Practical experiences with the reduction of prevalence of Salmonella infections in pig herds

Salmonella reduction is an issue with still increasing importance for the swine production. PIC in Germany has already started with specific interventions to reduce Salmonella prevalence in their breeding herds in 2001 – just one year before the “QS Qualität und Sicherheit GmbH” began to set up the serological Salmonella monitoring in German finishing pigs

The 3-53 keV Spectrum of the Quasar 1508+5714: X-rays from z = 4.3

We present a high-quality X-ray spectrum in the 3--53 keV rest-frame band of the radio-loud quasar 1508+5714, by far the brightest known X-ray source at z > 4. A simple power-law model with an absorption column density equal to the Galactic value in the direction of the source provides an excellent and fully adequate fit to the data; the measured power-law photon index Gamma = 1.42 (+0.13,-0.10). Upper limits to Fe K alpha line emission and Compton-reflection components are derived. We offer evidence for both X-ray and radio variability in this object and provide the first contemporaneous radio spectrum (alpha = -0.25). The data are all consistent with a picture in which the emission from this source is dominated by a relativistically beamed component in both the X-ray and radio bands.Comment: 8 pages, TeX, 2 postscript figures; to appear in ApJ Letter

Qualitative research within trials: developing a standard operating procedure for a clinical trials unit

<p>BACKGROUND: Qualitative research methods are increasingly used within clinical trials to address broader research questions than can be addressed by quantitative methods alone. These methods enable health professionals, service users, and other stakeholders to contribute their views and experiences to evaluation of healthcare treatments, interventions, or policies, and influence the design of trials. Qualitative data often contribute information that is better able to reform policy or influence design.</p> <p>METHODS: Health services researchers, including trialists, clinicians, and qualitative researchers, worked collaboratively to develop a comprehensive portfolio of standard operating procedures (SOPs) for the West Wales Organisation for Rigorous Trials in Health (WWORTH), a clinical trials unit (CTU) at Swansea University, which has recently achieved registration with the UK Clinical Research Collaboration (UKCRC). Although the UKCRC requires a total of 25 SOPs from registered CTUs, WWORTH chose to add an additional qualitative-methods SOP (QM-SOP).</p> <p>RESULTS: The qualitative methods SOP (QM-SOP) defines good practice in designing and implementing qualitative components of trials, while allowing flexibility of approach and method. Its basic principles are that: qualitative researchers should be contributors from the start of trials with qualitative potential; the qualitative component should have clear aims; and the main study publication should report on the qualitative component.</p> <p>CONCLUSIONS: We recommend that CTUs consider developing a QM-SOP to enhance the conduct of quantitative trials by adding qualitative data and analysis. We judge that this improves the value of quantitative trials, and contributes to the future development of multi-method trials.</p&gt

The asymmetric drift, the local standard of rest, and implications from RAVE data

Context. The determination of the local standard of rest (LSR), which corresponds to the measurement of the peculiar motion of the Sun based on the derivation of the asymmetric drift of stellar populations, is still a matter of debate. The classical value of the tangential peculiar motion of the Sun with respect to the LSR was challenged in recent years, claiming a significantly larger value. Aims. We present an improved Jeans analysis, which allows a better interpretation of the measured kinematics of stellar populations in the Milky Way disc. We show that the Radial Velocity Experiment (RAVE) sample of dwarf stars is an excellent data set to derive tighter boundary conditions to chemodynamical evolution models of the extended solar neighbourhood. Methods. We propose an improved version of the Stromberg relation with the radial scalelengths as the only unknown. We redetermine the asymmetric drift and the LSR for dwarf stars based on RAVE data. Additionally, we discuss the impact of adopting a different LSR value on the individual scalelengths of the subpopulations. Results. Binning RAVE stars in metallicity reveals a bigger asymmetric drift (corresponding to a smaller radial scalelength) for more metal-rich populations. With the standard assumption of velocity-dispersion independent radial scalelengths in each metallicity bin, we redetermine the LSR. The new Stromberg equation yields a joint LSR value of V-circle dot = 3.06 +/- 0.68 km s(-1), which is even smaller than the classical value based on Hipparcos data. The corresponding radial scalelength increases from 1.6 kpc for the metal-rich bin to 2.9 kpc for the metal-poor bin, with a trend of an even larger scalelength for young metal-poor stars. When adopting the recent Schonrich value of V-circle dot = 12.24 km s(-1) for the LSR, the new Stromberg equation yields much larger individual radial scalelengths of the RAVE subpopulations, which seem unphysical in part. Conclusions. The new Stromberg equation allows a cleaner interpretation of the kinematic data of disc stars in terms of radial scalelengths. Lifting the LSR value by a few km s(-1) compared to the classical value results in strongly increased radial scalelengths with a trend of smaller values for larger velocity dispersions

A Very Radio-Loud Narrow-Line Seyfert 1: PKS 2004-447

We have discovered a very radio-loud Narrow-Line Seyfert 1 candidate: PKS 2004-447. This Seyfert is consistent with the formal definition for NLS1s, although it does not have quite the same spectral features as some typical members of this subclass. Only ROSAT survey data is available at X-ray wavelengths, so it has not been possible to compare this source with other NLS1s at these wavelengths. A full comparison of this source with other members of the subclass will improve our physical understanding of NLS1s. In addition, using standard calculations, we estimate the central black hole to have a mass of $\sim 5 \times 10^6 M_{\odot}$. This does not agree with predictions in the literature, that radio-loud AGN host very massive black holes.Comment: 15 pages, 4 figures, accepted for publication in ApJ, minor typos change

The Radio Quiescence of Active Galaxies with High Accretion Rates

We present 6 cm Very Large Array observations of the Greene & Ho (2004) sample of 19 low-mass active galaxies with high accretion rates. This is one of the only studies of a uniform sample of narrow-line Seyfert 1 (NLS1) galaxies with such high sensitivity and resolution. Although we detect only one source, the entire sample is very radio-quiet down to strong limits. GH10 was found to have a radio power of 8.5 x 10^21 W/Hz, and a ratio R = f(6 cm)/f(4400 A) of 2.8. The 3 sigma upper limits for the remaining nondetections correspond to radio powers from 3 x 10^20 to 8 x 10^21 W/Hz and 0.47 < R <9.9. Stacking all nondetections yields an even stronger upper limit of R < 0.27. An assessment of existing observations in the literature confirms our finding that NLS1s are consistently radio-quiet, with a radio-loud fraction of 0%-6%, which is significantly lower than the 10%-20% observed in the general quasar population. By analogy with stellar-mass black holes, we argue that AGNs undergo a state transition at L_bol/L_Edd~0.01. Below this value a radiatively inefficient accretion flow effectively drives an outflow, which disappears when the flow turns into an optically thick, geometrically thin disk, or a radiation pressure-dominated slim disk at still higher L_bol/L_Edd.Comment: To appear in ApJ; 8 pages, 3 figures; uses emulateapj5.st