Global Journalist: International view as UN Security Council debates Iraq War

This conversation on the March 6, 2003 Global Journalist show features several journalists from around the globe describing how their countries' governments view the Iraq War as the United Nations Security Council continues to debate the matter. One of the guests, Bulgarian journalist Milena Dimitrova, was completing a Professional Development Year at the University of Missouri when she appeared on the show. Host: Byron Scott. Guests: Semih Idiz (Turkey), Milena Dimitrova (Bulgaria, completed Professional Development Year in journalism at Mizzou), Eoghan Shortt (?) (Spain), Ignacio Rodriguez Reyna (Mexico). Producers: Sara Andrea Fajardo, Augustine Pang. Director: Mary Furness

Elasticity and viscosity of ice measured in the experiment on wave propagation below the ice in HSVA ice tank

An experiment on the propagation of flexural-gravity waves was performed in the HSVA ice tank in 2018. Physical characteristics of the water-ice system were measured in different locations in the tank during the tests, with several sensors deployed in the water, on the ice and in the air. Periodical waves with frequencies of 0.5-1.5 Hz were generated by HSVA wave maker during 10 min in each test. The phase speeds and wave damping associated with anelastic deformations of ice were analyzed in the paper. Elastic modulus of ice was calculated for each wave period from the dispersion equation of flexural gravity waves where measured values of wave frequencies and wave speeds were substituted. Viscous coefficient of ice was calculated after the analysis of wave damping. Obtained values have relatively big dispersion which can be explained by natural variability of ice properties

Laboratory Investigations of the Bending Rheology of Floating Saline Ice and Physical Mechanisms of Wave Damping In the HSVA Hamburg Ship Model Basin Ice Tank

An experimental investigation of flexural-gravity waves was performed in the Hamburg Ship Model Basin HSVA ice tank. Physical characteristics of the water-ice system were measured in several locations of the tank with a few sensors deployed in the water and on the ice during the tests. The three-dimensional motion of ice was measured with the optical system Qualisys; water pressure was measured by several pressure sensors mounted on the tank wall, in-plane deformations of the ice and the temperatures of the ice and water were measured by fiber optic sensors; and acoustic emissions were recorded with compressional crystal sensors. The experimental setup and selected results of the tests are discussed in this paper. Viscous-elastic model (Burgers material) is adopted to describe the dispersion and attenuation of waves propagating below the ice. The elastic modulus and the coefficient of viscosity are calculated using the experimental data. The results of the measurements demonstrated the dependence of wave characteristics from the variability of ice properties during the experiment caused by the brine drainage. We showed that the cyclic motion of the ice along the tank, imitating ice drift, and the generation of under ice turbulence cause an increase of wave damping. Recorded acoustic emissions demonstrated cyclic microcracking occurring with wave frequencies and accompanying bending deformations of the ice. This explains the viscous and anelastic rheology of the model ice

Evaluation of work-based screening for early signs of alcohol-related liver disease in hazardous and harmful drinkers: the PrevAIL study

Background The direct cost of excessive alcohol consumption to health services is substantial but dwarfed by the cost borne by the workplace as a result of lost productivity. The workplace is also a promising setting for health interventions. The Preventing Alcohol Harm in Liverpool and Knowsley (PrevAIL) project aimed to evaluate a mechanism for detecting the prevalence of alcohol related liver disease using fibrosis biomarkers. Secondary aims were to identify the additive effect of obesity as a risk factor for early liver disease; to assess other impacts of alcohol on work, using a cross-sectional survey. Methods Participants (aged 36-55y) from 13 workplaces participated (March 2011–April 2012). BMI, waist circumference, blood pressure and self-reported alcohol consumption in the previous week was recorded. Those consuming more than the accepted UK threshold (men: >21 units; female: >14 units alcohol) provided a 20 ml venous blood sample for a biomarker test (Southampton Traffic Light Test) and completed an alcohol questionnaire (incorporating the Severity of Alcohol Dependence Questionnaire). Results The screening mechanism enrolled 363 individuals (52 % women), 39 % of whom drank above the threshold and participated in the liver screen (n = 141, complete data = 124 persons). Workplaces with successful participation were those where employers actively promoted, encouraged and facilitated attendance. Biomarkers detected that 30 % had liver disease (25 %, intermediate; 5 % probable). Liver disease was associated with the frequency of visits to the family physician (P = 0.036) and obesity (P = 0.052). Conclusions The workplace is an important setting for addressing alcohol harm, but there are barriers to voluntary screening that need to be addressed. Early detection and support of cases in the community could avert deaths and save health and social costs. Alcohol and obesity should be addressed simultaneously, because of their known multiplicative effect on liver disease risk, and because employers preferred a general health intervention to one that focused solely on alcohol consumption

Primary vs. Secondary Antibody Deficiency: Clinical Features and Infection Outcomes of Immunoglobulin Replacement

<div><p>Secondary antibody deficiency can occur as a result of haematological malignancies or certain medications, but not much is known about the clinical and immunological features of this group of patients as a whole. Here we describe a cohort of 167 patients with primary or secondary antibody deficiencies on immunoglobulin (Ig)-replacement treatment. The demographics, causes of immunodeficiency, diagnostic delay, clinical and laboratory features, and infection frequency were analysed retrospectively. Chemotherapy for B cell lymphoma and the use of Rituximab, corticosteroids or immunosuppressive medications were the most common causes of secondary antibody deficiency in this cohort. There was no difference in diagnostic delay or bronchiectasis between primary and secondary antibody deficiency patients, and both groups experienced disorders associated with immune dysregulation. Secondary antibody deficiency patients had similar baseline levels of serum IgG, but higher IgM and IgA, and a higher frequency of switched memory B cells than primary antibody deficiency patients. Serious and non-serious infections before and after Ig-replacement were also compared in both groups. Although secondary antibody deficiency patients had more serious infections before initiation of Ig-replacement, treatment resulted in a significant reduction of serious and non-serious infections in both primary and secondary antibody deficiency patients. Patients with secondary antibody deficiency experience similar delays in diagnosis as primary antibody deficiency patients and can also benefit from immunoglobulin-replacement treatment.</p></div

A pilot study demonstrating the altered gut microbiota functionality in stable adults with Cystic Fibrosis

peer-reviewedCystic Fibrosis (CF) and its treatment result in an altered gut microbiota composition compared to non-CF controls. However, the impact of this on gut microbiota functionality has not been extensively characterised. Our aim was to conduct a proof-of-principle study to investigate if measurable changes in gut microbiota functionality occur in adult CF patients compared to controls. Metagenomic DNA was extracted from faecal samples from six CF patients and six non-CF controls and shotgun metagenomic sequencing was performed on the MiSeq platform. Metabolomic analysis using gas chromatography-mass spectrometry was conducted on faecal water. The gut microbiota of the CF group was significantly different compared to the non-CF controls, with significantly increased Firmicutes and decreased Bacteroidetes. Functionality was altered, with higher pathway abundances and gene families involved in lipid (e.g. PWY 6284 unsaturated fatty acid biosynthesis (p = 0.016)) and xenobiotic metabolism (e.g. PWY-5430 meta-cleavage pathway of aromatic compounds (p = 0.004)) in CF patients compared to the controls. Significant differences in metabolites occurred between the two groups. This proof-of-principle study demonstrates that measurable changes in gut microbiota functionality occur in CF patients compared to controls. Larger studies are thus needed to interrogate this further

Analgesic use, pain and daytime sedation in people with and without dementia in aged care facilities: a cross-sectional, multisite, epidemiological study protocol

INTRODUCTION: People living with dementia may experience and express pain in different ways to people without dementia. People with dementia are typically prescribed fewer analgesics than people without dementia indicating a potential difference in how pain is identified and treated in these populations. The objectives of this study are to (1) investigate the prevalence of analgesic load, pain and daytime sedation in people with and without dementia in Australian residential aged care facilities (RACFs), and (2) investigate the clinical and diagnostic associations between analgesic load, pain and daytime sedation in people with and without dementia in Australian RACFs. METHODS/ANALYSIS: This will be a cross-sectional study of 300 permanent residents of up to 10 low-level and high-level RACFs in South Australia with and without dementia. Trained study nurses will administer validated and dementia-specific assessments of self-reported and clinician-observed pain, sedation and other clinical and humanistic outcomes. Medicine-use data will be extracted directly from each resident's medication administration chart. Binary and multinominal logistic regression will be used to compute unadjusted and adjusted ORs and 95% CIs for factors associated with pain, analgesic load and daytime sedation. These factors will include dementia severity, behavioural and psychological symptoms, quality of life, resident satisfaction, attitudes towards medicines, activities of daily living and nutritional status. ETHICS AND DISSEMINATION: Institutional ethics approval has been granted. The findings will be disseminated through public lectures, professional and scientific conferences and in peer-reviewed journal articles. The findings of this study will allow for a better understanding of the prevalence and factors associated with analgesic use, pain and other outcomes in residential care. The findings of this study will be used to inform the development and implementation of strategies to improve the quality of life of people with dementia.Edwin C K Tan, Renuka Visvanathan, Sarah N Hilmer, Agnes I Vitry, Tara Quirke, Tina Emery, Leonie Robson, Terry Shortt, Simon Sheldrick, Sunny, Soon Won, Lee, Robyn Clothier, Emily Reeve, Danijela Gnjidic, Jenni Ilomäki, J Simon Bel

Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene

The Eμ-Myc mouse is an extensively used model of MYC driven malignancy; however to date there has only been partial characterization of MYC co-operative mutations leading to spontaneous lymphomagenesis. Here we sequence spontaneously arising Eμ-Myc lymphomas to define transgene architecture, somatic mutations, and structural alterations. We identify frequent disruptive mutations in the PRC1-like component and BCL6-corepressor gene Bcor. Moreover, we find unexpected concomitant multigenic lesions involving Cdkn2a loss and other cancer genes including Nras, Kras and Bcor. These findings challenge the assumed two-hit model of Eμ-Myc lymphoma and demonstrate a functional in vivo role for Bcor in suppressing tumorigenesis.We acknowledge the following funding agencies: Leukaemia Foundation of Australia, Arrow Bone Marrow Transplant Foundation, National Health and Medical Research Council Australia, Cancer Council Victoria, Victorian Cancer Agency, Australian Cancer Research Foundation, Peter MacCallum Cancer Centre Foundation, National Institutes of Health