Literary Cultures in/and Italian Studies

The article opens by considering how contemporary Italian Studies scholarship is situated in relation to the long-standing dominance of literary culture as a major disciplinary concern, and the persistence of traditionally conceived canons, questions, and methods. The authors discuss how the scope of literary research has expanded in recent years and become more enmeshed with sociological, political, and ideological enquiry. They review how previous definitions of literary cultures and practices have been refreshed with new theoretical and interdisciplinary approaches, and through transnational dialogues and collaborative modes of research. A diachronic survey discusses key innovations both in the study of canonical or ‘high culture’ literary phenomena – such as Dante, Leopardi, or Futurism –, and in engagements with previously overlooked writing in popular genres or media, or by socially marginalised authors. It concludes by reflecting on how literary studies is both critiqued and defended within current debates over the standing of humanities research within and beyond the academy

SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study

Background: Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods: The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18-49, 50-69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. Results: NNVs were more favourable in surgical patients than the general population. The most favourable NNVs were in patients aged 70 years or more needing cancer surgery (351; best case 196, worst case 816) or non-cancer surgery (733; best case 407, worst case 1664). Both exceeded the NNV in the general population (1840; best case 1196, worst case 3066). NNVs for surgical patients remained favourable at a range of SARS-CoV-2 incidence rates in sensitivity analysis modelling. Globally, prioritizing preoperative vaccination of patients needing elective surgery ahead of the general population could prevent an additional 58 687 (best case 115 007, worst case 20 177) COVID-19-related deaths in 1 year. Conclusion: As global roll out of SARS-CoV-2 vaccination proceeds, patients needing elective surgery should be prioritized ahead of the general population. Trial registration: ClinicalTrials.gov NCT04509986

Biophysical and biochemical characterization of a liposarcoma-derived recombinant MnSOD protein acting as an anticancer agent

A recombinant MnSOD (rMnSOD) synthesized by specific cDNA clones derived from a liposarcoma cell line was shown to have the same sequence as the wild-type MnSOD expressed in the human myeloid leukaemia cell line U937, except for the presence of the leader peptide at the N-terminus. These results were fully confirmed by the molecular mass of rMnSOD as evaluated by ES/MS analysis (26662.7 Da) and the nucleotide sequence of the MnSOD cDNA. The role of the leader peptide in rMnSOD was investigated using a fluorescent and/or 68Gallium-labelled synthetic peptide. The labelled peptide permeated MCF-7 cells and uptake could be inhibited in the presence of an excess of oestrogen. In vivo it was taken up by the tumour, suggesting that the molecule can be used for both therapy and diagnosis. The in vitro and in vivo pharmacology tests confirmed that rMnSOD is only oncotoxic for tumour cells expressing oestrogen receptors. Pharmacokinetic studies in animals performed with 125I- and 131I-labelled proteins confirmed that, when administered systemically, rMnSOD selectively reached the tumour, where its presence was unambiguously demonstrated by scintigraphic and PET scans. PCR analysis revealed that Bax gene expression was increased and the Bcl2 gene was down regulated in MCF7 cells treated with rMnSOD, which suggests that the protein induces a pro-apoptotic mechanism

The role of digital technologies for the LCA empowerment towards circular economy goals: a scenario analysis for the agri-food system

Purpose This paper aims to develop a scenario analysis on the experts' perceptions of benefits and barriers related to adopting digital technologies for the life cycle assessment (LCA) to catalyse a circular economy transition in the agri-food system. Methods A literature review was performed to identify LCA's digital technologies that can be implemented within the agri-food system. Furthermore, an in-depth interview with a panel of senior researchers was conducted to establish a set of items and assess the perceived benefits and barriers associated with an "empowered LCA", i.e. a future-oriented LCA based on digital technologies. To this end, a two-stage exploratory factor analysis relying on the principal component analysis technique was carried out to refine the set of items. Finally, a covariance-based structural equation model was performed, built on a confirmatory factor analysis, to test the measurement model. Results and discussion The study's findings provide five constructs to explore the potential benefits and barriers related to adopting a digital technologies-based LCA (empowered LCA) for a circular economy transition in the agri-food system. More specifically, the benefits can be assessed using the following constructs: "benefits for the data collection and analysis", "benefits for the LCA analysts", "benefits for the management" and "benefits for traceability". In addition, the barriers have been evaluated using a single construct labelled "general barriers". Conclusions The study highlights the relevance of digital technologies for a circular economy transition to develop a more reliable LCA, enhancing legislative compliance and supporting the traceability processes in the agri-food system. The associated implications for LCA experts, agri-food managers and policymakers are presented. Furthermore, limitations and future research directions are also discussed

A Step Into the Definition of the Seismic Risk for the City of Benevento (Italy)

This paper gives a contribution in the definition of the seismic hazard for the city of Benevento in Southern Italy, from a geotechnical engineering viewpoint. To pursue this goal, an extensive geotechnical characterization of the city subsoil was achieved collecting data available at the Department of Geotechnical Engineering, University of Napoli and Benevento municipal technical office. Attention was paid in defining strain dependent shear stiffness and damping ratio for the geomaterials present in the urban area. A new method to correct the Masing criteria was adopted. Numerical analyses were performed considering the subsoil as a continuous one-phase equivalent linear medium. The 1-D analyses were carried out using Shake-like codes. The seismic hazard in the city was evaluated on the basis of two seismic scenarios, respectively characterized by low and high acceleration levels. The final result of the work is a seismic zonation of the city of Benevento. It was found that zonation maps are largely dependent from the chosen seismic scenario

A Step Into the Definition of the Seismic Risk for the City of Benevento (Italy)

This paper gives a contribution in the definition of the seismic hazard for the city of Benevento in Southern Italy, from a geotechnical engineering viewpoint. To pursue this goal, an extensive geotechnical characterization of the city subsoil was achieved collecting data available at the Department of Geotechnical Engineering, University of Napoli and Benevento municipal technical office. Attention was paid in defining strain dependent shear stiffness and damping ratio for the geomaterials present in the urban area. A new method to correct the Masing criteria was adopted. Numerical analyses were performed considering the subsoil as a continuous one-phase equivalent linear medium. The 1-D analyses were carried out using Shake-like codes. The seismic hazard in the city was evaluated on the basis of two seismic scenarios, respectively characterized by low and high acceleration levels. The final result of the work is a seismic zonation of the city of Benevento. It was found that zonation maps are largely dependent from the chosen seismic scenario

Letter to the Editor commenting on “Efficacy of serratus anterior plane block versus thoracic paravertebral block for postoperative analgesia after breast cancer surgery: a randomized trial”

We have read with very great interest the study published by Arora S et al.: “Efficacy of serratus anterior plane block versus thoracic paravertebral block for postoperative analgesia after breast cancer surgery: a randomized trial”, especially for the attention paid to the key points in the management of breast surgery: postoperative analgesia optimization, incidence of postoperative nausea and vomiting reduction, prevention of the onset of chronic pain and functional impotenc

What's wrong with this rebuttal?

A recent rebuttal to criticism of Bell's analysis is shown to be defective by fault of failure to consider all hypothetical conditions input into the derivation of Bell Inequalitites.Comment: 2 page

New Technologies for Ecosystem Analysis Planning and Management

Planning the rural environment is one of the most intriguing examples of technical challenge where a multi-disciplinary approach plays a crucial role. The agricultural production, both food and non-food, the social role of rural settlements, the state and diffusion of the infrastructural networks, the rural architectonic heritage that in many countries constitutes a major positive value, should be appropriately considered and sinergically interlaced for a sound planning of agricultural biosystems. Human activities impose a transformation of the extra-urban land that may lead to the modification of the frail equilibrium of whole ecosystems. Sound planning strategies should be therefore pursued, employing a multidisciplinary approach that should take into account geographical, environmental and landscape factors as variables interacting among themselves and with the social and economic aspects. In order to simultaneously analyse all these properties, tools able to manage, interpret and integrate several data are necessary

Mesenteric closure with polymer-ligating clips after right colectomy with complete mesocolic excision for cancer and mesentery-based ileocolic resection for Crohn's disease

Mesenteric closure following right colectomy remains controversial and, following the advent of laparoscopic surgery, many surgeons do not routinely close the mesentery after colorectal resection. Nevertheless, especially after the introduction of operations such as right colectomy with complete mesocolic excision and ileocolic resections with extensive mesentery removal for Crohn's disease, the wide mesenteric defect resulting from the dissections can certainly expose the patients to complications such as internal hernias or volvuli. In general, mesenteric closure requires intracorporeal suturing. We describe a simple technique for the closure of the mesentery after surgical resection using polymer-ligating clips. This novel technique seems to minimize the time, effort and risk inherent to the procedure, even after large mesenteric excisions