Comparison of mobile application using Swift and Objective-C

The subject of the article is to compare the methodologies for the production of mobile applications in Swift and Objective-C languages. The similarities and differences of the implementation of applications for these two programming languages will be identified as a part of the analysis. An Magic Drawing Board application using Quartz 2D engine was designed and implemented. Two identical functional applications were created. The comparative analysis was carried out only after a thorough explanation of the implemented views

Serotype-Specific Pneumococcal Status prior to PCV 13 Administration in Children and Adolescents with Inflammatory Bowel Disease

The aim of this study was to evaluate the serotype-specific pneumococcal status of children and adolescents with inflammatory bowel disease (IBD) who were naïve to pneumococcal vaccination before administering the 13-valent pneumococcal conjugate vaccine (PCV 13). This was an open, prospective study on children and adolescents aged 5–18 years who had IBD and were naïve to pneumococcal vac­cination. A single dose of PCV 13 was administered to each patient. The geometric mean concentrations (GMCs) were measured for all 13 serotypes. A total of 122 subjects completed the study. Prevaccination GMCs ranged from 0.55 μg/ml (serotype 4) to 4.26 μg/ml (sero­type 19A). Prior to the administration of PCV 13, high GMCs were detected in older children and adolescents who had IBD and were naïve to pneumococcal vaccination

No advantage of antimicrobial prophylaxis in AML/MDS/CMML patients treated with azacitidine—a prospective multicenter study by the Polish Adult Leukemia Group

IntroductionInfections represent one of the most frequent causes of death of higher-risk MDS patients, as reported previously also by our group. Azacitidine Infection Risk Model (AIR), based on red blood cell (RBC) transfusion dependency, neutropenia <0.8 × 109/L, platelet count <50 × 109/L, albumin <35g/L, and ECOG performance status ≥2 has been proposed based on the retrospective data to estimate the risk of infection in azacitidine treated patients.MethodsThe prospective non-intervention study aimed to identify factors predisposing to infection, validate the AIR score, and assess the impact of antimicrobial prophylaxis on the outcome of azacitidine-treated MDS/AML and CMML patients.ResultsWe collected data on 307 patients, 57.6 % males, treated with azacitidine: AML (37.8%), MDS (55.0%), and CMML (7.1%). The median age at azacitidine treatment commencement was 71 (range, 18-95) years. 200 (65%) patients were assigned to higher risk AIR group. Antibacterial, antifungal, and antiviral prophylaxis was used in 66.0%, 29.3%, and 25.7% of patients, respectively. In total, 169 infectious episodes (IE) were recorded in 118 (38.4%) patients within the first three azacitidine cycles. In a multivariate analysis ECOG status, RBC transfusion dependency, IPSS-R score, and CRP concentration were statistically significant for infection development (p < 0.05). The occurrence of infection within the first three azacitidine cycles was significantly higher in the higher risk AIR group – 47.0% than in lower risk 22.4% (odds ratio (OR) 3.06; 95% CI 1.82-5.30, p < 0.05). Administration of antimicrobial prophylaxis did not have a significant impact on all-infection occurrence in multivariate analysis: antibacterial prophylaxis (OR 0.93; 0.41-2.05, p = 0.87), antifungal OR 1.24 (0.54-2.85) (p = 0.59), antiviral OR 1.24 (0.53-2.82) (p = 0.60).DiscussionThe AIR Model effectively discriminates infection-risk patients during azacitidine treatment. Antimicrobial prophylaxis does not decrease the infection rate

Mechanical thrombectomy in acute stroke – Five years of experience in Poland

Objectives Mechanical thrombectomy (MT) is not reimbursed by the Polish public health system. We present a description of 5 years of experience with MT in acute stroke in Comprehensive Stroke Centers (CSCs) in Poland. Methods and results We retrospectively analyzed the results of a structured questionnaire from 23 out of 25 identified CSCs and 22 data sets that include 61 clinical, radiological and outcome measures. Results Most of the CSCs (74%) were founded at University Hospitals and most (65.2%) work round the clock. In 78.3% of them, the working teams are composed of neurologists and neuro-radiologists. All CSCs perform CT and angio-CT before MT. In total 586 patients were subjected to MT and data from 531 of them were analyzed. Mean time laps from stroke onset to groin puncture was 250±99min. 90.3% of the studied patients had MT within 6h from stroke onset; 59.3% of them were treated with IV rt-PA prior to MT; 15.1% had IA rt-PA during MT and 4.7% – emergent stenting of a large vessel. M1 of MCA was occluded in 47.8% of cases. The Solitaire device was used in 53% of cases. Successful recanalization (TICI2b–TICI3) was achieved in 64.6% of cases and 53.4% of patients did not experience hemorrhagic transformation. Clinical improvement on discharge was noticed in 53.7% of cases, futile recanalization – in 30.7%, mRS of 0–2 – in 31.4% and mRS of 6 in 22% of cases. Conclusion Our results can help harmonize standards for MT in Poland according to international guidelines

Anthropometric profile of the top-class female handball players participating in the Olympic Games Tokyo 2020

Study aim: The aim of this study was to try to determine the factors that differentiate the height, weight, BMI, and age of high-level female handball players participating in the Tokyo 2020 Olympic Games

The impact of fatigue on agility and responsiveness in boxing

Study aim: To assess the effects of fatigue on agility and responsiveness in boxing

Resistência anaeróbica de jogadores de futebol

Introdução: A resistência anaeróbica, ou seja, a capacidade de realizar séries repetidas de exercícios anaeróbicos na potência máxima é uma característica indispensável para os jogadores de futebol. O objetivo do estudo foi determinar a resistência anaeróbica de jogadores de futebol aplicando repetidos sprints em velocidade máxima. Materiais e Métodos: Um grupo de 14 jogadores de futebol com idades entre 19 e 27 anos foi submetido duas vezes, em janeiro e março, a um teste consistindo de corridas máximas de 6x50m com 15s de intervalo entre as corridas. Os tempos registrados foram convertidos para velocidades. A proporção da velocidade média para a máxima, obtida em todas as seis corridas, ou índice de performance (IP), foi a medida da resistência anaeróbica. Resultados: As velocidades média e máxima foram significativamente maiores em março (5,47±0,25 e 5,67±0,28, respectivamente) com relação a janeiro (5,73±0,31 e 5,97±0,31, respectivamente), apesar de ainda muito baixos. Os valores de IP foram similares nas duas ocasiões (0,960 e 0,965) e não foram correlacionados com as velocidades máximas. Discussão: O método apresentado pode servir como uma ferramenta útil para determinar e classificar atletas no que diz respeito a suas resistências anaeróbicas, aplicando séries repetidas de um exercício específico