Radiative decays of light vector mesons

The new data on $\rho,\omega,\phi$ radiative decays into $\pi^0\gamma,\eta\gamma,\eta'\gamma$ from SND experiment at VEPP-2M $e^+e^-$ collider are presented.Comment: 5 pages, 2 figures, talk given at 8th International Conference on Hadron Spectroscopy (HADRON 99), Beijing, China, 24-28 Aug 199

The process e+e−→π+π−π0e^+e^-\to\pi^+\pi^-\pi^0 in the energy range 2E_0=1.04 - 1.38 GeV

In the experiment with the SND detector at VEPP-2M e^+e^- collider the process $e^+e^-\to\pi^+\pi^-\pi^0$ was studied in the energy range 2E_0 from 1.04 to 1.38 GeV. A broad peak was observed with the visible mass $M_{vis}=1220\pm 20$ MeV and cross section in the maximum $\sigma_0\simeq 4$ nb. The peak can be interpreted as a $\omega$-like resonance $\omega (1200)$.Comment: 10 pages LATEX and 5 figure

New Data from SND Detector in Novosibirsk

The current status of experiments with SND detector at VEPP-2M e^+e^- collider in the energy range 2E_0=400-1400 MeV and recent results of data analysis for $\phi$, $\omega$ and $\rho$ decays and e^+e^- annihilation into hadrons are presented.Comment: 7 pages, 8 figures, Latex2e, uses espcrc1.sty. Talk given at 8th International Conference on Hadron Spectroscopy (HADRON 99), Beijing, China, 24-28 Aug 199

PCR assays for detection of human astroviruses: In silico evaluation and design, and in vitro application to samples collected from patients in the Netherlands

Molecular basis of virus replication, viral pathogenesis and antiviral strategie

Viral metagenomic sequencing in a cohort of international travellers returning with febrile illness

Background: Diagnosis of infections in returning international travellers can be challenging because of the broad spectrum of potential infectious etiologies potentially involved. Viral metagenomic next-generation sequencing (mNGS) has the potential to detect any virus present in a patient sample and is increasingly being used for difficult to diagnose cases. The aim of this study was to analyze the performance of mNGS for viral pathogen detection in the clinical setting of international travellers returning with febrile illness. Methods: Thirty-eight serum samples from international travellers returning with febrile illness and presenting at the outpatient clinic of the Leiden University Medical Center in the Netherlands in the time period 2015-2016 were selected retrospectively. Samples were processed for viral metagenomic sequencing using a probe panel capturing all known vertebrate viruses. Bioinformatic analysis was performed using Genome Detective software for metagenomic virus detection. Metagenomic virus findings were compared with viral pathogen detection using conventional methods. Results: In 8 out of the 38 patients (21%), a pathogenic virus was detected by mNGS. All viral pathogens detected by conventional assays were also detected by mNGS: dengue virus (n=4 patients), Epstein-Barr virus (n=2), hepatitis B virus (n=1). In addition, mNGS resulted in additional pathogenic findings in 2 patients (5%): dengue virus (n=1), and hepatitis C virus (n=1). Non-pathogenic viruses detected were: GB virus C (n=1) and torque teno viruses (n=3). High genome coverage and depth using capture probes enabled typing of the dengue viruses detected. Conclusions: Viral metagenomics has the potential to assist the detection of viral pathogens and co-infections in one step in international travellers with a febrile syndrome. Furthermore, viral enrichment by probes resulted in high genome coverage and depth which enabled dengue virus typing.Molecular basis of virus replication, viral pathogenesis and antiviral strategie

Search for direct production of a2(1320) and f2(1270) mesons in e+e- annihilation

A search for direct production of C-even resonances a2(1320) and f2(1270) in e+e- annihilation was performed with SND detector at VEPP-2M e+e- collider. The upper limits of electronic widths of these mesons were obtained at 90% confidence level: Gamma(a2(1320) \to e+e-) < 0.56 eV, Gamma(f2(1270) \to e+e-) < 0.11 eV.Comment: 6 pages, 5 figures, 1 table. Submitted to Phys. Lett.

New experimental data for the decays ϕ→μ+μ−\phi\to\mu^+\mu^- and ϕ→π+π−\phi\to\pi^+\pi^- from SND detector

The processes $e^+e^-\to\mu^+\mu^-$ and $e^+e^-\to\pi^+\pi^-$ have been studied with SND detector at VEPP-2M $e^+e^-$ collider in the vicinity of $\phi(1020)$ resonance. The branching ratios $B(\phi\to\mu^+\mu^-)=(3.30\pm 0.45\pm 0.32)\times 10^{-4}$ and $B(\phi\to\pi^+\pi^-)=(0.71\pm 0.11\pm 0.09)\times 10^{-4}$ were obtained.Comment: 5 pages, 4 figures, talk given at 8th International Conference on Hadron Spectroscopy (HADRON 99), Beijing, China, 24-28 Aug 199

Experimental Study of rho -> pi0 pi0 gamma and omega -> pi0 pi0 gamma Decays

The e+e- -> pi0 pi0 gamma process was studied in the SND experiment at VEPP-2M e+e- collider in the energy region 0.60-0.97 GeV. From the analysis of the energy dependence of measured cross section the branching ratios B(omega -> pi0 pi0 gamma)= (6.6 +1.4-0.8(stat) +-0.6(syst))x10^-5 and B(rho -> pi0 pi0 gamma)=(4.1 +1.0-0.9(stat) +-0.3(syst))x10^-5 were obtained.Comment: 16 pages, 7 figures, submitted to Phys. Lett.

Torque teno virus loads after kidney transplantation predict allograft rejection but not viral infection

The main challenge of immunosuppressive therapy after solid organ transplantation is to create a new immunological balance that prevents organ rejection and does not promote opportunistic infection. Torque teno virus (TTV), a ubiquitous and non-pathogenic single-stranded DNA virus, has been proposed as a marker of functional immunity in immunocompromised patients. Here we investigate whether TTV loads predict the risk of common viral infection and allograft rejection in kidney transplantation recipients.In a retrospective cohort of 389 kidney transplantation recipients, individual TTV loads in were measured by qPCR in consecutive plasma samples during one year follow-up. The endpoints were allograft rejection, BK polyomavirus (BKPyV) viremia and cytomegalovirus (CMV) viremia. Repeated TTV measurements and rejection and infection survival data were analysed in a joint model.During follow-up, TTV DNA detection in the transplant recipients increased from 85 to 100%. The median viral load increased to 107 genome copies/ml within three months after transplantation. Rejection, BKPyV viremia and CMV viremia occurred in 23%, 27% and 17% of the patients, respectively. With every 10-fold TTV load-increase, the risk of rejection decreased considerably (HR: 0.74, CI 95%: 0.71-0.76), while the risk of BKPyV and CMV viremia remained the same (HR: 1.03, CI 95%: 1.03-1.04 and HR: 1.01, CI 95%: 1.01-1.01).In conclusion, TTV load kinetics predict allograft rejection in kidney transplantation recipients, but not the BKPyV and CMV infection. The potential use of TTV load levels as a guide for optimal immunosuppressive drug dosage to prevent allograft rejection deserves further validation.Development and application of statistical models for medical scientific researc

Study of the radiative decay ϕ→ηγ\phi \to \eta \gamma with CMD-2 detector

Using the $1.9 pb^{-1}$ of data collected with the CMD-2 detector at VEPP-2M the decay mode $\phi \to \eta \gamma$, $\eta \to \pi^+\pi^-\pi^0$ has been studied. The obtained branching ratio is B($\phi \to \eta \gamma) = (1.18 \pm 0.03 \pm 0.06)$.Comment: 13 pages, 5 figures, LaTex2e, to be published in Phys. Lett.