Neuroprotective Effects of Pre-Treament with l-Carnitine and Acetyl-l-Carnitine on Ischemic Injury In Vivo and In Vitro

The therapeutic effect of stroke is hampered by the lack of neuroprotective drugs against ischemic insults beyond the acute phase. Carnitine plays important roles in mitochondrial metabolism and in modulating the ratio of coenzyme A (CoA)/acyl-CoA. Here, we investigate the neuroprotective effects of l-carnitine (LC) and Acetyl-l-carnitine (ALC) pre-treatment on ischemic insults under the same experimental conditions. We used a transient middle cerebral artery occlusion (MCAO) model to evaluate the protective roles of LC and ALC in acute focal cerebral ischemia in vivo and to understand the possible mechanisms using model of PC12 cell cultures in vitro. Results showed that ALC, but not LC, decreased infarction size in SD rats after MCAO in vivo. However, both LC and ALC pretreatment reduced oxygen-glucose deprivation (OGD)-induced cell injury and decreased OGD-induced cell apoptosis and death in vitro; at the same time, both of them increased the activities of super oxide dismutase (SOD) and ATPase, and decreased the concentration of malondialdehyde (MDA) in vitro. Thus, our findings suggested that LC and ALC pre-treatment are highly effective in the prevention of neuronal cell against ischemic injury in vitro, however, only ALC has the protective effect on neuronal cell injury after ischemia in vivo

A Mixed-Integer Convex Programming Algorithm for Security-Constrained Unit Commitment of Power System with 110-kV Network and Pumped-Storage Hydro Units

The secure operation of 110-kV networks should be considered in the optimal generation dispatch of regional power grids in large central cities. However, since 110-kV lines do not satisfy the premise of R << X in the direct current power flow (DCPF) model, the DCPF, which is mostly applied in the security-constrained unit commitment (SCUC) problem of high-voltage power grids, is no longer suitable for describing the active power flow of regional power grids in large central cities. Hence, the quadratic active power flow (QAPF) model considering the resistance of lines is proposed to describe the network security constraints, and an SCUC model for power system with 110-kV network and pumped-storage hydro (PSH) units is established. The analytical expressions of the spinning reserve (SR) capacity of PSH units are given considering different operational modes, and the SR capacity of PSH units is included in the constraint of the SR capacity requirement of the system. The QAPF is a set of quadratic equality constraints, making the SCUC model a mixed-integer nonlinear non-convex programming (MINNP) model. To reduce the computational complexity of solving the model when applied in actual large-scale regional networks, the QAPF model is relaxed by its convex hull, and the SCUC model is transformed into a mixed-integer convex programming (MICP) model, which can be solved to obtain the global optimal solution efficiently and reliably by the mature commercial solver GUROBI (24.3.3, GAMS Development Corporation, Guangzhou, China). Test results on the IEEE-9 bus system, the PEGASE 89 bus system and the Shenzhen city power grid including the 110-kV network demonstrate that the relaxed QAPF model has good calculation accuracy and efficiency, and it is suitable for solving the SCUC problem in large-scale regional networks

An Uncertain Optimal Energy Flow Model for CCHP Campus Microgrid Using Parameterized Probability Boxes

Due to the uncertain fluctuations of renewable energy and load power, the state variables such as bus voltages and pipeline mass flows in the combined cooling, heating, and power campus microgrid (CCHP-CMG) may exceed the secure operation limits. In this paper, an optimal energy flow (OEF) model for a CCHP-CMG using parameterized probability boxes (p-boxes) is proposed to describe the higher-order uncertainty of renewables and loads. In the model, chance constraints are used to describe the secure operation limits of the state variable p-boxes, and variance constraints are introduced to reduce their random fluctuation ranges. To solve this model, the chance and variance constraints are transformed into the constraints of interval cumulants (ICs) of state variables based on the p-efficient point theory and interval Cornish-Fisher expansion. With the relationship between the ICs of state variables and node power, and using the affine interval arithmetic method, the original optimization model is finally transformed into a deterministic nonlinear programming model. It can be solved by the CONOPT solver in GAMS software to obtain the optimal operation point of a CCHP-CMG that satisfies the secure operation requirements considering the higher-order uncertainty of renewables and loads. Case study on a CCHP-CMG demonstrates the correctness and effectiveness of the proposed OEF model

Robust Optimal Allocation of Decentralized Reactive Power Compensation in Three-Phase Four-Wire Low-Voltage Distribution Networks Considering the Uncertainty of Photovoltaic Generation

Due to the unbalanced three-phase loads, the single-phase distributed photovoltaic (PV) integration, the long feeders, and the heavy loads in a three-phase four-wire low voltage distribution network (LVDN), the voltage unbalance factor (VUF), the network loss and the voltage deviation are relatively high. Considering the uncertain fluctuation of the PV output and the load power, a robust optimal allocation of decentralized reactive power compensation (RPC) devices model for a three-phase four-wire LVDN is proposed. In this model, the uncertain variables are described as box uncertain sets, the three-phase simultaneous switching capacity and single-phase independent switching capacity of the RPC devices are taken as decision variables, and the objective is to minimize the total power loss of the LVDN under the extreme scenarios of uncertain variables. The bi-level optimization method is used to transform the robust optimization model with uncertain variables into bi-level deterministic optimization models, which could be solved alternately. The nonlinear programming solver IPOPT in the mature commercial software GAMS is adopted to solve the upper and lower deterministic optimization models to obtain a robust optimal allocation scheme of decentralized RPC devices. Finally, the simulation results for an actual LVDN show that the obtained decentralized RPC scheme can ensure that the voltage deviation and the VUF of each bus satisfied the secure operation requirement no matter how the PV output and load power changed within their own uncertain sets, and the network loss could be effectively reduced

A Mixed-Integer Second-Order Cone Programming Algorithm for the Optimal Power Distribution of AC-DC Parallel Transmission Channels

For the controllability of the transmission power of DC transmission channels, the optimal power distribution (OPD) of AC-DC parallel transmission channels is an effective measure for improving the economic operation of an AC-DC interconnected power grid. A dynamic optimal power flow model for day-ahead OPD of AC-DC parallel transmission channels is established in this paper. The power flow equation constraints of an AC-DC interconnected power grid and the constraints of the discrete regulation requirement of the transmission power of DC channels are considered, which make the OPD model of the AC-DC parallel transmission channels a mixed-integer nonlinear non-convex programming (MINNP) model. Through a cone relaxation transformation and a big M method equivalent transformation, the non-convex terms in the objective function and constraints are executed with the convex relaxation, and the MINNP model is transformed into a mixed-integer second-order cone programming model that can be solved reliably and efficiently using the mature optimization solver GUROBI. Taking an actual large-scale AC-DC interconnected power grid as an example, the results show that the OPD scheme of the AC-DC parallel transmission channels obtained by the proposed algorithm can effectively improve the economical operation of an AC-DC interconnected power grid