9 research outputs found
Epstein - Barr virus latent membrane protein 1 suppresses reporter activity through modulation of promyelocytic leukemia protein-nuclear bodies
- Publication venue
- BioMed Central
- Publication date
- 01/01/2011
- Field of study
The Epstein-Barr virus (EBV) encoded Latent Membrane Protein 1 (LMP1) has been shown to increase the expression of promyelocytic leukemia protein (PML) and the immunofluorescent intensity of promyelocytic leukemia nuclear bodies (PML NBs). PML NBs have been implicated in the modulation of transcription and the association of reporter plasmids with PML NBs has been implicated in repression of reporter activity. Additionally, repression of various reporters in the presence of LMP1 has been noted. This study demonstrates that LMP1 suppresses expression of reporter activity in a dose responsive manner and corresponds with the LMP1 induced increase in PML NB intensity. Disruption of PML NBs with arsenic trioxide or a PML siRNA restores reporter activity. These data offer an explanation for previously conflicting data on LMP1 signaling and calls attention to the possibility of false-positives and false-negatives when using reporter assays as a research tool in cells expressing LMP1
Retinal Effects of 6 Months of Daily Use of Tadalafil or Sildenafil
- Author
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 01/04/2009
- Field of study
Objective: To assess changes in electroretinography (ERG) and other retinal function parameters during 6 months of daily use of tadalafil, sildenafil citrate, or placebo
Demographic Change, Threat, and Presidential Voting: Evidence from U.S. Electoral Precincts, 2012 to 2016
- Author
- Anna Mayda
- Benjamin J Newman
- Benjamin J Newman
- Benjamin J Newman
- Cas Mudde
- Christopher S Parker
- Claudine Gay
- Corwin D Smidt
- Daniel J Hopkins
- Daniel J Hopkins
- Daniel J. Hopkins
- Daniel Oesch
- David Autor
- Donald P Green
- Eric Kaufmann
- Eric Kaufmann
- Gregory Huber
- Herbert Kitschelt
- Hersh
- J Oliver
- J Oliver
- John Sides
- Katherine J Cramer
- Leo Chavez
- Maneesh Arora
- Marisa Abrajano
- Michael W Giles
- Morris Levy
- Peter Dinesen
- Rafaela Dancygier
- Robert D Putnam
- Robert Ford
- Roger Eatwell
- Ryan D Enos
- Ryan D Enos
- Ryan D Enos
- Ryan T Moore
- Seth Hill
- Shang E Ha
- Tam Cho
- Tyler Reny
- Tyler T Reny
- V O Key
- Yuen J Huo
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Arsenic mediated disruption of promyelocytic leukemia protein nuclear bodies induces ganciclovir susceptibility in Epstein–Barr positive epithelial cells
- Author
- Adamson
- Adler
- Ahn
- Ardalan
- Au
- Bartolome
- Bell
- Berenson
- Bernardi
- Bin Shan
- Block
- Boisvert
- Boom
- Bowling
- Cheung
- Ching
- Connors
- Daibata
- Dellaire
- Edwards
- Eliopoulos
- Erik K. Flemington
- Eskiw
- Everett
- Faller
- Feng
- Feng
- Feng
- Feng
- Flemington
- Fox
- Freeman
- Gregory J. Block
- Hao
- Hilscher
- Hui
- Ishov
- Ishov
- Joseph A. Lasky
- Jung
- Kelly
- Kenney
- Kyle C. Esteves
- Lallemand-Breitenbach
- Lavau
- Levitskaya
- LTVCI
- Mark D. Sides
- Maul
- Maul
- Meng
- Mentzer
- Miller
- Miller
- Moore
- Moorthy
- Nakamura
- Neuhierl
- Nonoyama
- Nouri
- Oda
- Oh
- Peng
- Raab-Traub
- Rollig
- Sengupta
- Shan
- Shibata
- Sides
- Sivachandran
- Sivachandran
- Sizhong
- Soignet
- Speck
- Stadler
- Takada
- Takano
- Tang
- Tanvetyanon
- Tao
- Thompson
- Uede
- Vasef
- Wang
- Weisshaar
- Westphal
- Wolf
- Xu
- Yeager
- Yin
- Zhang
- Zhang
- Zhang
- Zhen Lin
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Ethical Security in Europe? Empirical Findings on Value Shifts and Dilemmas Across European Internal-External Security Policies
- Author
- &apos
- "
- A Burke
- A Gendron
- A Heinemann-Gr�der
- A Hyde-Price
- A Hyde-Price
- A S Hulnick
- Ansamed
- April
- Artan Mr
- B A De Graaf
- B Coppieters
- B De Graaf
- B M�ller-Wille
- B Pouligny
- C A S E Collective
- C Friesendorf
- Council Secretariat
- Council Secretariat
- D Allen
- D Bigo
- D Bigo
- D Bigo
- D Bigo
- D Bigo
- D Bigo
- D Carrick
- D Das
- D E Pressman
- D J Bem
- D Lutterbeck
- D Omand
- D Relji?
- Daniela Dicorrado Ms
- De Wet
- Den Boer
- Den Boer
- Doc
- Dr
- E Bakker
- E Guild
- E L Nickels
- E Patterson
- E Pond
- Edit Ms
- Eulex Kosovo
- Eulex Kosovo
- Eulex Kosovo
- Eupol Proxima
- European Parliament
- F Bieber
- F Buijs
- F Gregory
- F Tanner
- F Viviano
- G
- G Bono
- G Bono
- G Bono
- G Hofstede
- G Mounier
- G Mounier
- G M�ller-Brandeck-Bocquet
- G Stevens
- G T Felkenes
- H Aronovitch
- H Born
- H Grabbe
- H Oosterom-Staples
- Hanneke Ms
- I Ioannides
- I Ioannides
- I Ioannides
- I Loader
- I Manners
- Inex
- Isabelle Ioannides
- J A E Vervaele
- J Eriksson
- J G March
- J Huysmans
- J J Miller
- J Kleinig
- J Kleinig
- J Mcculloch
- J P Burgess
- J P Burgess
- J P Burgess
- J P Burgess
- J P Crank
- J Sides
- J Timmer
- J Timmer
- J Van Buuren
- June
- June
- Kosovar Stability Initiative
- L Aggestam
- L Offeddu
- L Phillips
- L Richardson
- L W J C Huberts
- L Westmarland
- L Zedner
- M Anderson
- M Anderson
- M Caparini
- M Derks
- M E Smith
- M Quinlan
- M Tondini
- M Tondini
- M Tondini
- M Tondini
- M Weiss
- Maria Ms
- Matteo Tondini
- Michel Mr
- Milos Mr
- Ministry Of Interior
- Mr
- Mr
- Ole Waever
- Oliver Mr
- P Abels
- P Feith
- P J Dimaggio
- P Pawlak
- P Robinson
- P Robinson
- Patrick Mr
- Quotidiano Nazionale
- R Janse
- R Peters
- R Peters
- R Youngs
- Rolf Mr
- S Derix
- S Duke
- S Hamood
- S Hamood
- S Lavenex
- S Miller
- S Miller
- S Nuttall
- S Trevisanut
- S Wolff
- S Wolff
- September
- September
- Stephen Mr
- T Erskine
- T Jones
- T Judah
- T Pfaff
- V D?ihi?
- W Koeth
- W Rees
- X Kurowska
- Y S Lincoln
- Yvonne Ms
- Z Van Der Wal
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2010
- Field of study
High School Civics Textbooks: What We Know Versus What We Teach about American Politics and Public Policy
- Author
- Altbach Philip G.
- Anderson Sarah
- Atkinson Rob.
- Barbour Christine
- Bardach Eugene.
- Bowman Scott R.
- Chambliss Marilyn
- Cigler Allan J.
- David Menefee-Libey
- Davis James E.
- Davis James E.
- Downey Matthew T.
- Edwards George C.
- Fang Lee.
- Finn Jr.
- Fraga Luis Ricardo
- Ginsberg Benjamin
- Halpern Robert.
- Hartley William H.
- Hudson William E.
- Janda Kenneth
- Kumar Anita.
- Lasswell Harold D.
- Light Paul Charles
- Lindblom Charles E.
- Mandel Michael.
- Markon Jerry
- Massing Gregory I.
- Mayer Kenneth R.
- Mazzucato Mariana.
- McCartney Allison Rios Millett
- McClenaghan William A.
- Menefee-Libey David.
- Menefee-Libey David.
- Minow Martha.
- Ogg Frederick Austin
- Pangle Lorraine Smith
- Peters B. Guy
- Pinto Arthur R.
- Remy Richard C.
- Remy Richard C.
- Roy William G.
- Salamon Lester M.
- Schmidt Steffen W.
- Sides John
- Smith Jane W.
- Smith Steven Rathgeb
- Stanger Allison.
- Stillman Lauren
- Tyack David
- Wallace Sherri L.
- Wang Marian.
- Wichowski Amber
- Wilson James Q.
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
CD8+ T Cell Response to Gammaherpesvirus Infection Mediates Inflammation and Fibrosis in Interferon Gamma Receptor-Deficient Mice
- Author
- A Mantovani
- A Takemasa
- A Wangoo
- A Zamo
- AD Gregory
- AG Besnard
- AG Evans
- AL Mora
- AL Mora
- AL Mora
- AnaPatricia Garcia
- AP Malizia
- AV Misharin
- B Ebrahimi
- BB Moore
- BB Moore
- BB Moore
- BD Bringardner
- Bethany B. Moore
- BG Kelly
- BM Dutia
- Brian S. Wakeman
- Brigid M. O’Flaherty
- CA Feghali-Bostwick
- Caline G. Matar
- Carol A. Wilke
- CR Paden
- Cynthia L. Courtney
- D Pohlers
- David A. Leib
- E Corsini
- E Fireman
- E Flano
- EB Meltzer
- ER Parra
- ET Clambey
- G Raghu
- GJ Nuovo
- GW Hunninghake
- H Yamanouchi
- IG Luzina
- IG Luzina
- JA Kropski
- JA Kropski
- JA Kropski
- JD Herazo-Maya
- JJ Egan
- JP Simas
- JP Stewart
- JS Song
- JS Stoolman
- K Manika
- KM Vannella
- KR Flaherty
- KS Lee
- L Liu
- L Richeldi
- LT Krug
- LT Krug
- M Abe
- M Helene
- MA Coppola
- MD Sides
- ML Freeman
- ML Freeman
- PG Stevenson
- PG Stevenson
- PG Stevenson
- PJ Christensen
- PJ Wolters
- PK Naik
- PL Molyneaux
- RA Tripp
- RL Kradin
- S Nagai
- SA Papiris
- SA Papiris
- Samuel H. Speck
- SR Gilani
- T Okazaki
- TA Wynn
- TE King Jr.
- V Pozharskaya
- VP. Pozharskaya
- Y Obayashi
- YW Tang
- Z Daniil
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Ezetimibe added to statin therapy after acute coronary syndromes
- Author
- Aagnes I
- Aambakk MB
- Aase O
- Aaser E
- Abdel-Latief A
- Abell T
- Aboufakher R
- Abramson B
- Abrantes J
- Achilli A
- Adams A
- Adams K
- Adamus J
- Addington J
- Adgey A
- Adjei A
- Agarwal J
- Aggarwal A
- Aggarwal K
- Aggarwal R
- Agocha A
- Agraou B
- Aguirre O
- Ahmed A
- Ahmed O
- Ahsan A
- Airaksinen J
- Airoldi F
- Aji J
- Akkad H
- Akubzanova E
- Al-Ani R
- Al-Jumaily J
- Alameda J
- Albirini A
- Albuquerque A
- Albuquerque D
- Alcasena S
- Alexander J
- Alfonso F
- Ali MI
- Alings MA
- Allall O
- Allen J
- Allen RP
- Allred S
- Almeira AS
- Alonso L
- Alsagheer S
- Alshaher M
- Altschuller A
- Alvarez J
- Alvarez J
- Alvarez Y
- Alves A
- Amidon T
- Amos M
- Anaszewicz M
- Andersen M
- Andersen O
- Andersson E
- Andersson G
- Andrade G
- Andrade M
- Andrea B
- Andreou C
- Antonangelo A
- Antorrena I
- Appel K
- Arana C
- Aranda M
- Araujo J
- Arce R
- Ardito RV
- Ardito W
- Arend C
- Arias V
- Armada E
- Armstrong P
- Arnold A
- Arnold M
- Arntsen BI
- Arora P
- Aros F
- Arriagada G
- Arriagada G
- Artaecheverria J
- Arvesen K
- Arvigo L
- Ash Y
- Aske R
- Ata N
- Atar D
- Atar S
- Atassi K
- Atieh M
- Atkinson C
- Atzenhofer-Baumgartner K
- Auer J
- Aug L
- Ausen K
- Aycock G
- Aylward P
- Aylward P
- Ayres T
- Azize G
- Azrin M
- Azzolini P
- Babu R
- Bach R
- Badings EA
- Baeza N
- Baig M
- Baiz A
- Bajcsi É
- Balaguera J
- Balcells E
- Baldari D
- Baldus S
- Bali H
- Ballantyne C
- Ballmer P
- Banerjee S
- Bang-Hansen T
- Banikova A
- Bankowski D
- Banks K
- Bansal M
- Baraona F
- Barber C
- Barber C
- Barbir M
- Barillas O
- Barnes D
- Barnett O
- Barr C
- Barrett J
- Barringhaus K
- Barron M
- Bartels GL
- Basilio E
- Bass M
- Bassand J
- Bassand JP
- Bassand JP
- Basso V
- Bata I
- Battikadi S
- Battin D
- Bauer B
- Baumanns S
- Bautista J
- Bayat J
- Bayer M
- Bayer M
- Bayles A
- Bazzi A
- Beaudry M
- Bedoya R
- Been M
- Belicova M
- Bell K
- Belle L
- Beloscar J
- Beltran R
- Beltrano MC
- Ben-Aharon J
- Ben-Yehuda O
- Benetar J
- Bengtsson PO
- Bennermo M
- Bennett J
- Benyahya L
- Beresford P
- Berezniakov I
- Berger M
- Berger-Kucza A
- Bergeron J
- Berglund M
- Berglund R
- Bergsten J
- Berk M
- Berli M
- Bernardi D
- Berra F
- Berrospi P
- Bertolet B
- Bescos L
- Bethea C
- Bethencourt A
- Betti I
- Betzu R
- Bhalla H
- Bhalodkar N
- Bhargava M
- Bhargava R
- Bhargavi M
- Bhesania T
- Biasucci L
- Biedermann B
- Bikkina M
- Bilazarian S
- Bilodeau N
- Bin Ismail O
- Binaghi G
- Birkemeyer R
- Birnbaum Y
- Bishop A
- Bishop B
- Bishop C
- Bissett J
- Bissett J
- Bittel B
- Bitzer V
- Bjornstad H
- Blacher MG
- Blais D
- Blank E
- Blazing M
- Blazing M
- Blazing M
- Blazing Michael A.
- Blessing E
- Block D
- Bluguermann J
- Blumberg E
- Bobek M
- Bocconcelli P
- Bocconcelli P
- Bodanese L
- Bodenstein W
- Boehm S
- Bogomolny N
- Bohle D
- Bohlscheid V
- Bohorquez R
- Bohula Erin A.
- Boliek W
- Bolli R
- Bolsman C
- Bonatti S
- Bondi L
- Bondio M
- Bone C
- Bonnet J
- Bono J
- Book K
- Boomer L
- Boos C
- Botero R
- Bottzauw J
- Botwin S
- Boudriot E
- Bouvier JM
- Bowden W
- Bozek B
- Bradford L
- Bradford L
- Brady A
- Brady A
- Brady A
- Braga J
- Branca G
- Branny M
- Branzi A
- Braun P
- Braunwald Eugene
- Breen J
- Brike C
- Britto F
- Britto F
- Britto F
- Broadwater S
- Bronnum-Schou J
- Brossoit R
- Brown C
- Brown C
- Brown C
- Brown J
- Brunelli C
- Brunelli C
- Brunk S
- Bruno N
- Brunvand H
- Brussee H
- Bryniarski L
- Budzon S
- Bueno M
- Buerke M
- Buerke M
- Bugos V
- Buijs EM
- Buijs F
- Bullivant M
- Burgess L
- Burghard S
- Burley T
- Burton J
- Buss I
- Bustamante G
- Butcher R
- Butkus E
- Butter C
- Buzetti C
- Byfuglien A
- Cabrera-Santamaria A
- Calderón MJ
- Calic S
- Califf
- Calpar I
- Calzolari D
- Campbell C
- Campbell T
- Campos C
- Cannon C
- Cannon C
- Cannon Christopher P.
- Canto J
- Cappelen H
- Capucci A
- Capucci A
- Cardillo MT
- Cardinal F
- Cardoso A
- Carell E
- Carell E
- Carey C
- Carlessi C
- Carlevaro O
- Carling-Chambers L
- Carlsson F
- Carmelo M
- Carr K
- Carrageta M
- Carrageta M
- Carrageta M
- Carrié D
- Carswell BS
- Cartasegna L
- Caruso O
- Casalins M
- Casares G
- Caso P
- Caspi A
- Cassadonte F
- Cassavar D
- Cassel G
- Castoldi M
- Castro P
- Castro R
- Catarino C
- Caussin C
- Cauthren T
- Cavallini C
- Ceder-Brolin K
- Centeno E
- Centurion C
- Cepeda M
- Cequier A
- Chadwyn D
- Chae SC
- Chalavarya G
- Chambers J
- Chandler G
- Chandna H
- Chandna H
- Chandna H
- Chandra P
- Chandraratna P
- Chandrasekaran S
- Chang D
- Chang G
- Chang K
- Chang K
- Chang M
- Charng M
- Chattree K
- Chavarri M
- Chavez V
- Chee K
- Chernick R
- Chessa P
- Cheung S
- Chew D
- Chhabra A
- Chian-Yi W
- Chiariello M
- Chilakamarri V
- Childs A
- Childs C
- Chiodi L
- Chiu A
- Cho M
- Choi Y
- Cholewa M
- Chopra A
- Chopra V
- Christopher J
- Christy L
- Chronos N
- Chu A
- Chui K
- Chung W
- Ciampricotti R
- Cianflone D
- Cicia G
- Cihalik C
- Ciliberti D
- Cirillo W
- Ciuti G
- Cizinsky S
- Clarke A
- Clarus S
- Clausen H
- Clausen H
- Clavero X
- Clemmensen P
- Cleveland D
- Cleveland T
- Cloud B
- Cobos M
- Cocco N
- Coelho O
- Coetzee C
- Coffin N
- Coffman A
- Cohen B
- Cohen LE
- Cohen Y
- Coisne D
- Coldwell J
- Colfer H
- Collins J
- Collins J
- Collins T
- Colombo H
- Commerford P
- Conaway D
- Connolly T
- Constance C
- Conti M
- Cooke J
- Cooke L
- Corbalan R
- Corbalan R
- Corbett C
- Cortada J
- Corut S
- Cossett J
- Costa M
- Costantini C
- Costello T
- Cottin Y
- Coviaux F
- Coy K
- Craig M
- Crandall L
- Crawford K
- Cristaldi J
- Cristell N
- Cronje T
- Cross D
- Crutchfield B
- Cryderman C
- Csapó K
- Cubeddu L
- Cuccia C
- Cullen T
- Curry R
- Curtis S
- Cush S
- Cusimano S
- Cyncar R
- D'Urso M
- da Costa FA
- da Cunha C
- Dagefoerde N
- Dahiya R
- Dalby A
- Dalby A
- Dalby A
- Dale H
- Daley P
- Dalin L
- Dambrine P
- Damiano M
- Damiano S
- Damm T
- Dani S
- Daniel D
- Daniels MC
- Danse IY
- Darcel I
- Darius H
- Darius H
- Darius H
- Darius Harald
- Darnell Z
- Dauber I
- Dave R
- David M
- Davidovits S
- Davidson L
- Davis B
- Davis C
- Davis G
- Davis T
- Davis W
- Davy J
- Dawson G
- De Andrade M
- De Belder M
- de Carvalho Moreira R
- De Caterina R
- De Clippel M
- De Feo S
- De Ferrari G
- De Ferrari G
- De Ferrari Gaetano M.
- De Ferrari GM
- De Gregorio M
- de la Guia F
- de la Guia F
- De Larochelliere R
- de Lemos J
- De Lemos J
- De Lucca Paul
- De Maria E
- de Sa E
- de Salazar D
- de Souza J
- de Teresa E
- de Valdecilla H
- De Velder L
- De Wolf L
- Debrouwer K
- Decker S
- DeFranco A
- Del Core M
- del Rio A
- Dela Cruz C
- Delahaye F
- Delgado J
- Delio-Cox B
- Della Siega A
- Dellatorre M
- Dellborg M
- Dellborg M
- Dellborg M
- Delport E
- Demarcq JM
- Dempsey K
- Den Hartog FR
- DeRaad R
- Desai V
- Desalca M
- DeSimone L
- DeVault S
- Devlin G
- Dhooghe G
- Di Biase M
- Di Fazio J
- Di Pasquale G
- Diadema B
- Dias D
- Dickinson D
- Dietz S
- Dietz W
- Diffenback M
- Dignen K
- Dijkshoorn-Giesen AH
- Dimenna J
- Diogo A
- Dion D
- Dionisopoulos P
- Dirkali A
- DiVito P
- Dobies D
- Dodt K
- Doerr M
- Dohmann H
- Dohmann H
- Domingo D
- Donegan R
- Donnelly B
- Donovan C
- Dos Santos ES
- Dos Santos LB
- Doty W
- Doucet M
- Doughty A
- Douglas L
- Dourmap-Collas C
- Doux N
- Dragu R
- Drenning D
- Drexel H
- Droste HT
- Duarte YC
- Dubiel J
- Dubois-Rande JL
- Duda N
- Duengen H
- Dujardin J
- Dujardin K
- Dunselman PH
- Dupuis R
- Duris T
- Duris T
- Duris T
- Duronto E
- Dussaubat A
- Dutra O
- Dwenger E
- Dzupina A
- Eaton C
- Eaton C
- Eaton G
- Ebelt H
- Eber B
- Ebrahim I
- Ebrahimi R
- Effat M
- Effron B
- Egger F
- Egido J
- Eisenberg D
- Eisenberg S
- Eisenberg S
- Eisenhauer M
- Ekpo E
- El Allaf D
- El Jarroudi M
- El Khadra M
- El Mansour N
- Elbaz M
- Eldar M
- Elis A
- Ellis J
- Elmore N
- Elsner G
- Emanuele V
- Encina L
- Erickson B
- Eriksson K
- Eriksson M
- Erlinge D
- Ervin F
- Erwin J
- Escalante A
- Escalera P
- Escande M
- Escobar E
- Escorihuela A
- Esham G
- Esplugas E
- Esteban I
- Evans M
- Ezechiels JP
- Facchi TL
- Facciorusso A
- Fadel M
- Fageraas ER
- Fahdi I
- Fahdi I
- Fanelli R
- Fanelli R
- Fanuele M
- Farhat N
- Farley A
- Farnier M
- Fast JH
- Fasulo A
- Fattore L
- Faucett S
- Fauser CG
- Faynyk A
- Fedacko J
- Fedele Francesco
- Feld RJ
- Feldman T
- Fele N
- Felgueres M
- Felix S
- Felten W
- Fenton S
- Ferdinandis H
- Fernandes A
- Fernandez H
- Fernandez R
- Ferrante R
- Ferrari M
- Ferraz RF
- Ferreira AR
- Ferres R
- Feskov O
- Fiala T
- Fielding M
- Fife B
- Fikes W
- Filardi P
- Filipiak K
- Fine D
- Fini G
- Finkle C
- Firek C
- Firth B
- Fischell T
- Fishbein G
- Fishberg R
- Fisher M
- Fisher R
- Flagstad E
- Fletcher A
- Flock C
- Flores A
- Flores E
- Fluck D
- Foeger B
- Fogel A
- Foltz J
- Fonseca Y
- Forgione C
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- Édes I
- Östberg S
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2015
- Field of study
BACKGROUND: Statin therapy reduces low-density lipoprotein (LDL) cholesterol levels and the risk of cardiovascular events, but whether the addition of ezetimibe, a nonstatin drug that reduces intestinal cholesterol absorption, can reduce the rate of cardiovascular events further is not known. METHODS: We conducted a double-blind, randomized trial involving 18,144 patients who had been hospitalized for an acute coronary syndrome within the preceding 10 days and had LDL cholesterol levels of 50 to 100 mg per deciliter (1.3 to 2.6 mmol per liter) if they were receiving lipid-lowering therapy or 50 to 125 mg per deciliter (1.3 to 3.2 mmol per liter) if they were not receiving lipid-lowering therapy. The combination of simvastatin (40 mg) and ezetimibe (10 mg) (simvastatin-ezetimibe) was compared with simvastatin (40 mg) and placebo (simvastatin monotherapy). The primary end point was a composite of cardiovascular death, nonfatal myocardial infarction, unstable angina requiring rehospitalization, coronary revascularization ( 6530 days after randomization), or nonfatal stroke. The median follow-up was 6 years. RESULTS: The median time-weighted average LDL cholesterol level during the study was 53.7 mg per deciliter (1.4 mmol per liter) in the simvastatin-ezetimibe group, as compared with 69.5 mg per deciliter (1.8 mmol per liter) in the simvastatin-monotherapy group (P<0.001). The Kaplan-Meier event rate for the primary end point at 7 years was 32.7% in the simvastatin-ezetimibe group, as compared with 34.7% in the simvastatin-monotherapy group (absolute risk difference, 2.0 percentage points; hazard ratio, 0.936; 95% confidence interval, 0.89 to 0.99; P = 0.016). Rates of pre-specified muscle, gallbladder, and hepatic adverse effects and cancer were similar in the two groups. CONCLUSIONS: When added to statin therapy, ezetimibe resulted in incremental lowering of LDL cholesterol levels and improved cardiovascular outcomes. Moreover, lowering LDL cholesterol to levels below previous targets provided additional benefit