Age-related differences in the relationship between activity familiarity and well-being.

Background and Objectives: This study explored age-related differences in the relationship between activity novelty/familiarity and well-being, conceptualized within theories including Selection, Optimization, and Compensation (SOC), Self-Determination Theory (SDT), and Socioemotional Selectivity Theory (SST). For all ages, participation in activities has been shown to enhance well-being. Known mediators of this relationship include psychological, physical, and psychosocial benefits. It is less clear what types of experiences are optimal across the lifespan. Research Design and Methods: A online cross-sectional, correlational study (N= 200) was conducted. Measures included demographic data, ratings of three self-identified recent activities, three activity choices of familiar or novel activity options, measures of well-being, and control variables including measures of overall activity level, physical health, personality traits, and COVID-19 stress. Results: An 8-item familiarity scale was developed and validated. Chronological age was not correlated with familiar activity choice. However, age was significantly positively correlated with mean ratings of activity familiarity. Age did not moderate the relationship between the familiarity of activity and eudaimonic well-being as hypothesized. Overall activity level had a significant direct effect on hedonic well-being and hedonic well-being had a significant direct effect on eudaimonic well-being, but there was no direct effect of overall activity level on eudaimonic well-being. Ratings of activity familiarity were significantly positively related to ratings of activity automaticity, and mean familiarity ratings across three self-identified activities were significantly negatively related to extraversion. Controlling for negative impacts of the COVID-19 pandemic using the COVID Stress Scales did not improve model fit for any of the analyses. Discussion and Implications: This study highlights the complexity of research on activity participation and preferences, and the need for use of techniques such as ecological momentary assessment, qualitative research, and longitudinal studies to better capture complex constructs such as activity familiarity and participation. Future research on age-related differences in the relationship between activity familiarity and well-being may contribute to a lifespan theory of activity benefits and will be useful in personalizing interventions that increase well-being, such as weighting selection of activities in behavioral activation treatments or designing activity programs for older adults

The intersection of gender and generation in Albanian migration, remittances and transnational care

The Albanian case represents the most dramatic instance of post-communist migration: about one million Albanians, a quarter of the country's total population, are now living abroad, most of them in Greece and Italy, with the UK becoming increasingly popular since the late 1990s. This paper draws on three research projects based on fieldwork in Italy, Greece, the UK and Albania. These projects have involved in-depth interviews with Albanian migrants in several cities, as well as with migrant-sending households in different parts of Albania. In this paper we draw out those findings which shed light on the intersections of gender and generations in three aspects of the migration process: the emigration itself, the sending and receiving of remittances, and the care of family members (mainly the migrants' elderly parents) who remain in Albania. Theoretically, we draw on the notion of `gendered geographies of power and on how spatial change and separation through migration reshapes gender and generational relations. We find that, at all stages of the migration, Albanian migrants are faced with conflicting and confusing models of gender, behavioural and generational norms, as well as unresolved questions about their legal status and the likely economic, social and political developments in Albania, which make their future life plans uncertain. Legal barriers often prevent migrants and their families from enjoying the kinds of transnational family lives they would like

Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.

In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in genome-wide association studies of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis of the blood pressure clinical phenome in MVP. Our transcriptome-wide association study detected 4,043 blood pressure associations with genetically predicted gene expression of 840 genes in 45 tissues, and mouse renal single-cell RNA sequencing identified upregulated blood pressure genes in kidney tubule cells

Nicotinamide as Independent Variable for Intelligence, Fertility, and Health: Origin of Human Creative Explosions?

Meat and nicotinamide acquisition was a defining force during the 2-million-year evolution of the big brains necessary for, anatomically modern, to survive. Our next move was down the food chain during the Mesolithic 'broad spectrum', then horticultural, followed by the Neolithic agricultural revolutions and progressively lower average 'doses' of nicotinamide. We speculate that a fertility crisis and population bottleneck around 40 000 years ago, at the time of the Last Glacial Maximum, was overcome by (but not the ) by concerted dietary change plus profertility genes and intense sexual selection culminating in behaviourally modern . Increased reliance on the 'de novo' synthesis of nicotinamide from tryptophan conditioned the immune system to welcome symbionts, such as TB (that excrete nicotinamide), and to increase tolerance of the foetus and thereby fertility. The trade-offs during the warmer Holocene were physical and mental stunting and more infectious diseases and population booms and busts. Higher nicotinamide exposure could be responsible for recent demographic and epidemiological transitions to lower fertility and higher longevity, but with more degenerative and auto-immune disease