596 research outputs found
Mass equidistribution of Hilbert modular eigenforms
Let F be a totally real number field, and let f traverse a sequence of
non-dihedral holomorphic eigencuspforms on GL(2)/F of weight (k_1,...,k_n),
trivial central character and full level. We show that the mass of f
equidistributes on the Hilbert modular variety as max(k_1,...,k_n) tends to
infinity.
Our result answers affirmatively a natural analogue of a conjecture of
Rudnick and Sarnak (1994). Our proof generalizes the argument of
Holowinsky-Soundararajan (2008) who established the case F = Q. The essential
difficulty in doing so is to adapt Holowinsky's bounds for the Weyl periods of
the equidistribution problem in terms of manageable shifted convolution sums of
Fourier coefficients to the case of a number field with nontrivial unit group.Comment: 40 pages; typos corrected, nearly accepted for
A finite model of two-dimensional ideal hydrodynamics
A finite-dimensional su() Lie algebra equation is discussed that in the
infinite limit (giving the area preserving diffeomorphism group) tends to
the two-dimensional, inviscid vorticity equation on the torus. The equation is
numerically integrated, for various values of , and the time evolution of an
(interpolated) stream function is compared with that obtained from a simple
mode truncation of the continuum equation. The time averaged vorticity moments
and correlation functions are compared with canonical ensemble averages.Comment: (25 p., 7 figures, not included. MUTP/92/1
Dual mechanism of brain injury and novel treatment strategy in maple syrup urine disease
Maple syrup urine disease (MSUD) is an inherited disorder of branched-chain amino acid metabolism presenting with lifethreatening cerebral oedema and dysmyelination in affected individuals. Treatment requires life-long dietary restriction and monitoring of branched-chain amino acids to avoid brain injury. Despite careful management, children commonly suffer metabolic decompensation in the context of catabolic stress associated with non-specific illness. The mechanisms underlying this decompensation and brain injury are poorly understood. Using recently developed mouse models of classic and intermediate maple syrup urine disease, we assessed biochemical, behavioural and neuropathological changes that occurred during encephalopathy in these mice. Here, we show that rapid brain leucine accumulation displaces other essential amino acids resulting in neurotransmitter depletion and disruption of normal brain growth and development. A novel approach of administering norleucine to heterozygous mothers of classic maple syrup urine disease pups reduced branched-chain amino acid accumulation in milk as well as blood and brain of these pups to enhance survival. Similarly, norleucine substantially delayed encephalopathy in intermediate maple syrup urine disease mice placed on a high protein diet that mimics the catabolic stress shown to cause encephalopathy in human maple syrup urine disease. Current findings suggest two converging mechanisms of brain injury in maple syrup urine disease including: (i) neurotransmitter deficiencies and growth restriction associated with branchedchain amino acid accumulation and (ii) energy deprivation through Krebs cycle disruption associated with branched-chain ketoacid accumulation. Both classic and intermediate models appear to be useful to study the mechanism of brain injury and potential treatment strategies for maple syrup urine disease. Norleucine should be further tested as a potential treatment to prevent encephalopathy in children with maple syrup urine disease during catabolic stress
Recommended from our members
Debiasing Decisions. Improved Decision Making With A Single Training Intervention
From failures of intelligence analysis to misguided beliefs about vaccinations, biased judgment and decision making contributes to problems in policy, business, medicine, law, and private life. Early attempts to reduce decision biases with training met with little success, leading scientists and policy makers to focus on debiasing by using incentives and changes in the presentation and elicitation of decisions. We report the results of two longitudinal experiments that found medium to large effects of one-shot debiasing training interventions. Participants received a single training intervention, played a computer game or watched an instructional video, which addressed biases critical to intelligence analysis (in Experiment 1: bias blind spot, confirmation bias, and fundamental attribution error; in Experiment 2: anchoring, representativeness, and social projection). Both kinds of interventions produced medium to large debiasing effects immediately (games ≥ -31.94% and videos ≥ -18.60%) that persisted at least 2 months later (games ≥ -23.57% and videos ≥ -19.20%). Games, which provided personalized feedback and practice, produced larger effects than did videos. Debiasing effects were domain-general: bias reduction occurred across problems in different contexts, and problem formats that were taught and not taught in the interventions. The results suggest that a single training intervention can improve decision making. We suggest its use alongside improved incentives, information presentation, and nudges to reduce costly errors associated with biased judgments and decisions
Simulating the Formation of the Local Galaxy Population
We simulate the formation and evolution of the local galaxy population
starting from initial conditions with a smoothed linear density field which
matches that derived from the IRAS 1.2 Jy galaxy survey. Our simulations track
the formation and evolution of all dark matter haloes more massive than 10e+11
solar masses out to a distance of 8000 km/s from the Milky Way. We implement
prescriptions similar to those of Kauffmann et al. (1999) to follow the
assembly and evolution of the galaxies within these haloes. We focus on two
variants of the CDM cosmology: an LCDM and a tCDM model. Galaxy formation in
each is adjusted to reproduce the I-band Tully-Fisher relation of Giovanelli et
al. (1997). We compare the present-day luminosity functions, colours,
morphology and spatial distribution of our simulated galaxies with those of the
real local population, in particular with the Updated Zwicky Catalog, with the
IRAS PSCz redshift survey, and with individual local clusters such as Coma,
Virgo and Perseus. We also use the simulations to study the clustering bias
between the dark matter and galaxies of differing type. Although some
significant discrepancies remain, our simulations recover the observed
intrinsic properties and the observed spatial distribution of local galaxies
reasonably well. They can thus be used to calibrate methods which use the
observed local galaxy population to estimate the cosmic density parameter or to
draw conclusions about the mechanisms of galaxy formation. To facilitate such
work, we publically release our z=0 galaxy catalogues, together with the
underlying mass distribution.Comment: 25 pages, 20 figures, submitted to MNRAS. High resolution copies of
figures 1 and 3, halo and galaxy catalogues can be found at
http://www.mpa-garching.mpg.de/NumCos/CR/index.htm
Beyond Controlled Environments: 3D Camera Re-Localization in Changing Indoor Scenes
Long-term camera re-localization is an important task with numerous computer
vision and robotics applications. Whilst various outdoor benchmarks exist that
target lighting, weather and seasonal changes, far less attention has been paid
to appearance changes that occur indoors. This has led to a mismatch between
popular indoor benchmarks, which focus on static scenes, and indoor
environments that are of interest for many real-world applications. In this
paper, we adapt 3RScan - a recently introduced indoor RGB-D dataset designed
for object instance re-localization - to create RIO10, a new long-term camera
re-localization benchmark focused on indoor scenes. We propose new metrics for
evaluating camera re-localization and explore how state-of-the-art camera
re-localizers perform according to these metrics. We also examine in detail how
different types of scene change affect the performance of different methods,
based on novel ways of detecting such changes in a given RGB-D frame. Our
results clearly show that long-term indoor re-localization is an unsolved
problem. Our benchmark and tools are publicly available at
waldjohannau.github.io/RIO10Comment: ECCV 2020, project website https://waldjohannau.github.io/RIO1
Adult women and ADHD: on the temporal dimensions of ADHD identities
This paper uses conceptual resources drawn psychosocial process thinking (Stenner, 2017, Brown and Reavey, 2015, Brown and Stenner, 2009) and from G.H. Mead in particular, to contribute to an emerging body of work on the experiences of adult women with ADHD (Singh, 2002, Waite and Ivey, 2009, Quinn and Madhoo, 2014, Horton-Salway and Davies, 2018). It has a particular focus on how ADHD features in the construction of women’s identities and life-stories and it draws upon findings from a qualitative investigation of adult women diagnosed or self-diagnosed with Attention Deficit Hyperactivity Disorder (ADHD). A theoretically informed ‘thematic decomposition’ of 16 depth interviews reveals how complex processes of identity transformation are mediated by the social category of ADHD. Through this process, pasts are reconstructed from the perspective of an ‘emergent’ identity that offers participants the potential for a more enabling and positive future
Power Spectrum Estimation from Peculiar Velocity Catalogues
The peculiar velocities of galaxies are an inherently valuable cosmological
probe, providing an unbiased estimate of the distribution of matter on scales
much larger than the depth of the survey. Much research interest has been
motivated by the high dipole moment of our local peculiar velocity field, which
suggests a large scale excess in the matter power spectrum, and can appear to
be in some tension with the LCDM model. We use a composite catalogue of 4,537
peculiar velocity measurements with a characteristic depth of 33 h-1 Mpc to
estimate the matter power spectrum. We compare the constraints with this
method, directly studying the full peculiar velocity catalogue, to results from
Macaulay et al. (2011), studying minimum variance moments of the velocity
field, as calculated by Watkins, Feldman & Hudson (2009) and Feldman, Watkins &
Hudson (2010). We find good agreement with the LCDM model on scales of k > 0.01
h Mpc-1. We find an excess of power on scales of k < 0.01 h Mpc-1, although
with a 1 sigma uncertainty which includes the LCDM model. We find that the
uncertainty in the excess at these scales is larger than an alternative result
studying only moments of the velocity field, which is due to the minimum
variance weights used to calculate the moments. At small scales, we are able to
clearly discriminate between linear and nonlinear clustering in simulated
peculiar velocity catalogues, and find some evidence (although less clear) for
linear clustering in the real peculiar velocity data.Comment: 10 pages, 13 figures, updated to match version accepted by MNRA
Antibody Duration after infection From Sars-Cov-2 in the Texas Coronavirus antibody Response Survey
Understanding the duration of antibodies to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus that causes COVID-19 is important to controlling the current pandemic. Participants from the Texas Coronavirus Antibody Response Survey (Texas CARES) with at least 1 nucleocapsid protein antibody test were selected for a longitudinal analysis of antibody duration. A linear mixed model was fit to data from participants (n = 4553) with 1 to 3 antibody tests over 11 months (1 October 2020 to 16 September 2021), and models fit showed that expected antibody response after COVID-19 infection robustly increases for 100 days postinfection, and predicts individuals may remain antibody positive from natural infection beyond 500 days depending on age, body mass index, smoking or vaping use, and disease severity (hospitalized or not; symptomatic or not)
- …