Optimising the Structure-Function Relationship at the Locus of Deficit in Retinal Disease

Technologies such as optical coherence tomography have facilitated the visualization of anatomical tissues such as that of the retina. The availability of in vivo retinal anatomical data has led to the hypothesis that it may be able to accurately predict visual function from anatomical information. However, accurate determination of the structure-function relationship has remained elusive in part due to contributions of non-retinal sources of variability, thus imposing potential limitations in the fidelity of the relationship. Furthermore, differences in manifestation of functional loss due to different retinal loci of change (inner retina or outer retinal elements) have also been the subject of debate. Here, we assessed the application of a novel, more objective psychophysical paradigm to better characterize the relationship between functional and structural characteristics in the eye. Using ocular diseases with known loci of anatomical change (glaucoma, inner retinal loss; and retinitis pigmentosa, outer retinal loss), we compared conventional more subjective psychophysical techniques that may be contaminated by the presence of non-retinal sources of variability with our more objective approach. We show that stronger correlations between underlying retinal structure and visual function can be achieved across a breadth of anatomical change by using a more objective psychophysical paradigm. This was independent of the locus of structural loss (at the ganglion cells for glaucoma or photoreceptors for retinitis pigmentosa), highlighting the role of downstream retinal elements to serve as anatomical limiting factors for studying the structure-function relationship. By reducing the contribution of non-retinal sources of variability in psychophysical measurements, we herein provide a structure-function model with higher fidelity. This reinforces the need to carefully consider the psychophysical protocol when examining the structure-function relationship in sensory systems

Context and Crowding in Perceptual Learning on a Peripheral Contrast Discrimination Task: Context-Specificity in Contrast Learning

Perceptual learning is an improvement in sensitivity due to practice on a sensory task and is generally specific to the trained stimuli and/or tasks. The present study investigated the effect of stimulus configuration and crowding on perceptual learning in contrast discrimination in peripheral vision, and the effect of perceptual training on crowding in this task. 29 normally-sighted observers were trained to discriminate Gabor stimuli presented at 9° eccentricity with either identical or orthogonally oriented flankers with respect to the target (ISO and CROSS, respectively), or on an isolated target (CONTROL). Contrast discrimination thresholds were measured at various eccentricities and target-flanker separations before and after training in order to determine any learning transfer to untrained stimulus parameters. Perceptual learning was observed in all three training stimuli; however, greater improvement was obtained with training on ISO-oriented stimuli compared to CROSS-oriented and unflanked stimuli. This learning did not transfer to untrained stimulus configurations, eccentricities or target-flanker separations. A characteristic crowding effect was observed increasing with viewing eccentricity and decreasing with target-flanker separation before and after training in both configurations. The magnitude of crowding was reduced only at the trained eccentricity and target-flanker separation; therefore, learning for contrast discrimination and for crowding in the present study was configuration and location specific. Our findings suggest that stimulus configuration plays an important role in the magnitude of perceptual learning in contrast discrimination and suggest context-specificity in learning

Glass-pattern detection is tuned for stereo-depth

AbstractWe investigated the role of disparity information in the detection of global form. Glass patterns, which allow insight into processing at both local and global stages of form analysis, were used as stimuli. We determined how detection of concentric Glass patterns is affected by a disparity difference introduced between partner dots forming local dipoles (Experiment 1), and how detection is affected by the addition of randomly oriented dot-pairs (noise dots) at crossed and uncrossed disparities (Experiment 2). The first experiment showed that detection thresholds increased when partner dots were separated in depth at disparities greater than approximately 17min arc; the second experiment showed that noise dots disrupted the detection of form if they were presented at disparities of between approximately ±20min arc from the Glass pattern’s presentation depth plane. Our findings suggest that disparity information plays a role in the recovery of the image structure and, importantly, local and global form mechanisms were found to be selective for a small range of stereo-depths. We discuss the findings of our study in the light of current evidence indicating that a common neural substrate is responsible for the analysis of form and binocular disparity

The processing of coherent global form and motion patterns without visual awareness

In the present study we addressed whether the processing of global form and motion was dependent on visual awareness. Continuous flash suppression (CFS) was used to suppress from awareness Global Dot Motion (GDM) and Glass-pattern stimuli. We quantified the minimum time taken for both pattern types to break suppression with the signal coherence of the pattern (0, 25, 50 and 100 % signal) and the type of global structure (rotational, and radial) as independent variables. For both form and motion patterns increasing signal coherence decreased the time required to break suppression. This was the same for both rotational and radial global patterns. However, GDM patterns broke suppression faster than Glass patterns. In a supplementary experiment, we confirmed that this difference in break times is not because of the temporal nature of GDM patterns in attracting attention. In Experiment 2, we examined whether the processing of dynamic Glass patterns were similarly dependent on visual awareness. The processing of dynamic Glass patterns is involves both motion and form systems, and we questioned whether the interaction of these two systems was dependent on visual awareness. The suppression of dynamic Glass patterns was also dependent on signal coherence and the time course of suppression break resembled the detection of global motion and not global form. In Experiment 3 we ruled out the possibility that faster suppression break times was because the visual system is more sensitive to highly coherent form and motion patterns. Here contrast changing GDM and Glass patterns were superimposed on the dynamic CFS mask, and the minimum time required for them to be detected was measured. We showed that there was no difference in detection times for patterns of 0 and 100 % coherence. The advantage of highly coherent global motion and form patterns in breaking suppression indicated that the processing and interaction of global motion and form systems occur without visual awareness

Apparent position in depth of stationary moving three-dimensional objects

AbstractMotion signals contained within a stationary object projected on the fronto-parallel plane shift the object’s apparent spatial position in the direction of the motion [see De Valois, R. L., & De Valois, K. K. (1991). Vernier acuity with stationary moving Gabors. Vision Research, 31(9), 1619–1626]. We report an analogous apparent position shift of three-dimensional objects that contain local elements that move in depth. Our stimulus was a transparent three-dimensional cylinder defined by 150 limited-lifetime dots, oriented such that it was end on and its tangent plane was circular. Dots moved in depth by changes in their binocular disparities. In the first experiment, observers judged the positions of the near and far ends of the cylinder, by moving marker lines in depth, for different dot speeds. The results showed that when dots moved towards the observer, the perceived location of the two ends of the cylinder appeared closer in depth. When dots moved away from the observer, the opposite effect was produced. Additionally, the amount of apparent position shift produced was dependent on dot speed, with faster speeds producing larger positional offsets. However, we found in the second experiment that when the cylinder contained randomly moving dots, or when the cylinder contained equal amounts of dots moving towards and away from the observer, positional shifts were very much reduced, or abolished. Our findings suggest that motion signals can induce a misperception of position in depth that is similar manner to that produced by motion within an object in the two-dimensional image plane

The color "fruit": object memories defined by color.

Most fruits and other highly color-diagnostic objects have color as a central aspect of their identity, which can facilitate detection and visual recognition. It has been theorized that there may be a large amount of overlap between the neural representations of these objects and processing involved in color perception. In accordance with this theory we sought to determine if the recognition of highly color diagnostic fruit objects could be facilitated by the visual presentation of their known color associates. In two experiments we show that color associate priming is possible, but contingent upon multiple factors. Color priming was found to be maximally effective for the most highly color diagnostic fruits, when low spatial-frequency information was present in the image, and when determination of the object's specific identity, not merely its category, was required. These data illustrate the importance of color for determining the identity of certain objects, and support the theory that object knowledge involves sensory specific systems

The influence of spatial orientation on the perceived path of visual saltatory motion

Visual saltation is the illusory mislocalization that occurs when multiple elements are rapidly presented to two peripheral locations; mislocalized elements appear to fill in the intermediate space. We investigated the influence of element orientation on the path of illusory saltatory motion. Experiment 1 showed that congruence in element orientation at the two locations (horizontal-horizontal or vertical-vertical) produced rectilinear saltation, while incongruent orientations (verticalhorizontal or horizontal-vertical) elicited curvilinear saltation consistent with rigid rotation around a common point. In curvilinear saltation, mislocalized elements were perceived with an intermediate orientation. Experiment 2 showed that the perceived shape of the motion path was directly dependent on the salience of orientation information. In Experiment 3, we showed that the circular path of curvilinear saltation (induced by orientation incongruence) is altered by background motion (wedge-shaped regions of inward and outward moving dots) that overlaps only with the inter-element space. An ellipsoid path, where the major axis corresponds to the mislocalized element overlapping with outward motion and the minor axis corresponds to the mislocalized element overlapping with inward motion, is produced. These findings reveal that the interpretation of visual saltation arises from high-level computations in which the percept is derived through an interaction of form and motion

Exposure to organic solvents used in dry cleaning reduces low and high level visual function

Purpose: To investigate whether exposure to occupational levels of organic solvents in the dry cleaning industry is associated with neurotoxic symptoms and visual deficits in the perception of basic visual features such as luminance contrast and colour, higher level processing of global motion and form (Experiment 1), and cognitive function as measured in a visual search task (Experiment 2). Methods: The Q16 neurotoxic questionnaire, a commonly used measure of neurotoxicity (by the World Health Organization), was administered to assess the neurotoxic status of a group of 33 dry cleaners exposed to occupational levels of organic solvents (OS) and 35 age-matched non dry-cleaners who had never worked in the dry cleaning industry. In Experiment 1, to assess visual function, contrast sensitivity, colour/hue discrimination (Munsell Hue 100 test), global motion and form thresholds were assessed using computerised psychophysical tests. Sensitivity to global motion or form structure was quantified by varying the pattern coherence of global dot motion (GDM) and Glass pattern (oriented dot pairs) respectively (i.e., the percentage of dots/dot pairs that contribute to the perception of global structure). In Experiment 2, a letter visual-search task was used to measure reaction times (as a function of the number of elements: 4, 8, 16, 32, 64 and 100) in both parallel and serial search conditions. Results: Dry cleaners exposed to organic solvents had significantly higher scores on the Q16 compared to non dry-cleaners indicating that dry cleaners experienced more neurotoxic symptoms on average. The contrast sensitivity function for dry cleaners was significantly lower at all spatial frequencies relative to non dry-cleaners, which is consistent with previous studies. Poorer colour discrimination performance was also noted in dry cleaners than non dry-cleaners, particularly along the blue/yellow axis. In a new finding, we report that global form and motion thresholds for dry cleaners were also significantly higher and almost double than that obtained from non dry-cleaners. However, reaction time performance on both parallel and serial visual search was not different between dry cleaners and non dry-cleaners. Conclusions: Exposure to occupational levels of organic solvents is associated with neurotoxicity which is in turn associated with both low level deficits (such as the perception of contrast and discrimination of colour) and high level visual deficits such as the perception of global form and motion, but not visual search performance. The latter finding indicates that the deficits in visual function are unlikely to be due to changes in general cognitive performance