Spray Ejected from the Lunar Surface by Meteoroid Impact

Fragments ejected from lunar surface by meteoroid impact analyzed on basis of studies of hypervelocity impact in rock and san

Reorientation dynamics of nanoconfined water: Power-law decay, hydrogen-bond jumps, and test of a two-state model

This is the publisher's version, also available electronically from http://scitation.aip.org/content/aip/journal/jcp/136/4/10.1063/1.3679404.The reorientation dynamics of water confined within nanoscale, hydrophilicsilica pores are investigated using molecular dynamics simulations. The effect of surface hydrogen-bonding and electrostatic interactions are examined by comparing with both a silica pore with no charges (representing hydrophobic confinement) and bulk water. The OH reorientation in water is found to slow significantly in hydrophilic confinement compared to bulk water, and is well-described by a power-law decay extending beyond one nanosecond. In contrast, the dynamics of water in the hydrophobic pore are more modestly affected. A two-state model, commonly used to interpret confined liquid properties, is tested by analysis of the position-dependence of the water dynamics. While the two-state model provides a good fit of the orientational decay, our molecular-level analysis evidences that it relies on an over-simplified picture of water dynamics. In contrast with the two-state model assumptions, the interface dynamics is markedly heterogeneous, especially in the hydrophilic pore and there is no single interfacial state with a common dynamics

Adaphostin toxicity in a sensitive non-small cell lung cancer model is mediated through Nrf2 signaling and heme oxygenase 1

<p>Abstract</p> <p>Background</p> <p>Preclinical toxicity of adaphostin has been related to oxidative stress. This study investigated the regulatory mechanism underlying adaphostin induction of heme oxygenase 1 (HMOX1) which plays a significant role in modulation of drug-induced toxicity in the non-small cell lung cancer cell line model, NCI-H522.</p> <p>Methods</p> <p>The transcriptional response of NCI-H522 to adaphostin prominently involved oxidative stress genes, particularly HMOX1. Reactive oxygen species (ROS) involvement was additionally established by generation of ROS prior to modulation of adaphostin-toxicity with antioxidants. To identify up-stream regulatory elements of HMOX1, immunofluorescence was used to evaluate nuclear translocation of the transcription factor, NF-E2-related factor 2 (Nrf2), in the presence of adaphostin. The PI3-kinase inhibitor, wortmannin, was employed as a pharmacological inhibitor of this process.</p> <p>Results</p> <p>Generation of ROS provided a substantial foundation for the sensitivity of NCI-H522 to adaphostin. However, in contrast to leukemia cell lines, transcriptional response to oxidative stress was associated with induction of HMOX1, which was dependent on nuclear translocation of the transcription factor, Nrf2. Pretreatment of cells with wortmannin inhibited translocation of Nrf2 and induction of HMOX1. Wortmannin pretreatment was also able to diminish adaphostin induction of HMOX1, and as a consequence, enhance the toxicity of adaphostin to NCI-H522.</p> <p>Conclusions</p> <p>Adaphostin-induced oxidative stress in NCI-H522 was mediated through nuclear translocation of Nrf2 leading to upregulation of HMOX1. Inhibition of Nrf2 translocation by wortmannin inhibited this cytoprotective response, and enhanced the toxicity of adaphostin, suggesting that inhibitors of the PI3K pathway, such as wortmannin, might augment the antiproliferative effects of adaphostin in solid tumors that depend on the Nrf2/ARE pathway for protection against oxidative stress.</p

Preliminary geologic investigations in the Colorado Plateau using enhanced ERTS images

Bulk and computer enhanced frames of the Verde Valley region of Central Arizona, have been analyzed for structural information and rock unit identification. Most major rock units in areas of sparse ground cover are identifiable on enhanced false-color composites. Regional structural patterns are strikingly visible on the ERTS images. New features have been identified which will aid in the search for ground water near Flagstaff, Sedona and Stewart Ranch

Geologic applications of ERTS images on the Colorado Plateau, Arizona

Three areas in central and northern Arizona centered on the (1) Verde Valley, (2) Coconino Plateau, and (3) Shivwits Plateau were studied using ERTS photography. Useful applications results include: (1) upgrading of the existing state geologic map of the Verde Valley region; (2) detection of long NW trending lineaments in the basalt cap SE of Flagstaff which may be favorable locations for drilling for new water supplies; (3) tracing of the Bright Angel and Butte faults to twice their previously known length and correlating the extensions with modern seismic events, showing these faults to be present-day earthquake hazards; (4) discovering and successfully drilling perched sandstone aquifers in the Kaibab Limestone on the Coconino Plateau; and (5) determining the relationship between the Shivwits lavas and the formation of the lower Grand Canyon and showing that the lavas should be an excellent aquifer, as yet untapped

Application of ERTS and EREP images to geologic investigations of the basin and range: Colorado plateau boundary in northwestern and north-central Arizona

The author has identified the following significant results. In the course of the ERTS investigation in the Cataract Creek Basin of the Coconino Plateau it was recognized that shallow perched ground water associated with the Kaibab Limestone could be discovered by means of drilling guided by geologic mapping aided by the use of ERTS imagery. At the Globe Ranch, the perched water table is only 5 meters beneath the surface at the site of the original, hand dug well. Recharge occurs from local runoff and from direct precipitation on the outcrop belt of the sandstone. This well provides water for the ranch at the rate of about 1,000 gallons a week. In order to explore the possibility of further developing this aquifer, unit 5 was mapped over an area of about 50 square miles in the vicinity of the hand-dug well, with negative results. A new location was then picked for drilling based on the occurrence of unit 5 in a favorable structural setting. This location was along a normal fault, and it was anticipated that water might be structurally trapped within the down-dropped block of the fault. Four shallow testholes were drilled and all encountered water. These four water-bearing holes are currently being monitored and will be tested to determine potential production of water from the local sandstone aquifer

Numerical stability of a new conformal-traceless 3+1 formulation of the Einstein equation

There is strong evidence indicating that the particular form used to recast the Einstein equation as a 3+1 set of evolution equations has a fundamental impact on the stability properties of numerical evolutions involving black holes and/or neutron stars. Presently, the longest lived evolutions have been obtained using a parametrized hyperbolic system developed by Kidder, Scheel and Teukolsky or a conformal-traceless system introduced by Baumgarte, Shapiro, Shibata and Nakamura. We present a new conformal-traceless system. While this new system has some elements in common with the Baumgarte-Shapiro-Shibata-Nakamura system, it differs in both the type of conformal transformations and how the non-linear terms involving the extrinsic curvature are handled. We show results from 3D numerical evolutions of a single, non-rotating black hole in which we demonstrate that this new system yields a significant improvement in the life-time of the simulations.Comment: 7 pages, 2 figure

Against the complex versus simple distinction

This paper examines three proposals on the difference between complex and simple views about personal identity: Parfit’s original introduction of the distinction, Gasser and Stefan’s definition and Noonan’s recent proposal. I argue that the first two classify the paradigm cases of simplicity as complex, while Noonan’s proposal makes simplicity and complexity turn on features whose relevance for the distinction is questionable. Given these difficulties, I examine why we should be interested in whether a position is complex or simple. I describe two purposes of having a distinction, and show that extant accounts of the complex vs. simple distinction fail to serve these. I argue that unless we find a satisfying account of the difference between complex and simple positions, we should not frame discourses on personal identity in these terms.Publisher PDFPeer reviewe

Protective coatings for chromium alloys Final summary report, 31 May 1965 - 30 Jun. 1966

Protective coatings for chromium-5 tungsten allo