An Upgraded Transverse Electromagnetic Parallel Plates for Dielectric Measurement

A new version of transverse electromagnetic parallel plates with irregular plates’ width and plate separation has been developed for dielectric measurement. The separations between the plates are supported by four rectangular Teflon block and 1 mm of groove is proposed at the center of the upper plate to maintain the measurement repeatability. The groove enables the samples which are slightly higher than 2 cm to be fitted well between the plates without introducing extra force to the plates. Theperformance of both parallel plates has been compared in the frequency range from 100 MHz to 1.1 GHz. It is found that the upgraded parallel plate offers better return loss and insertion loss above 500 MHz compared to the previous parallel plate. It is reported from this work that the return loss of the parallel plate must be lower than -15 dB in order to achieve accurate dielectric constant. However, the insertion loss of the parallel plates does not influence the real permeability significantly. The upgraded TEM parallel plateproduces a consistent reading with a standard deviation of less than 0.05 above frequency 200 MHz. The dielectric measurement of Polypropylene (PP) has proven the capability of this upgraded TEM parallelplate

Performance of a C4F8O Gas Radiator Ring Imaging Cherenkov Detector Using Multi-anode Photomultiplier Tubes

We report on test results of a novel ring imaging Cherenkov (RICH) detection system consisting of a 3 meter long gaseous C4F8O radiator, a focusing mirror, and a photon detector array based on Hamamatsu multi-anode photomultiplier tubes. This system was developed to identify charged particles in the momentum range from 3-70 GeV/c for the BTeV experiment.Comment: 28 pages, 23 figures, submitted to Nuclear Instruments and Method

An auxin-inducible, GAL4-compatible, gene expression system for Drosophila

The ability to control transgene expression, both spatially and temporally, is essential for studying model organisms. In Drosophila, spatial control is primarily provided by the GAL4/UAS system, whilst temporal control relies on a temperature-sensitive GAL80 (which inhibits GAL4) and drug-inducible systems. However, these are not ideal. Shifting temperature can impact on many physiological and behavioural traits, and the current drug-inducible systems are either leaky, toxic, incompatible with existing GAL4-driver lines, or do not generate effective levels of expression. Here, we describe the auxin-inducible gene expression system (AGES). AGES relies on the auxin-dependent degradation of a ubiquitously expressed GAL80, and therefore, is compatible with existing GAL4-driver lines. Water-soluble auxin is added to fly food at a low, non-lethal, concentration, which induces expression comparable to uninhibited GAL4 expression. The system works in both larvae and adults, providing a stringent, non-lethal, cost-effective, and convenient method for temporally controlling GAL4 activity in Drosophila

From START to FINISH : the influence of osmotic stress on the cell cycle

Peer reviewedPublisher PD

Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes.

Alzheimer's disease is a neurodegenerative disorder associated with the aberrant aggregation of the amyloid-β peptide. Although increasing evidence implicates cholesterol in the pathogenesis of Alzheimer's disease, the detailed mechanistic link between this lipid molecule and the disease process remains to be fully established. To address this problem, we adopt a kinetics-based strategy that reveals a specific catalytic role of cholesterol in the aggregation of Aβ42 (the 42-residue form of the amyloid-β peptide). More specifically, we demonstrate that lipid membranes containing cholesterol promote Aβ42 aggregation by enhancing its primary nucleation rate by up to 20-fold through a heterogeneous nucleation pathway. We further show that this process occurs as a result of cooperativity in the interaction of multiple cholesterol molecules with Aβ42. These results identify a specific microscopic pathway by which cholesterol dramatically enhances the onset of Aβ42 aggregation, thereby helping rationalize the link between Alzheimer's disease and the impairment of cholesterol homeostasis

Update of the measurement of the cross section for e^+e^- -> psi(3770) -> hadrons

We have updated our measurement of the cross section for e^+e^- -> psi(3770) -> hadrons, our publication "Measurement of sigma(e^+e^- -> psi(3770) -> hadrons) at E_{c.m.} = 3773 MeV", arXiv:hep-ex/0512038, Phys.Rev.Lett.96, 092002 (2006). Simultaneous with this arXiv update, we have published an erratum in Phys.Rev.Lett.104, 159901 (2010). There, and in this update, we have corrected a mistake in the computation of the error on the difference of the cross sections for e^+e^- -> psi(3770) -> hadrons and e^+e^- -> psi(3770) -> DDbar. We have also used a more recent CLEO measurement of cross section for e^+e^- -> psi(3770) -> DDbar. From this, we obtain an upper limit on the branching fraction for psi(3770) -> non-DDbar of 9% at 90% confidence level.Comment: 3 pages, 0 figures. This is an erratum to Phys.Rev.Lett.96:092002,2006. Added a reference

Acute Modulation of Toll-Like Receptors by Insulin

OBJECTIVE—Low-dose insulin infusion has been shown to exert a prompt and powerful anti-inflammatory effect. Toll-like receptors (TLRs) are major determinants of the inflammatory response to viral and bacterial pathogens. We have now hypothesized that low-dose insulin infusion in obese type 2 diabetic patients suppresses TLR expression

Radiative Decays of the Upsilon(1S) to a Pair of Charged Hadrons

Using data obtained with the CLEO~III detector, running at the Cornell Electron Storage Ring (CESR), we report on a new study of exclusive radiative Upsilon(1S) decays into the final states gamma pi^+ pi^-, gamma K^+ K^-, and gamma p pbar.. We present branching ratio measurements for the decay modes Upsilon(1S) to gamma f_2(1270), Upsilon(1S) to gamma f_2'(1525), and Upsilon(1S) to gamma K^+K^-; helicity production ratios for f_2(1270) and f_2'(1525); upper limits for the decay Upsilon(1S) to gamma f_J(2200), with f_J(2220) to pi^+ pi^-, K^+ K^-, p pbar; and an upper limit for the decay Upsilon(1S) to gamma X(1860), with X(1860) to gamma p pbar.Comment: 17 pages postscript,also available through http://www.lns.cornell.edu/public/CLNS/2005/, Submitted to PR

Search for psi(2S)--> eta_c pi^+ pi^- pi^0

Using 5.63 pb^-1 of data accumulated at the psi(2S) resonance with the CLEO III and CLEO-c detectors corresponding to 3.08 million psi(2S) decays, a search is performed for the decay psi(2S) -> eta_c pi^+pi^-pi^0 to test a theoretical prediction based upon the assumption that the c \bar c pair in the psi(2S) does not annihilate directly into three gluons but rather survives before annihilating. No signal is observed, and a combined upper limit from six eta_c decay modes is determined to be B(psi(2S) -> eta_c pi^+pi^-pi^0) < 1.0 x 10^-3 at 90% C.L. This upper limit is about an order of magnitude below the theoretical expectation.Comment: 8 pages postscript,also available through http://www.lns.cornell.edu/public/CLNS/2006

Moments of the B Meson Inclusive Semileptonic Decay Rate using Neutrino Reconstruction

We present a measurement of the composition of B meson inclusive semileptonic decays using 9.4 fb^-1 of e^+e^- data taken with the CLEO detector at the Upsilon(4S) resonance. In addition to measuring the charged lepton kinematics, the neutrino four-vector is inferred using the hermiticity of the detector. We perform a maximum likelihood fit over the full three-dimensional differential decay distribution for the fractional contributions from the B -> X_c l nu processes with X_c = D, D*, D**, and nonresonant X_c, and the process B -> X_u l nu. From the fit results we extract the first and second moments of the M_X^2 and q^2 distributions with minimum lepton-energy requirements of 1.0 GeV and 1.5 GeV. We find = 0.456 +- 0.014 +- 0.045 +- 0.109 (GeV/c^2)^2 with a minimum lepton energy of 1.0 GeV and = 0.293 +- 0.012 +- 0.033 +- 0.048 (GeV/c^2)^2 with minimum lepton energy of 1.5 GeV. The uncertainties are from statistics, detector systematic effects, and model dependence, respectively. As a test of the HQET and OPE calculations, the results for the M^X_c moment as a function of the minimum lepton energy requirement are compared to the predictions.Comment: 26 pages postscript, als available through http://w4.lns.cornell.edu/public/CLNS/, Submitted to PRD (back-to-back with following preprint hep-ex/0403053