695 research outputs found
After Regions: what next for local enterprise partnerships?
Standing out as an oddity in comparison to the convergence of policy across EU nations whereby the merits of regional apparatus â however defined â for administering development support appear to be accepted, the UK Government has abandoned Englandâs experiment with regionalism. Under the banner of localism, providing the thinnest of masks for swingeing public expenditure cuts, sub-national development activity (encompassing planning, regeneration, infrastructure development, enterprise support and spatial leadership) is in the throes of considerable economic shifts, policy flux and institutional upheaval (Ward & Hardy, 2012). This article attempts to address some of the questions posed in The regional lacuna: a preliminary map of the transition from Regional Development Agencies to Local Economic Partnerships (Pugalis, 2011) and helps to advance some of the points relating to the emerging sub-national development landscape published in recent issues of Regions (e.g. Bailey, 2011). The purpose is to take stock of policy developments underway by means of a post-regional sub-national review in order to outline the future development trajectory of Local Enterprise Partnerships
Non-invasive monitoring of physiological stress in the Western lowland gorilla (Gorilla gorilla gorilla): validation of a fecal glucocorticoid assay and methods for practical application in the field
Enzymeimmunoassays (EIAs) allow researchers to monitor stress hormone output via measurement of fecal glucocorticoid metabolites (FGCMs) in many vertebrates. They can be powerful tools which allow the acquisition of otherwise unobtainable physiological information from both captive animals and wild animals in remote forest habitats, such as great apes. However, methods for hormone measurement, extraction and preservation need to be adapted and validated for field settings. In preparation for a field study of Western lowland gorillas (Gorilla gorilla gorilla) in the Central African Republic we used samples from captive gorillas collected around opportunistic stressful situations to test whether four different glucocorticoid EIAs reflected adrenocortical activity reliably and to establish the lag-time from the stressor to peak excretion. We also validated a field extraction technique and established a simple, non-freezer-reliant method to preserve FGCMs in extracts long-term. We determined the rate of FGCM change over 28 days when samples cannot be extracted immediately and over 12 h when feces cannot be preserved immediately in alcohol. Finally, we used repeat samples from identified individuals to test for diurnal variation in FGCM output. Two group-specific assays measuring major cortisol metabolites detected the predicted FGCM response to the stressor reliably, whereas more specific cortisol and corticosterone assays were distinctly less responsive and thus less useful. We detected a lag time of 2â3 days from stressor to peak FGCM excretion. Our field extraction method performed as well as an established laboratory extraction method and FGCMs in dried extracts stored at ambient temperatures were as stable as those at â20 °C over 1 yr. Hormones in non-extracted feces in alcohol were stable up to 28 days at ambient temperatures. FGCMs in un-fixed gorilla feces deteriorated to almost 50% of the original values within 6 h under field conditions. We detected no diurnal variation in FGCMs in samples from wild gorillas. Our study highlights the importance of thorough biological and immunological validation of FGCM assays, and presents validated, practical methods for the application of non-invasive adrenocortical monitoring techniques to field conservation contexts where it is crucially needed
Repeated Restraint and Sampling Results in Reduced Corticosterone Levels in Developing and Adult Captive American Kestrels (Falco sparverius)
Presents a study which evaluated the effects of repeated restraint on the ability of postnatally developing chicks and adults to respond to a repeated standardized stressor of capture and handling in a semialtricial raptorial species, the American kestrel. Blood sampling and general procedure; Corticosterone radioimmunoassay analysis; Corticosterone levels in postnatally developing chicks and adults
Low-Energy Electron-Track Imaging for a Liquid Argon Time-Projection-Chamber Telescope Concept using Probabilistic Deep Learning
The GammaTPC is an MeV-scale single-phase liquid argon
time-projection-chamber gamma-ray telescope concept with a novel dual-scale
pixel-based charge-readout system. It promises to enable a significant
improvement in sensitivity to MeV-scale gamma-rays over previous telescopes.
The novel pixel-based charge readout allows for imaging of the tracks of
electrons scattered by Compton interactions of incident gamma-rays. The two
primary contributors to the accuracy of a Compton telescope in reconstructing
an incident gamma-ray's original direction are its energy and position
resolution. In this work, we focus on using deep learning to optimize the
reconstruction of the initial position and direction of electrons scattered in
Compton interactions, including using probabilistic models to estimate
predictive uncertainty. We show that the deep learning models are able to
predict locations of Compton scatters of MeV-scale gamma-rays from simulated
pixel-based data to better than 0.6 mm RMS error, and are sensitive to the
initial direction of the scattered electron. We compare and contrast different
deep learning uncertainty estimation algorithms for reconstruction
applications. Additionally, we show that event-by-event estimates of the
uncertainty of the locations of the Compton scatters can be used to select
those events that were reconstructed most accurately, leading to improvement in
locating the origin of gamma-ray sources on the sky
Model-Independent Comparison of Direct vs. Indirect Detection of Supersymmetric Dark Matter
We compare the rate for elastic scattering of neutralinos from various nuclei
with the flux of upward muons induced by energetic neutrinos from neutralino
annihilation in the Sun and Earth. We consider both scalar and axial-vector
interactions of neutralinos with nuclei. We find that the event rate in a kg of
germanium is roughly equivalent to that in a - to -m muon
detector for a neutralino with primarily scalar coupling to nuclei. For an
axially coupled neutralino, the event rate in a 50-gram hydrogen detector is
roughly the same as that in a 10- to 500-m muon detector. Expected
experimental backgrounds favor forthcoming elastic-scattering detectors for
scalar couplings while the neutrino detectors have the advantage for
axial-vector couplings.Comment: 10 pages, self-unpacking uuencoded PostScript fil
A Family Showing No Evidence of Linkage Between the Ataxia Telangiectasia Gene and Chromosome
We have studied an inbred family in which two cousins presented with the same clinical features of ataxia telangiectasia (AT). Both patients are still ambulatory at ages 25 and 20. Cellular features of both patients are typical of AT and include increased radiosensitivity and an increased level of spontaneously occurring chromosome aberrations in peripheral blood lymphocytes. Linkage studies and haplotype analysis show no clear evidence that the gene for AT in this family is on chromosome 11q22-23. As previously reported AT families from complementation groups AB, C, and D have all shown linkage to this region of 11q22-23. Our study is of importance in suggesting additional locus heterogeneity
Indirect Detection of a Light Higgsino Motivated by Collider Data
Kane and Wells recently argued that collider data point to a Higgsino-like
lightest supersymmetric partner which would explain the dark matter in our
Galactic halo. They discuss direct detection of such dark-matter particles in
laboratory detectors. Here, we argue that such a particle, if it is indeed the
dark matter, might alternatively be accessible in experiments which search for
energetic neutrinos from dark-matter annihilation in the Sun. We provide
accurate analytic estimates for the rates which take into account all relevant
physical effects. Currently, the predicted signal falls roughly one to three
orders of magnitude below experimental bounds, depending on the mass and
coupling of the particle; however, detectors such as MACRO, super-Kamiokande,
and AMANDA will continue to take data and should be able to rule out or confirm
an interesting portion of the possible mass range for such a dark-matter
particle within the next five years.Comment: 10 pages, RevTe
Background discrimination capabilities of a heat and ionization germanium cryogenic detector
The discrimination capabilities of a 70 g heat and ionization Ge bolometer
are studied. This first prototype has been used by the EDELWEISS Dark Matter
experiment, installed in the Laboratoire Souterrain de Modane, for direct
detection of WIMPs. Gamma and neutron calibrations demonstrate that this type
of detector is able to reject more than 99.6% of the background while retaining
95% of the signal, provided that the background events distribution is not
biased towards the surface of the Ge crystal. However, the 1.17 kg.day of data
taken in a relatively important radioactive environment show an extra
population slightly overlapping the signal. This background is likely due to
interactions of low energy photons or electrons near the surface of the
crystal, and is somewhat reduced by applying a higher charge-collecting inverse
bias voltage (-6 V instead of -2 V) to the Ge diode. Despite this
contamination, more than 98% of the background can be rejected while retaining
50% of the signal. This yields a conservative upper limit of 0.7
event.day^{-1}.kg^{-1}.keV^{-1}_{recoil} at 90% confidence level in the 15-45
keV recoil energy interval; the present sensitivity appears to be limited by
the fast ambient neutrons. Upgrades in progress on the installation are
summarized.Comment: Submitted to Astroparticle Physics, 14 page
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