Mental Health among Chicanos and Chicanas: Barriers to Mental Health Care, Consequences of Disparities, and Resources

Mexican Americans, or Chicanos and Chicanas, face many barriers to mental health care. This literature review was conducted by the Collective Corazón—a VCU student organization, mentored by Dr. Indira Sultanić, that addresses Latinx health equity through service and advocacy—in order to examine the underlying causes and consequences of disparities in mental health in Chicanos and Chicanas. Some of the barriers that affect mental health care in Mexican Americans are racial inequities and discrimination, the societal and/or cultural stigma associated with receiving care, language barriers, lack of health insurance, and legal status. Furthermore, among Chicanos, machismo culture is associated with an increased risk for depression and higher stress levels. Colorism has also been correlated with depression among Chicanos with darker skin phenotypes. Cultural identity also plays a role in mental health for Mexican Americans; a balance of Mexican and American culture is associated with a decreased risk for depression. Among Chicanas, there may be justified mistrust of healthcare systems and services due to historical events. The Latina paradox also has unintended health consequences; Latina women are not screened for prenatal depression as often as other ethnic groups. Lastly, are mental health resources for Latinx communities, like Therapy for Latinx and The Focus on You. However, this review argues that in order to reduce the mental health disparities that Chicanos and Chicanas face, there must be increased awareness of the disparities as well as changes in the healthcare system that address current inequities and barriers.https://scholarscompass.vcu.edu/uresposters/1408/thumbnail.jp

Variants in PRKAR1B cause a neurodevelopmental disorder with autism spectrum disorder, apraxia, and insensitivity to pain

Purpose We characterize the clinical and molecular phenotypes of six unrelated individuals with intellectual disability and autism spectrum disorder who carry heterozygous missense variants of the PRKAR1B gene, which encodes the R1 beta subunit of the cyclic AMP-dependent protein kinase A (PKA). Methods Variants of PRKAR1B were identified by single- or trio-exome analysis. We contacted the families and physicians of the six individuals to collect phenotypic information, performed in vitro analyses of the identified PRKAR1B-variants, and investigated PRKAR1B expression during embryonic development. Results Recent studies of large patient cohorts with neurodevelopmental disorders found significant enrichment of de novo missense variants in PRKAR1B. In our cohort, de novo origin of the PRKAR1B variants could be confirmed in five of six individuals, and four carried the same heterozygous de novo variant c.1003C>T (p.Arg335Trp; NM_001164760). Global developmental delay, autism spectrum disorder, and apraxia/dyspraxia have been reported in all six, and reduced pain sensitivity was found in three individuals carrying the c.1003C>T variant. PRKAR1B expression in the brain was demonstrated during human embryonal development. Additionally, in vitro analyses revealed altered basal PKA activity in cells transfected with variant-harboring PRKAR1B expression constructs. Conclusion Our study provides strong evidence for a PRKAR1B-related neurodevelopmental disorder