The impact of methodological and temporal variation on infarct size quantification in acute myocardial infarction with late enhancement CMR

Funding This project was funded by a grant from the MRC(UK).Peer reviewedPublisher PD

MOLLI T1 mapping versus T2 W-SPAIR at 3T : myocardial area at risk measurements and the influence of microvascular obstruction

Funding Information: This study was supported by a Medical Research Council (UK) grant, as a sub-study of Nitrites in Acute Myocardial Infarction, NCT01388504.Peer reviewe

T₁ mapping for assessment of myocardial injury and microvascular obstruction at one week post myocardial infarction

OBJECTIVES: To compare 3T T1 mapping to conventional T2-weighted (T2W) imaging for delineating myocardial oedema one week after ST-elevation myocardial infarction (STEMI), and to explore the confounding effects of microvascular obstruction (MVO) on each technique.  METHODS: T2W spectral attenuated inversion recovery and native T1 mapping were applied in 10 healthy volunteers and 62 STEMI patients, and late gadolinium enhancement was included for infarct localisation at 1 week and at 6 months post-STEMI. Segmental T1 values and T2W signal intensity ratios were calculated; oedema volumes and salvage indices were determined in patients using image thresholding-a receiver operator characteristic (ROC) derived T1 threshold, and a 2SD T2W threshold; and the results were compared between patients with/without MVO (n=35/27).  RESULTS: Native T1 mapping delineated oedema with significantly better discriminatory power than T2W-as indicated by ROC analysis (area-under-the-curve, AUC=0.89 versus 0.83, p=0.009; and sensitivity/specificity=83/83% versus 73/73%). The optimal ROC threshold derived for T1 mapping was 1241ms, which gave significantly larger oedema volumes than 2SD T2W (p=0.006); with this threshold, patients with and without MVO showed similar oedema volumes, but patients with MVO had significantly poorer salvage indices (p<0.05) than those without. Neither method was significantly affected by MVO, the volume of which was seen to increase exponentially with infarct size.  CONCLUSIONS: Native T1 mapping at 3T can delineate oedema one week post-STEMI, showing larger oedema volumes and better discriminatory power than T2W imaging, and it is suitable for quantitative thresholding. Both techniques are robust against MVO-related magnetic susceptibility

Synthesis and characterization of a new pyrimidine derivative and its metal chelates

1070-1072A new ligand, 1,3 -disuccinimido(4-phenyl-5-ethoxycarbonyl- 6-methylpyrimidine-2-one) L, has been synthesized by the interaction of 4-phenyl -5-ethoxycarbonyl-6-methyl-1,3 -dihydropyrimidine- 2-one with N-bromosuccinimide. Its metal chelates with Cr(III), Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) have been characterized by elemental analysis, IR & electronic spectra,  molar conductance and magnetic measurements. The molar conductance values suggest that complexes of divalent metal ions are covalent while those of trivalent metal ions are 1:1 electrolytes. The electronic spectra and magnetic moment measurements indicate that all the complexes have octahedral geometry. The β values show a considerable orbital overlap between M-L bond.</span

Cerebral venous sinus thrombosis: association with primary varicella zoster infection

Varicella zoster virus (VZV) has been known to cause cerebral arterial vasculopathy as well as an acquired antibody-mediated coagulopathy associated with purpurafulminans and generalized thrombo-embolism. There is no published report on cerebral venous sinus thrombosis (CVST) associated with primary VZV infection. We hereby report two cases to highlight an unusual presentation of VZV infection i.e. CVST with primary varicella infection. One patient had extensive CVST with co-existent middle cerebral artery involvement as well. .Primary VZV infection can be associated with thrombosis of cerebral arteries and venous sinuses

Cerebral Venous Sinus Thrombosis: Association with Primary Varicella Zoster Virus Infection

Varicella zoster virus (VZV) has been known to cause cerebral arterial vasculopathy and an acquired antibody-mediated coagulopathy associated with purpura fulminans and generalized thromboembolism. There are no published reports of cerebral venous sinus thrombosis (CVST) associated with primary VZV infection. We report 2 cases that highlight an unusual presentation of VZV infection: CVST with primary varicella infection. One patient had extensive CVST with coexistent middle cerebral artery involvement. Primary VZV infection can be associated with thrombosis of cerebral arteries and venous sinuses

Synthesis, physico-chemical and antimicrobial screening studies on 14 and 16-membered hexaazamacrocyclic complexes bearing pendant amine groups

The synthesis and characterization of a series of 14 and 16-membered hexaazamacrocyclic complexes, which were obtained via template condensation of 1,2- diaminoethane or 1,3-diaminopropane, formaldehyde and hydrazine hydrate in the presence of first row transition metal salts are reported. Complexes of the types, [ML¹(NO3)2]; [CuL¹](NO3)2 and [ML²Cl2]; [CuL²]Cl2 (where M = Co(II), Ni(II) and Zn(II)), were obtained. Elemental analyses, IR spectra, ¹H NMR, EPR, UV-Vis, magnetic susceptibility and conductivity measurements have ascertained the overall geometry and stereochemistry of the complexes. An octahedral geometry has been suggested for all the complexes, except for copper compounds, in which the metal centre coordinates to the four nitrogen atoms of macrocyclic ligand in a square planar fashion. These complexes were screened against different fungi and bacteria in vitro and were found to be potentially active in the concentration 5 mg mL-1