Modelling and prediction of bacterial attachment to polymers

Infection by pathogenic bacteria on implanted and indwelling medical devices during surgery causes large morbidity and mortality worldwide. Attempts to ameliorate this important medical issue have included development of antimicrobial surfaces on materials, ‘no touch’ surgical procedures, and development of materials with inherent low pathogen attachment. The search for new materials is increasingly being carried out by high throughput methods. Efficient methods for extracting knowledge from these large data sets are essential. We used data from a large polymer microarray exposed to three clinical pathogens to derive robust and predictive machine-learning models of pathogen attachment. The models could predict pathogen attachment for the polymer library quantitatively. The models also successfully predicted pathogen attachment for a second-generation library, and identified polymer surface chemistries that enhance or diminish pathogen attachment

Engineering serendipity: high-throughput discovery of materials that resist bacterial attachment

Controlling the colonisation of materials by microorganisms is important in a wide range of industries and clinical settings. To date, the underlying mechanisms that govern the interactions of bacteria with material surfaces remain poorly understood, limiting the ab initio design and engineering of biomaterials to control bacterial attachment. Combinatorial approaches involving high-throughput screening have emerged as key tools for identifying materials to control bacterial attachment. The hundreds of different materials assessed using these methods can be carried out with the aid of computational modelling. This approach can develop an understanding of the rules used to predict bacterial attachment to surfaces of non-toxic synthetic materials. Here we outline our view on the state of this field and the challenges and opportunities in this area for the coming years

Personelle Mobilitaet in Organisationen und organisatorischer Wandel Eine Untersuchung potentieller Beitraege der Neuallokation von Personen und Stellen zur Organisationsentwicklung

Bibliothek Weltwirtschaft Kiel A155,179 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Die Inklusion von Schülerinnen und Schülern mit dem Förderschwerpunkt emotionale und soziale Entwicklung aus Sicht von Mitschülern

Textor A. Die Inklusion von Schülerinnen und Schülern mit dem Förderschwerpunkt emotionale und soziale Entwicklung aus Sicht von Mitschülern. In: Siedenbiedel C, Theurer C, eds. Grundlagen inklusiver Bildung. Teil 1: Inklusive Unterrichtspraxis und -entwicklung. Reihe: Theorie und Praxis der Schulpädagogik. Vol 28. Prolog-Verl.: Immenhausen; 2015: 230-247

Antimicrobial Polymers in Solution and on Surfaces: Overview and Functional Principles

The control of microbial infections is a very important issue in modern society. In general there are two ways to stop microbes from infecting humans or deteriorating materials—disinfection and antimicrobial surfaces. The first is usually realized by disinfectants, which are a considerable environmental pollution problem and also support the development of resistant microbial strains. Antimicrobial surfaces are usually designed by impregnation of materials with biocides that are released into the surroundings whereupon microbes are killed. Antimicrobial polymers are the up and coming new class of disinfectants, which can be used even as an alternative to antibiotics in some cases. Interestingly, antimicrobial polymers can be tethered to surfaces without losing their biological activity, which enables the design of surfaces that kill microbes without releasing biocides. The present review considers the working mechanisms of antimicrobial polymers and of contact-active antimicrobial surfaces based on examples of recent research as well as on multifunctional antimicrobial materials

Antimicrobial Polymers in Solution and on Surfaces: Overview and Functional Principles

The control of microbial infections is a very important issue in modern society. In general there are two ways to stop microbes from infecting humans or deteriorating materials—disinfection and antimicrobial surfaces. The first is usually realized by disinfectants, which are a considerable environmental pollution problem and also support the development of resistant microbial strains. Antimicrobial surfaces are usually designed by impregnation of materials with biocides that are released into the surroundings whereupon microbes are killed. Antimicrobial polymers are the up and coming new class of disinfectants, which can be used even as an alternative to antibiotics in some cases. Interestingly, antimicrobial polymers can be tethered to surfaces without losing their biological activity, which enables the design of surfaces that kill microbes without releasing biocides. The present review considers the working mechanisms of antimicrobial polymers and of contact-active antimicrobial surfaces based on examples of recent research as well as on multifunctional antimicrobial materials