2,157 research outputs found

    Internet-based Framework to Support Integration of Customer in the Design of Customizable Products

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    A necessary element to design and produce customer-centric products is the integration of customers in the design process. Challenges faced during customer integration into the design process include generating models of the customized product, performing analysis of these to determine feasibility, and optimizing to increase the performance. These tasks have to be performed relatively quickly, if not in real time, to provide feedback to the customer. The focus of this article is to present a framework that utilizes CAD, finite element analysis (FEA), and optimization to integrate the customer into the design process via the Internet for delivering user customized products. The design analysis, evaluation, and optimization need to be automated and enhanced to enable operation over the Internet. A product family CAD/FEA template has been developed to perform analysis, along with a general formulation to optimize the customized product. The CAD/FEA template generalizes the geometry building and analysis of each configuration developed using a product platform approach. The proposed setup is demonstrated through the use of a bicycle frame family. In this study, the focus is on the application of optimization and FEA to facilitate the design of customer-centric products.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline

    Calcium carbonate precipitation by different bacterial strains

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    Bacteria are capable of performing metabolic activities which thereby promote precipitation of calcium carbonate in the form of calcite. In this study, it is shown that microbial mineral precipitation was a result of metabolic activities of some specific microorganisms. Concrete microorganisms were used to improve the overall behavior of concrete. It was predicted that bacterial calcium carbonate (CaCO3) precipitation occurs as a byproduct of common metabolic processes such as urea hydrolysis. In this study, ureolytic bacteria that were capable of precipitating calcium carbonate were isolated and further their urease activity was tested based on the production of urease. Scanning electron microscopy (SED) analysis revealed the direct involvement of these isolates in calcium carbonate precipitation. The production of calcite was further confirmed by x-ray diffraction (XRD) and energy-dispersive x-ray (EDX) analysis.Key words: Bacteria, urease activity, microbial mineral precipitation, scanning electron microscope-energydispersive x-ray, x-ray diffraction

    Theoretical Antecedent Of Customer Relationship Management Of Banks In India

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    This paper has attempted to study the theoretical antecedents of CRM in banks and validate the instrument scale for CRM especially for customer perspective. The researcher has developed the hypothetical model of CRM Practices for banks. Due to insufficient literature in CRM model development study, the researcher has concentrated universal study to focus and form the study conundrum.  The research design of the present study is both descriptive and empirical in nature. The sample was identified with the help of online sample service portal. The study data collected with the sample size of 384 with judgment sampling method. At the time of analyzing the data for envisage the results the researcher applies training and hold out method was adopted for better results. To achieve the validity aspects of scale used for this study evaluated with factor analysis. Both factor analysis methods were adopted. To check the existing theory latent construct EFA is conducted and its results validated through CFA. At the end of the process the researcher offers recommendation for better development and practices for CRM in banks of India

    Estimating the Social Welfare Effects of New Zealand Apple Imports

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    This paper provides a demonstration of how a comprehensive economic framework, which takes into account both the gains from trade and the costs of invasive species outbreaks, can inform decision-makers when making quarantine decisions. Using the theoretical framework developed in Cook and Fraser (2008) an empirical estimation is made of the economic welfare consequences for Australia of allowing quarantine-restricted trade in New Zealand apples to take place. The results suggest the returns to Australian society from importing New Zealand apples are likely to be negative. The price differential between the landed product with SPS measures in place and the autarkic price is insufficient to outweigh the increase in expected damage resulting from increased fire blight risk. As a consequence, this empirical analysis suggests the net benefits created by opening up this trade are marginal.International Relations/Trade,

    Intimate Partner Violence:The influence of job opportunities for men and women

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    This study examines the association of unemployment variation with intimate partner violence using representative data from thirty one developing countries, through 2005 to 2016. It finds that a 1 percent increase in the male unemployment rate is associated with an increase in the incidence of physical violence against women by 0.50 percentage points, or 2.75 percent. This is consistent with financial and psychological stress generated by unemployment. Female unemployment rates have the opposite effect, a 1 percent decrease being associated with an increase in the probability of victimization of 0.52 percentage points, or 2.87 percent. That an improvement in women’s employment opportunities is associated with increased violence is consistent with male backlash. The study finds that this pattern of behaviours emerges entirely from countries in which women have more limited access to divorce than men

    Disrupted Lipid Metabolism in Multiple Sclerosis: A Role for Liver X Receptors?

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    Multiple sclerosis (MS) is a chronic neurological disease driven by autoimmune, inflammatory and neurodegenerative processes leading to neuronal demyelination and subsequent degeneration. Systemic lipid metabolism is disturbed in people with MS, and lipid metabolic pathways are crucial to the protective process of remyelination. The lipid-activated transcription factors liver X receptors (LXRs) are important integrators of lipid metabolism and immunity. Consequently, there is a strong interest in targeting these receptors in a number of metabolic and inflammatory diseases, including MS. We have reviewed the evidence for involvement of LXR-driven lipid metabolism in the dysfunction of peripheral and brain-resident immune cells in MS, focusing on human studies, both the relapsing remitting and progressive phases of the disease are discussed. Finally, we discuss the therapeutic potential of modulating the activity of these receptors with existing pharmacological agents and highlight important areas of future research

    Comparative flower transcriptome network analysis reveals DEGs involved in chickpea reproductive success during salinity

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    Salinity is increasingly becoming a significant problem for the most important yet intrinsically salt-sensitive grain legume chickpea. Chickpea is extremely sensitive to salinity during the reproductive phase. Therefore, it is essential to understand the molecular mechanisms by comparing the transcriptomic dynamics between the two contrasting genotypes in response to salt stress. Chickpea exhibits considerable genetic variation amongst improved cultivars, which show better yields in saline conditions but still need to be enhanced for sustainable crop production. Based on previous extensive multi-location physiological screening, two identified genotypes, JG11 (salt-tolerant) and ICCV2 (salt-sensitive), were subjected to salt stress to evaluate their phenological and transcriptional responses. RNA-Sequencing is a revolutionary tool that allows for comprehensive transcriptome profiling to identify genes and alleles associated with stress tolerance and sensitivity. After the first flowering, the whole flower from stress-tolerant and sensitive genotypes was collected. A total of ~300 million RNA-Seq reads were sequenced, resulting in 2022 differentially expressed genes (DEGs) in response to salt stress. Genes involved in flowering time such as FLOWERING LOCUS T (FT) and pollen development such as ABORTED MICROSPORES (AMS), rho-GTPase, and pollen-receptor kinase were significantly differentially regulated, suggesting their role in salt tolerance. In addition to this, we identify a suite of essential genes such as MYB proteins, MADS-box, and chloride ion channel genes, which are crucial regulators of transcriptional responses to salinity tolerance. The gene set enrichment analysis and functional annotation of these genes in flower development suggest that they can be potential candidates for chickpea crop improvement for salt tolerance
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