Peridynamic modeling of composite laminates under explosive loading

Peer reviewedPostprin

India-ICRISAT Day: First 20 Year of Research Partnership

On March 28 1972 the Consultative Group on International Agricultural Research (CGIAR) and the Republic of lndia signed the Memorandum of Understanding for the establishment of the International Crop Research Institute or Semi-Arid Tropics (ICRISAT) at Hyderabad (India)Thls historic event the first ever expression of global concern for one billion unfortunates inhabiting the world's harshest environment marked the begining of India's partnershlp with ICRISA

Three-dimensional in situ observations of compressive damage mechanisms in syntactic foam using X-ray microcomputed tomography

Royal Society Grant number RG140680 Lloyd's Register Foundation (GB) Oil and Gas Academy of Scotland Open access via Springer Compact AgreementPeer reviewedPublisher PD

Representative volume element (RVE) based crystal plasticity study of void growth on phase boundary in titanium alloys

Author is thankful to University of Aberdeen for the award of Elphinstone Scholarship which covers the tuition fee of PhD study of author.Peer reviewedPostprin

Conserved Quantities in Noncommutative Principal Chiral Model with Wess-Zumino Term

We construct noncommutative extension of U(N) principal chiral model with Wess-Zumino term and obtain an infinite set of local and non-local conserved quantities for the model using iterative procedure of Brezin {\it et.al} \cite{BIZZ}. We also present the equivalent description as Lax formalism of the model. We expand the fields perturbatively and derive zeroth- and first-order equations of motion, zero-curvature condition, iteration method, Lax formalism, local and non-local conserved quantities.Comment: 14 Page

Kajian Pengaruh Adat Istiadat, Religi, dan Alam pada Bangunan Adat, Lembah Kuta Ciamis

Impact ofdevelopment period, building and material grown sophisticated that is in use for building Vernacular Architecture in Indonesian, particulary at theKampung Kuta Ciamis. Furthermore, there is certain factors that affect the building such as custom, religion and nature. That factors have effected form, space and structure. Whichthis Factors have been tradition for generation were maintained. Therefore, in this study has been observe for building to find out the factors dominant. Used esplorative,qualitative descriptive methodwith motode scoring.With this metode, the result is costume factor has effected for form, space and structure. In this study, the conclution is costume factor is the major factor at house of Kampung Adat Kuta. Seen from the result obtained from research traditional building of Kampung Kuta, still have Vernacular Architectural value

Invariant solutions of the supersymmetric sine-Gordon equation

A comprehensive symmetry analysis of the N=1 supersymmetric sine-Gordon equation is performed. Two different forms of the supersymmetric system are considered. We begin by studying a system of partial differential equations corresponding to the coefficients of the various powers of the anticommuting independent variables. Next, we consider the super-sine-Gordon equation expressed in terms of a bosonic superfield involving anticommuting independent variables. In each case, a Lie (super)algebra of symmetries is determined and a classification of all subgroups having generic orbits of codimension 1 in the space of independent variables is performed. The method of symmetry reduction is systematically applied in order to derive invariant solutions of the supersymmetric model. Several types of algebraic, hyperbolic and doubly periodic solutions are obtained in explicit form.Comment: 27 pages, major revision, the published versio

Occurrence of Equine West Nile VirusAmongHorses in Qatar :A Preliminary Investigation

West Nile Virus (WNV) is an emerging threat to public health authorities around the globe. WNV is maintained in ecosystems primarily in enzootic cycles involving mosquito vector and avian hosts, with epizootic spread to mammals including horses and humans. Outbreaks of WNV disease in mammals have been associated with significant losses. The factors that play roles in the evaluation of these outbreaks are not fully known and the disease has not been reported in Qatar. We carried out a study to determine the prevalence of exposure to WNV in the State of Qatar and identify the factors that are likely to associate with seroconverion

Small molecule inhibitors of Late SV40 Factor (LSF) abrogate hepatocellular carcinoma (HCC): evaluation using an endogenous HCC model

Hepatocellular carcinoma (HCC) is a lethal malignancy with high mortality and poor prognosis. Oncogenic transcription factor Late SV40 Factor (LSF) plays an important role in promoting HCC. A small molecule inhibitor of LSF, Factor Quinolinone Inhibitor 1 (FQI1), significantly inhibited human HCC xenografts in nude mice without harming normal cells. Here we evaluated the efficacy of FQI1 and another inhibitor, FQI2, in inhibiting endogenous hepatocarcinogenesis. HCC was induced in a transgenic mouse with hepatocyte-specific overexpression of c-myc (Alb/c-myc) by injecting N-nitrosodiethylamine (DEN) followed by FQI1 or FQI2 treatment after tumor development. LSF inhibitors markedly decreased tumor burden in Alb/c-myc mice with a corresponding decrease in proliferation and angiogenesis. Interestingly, in vitro treatment of human HCC cells with LSF inhibitors resulted in mitotic arrest with an accompanying increase in CyclinB1. Inhibition of CyclinB1 induction by Cycloheximide or CDK1 activity by Roscovitine significantly prevented FQI-induced mitotic arrest. A significant induction of apoptosis was also observed upon treatment with FQI. These effects of LSF inhibition, mitotic arrest and induction of apoptosis by FQI1s provide multiple avenues by which these inhibitors eliminate HCC cells. LSF inhibitors might be highly potent and effective therapeutics for HCC either alone or in combination with currently existing therapies.The present study was supported in part by grants from The James S. McDonnell Foundation, National Cancer Institute Grant R01 CA138540-01A1 (DS), National Institutes of Health Grant R01 CA134721 (PBF), the Samuel Waxman Cancer Research Foundation (SWCRF) (DS and PBF), National Institutes of Health Grants R01 GM078240 and P50 GM67041 (SES), the Johnson and Johnson Clinical Innovation Award (UH), and the Boston University Ignition Award (UH). JLSW was supported by Alnylam Pharmaceuticals, Inc. DS is the Harrison Endowed Scholar in Cancer Research and Blick scholar. PBF holds the Thelma Newmeyer Corman Chair in Cancer Research. The authors acknowledge Dr. Lauren E. Brown (Dept. Chemistry, Boston University) for the synthesis of FQI1 and FQI2, and Lucy Flynn (Dept. Biology, Boston University) for initially identifying G2/M effects caused by FQI1. (James S. McDonnell Foundation; R01 CA138540-01A1 - National Cancer Institute; R01 CA134721 - National Institutes of Health; R01 GM078240 - National Institutes of Health; P50 GM67041 - National Institutes of Health; Samuel Waxman Cancer Research Foundation (SWCRF); Johnson and Johnson Clinical Innovation Award; Boston University Ignition Award; Alnylam Pharmaceuticals, Inc.)Published versio

Genetic risk variants associated with in situ breast cancer

INTRODUCTION: Breast cancer in situ (BCIS) diagnoses, a precursor lesion for invasive breast cancer, comprise about 20 % of all breast cancers (BC) in countries with screening programs. Family history of BC is considered one of the strongest risk factors for BCIS. METHODS: To evaluate the association of BC susceptibility loci with BCIS risk, we genotyped 39 single nucleotide polymorphisms (SNPs), associated with risk of invasive BC, in 1317 BCIS cases, 10,645 invasive BC cases, and 14,006 healthy controls in the National Cancer Institute's Breast and Prostate Cancer Cohort Consortium (BPC3). Using unconditional logistic regression models adjusted for age and study, we estimated the association of SNPs with BCIS using two different comparison groups: healthy controls and invasive BC subjects to investigate whether BCIS and BC share a common genetic profile. RESULTS: We found that five SNPs (CDKN2BAS-rs1011970, FGFR2-rs3750817, FGFR2-rs2981582, TNRC9-rs3803662, 5p12-rs10941679) were significantly associated with BCIS risk (P value adjusted for multiple comparisons <0.0016). Comparing invasive BC and BCIS, the largest difference was for CDKN2BAS-rs1011970, which showed a positive association with BCIS (OR = 1.24, 95 % CI: 1.11-1.38, P = 1.27 x 10(-4)) and no association with invasive BC (OR = 1.03, 95 % CI: 0.99-1.07, P = 0.06), with a P value for case-case comparison of 0.006. Subgroup analyses investigating associations with ductal carcinoma in situ (DCIS) found similar associations, albeit less significant (OR = 1.25, 95 % CI: 1.09-1.42, P = 1.07 x 10(-3)). Additional risk analyses showed significant associations with invasive disease at the 0.05 level for 28 of the alleles and the OR estimates were consistent with those reported by other studies. CONCLUSIONS: Our study adds to the knowledge that several of the known BC susceptibility loci are risk factors for both BCIS and invasive BC, with the possible exception of rs1011970, a putatively functional SNP situated in the CDKN2BAS gene that may be a specific BCIS susceptibility locus