Experimental Report on the Effectiveness of the Insecticide Chloromethiuron 3

No. 3 diflubenzuron is one type of benzoyl N-Phenylurea compound, a type of insect chitin synthesis inhibitor, and has a unique disinsection mechanism. It can depress the chitinous formation on the insect epidermis, and make it die in the process of ecdysis or metamorphism. It has particularly effective impact on lepidopterous larvae, and it can control many kinds of pests?such as armyworm, cabbage worm, cotton bollworm?Clanis bilineata, Pine caterpillar, Hyphantria cunea? mosquito screwworm etc. No. 3 diflubenzuron hardly has effect on imagoes, and has low virulence on higher animals; the medium lethal dose of white rats is 15,000 mg/kg on w/w basis. It has high virulence on target insects, but low virulence on non-target insects. This chemical has no specific smell, does not pollute the environment, and is safe for humans and animals. Thus, it is a new diflubenzuron with high-effect and low-virulence, and could replace some organochlorine insecticides such as DDT, Hexachlorocyclohexane and others. Mythimna separata Walker is one of the main pests of crops in Jilin Province. The infested area per year is usually 5 – 10 million mu [666.7m2 ] in the whole province; and it will reach above 10 million mu in years of mass-outbreak. It leads to severe reduction of yield or even no yield if the M. separata are not controlled in time. In order to replace the organo-chlorine pesticides with their highly toxic residue?we have been doing experimental investigations and research on the chitin synthesis inhibitors - No. 1 diflubenzuron and No. 2 diflubenzuron - since 1977. In addition, we have done systemic research on No. 3 diflubenzuron supported by leaders in the Science Committee of our province since 1979. Our results are from indoor control experiments of No. 3 diflubenzuron colloidal suspension M. separata, which was synthesized and provided by the Tonghua Chemical Engineering Institute, and field-plot experiments and demonstration extension experiments within Jilin province. In this paper, the partial results of our research are summarized as follows.Originating text in Chinese.Citation: Liang, Shulian, Sun, Yajie, Chen, Ruilu. (1985). Experimental Report on the Effectiveness of the Insecticide Chloromethiuron 3. Journal of Jilin Agricultural Sciences, 35(2), 36-44

Prognostic Model for Predicting Overall and Cancer-Specific Survival Among Patients With Superficial Spreading Melanoma: A SEER Based Study

Skin malignant melanoma is one of the most aggressive skin tumors. Superficial spreading melanoma (SSM) is the most common histological type, which can originate from different body skin sites, and some patients can still accumulate regional lymph nodes and even have distant metastasis in some cases. This study used the relevant data from the monitoring, epidemiology and results database of the National Cancer Institute database to study the overall survival (OS) and cancer-specific survival (CSS) of SSM patients and established an SSM nomogram to evaluate the prognosis of patients. A total of 13,922 patients were collected from the monitoring, epidemiology and results database of the National Cancer Institute and randomly divided into a training cohort (8353 cases) and a validation cohort (5569 cases). Univariate and multivariate Cox regression analysis were used to determine prognostic factors, and these factors were used to construct OS and CSS nomograms for patients with SSM. Finally, the discrimination and consistency of the nomogram model were evaluated by the consistency index (C-index), area under the curve (AUC) and calibration curve. Multivariate Cox regression analysis suggested that age, sex, tumor site, the American joint committee on cancer T stage and the first primary melanoma were independent predictors of OS and CSS in patients with SSM and that the American joint committee on cancer N stage was also an independent predictor of CSS in patients with SSM. Based on the above prognostic factors, this study constructed a predictive model. The C-index of the model OS and CSS for this training cohort was 0.805 [95% CI: 0.793-0.817] and 0.896 [95% CI: 0.878-0.913], respectively. The AUC values for 1-, 3-, and 5-year OS were 0.822, 0.820, and 0.821, respectively, and the AUC values for CSS were 0.914, 0.922, and 0.893, respectively. The data indicated that both nomograms showed better predictive accuracy. The calibration curves of the training cohort and the validation cohort were in good agreement. The nomogram has superior predictive performance in predicting 1-, 3-, and 5-year OS and CSS prognosis in patients with SSM and can provide a reference for individualized treatment and clinical counseling of SSM

Cell surface-specific N-glycan profiling in breast cancer

Aberrant changes in specific glycans have been shown to be associated with immunosurveillance, tumorigenesis, tumor progression and metastasis. In this study, the N-glycan profiling of membrane proteins from human breast cancer cell lines and tissues was detected using modified DNA sequencer-assisted fluorophore-assisted carbohydrate electrophoresis (DSA-FACE). The N-glycan profiles of membrane proteins were analyzed from 7 breast cancer cell lines and MCF 10A, as well as from 100 pairs of breast cancer and corresponding adjacent tissues. The results showed that, compared with the matched adjacent normal tissue samples, two biantennary N-glycans (NA2 and NA2FB) were significantly decreased (p <0.0001) in the breast cancer tissue samples, while the triantennary glycan (NA3FB) and a high-mannose glycan (M8) were dramatically increased (p = 0.001 and p <0.0001, respectively). Moreover, the alterations in these specific N-glycans occurred through the oncogenesis and progression of breast cancer. These results suggested that the modified method based on DSA-FACE is a high-throughput detection technology that is suited for analyzing cell surface N-glycans. These cell surface-specific N-glycans may be helpful in recognizing the mechanisms of tumor cell immunologic escape and could be potential targets for new breast cancer drugs

5 T Permanent Magnetic Resonance Imaging Device and Its Application for Mouse Imaging

By improving the main magnet, gradient, and RF coils design technology, manufacturing methods, and inventing new magnetic resonance imaging (MRI) special alloy, a cost-effective and small animal specific permanent magnet-type three-dimensional magnetic resonance imager was developed. The main magnetic field strength of magnetic resonance imager with independent intellectual property rights is 1.2∼1.5 T. To demonstrate its effectiveness and validate the mouse imaging experiments in different directions, we compared the images obtained by small animal specific permanent magnet-type three-dimensional magnetic resonance imager with that obtained by using superconductor magnetic resonance imager for clinical diagnosis

A case report of primary para-testicular spindle cell rhabdomyosarcoma

Para-testicular rhabdomyosarcoma (PTRMS) is a rare tumor, and it accounts for 7% of all rhabdomyosarcoma tumors. Among all the rhabdomyosarcoma (RMS) types, the spindle cell RMS is extremely rare. The present study describes a case of a para-testicular spindle cell RMS that was treated with a radical inguinal orchiectomy (RIO) and right scrotal resection. A 17-year-old male patient presented with a half-year history of a rapidly growing, painless, right scrotal mass. His CT of the pelvic cavity showed a mixed-density mass in the right scrotum, and the maximum cross-sectional area was approximately 76.5 mm × 64.5 mm. An X-ray of the chest demonstrated no evidence of metastasis, and a local surgical excision was performed subsequently. The histopathological and immunohistochemical examination confirmed the final diagnosis of spindle cell RMS. As a newly diagnosed case, strict and regular follow-up is needed. This article focuses on the importance of prompt recognition, diagnosis, pathological features, and appropriate management of para-testicular spindle cell RMS

Prominent edge detection with deep metric expression and multi-scale features

Abstract(#br)Edge detection is one of today’s hottest computer vision issues with widely applications. It is beneficial for improving the capability of many vision systems, such as semantic segmentation, salient object detection and object recognition. Deep convolution neural networks (CNNs) recently have been employed to extract robust features, and have achieved a definite improvement. However, there is still a long run to study this hotspot with the main reason that CNNs-based approaches may cause the edges thicker. To address this problem, a novel semantic edge detection algorithm using multi-scale features is proposed. Our model is deep symmetrical metric learning network, which includes 3 key parts. Firstly, the deep detail layer, as a preprocessing layer and a guide module, is..

Long segment ureterectomy with tapered demucosalized ileum replacement of ureter for ureteral cancer: a case report and literature review

Radical nephroureterectomy (RNU) with bladder sleeve resection is currently the gold standard for the treatment of high-risk ureteral cancer. However, in certain special cases, such as bilateral upper tract urothelial carcinoma(UTUC), isolated and chronic kidney disease, and low-risk UTUC, kidney sparing surgery(KSS) may represent a viable alternative, though it remains highly challenging. The current KSS options for ureteral cancer include endoscopic treatment, segmental ureterectomy, total ureterectomy combined with kidney autotransplantation and nephrostomy. These methods are associated with significant disadvantages, such as a high risk of recurrence and vascular-related complications. On the basis of previous studies, we creatively proposed a surgical method of long segment ureterectomy with tapered demucosalized ileum(TDI) replacement of the ureter for ureteral cancer, and successfully performed this operation on a patient with ureteral cancer. The follow-up results showed that this surgical method provides good tumor control while preserving the patient’s renal function and improves the inherent defect of the ileal replacement of the ureter, which is a feasible choice for patients with ureteral cancer and kidney preservation

Management of acquired rectourethral fistulas in adults

Rectourethral fistula is an uncommon but devastating condition resulting from surgery, radiation, trauma, inflammation, or occasionally anorectal anomaly. Because of involving the urinary and the digestive system, surgical repair can be challenging. More than 40 different surgical approaches were described in the literature. However, no standardized management exists due to the rarity and complexity of the problem. Spontaneous closure of fistula is rare and most cases need reconstructive procedures. Appropriate preoperative assessment is crucial for the decision of operation time and method. Gradually accumulating evidence indicates surgeons should take fistula size, tissue health and vascularity associated with radiation or infection, urethral stricture, and bladder neck sclerosis into consideration and make a proper treatment plan according to the features of various approaches. Accurate preoperative evaluation and proper approach selection would increase success rates. Multiple surgical team corporation, including colorectal, urological and plastic surgeons, would optimize the outcomes. Keywords: Rectourethral fistula, Prostate cancer, Radical prostatectomy, Radiation therapy, Diagnosis, Managemen

Development of High-Field Permanent Magnetic Circuits for NMRI/MRI and Imaging on Mice

The high-field permanent magnetic circuits of 1.2 T and 1.5 T with novel magnetic focusing and curved-surface correction are developed. The permanent magnetic circuit comprises a magnetic yoke, main magnetic steel, nonspherical curved-surface magnetic poles, plugging magnetic steel, and side magnetic steel. In this work, a novel shimming method is proposed for the effective correction of base magnetic field (B0) inhomogeneities, which is based on passive shimming on the telescope aspheric cutting, grinding, and fine processing technology of the nonspherical curved-surface magnetic poles and active shimming adding higher-order gradient coils. Meanwhile, the magnetic resonance imaging dedicated alloy with high-saturation magnetic field induction intensity and high electrical resistivity is developed, and nonspherical curved-surface magnetic poles which are made of the dedicated alloy have very good anti-eddy-current effect. In addition, the large temperature coefficient problem of permanent magnet can be effectively controlled by using a high quality temperature controller and deuterium external locking technique. Combining our patents such as gradient coil, RF coil, and integration computer software, two kinds of small animal Micro-MRI instruments are developed, by which the high quality MRI images of mice were obtained

Macroscopic and Microscopic Analysis of Chinese Typical Driving Behavior from UAV View

For improving the performance of ADAS and AD system in China, the driving behavior of Chinese drivers is being increasingly focused. The purpose of this study is to investigate the macroscopic and microscopic characteristics of typical Chinese driving behavior, by using UAV to capture and extract them. Traffic flow rate, traffic density, velocity, acceleration and offset from the lane center were acquired and their influence by the vehicle types and lane types studied. Minimum TTC and THW during lane changing and car following and their influence by following types and lane types were also studied. Results showed that the Chinese traffic state was more stable than in Germany, however, with more aggressive behavior, compared to HighD. The entire velocity was small due to strict speed regulation in China. Different characteristics were found for different vehicle types, following types and lanes. Car and car-car following showed more dangerous potential. Cars tended to drive left and trucks tended to right of the lane center. Conclusions can be made that Chinese driving behavior is largely different from German driving behavior. These driver characteristics in China provided data support for the training of an AI-based decision algorithm, development from a localized system and design of roads