Shock Index Predicts Patient‐Related Clinical Outcomes in Stroke

The Get With The Guidelines–Stroke (GWTG-Stroke) program is currently supported in part by a charitable contribution from Bristol-Myers Squibb/Sanofi Pharmaceutical Partnership and the American Heart Association Pharmaceutical Roundtable. GWTG-Stroke has been funded in the past through support from Boehringer-Ingelheim and Merck. These funding agencies did not participate in the design or analysis, article preparation, or approval of this study.Peer reviewedPublisher PD

Shock Index Predicts Patient‐Related Clinical Outcomes in Stroke

The Get With The Guidelines–Stroke (GWTG-Stroke) program is currently supported in part by a charitable contribution from Bristol-Myers Squibb/Sanofi Pharmaceutical Partnership and the American Heart Association Pharmaceutical Roundtable. GWTG-Stroke has been funded in the past through support from Boehringer-Ingelheim and Merck. These funding agencies did not participate in the design or analysis, article preparation, or approval of this study.Peer reviewedPublisher PD

Aridity-driven shift in biodiversity–soil multifunctionality relationships

From Springer Nature via Jisc Publications RouterHistory: received 2021-01-07, accepted 2021-08-12, registration 2021-08-25, pub-electronic 2021-09-09, online 2021-09-09, collection 2021-12Publication status: PublishedFunder: National Natural Science Foundation of China (National Science Foundation of China); doi: https://doi.org/10.13039/501100001809; Grant(s): 31770430Abstract: Relationships between biodiversity and multiple ecosystem functions (that is, ecosystem multifunctionality) are context-dependent. Both plant and soil microbial diversity have been reported to regulate ecosystem multifunctionality, but how their relative importance varies along environmental gradients remains poorly understood. Here, we relate plant and microbial diversity to soil multifunctionality across 130 dryland sites along a 4,000 km aridity gradient in northern China. Our results show a strong positive association between plant species richness and soil multifunctionality in less arid regions, whereas microbial diversity, in particular of fungi, is positively associated with multifunctionality in more arid regions. This shift in the relationships between plant or microbial diversity and soil multifunctionality occur at an aridity level of ∼0.8, the boundary between semiarid and arid climates, which is predicted to advance geographically ∼28% by the end of the current century. Our study highlights that biodiversity loss of plants and soil microorganisms may have especially strong consequences under low and high aridity conditions, respectively, which calls for climate-specific biodiversity conservation strategies to mitigate the effects of aridification

Estrogen Receptor Ligands and Regulation of Gene Expression

93 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2007.Keratin13 (KRT13) and calcitonin receptor (CALCR) gene expression is differentially regulated by estradiol (E2) and the selective estrogen receptor modulators (SERMs) tamoxifen and raloxifene. KRT13 is a cytoskeleton protein while CALCR mediates the biological effects of calcitonin. These two genes may play important roles in breast cancer growth and metastasis. Analysis of the promoters and regulatory regions of these two genes was performed to explore the mechanism of estradiol and SERM regulation of these genes in breast cancer cells. Using a ChIP scanning approach, we identified a 2.5 kb regulatory region for KRT13 and two enhancer regions for CALCR. The regulatory activities of these regions were confirmed by reporter transactivation assays. The 2.5 kb regulatory region of KRT13 was further analyzed using progressive deletions and point mutations. The results demonstrated that three estrogen responsive elements (EREs) and three Sp1 sites were involved in the ligand dependent up-regulation of KRT13. The ERE at site1 is mainly involved in E2 activity, whereas the EREs at site2, site3 and the three Sp1 sites are involved in both E2 and tamoxifen activities. Next, ChIP assays were performed to examine the time courses of E2 and SERM-induced recruitment of ERalpha and cofactors on KRT13 and CALCR regulatory regions. I found that the differential recruitment of factors to the regulatory regions accompanied the time-dependent differential regulation of these genes. Taken together, my results suggest that: (1) the ligand-differential regulations of KRT13/CALCR are due to ligand-differential recruitment of ER and coactivators; (2) EREs mediate both E2 and tamoxifen effects, while certain EREs preferentially mediate the E2 effect, presumably dependent on the ERE sequence and promoter context. These findings provide new insight about gene regulation by different estrogen receptor ligands and mediation via estrogen receptors.U of I OnlyRestricted to the U of I community idenfinitely during batch ingest of legacy ETD

Emissions of Airport Monitoring with Solar Occultation Flux-Fourier Transform Infrared Spectrometer

Both domestic and international aviation industries have experienced a boom, which results in a dramatic increase in emissions of the aviation industry in recent decades. Therefore, domestic and abroad scientists adopted different methods to measure emissions; however, there are no appropriate methods to measure the emissions of the whole airport. In order to provide data support for the relevant departments to take appropriate emission reduction measures, solar occultation flux-Fourier transform infrared spectrometer (SOF-FT-IR) is used to monitor the emissions of Beijing Capital International Airport. CO, CO2, C2H4, and CH2O are selected as the target gases and are quantitatively analyzed with the nonlinear least squares method to get the column concentration. Then, the flux can also be calculated by linking the wind velocity and direction with the column concentration. A comparison between the results measured by SOF-FT-IR and the results measured by the method published by the Intergovernmental Panel on Climate Change (IPCC) indicates that auxiliary power equipment and ground support equipment for the emission of the airport are also important emission sources besides the aircraft and the concentration distribution gives powerful and useful pieces of evidence to locate the emission sources. In order to decrease the contribution of the airport to the air pollution, the key point is to reduce the emissions of the APU and mobiles in the airport