΎΡΡΡΠΏΠ½ΠΈΡ
2-Ρ
Π»ΠΎΡΠΎΠΏΡΡΠΈΠ΄ΠΈΠ½-3-, 2-Ρ
Π»ΠΎΡΠΎΠΏΡΡΠΈΠ΄ΠΈΠ½-4-, 2-Ρ
Π»ΠΎΡΠΎΠΏΡΡΠΈΠ΄ΠΈΠ½-5-ΠΊΠ°ΡΠ±ΠΎΠ½ΠΎΠ²ΠΈΡ
ΠΊΠΈΡΠ»ΠΎΡ Π· Π°ΠΌΡΠ΄ΠΎΠΊΡΠΈΠΌΠ°ΠΌΠΈ Π· ΡΡΠ²ΠΎΡΠ΅Π½Π½ΡΠΌ Π²ΡΠ΄ΠΏΠΎΠ²ΡΠ΄Π½ΠΈΡ
2-Ρ
Π»ΠΎΡΠΎ-[3-R1-1,2,4-ΠΎΠΊΡΠ°Π΄ΡΠ°Π·ΠΎΠ»-5-ΡΠ»]ΠΏΡΡΠΈΠ΄ΠΈΠ½ΡΠ², ΠΏΡΡΠ»Ρ ΡΠΎΠ³ΠΎ ΠΏΠ΅ΡΠ΅Π±ΡΠ³Π°Ρ ΡΠ΅Π°ΠΊΡΡΡ Π³ΡΠ΄ΡΠ°Π·ΠΈΠ½ΠΎΠ»ΡΠ·Ρ Π· Π½Π°Π΄Π»ΠΈΡΠΊΠΎΠΌ Π³ΡΠ΄ΡΠ°Π·ΠΈΠ½ Π³ΡΠ΄ΡΠ°ΡΡ. ΠΡΠΎΡΠ΅Ρ ΠΏΡΠΎΠ΄ΠΎΠ²ΠΆΡΡΡΡΡΡ ΡΠ»ΡΡ
ΠΎΠΌ ΡΡΠ²ΠΎΡΠ΅Π½Π½Ρ Π΅ΡΡΡΡ Π· Π·Π°ΠΊΡΠΈΡΡΡΠΌ ΠΏΡΡΠΈΠ΄ΠΈΠ½ΠΎΠ²ΠΎΠ³ΠΎ ΠΊΡΠ»ΡΡΡ, ΠΏΠΎΡΡΠΌ ΡΠ΅ΡΠ΅Π· Π³ΡΠ΄ΡΠΎΠ»ΡΠ· Π΄ΠΎ ΠΎΡΡΠΎΠ²ΠΎΡ ΠΊΠΈΡΠ»ΠΎΡΠΈ ΠΌΠΈ ΠΎΡΡΠΈΠΌΡΡΠΌΠΎ Π°ΠΌΡΠ΄Π½Ρ ΡΡΠ²ΠΎΡΠ΅Π½Π½Ρ ΠΊΡΠ½ΡΠ΅Π²ΠΈΡ
ΠΏΡΠΎΠ΄ΡΠΊΡΡΠ².ΠΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½Π° ΡΠ°ΡΡΠΈΠ½Π°. Π ΡΠ΄ Π½ΠΎΠ²ΠΈΡ
2-[6-(1,2,4-ΠΎΠΊΡΠ°Π΄ΡΠ°Π·ΠΎΠ»-5-ΡΠ»)-, 2-[7-(1,2,4-ΠΎΠΊΡΠ°Π΄ΡΠ°Π·ΠΎΠ»-5-ΡΠ»)-, 2-[8-(1,2,4-ΠΎΠΊΡΠ°Π΄ΡΠ°Π·ΠΎΠ»-5-ΡΠ»)-[1,2,4]ΡΡΠΈΠ°Π·ΠΎΠ»ΠΎ[4,3-Π°]ΠΏΡΡΠΈΠ΄ΠΈΠ½-3-ΡΠ»]Π°ΡΠ΅ΡΠ°ΠΌΡΠ΄ΡΠ² Π±ΡΠ² ΠΎΡΡΠΈΠΌΠ°Π½ΠΈΠΉ Π· Π΄ΠΎΠ±ΡΠΈΠΌΠΈ Π²ΠΈΡ
ΠΎΠ΄Π°ΠΌΠΈ, Π° ΡΡ
ΡΡΡΡΠΊΡΡΡΠΈ ΠΏΡΠ΄ΡΠ²Π΅ΡΠ΄ΠΆΠ΅Π½Ρ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π―ΠΠ 1H-ΡΠΏΠ΅ΠΊΡΡΠΎΡΠΊΠΎΠΏΡΡ. Π’Π°ΠΊΠΎΠΆ Π±ΡΠ»ΠΎ Π·ΡΠΎΠ±Π»Π΅Π½ΠΎ ΠΏΡΠΎΠ³Π½ΠΎΠ· ΡΠ° Π²ΠΈΠ²ΡΠ΅Π½Π½Ρ ΡΡ
ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΎΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ.ΠΠΈΡΠ½ΠΎΠ²ΠΊΠΈ. Π‘ΠΈΠ½ΡΠ΅ΡΠΈΡΠ½ΠΈΠΉ ΠΏΡΠ΄Ρ
ΡΠ΄ Π΄ΠΎ ΠΎΡΡΠΈΠΌΠ°Π½Π½Ρ ΡΠ°Π½ΡΡΠ΅ Π½Π΅Π²ΡΠ΄ΠΎΠΌΠΈΡ
ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π½ΠΈΠΊΡΠ² 2-[(1,2,4-ΠΎΠΊΡΠ°Π΄ΡΠ°Π·ΠΎΠ»-5-ΡΠ»)-[1,2,4]ΡΡΠΈΠ°Π·ΠΎΠ»ΠΎ[4,3-Π°]ΠΏΡΡΠΈΠ΄ΠΈΠ½-3-ΡΠ»]Π°ΡΠ΅ΡΠ°ΠΌΡΠ΄ΡΠ² ΠΌΠΎΠΆΠ΅ Π±ΡΡΠΈ Π·Π°ΡΡΠΎΡΠΎΠ²Π°Π½ΠΈΠΉ Π΄Π»Ρ ΡΠΈΠ½ΡΠ΅Π·Ρ ΡΡΠ·Π½ΠΎΠΌΠ°Π½ΡΡΠ½ΠΈΡ
ΡΡΠ½ΠΊΡΡΠΎΠ½Π°Π»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ
[1,2,4]ΡΡΠΈΠ°Π·ΠΎΠ»ΠΎ[4,3-Π°]ΠΏΡΡΠΈΠ΄ΠΈΠ½ΠΎΠ²ΠΈΡ
ΠΏΠΎΡ
ΡΠ΄Π½ΠΈΡ
True Dielectric and Ideal Conductor in Theory of the Dielectric Function for Coulomb System
On the basis of the exact relations the general formula for the static
dielectric permittivity e(q,0) for Coulomb system is found in the region of
small wave vectors q. The obtained formuladescribes the dielectric function
e(q,0) of the Coulomb system in both states in the "metallic" state and in the
"dielectric" one. The parameter which determines possible states of the Coulomb
system - from the "true" dielectric till the "ideal" conductor is found. The
exact relation for the pair correlation function for two-component system of
electrons and nuclei g_ei(r) is found for the arbitrary thermodynamic
parameters.Comment: 5 pages, no figure
Linear theory of nonlocal transport in a magnetized plasma
A system of nonlocal electron-transport equations for small perturbations in
a magnetized plasma is derived using the systematic closure procedure of V. Yu.
Bychenkov et al., Phys. Rev. Lett. 75, 4405 (1995). Solution to the linearized
kinetic equation with a Landau collision operator is obtained in the diffusive
approximation. The Fourier components of the longitudinal, oblique, and
transversal electron fluxes are found in an explicit form for quasistatic
conditions in terms of the generalized forces: the gradients of density and
temperature, and the electric field. The full set of nonlocal transport
coefficients is given and discussed. Nonlocality of transport enhances electron
fluxes across magnetic field above the values given by strongly collisional
local theory. Dispersion and damping of magnetohydrodynamic waves in weakly
collisional plasmas is discussed. Nonlocal transport theory is applied to the
problem of temperature relaxation across the magnetic field in a laser hot
spot.Comment: 27 pages, 13 figure
Comment on ``Damping of energetic gluons and quarks in high-temperature QCD''
Burgess and Marini have recently pointed out that the leading contribution to
the damping rate of energetic gluons and quarks in the QCD plasma, given by
, can be obtained by simple arguments obviating the need
of a fully resummed perturbation theory as developed by Braaten and Pisarski.
Their calculation confirmed previous results of Braaten and Pisarski, but
contradicted those proposed by Lebedev and Smilga. While agreeing with the
general considerations made by Burgess and Marini, I correct their actual
calculation of the damping rates, which is based on a wrong expression for the
static limit of the resummed gluon propagator. The effect of this, however,
turns out to be cancelled fortuitously by another mistake, so as to leave all
of their conclusions unchanged. I also verify the gauge independence of the
results, which in the corrected calculation arises in a less obvious manner.Comment: 5 page
ΠΠΎΡΡΠΊ Π½ΠΎΠ²ΠΈΡ ΠΏΠΎΡΠ΅Π½ΡΡΠΉΠ½ΠΈΡ ΡΠ½Π³ΡΠ±ΡΡΠΎΡΡΠ² ΠΏΡΠΎΡΠ΅ΡΠ½ΠΊΡΠ½Π°Π·ΠΈ Pim-1 ΡΠ΅ΡΠ΅Π΄ Π°ΠΌΡΠ΄ΡΠ² 1,2,4-ΡΡΠΈΠ°Π·ΠΎΠ»ΠΎ[4,3-Π°]ΠΏΡΡΠΈΠ΄ΠΈΠ½-3-ΠΌΠ΅ΡΠ°Π½Π°ΠΌΡΠ½Ρ Π· 1,2,4-ΠΎΠΊΡΠ°Π΄ΡΠ°Π·ΠΎΠ»ΡΠ½ΠΈΠΌ ΡΠΈΠΊΠ»ΠΎΠΌ Ρ 7 ΡΠ° 8 ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½Π½ΡΡ
The Pim-1 enzyme from the serine/threonine protein kinase family is a likely target for the targeted therapy of tumors of hematopoietic and lymphoid tissues. Triazolopyridine is an universal scaffold upon which international scientific programs have been launched to develop potential anticancer agents.Aim. To create a pharmacophore model to find new potential Pim-1 inhibitors; conduct a virtual screening of a simulated base of new 1,2,4-triazolo[4,3-a]pyridine derivatives; develop a method for the synthesis of 1,2,4-triazolo[4,3-a]pyridine-3-methanamines with the 1,2,4-isoxadiazole cycle.Results and discussion. In this study, a ligand-based pharmacophore model for Pim-1 inhibitors was constructed and validated. A virtual screening of the library with 912 compounds resulted in a hit list of 175 compounds. For the synthesis, 15 compounds were selected with the highest pharmacophore-fit score. 15 compounds were synthesized as potential inhibitors of Pim-1 kinase.Experimental part. The synthetic approach has been developed, and systematic series of new amides of (7-(1,2,4-oxadiazol-5-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)methanamine and (8-(1,2,4-oxadiazol-5-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)methanamine have been synthesized.Conclusions. The compounds obtained are potential inhibitors of Pim-1 kinase. Further studies will focus on the determination of the antitumor activity of the compounds synthesized by in vitro and in vivo methods.Π€Π΅ΡΠΌΠ΅Π½Ρ Pim-1 ΠΈΠ· ΡΠ΅ΠΌΠ΅ΠΉΡΡΠ²Π° ΡΠ΅ΡΠΈΠ½/ΡΡΠ΅ΠΎΠ½ΠΈΠ½ ΠΏΡΠΎΡΠ΅ΠΈΠ½ΠΊΠΈΠ½Π°Π·Ρ ΡΠ²Π»ΡΠ΅ΡΡΡ Π²Π΅ΡΠΎΡΡΠ½ΠΎΠΉ ΠΌΠΈΡΠ΅Π½ΡΡ Π΄Π»Ρ ΡΠ°ΡΠ³Π΅ΡΠ½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΎΠΏΡΡ
ΠΎΠ»Π΅ΠΉ ΠΊΡΠΎΠ²Π΅ΡΠ²ΠΎΡΠ½ΠΎΠΉ ΠΈ Π»ΠΈΠΌΡΠΎΠΈΠ΄Π½ΠΎΠΉ ΡΠΊΠ°Π½Π΅ΠΉ. Π’ΡΠΈΠ°Π·ΠΎΠ»ΠΎΠΏΠΈΡΠΈΠ΄ΠΈΠ½Ρ β ΡΡΠΎ ΡΠ½ΠΈΠ²Π΅ΡΡΠ°Π»ΡΠ½ΡΠΉ ΡΠΊΠ°ΡΡΠΎΠ»Π΄, Π½Π° Π±Π°Π·Π΅ ΠΊΠΎΡΠΎΡΠΎΠ³ΠΎ ΠΏΡΠΎΠ²ΠΎΠ΄ΡΡΡΡ ΠΌΠ΅ΠΆΠ΄ΡΠ½Π°ΡΠΎΠ΄Π½ΡΠ΅ Π½Π°ΡΡΠ½ΡΠ΅ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΡ ΠΏΠΎ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ΅ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΡ
ΠΏΡΠΎΡΠΈΠ²ΠΎΡΠ°ΠΊΠΎΠ²ΡΡ
ΡΡΠ΅Π΄ΡΡΠ².Π¦Π΅Π»Ρ. Π‘ΠΎΠ·Π΄Π°ΡΡ ΡΠ°ΡΠΌΠ°ΠΊΠΎΡΠΎΡΠ½ΡΡ ΠΌΠΎΠ΄Π΅Π»Ρ Π΄Π»Ρ ΠΏΠΎΠΈΡΠΊΠ° Π½ΠΎΠ²ΡΡ
ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΡ
ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΡΠΎΠ² Pim-1. ΠΡΠΎΠ²Π΅ΡΡΠΈ Π²ΠΈΡΡΡΠ°Π»ΡΠ½ΡΠΉ ΡΠΊΡΠΈΠ½ΠΈΠ½Π³ ΡΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ Π±Π°Π·Ρ Π½ΠΎΠ²ΡΡ
ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΡ
1,2,4-ΡΡΠΈΠ°Π·ΠΎΠ»ΠΎ[4,3-Π°]ΠΏΠΈΡΠΈΠ΄ΠΈΠ½ΠΎΠ² ΠΈ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°ΡΡ ΠΌΠ΅ΡΠΎΠ΄ ΡΠΈΠ½ΡΠ΅Π·Π° Π°ΠΌΠΈΠ΄ΠΎΠ² 1,2,4-ΡΡΠΈΠ°Π·ΠΎΠ»ΠΎ[4,3-Π°]ΠΏΠΈΡΠΈΠ΄ΠΈΠ½-3-ΠΌΠ΅ΡΠ°Π½Π°ΠΌΠΈΠ½Π°, ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΡ
1,2,4-ΠΈΠ·ΠΎΠΊΡΠ°Π΄ΠΈΠ°Π·ΠΎΠ»ΡΠ½ΡΠΉ ΡΠΈΠΊΠ».Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈ ΠΎΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΠ΅. Π‘ΠΎΠ·Π΄Π°Π½Π° ΠΈ Π²Π°Π»ΠΈΠ΄ΠΈΡΠΎΠ²Π°Π½Π° ΡΠ°ΡΠΌΠ°ΠΊΠΎΡΠΎΡΠ½Π°Ρ ΠΌΠΎΠ΄Π΅Π»Ρ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΡΠΎΠ² Pim-1 Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΈΠ·Π²Π΅ΡΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΈ ΠΎ ΡΡΡΡΠΊΡΡΡΠ°Ρ
Π°ΠΊΡΠΈΠ²Π½ΡΡ
Π»ΠΈΠ³Π°Π½Π΄ΠΎΠ². ΠΡΠΎΠ²Π΅Π΄Π΅Π½ Π²ΠΈΡΡΡΠ°Π»ΡΠ½ΡΠΉ ΡΠΊΡΠΈΠ½ΠΈΠ½Π³ Π±ΠΈΠ±Π»ΠΈΠΎΡΠ΅ΠΊΠΈ ΠΈΠ· 912 ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ, ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠΌ ΠΊΠΎΡΠΎΡΠΎΠ³ΠΎ ΡΡΠ°Π» ΡΠΏΠΈΡΠΎΠΊ Ρ
ΠΈΡΠΎΠ² ΠΈΠ· 175 ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ. ΠΠ»Ρ ΡΠΈΠ½ΡΠ΅Π·Π° Π±ΡΠ»ΠΈ ΠΎΡΠΎΠ±ΡΠ°Π½Ρ 15 ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ Ρ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ Π²ΡΡΠΎΠΊΠΎΠΉ ΡΠ°ΡΠΌΠ°ΠΊΠΎΡΠΎΡΠ½ΠΎΠΉ ΠΎΡΠ΅Π½ΠΊΠΎΠΉ. Π‘ΠΈΠ½ΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½Ρ 15 ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ, ΡΠ²Π»ΡΡΡΠΈΡ
ΡΡ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΠΌΠΈ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΡΠ°ΠΌΠΈ ΠΊΠΈΠ½Π°Π·Ρ Pim-1.ΠΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½Π°Ρ ΡΠ°ΡΡΡ. Π Π°Π·ΡΠ°Π±ΠΎΡΠ°Π½Π° ΡΡ
Π΅ΠΌΠ°, ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠΈ ΡΠΈΠ½ΡΠ΅Π·Π° ΠΈ ΡΠΈΠ½ΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½Ρ ΡΠΈΡΡΠ΅ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΡΠ΄Ρ Π½ΠΎΠ²ΡΡ
Π°ΠΌΠΈΠ΄ΠΎΠ² (7-(1,2,4-ΠΎΠΊΡΠ°Π΄ΠΈΠ°Π·ΠΎΠ»-5-ΠΈΠ»)-[1,2,4]ΡΡΠΈΠ°Π·ΠΎΠ»ΠΎ[4,3-Π°]ΠΏΠΈΡΠΈΠ΄ΠΈΠ½-3-ΠΈΠ»)ΠΌΠ΅ΡΠ°Π½Π°ΠΌΠΈΠ½Π° ΠΈ (8-(1,2,4-ΠΎΠΊΡΠ°Π΄ΠΈΠ°Π·ΠΎΠ»-5-ΠΈΠ»)-[1,2,4]ΡΡΠΈΠ°Π·ΠΎΠ»ΠΎ[4,3-Π°]ΠΏΠΈΡΠΈΠ΄ΠΈΠ½-3-ΠΈΠ»)ΠΌΠ΅ΡΠ°Π½Π°ΠΌΠΈΠ½Π°.ΠΡΠ²ΠΎΠ΄Ρ. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡ ΡΠ²Π»ΡΡΡΡΡ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΠΌΠΈ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΡΠ°ΠΌΠΈ ΠΊΠΈΠ½Π°Π·Ρ Pim-1. ΠΠ°Π»ΡΠ½Π΅ΠΉΡΠΈΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π±ΡΠ΄ΡΡ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Ρ Π½Π° Π²ΡΡΠ²Π»Π΅Π½ΠΈΠ΅ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΠΈΠ½ΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ in vitro ΠΈ in vivo.Π€Π΅ΡΠΌΠ΅Π½Ρ Pim-1 Π· ΡΡΠΌΠ΅ΠΉΡΡΠ²Π° ΡΠ΅ΡΠΈΠ½/ΡΡΠ΅ΠΎΠ½ΡΠ½ ΠΏΡΠΎΡΠ΅ΡΠ½ΠΊΡΠ½Π°Π· Ρ ΠΉΠΌΠΎΠ²ΡΡΠ½ΠΎΡ ΠΌΡΡΠ΅Π½Π½Ρ Π΄Π»Ρ ΡΠ°ΡΠ³Π΅ΡΠ½ΠΎΡ ΡΠ΅ΡΠ°ΠΏΡΡ ΠΏΡΡ
Π»ΠΈΠ½ ΠΊΡΠΎΠ²ΠΎΡΠ²ΠΎΡΠ½ΠΎΡ ΡΠ° Π»ΡΠΌΡΠΎΡΠ΄Π½ΠΎΡ ΡΠΊΠ°Π½ΠΈΠ½ΠΈ. Π’ΡΠΈΠ°Π·ΠΎΠ»ΠΎΠΏΡΡΠΈΠ΄ΠΈΠ½ΠΈ β ΡΠ΅ ΡΠ½ΡΠ²Π΅ΡΡΠ°Π»ΡΠ½ΠΈΠΉ ΡΠΊΠ°ΡΠΎΠ»Π΄, Π½Π° Π±Π°Π·Ρ ΡΠΊΠΎΠ³ΠΎ ΡΠ΅Π°Π»ΡΠ·ΡΡΡΡΡΡ ΠΌΡΠΆΠ½Π°ΡΠΎΠ΄Π½Ρ Π½Π°ΡΠΊΠΎΠ²Ρ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΈ Π· ΡΠΎΠ·ΡΠΎΠ±ΠΊΠΈ ΠΏΠΎΡΠ΅Π½ΡΡΠΉΠ½ΠΈΡ
ΠΏΡΠΎΡΠΈΡΠ°ΠΊΠΎΠ²ΠΈΡ
Π·Π°ΡΠΎΠ±ΡΠ².ΠΠ΅ΡΠ°. Π‘ΡΠ²ΠΎΡΠΈΡΠΈ ΡΠ°ΡΠΌΠ°ΠΊΠΎΡΠΎΡΠ½Ρ ΠΌΠΎΠ΄Π΅Π»Ρ Π΄Π»Ρ ΠΏΠΎΡΡΠΊΡ Π½ΠΎΠ²ΠΈΡ
ΠΏΠΎΡΠ΅Π½ΡΡΠΉΠ½ΠΈΡ
ΡΠ½Π³ΡΠ±ΡΡΠΎΡΡΠ² Pim-1. ΠΡΠΎΠ²Π΅ΡΡΠΈ Π²ΡΡΡΡΠ°Π»ΡΠ½ΠΈΠΉ ΡΠΊΡΠΈΠ½ΡΠ½Π³ Π·ΠΌΠΎΠ΄Π΅Π»ΡΠΎΠ²Π°Π½ΠΎΡ Π±Π°Π·ΠΈ Π½ΠΎΠ²ΠΈΡ
ΠΏΠΎΡ
ΡΠ΄Π½ΠΈΡ
1,2,4-ΡΡΠΈΠ°Π·ΠΎΠ»ΠΎ[4,3-Π°]ΠΏΡΡΠΈΠ΄ΠΈΠ½Ρ ΡΠ° ΡΠΎΠ·ΡΠΎΠ±ΠΈΡΠΈ ΠΌΠ΅ΡΠΎΠ΄ ΡΠΈΠ½ΡΠ΅Π·Ρ Π°ΠΌΡΠ΄ΡΠ² 1,2,4-ΡΡΠΈΠ°Π·ΠΎΠ»ΠΎ[4,3-Π°]ΠΏΡΡΠΈΠ΄ΠΈΠ½-3-ΠΌΠ΅ΡΠ°Π½Π°ΠΌΡΠ½Ρ, ΡΠΎ ΠΌΡΡΡΡΡΡ 1,2,4-ΡΠ·ΠΎΠΊΡΠ°Π΄ΡΠ°Π·ΠΎΠ»ΡΠ½ΠΈΠΉ ΡΠΈΠΊΠ».Π Π΅Π·ΡΠ»ΡΡΠ°ΡΠΈ ΡΠ° ΠΎΠ±Π³ΠΎΠ²ΠΎΡΠ΅Π½Π½Ρ. Π‘ΡΠ²ΠΎΡΠ΅Π½ΠΎ ΡΠ° Π²Π°Π»ΡΠ΄ΠΎΠ²Π°Π½ΠΎ ΡΠ°ΡΠΌΠ°ΠΊΠΎΡΠΎΡΠ½Ρ ΠΌΠΎΠ΄Π΅Π»Ρ ΡΠ½Π³ΡΠ±ΡΡΠΎΡΡΠ² Pim-1 Π½Π° ΠΎΡΠ½ΠΎΠ²Ρ Π²ΡΠ΄ΠΎΠΌΠΎΡ ΡΠ½ΡΠΎΡΠΌΠ°ΡΡΡ ΠΏΡΠΎ ΡΡΡΡΠΊΡΡΡΠΈ Π°ΠΊΡΠΈΠ²Π½ΠΈΡ
Π»ΡΠ³Π°Π½Π΄ΡΠ². ΠΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ Π²ΡΡΡΡΠ°Π»ΡΠ½ΠΈΠΉ ΡΠΊΡΠΈΠ½ΡΠ½Π³ Π±ΡΠ±Π»ΡΠΎΡΠ΅ΠΊΠΈ Π· 912 ΡΠΏΠΎΠ»ΡΠΊ, ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠΌ ΡΠΊΠΎΠ³ΠΎ ΡΡΠ°Π² ΡΠΏΠΈΡΠΎΠΊ Ρ
ΡΡΡΠ² ΡΠ· 175 ΡΠΏΠΎΠ»ΡΠΊ. ΠΠ»Ρ ΡΠΈΠ½ΡΠ΅Π·Ρ Π±ΡΠ»ΠΎ Π²ΡΠ΄ΡΠ±ΡΠ°Π½ΠΎ 15 ΡΠΏΠΎΠ»ΡΠΊ Π· Π½Π°ΠΉΠ²ΠΈΡΠΎΡ ΡΠ°ΡΠΌΠ°ΠΊΠΎΡΠΎΡΠ½ΠΎΡ ΠΎΡΡΠ½ΠΊΠΎΡ. Π‘ΠΈΠ½ΡΠ΅Π·ΠΎΠ²Π°Π½ΠΎ 15 ΡΠΏΠΎΠ»ΡΠΊ, ΡΠΎ Ρ ΠΏΠΎΡΠ΅Π½ΡΡΠΉΠ½ΠΈΠΌΠΈ ΡΠ½Π³ΡΠ±ΡΡΠΎΡΠ°ΠΌΠΈ ΠΊΡΠ½Π°Π·ΠΈ Pim-1.ΠΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½Π° ΡΠ°ΡΡΠΈΠ½Π°. Π ΠΎΠ·ΡΠΎΠ±Π»Π΅Π½ΠΎ ΡΡ
Π΅ΠΌΡ, ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠΈ ΡΠΈΠ½ΡΠ΅Π·Ρ ΡΠ° ΡΠΈΠ½ΡΠ΅Π·ΠΎΠ²Π°Π½ΠΎ ΡΠΈΡΡΠ΅ΠΌΠ°ΡΠΈΡΠ½Ρ ΡΡΠ΄ΠΈ Π½ΠΎΠ²ΠΈΡ
Π°ΠΌΡΠ΄ΡΠ² (7-(1,2,4-ΠΎΠΊΡΠ°Π΄ΡΠ°Π·ΠΎΠ»-5-ΡΠ»)-[1,2,4]ΡΡΠΈΠ°Π·ΠΎΠ»ΠΎ[4,3-Π°]ΠΏΡΡΠΈΠ΄ΠΈΠ½-3-ΡΠ»)ΠΌΠ΅ΡΠ°Π½Π°ΠΌΡΠ½Ρ ΡΠ° (8-(1,2,4-ΠΎΠΊΡΠ°Π΄ΡΠ°Π·ΠΎΠ»-5-ΡΠ»)-[1,2,4]ΡΡΠΈΠ°Π·ΠΎΠ»ΠΎ[4,3-Π°]ΠΏΡΡΠΈΠ΄ΠΈΠ½-3-ΡΠ»)ΠΌΠ΅ΡΠ°Π½Π°ΠΌΡΠ½Ρ.ΠΠΈΡΠ½ΠΎΠ²ΠΊΠΈ. ΠΡΡΠΈΠΌΠ°Π½Ρ ΡΠΏΠΎΠ»ΡΠΊΠΈ Ρ ΠΏΠΎΡΠ΅Π½ΡΡΠΉΠ½ΠΈΠΌΠΈ ΡΠ½Π³ΡΠ±ΡΡΠΎΡΠ°ΠΌΠΈ ΠΊΡΠ½Π°Π·ΠΈ Pim-1. ΠΠΎΠ΄Π°Π»ΡΡΡ Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½Ρ Π±ΡΠ΄ΡΡΡ ΡΠΏΡΡΠΌΠΎΠ²Π°Π½Ρ Π½Π° Π²ΠΈΡΠ²Π»Π΅Π½Π½Ρ ΠΏΡΠΎΡΠΈΠΏΡΡ
Π»ΠΈΠ½Π½ΠΎΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΠΈΠ½ΡΠ΅Π·ΠΎΠ²Π°Π½ΠΈΡ
ΡΠΏΠΎΠ»ΡΠΊ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ in vitro ΡΠ° in vivo
Enhanced inverse bremsstrahlung heating rates in a strong laser field
Test particle studies of electron scattering on ions, in an oscillatory
electromagnetic field have shown that standard theoretical assumptions of small
angle collisions and phase independent orbits are incorrect for electron
trajectories with drift velocities smaller than quiver velocity amplitude. This
leads to significant enhancement of the electron energy gain and the inverse
bremsstrahlung heating rate in strong laser fields. Nonlinear processes such as
Coulomb focusing and correlated collisions of electrons being brought back to
the same ion by the oscillatory field are responsible for large angle, head-on
scattering processes. The statistical importance of these trajectories has been
examined for mono-energetic beam-like, Maxwellian and highly anisotropic
electron distribution functions. A new scaling of the inverse bremsstrahlung
heating rate with drift velocity and laser intensity is discussed.Comment: 12 pages, 12 figure
High Temperature Response Functions and the Non-Abelian Kubo Formula
We describe the relationship between time-ordered and retarded response
functions in a plasma. We obtain an expression, including the proper
-prescription, for the induced current due to hard thermal loops in
a non-Abelian theory, thus giving the non-Abelian generalization of the Kubo
formula. The result is closely related to the eikonal for a Chern-Simons theory
and is relevant for a gauge-invariant description of Landau damping in the
quark-gluon plasma at high temperature.Comment: 14 pages in LaTeX, MIT CTP #2205 and CU-TP #59
Heating mechanisms in radio frequency driven ultracold plasmas
Several mechanisms by which an external electromagnetic field influences the
temperature of a plasma are studied analytically and specialized to the system
of an ultracold plasma (UCP) driven by a uniform radio frequency (RF) field.
Heating through collisional absorption is reviewed and applied to UCPs.
Furthermore, it is shown that the RF field modifies the three body
recombination process by ionizing electrons from intermediate high-lying
Rydberg states and upshifting the continuum threshold, resulting in a
suppression of three body recombination. Heating through collisionless
absorption associated with the finite plasma size is calculated in detail,
revealing a temperature threshold below which collisionless absorption is
ineffective.Comment: 14 pages, 7 figure
Kinetic Equations for Longwavelength Excitations of the Quark-Gluon Plasma
We show that longwavelength excitations of the quark-gluon plasma are
described by simple kinetic equations which represent the exact equations of
motion at leading order in . Properties of the so-called ``hard thermal
loops'', i.e. the dominant contributions to amplitudes with soft external
lines, find in this approach a natural explanation. In particular, their
generating functional appears here as the effective action describing long
wavelength excitations of the plasma.Comment: January 8, 1993; 8 pages; SPhT/93-
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