Association Between IL1B and SCN1A Polymorphism and Febrile Seizures in Children in Siberia

Background: Febrile seizures (FS) are a benign, age-dependent, genetically determined state, in which the child’s brain is susceptible to epileptic seizures occurring in response to hyperthermia. We assessed whether polymorphisms of IL1B and SCN1A genes, encoding the proinflammatory cytokine IL1B and SCN1A, respectively, could help to predict FS development and find a new way to treat FS. Methods: We examined 121 children with FS and 30 children with HTS aged from 3 to 36 months. SNPs rs1143634 and rs16944 of IL1B gene, and rs3812718 and rs16851603 of SCN1A gene were determined by quantitative real-time PCR. Results: The analysis for rs1143634 revealed an association between the CC genotype and increased risk of FS development (OR 6.56; P=0.0008) against the background of acute respiratory viral infection. The same result was obtained for rs16944 (OR 3.13; P=0.04) and an association of two homozygous genotypes CC/CC. For rs3812718, the carriage of heterozygous genotype CT demonstrated a direct relationship with FS development (OR 44.95; P=0.000). Conclusion: Children with high FS risk need preventive treatment and joint observation of a pediatrician, pediatric infectionist, and a neurologist-epileptologist

Associations Between Neuropsychophysiological and Dermatoglyphic Indicators in the Assessment of Human Health

The purpose of this study was to explore the relationship between psycho-physiological markers of human health and dermatoglyphic indicators in young people. Materials and Methods: The study included 920 healthy volunteers aged between 18 and 21 years. All volunteers underwent the following examinations: EEG, an assessment of the anxiety level according to the BAI, and dermatoglyphic scanning. Results: According to the data obtained, there was a statistically significant strong negative correlation between the stress load indicator and dermatoglyphic data, such as the summary delta index (DI) and summary ridge count. A strong positive correlation was found between the percentage of whorls and stress (r=0.88). The predominant increase in anxiety is characteristic of persons with total ridge count (TRC) on the thumb of the right hand in the range from 19 to 23. Conclusion: Results demonstrate the interrelationships (association) between psycho-physiological (anxiety level, stress load indicator) and dermatoglyphic markers (DI, TRC and whorl pattern type) in young healthy people

Auf dem Weg zu einer gemeinschaftlichen Meta-Analyse des Endpaläolithikums/frühesten Mesolithikums in Europa. Bericht über den 2. CLIOARCH-Workshop, 26.-27. November 2020

We report on a virtual workshop aimed at advancing a new synthesis of techno-cultural patterns at the Pleistocene-Holocene boundary in Europe. We respond to the growing need of developing meta-analytical frameworks for comparing and eventually integrating disparate regional datasets and stress the opportunities of collaborative approaches. We propose that expert-sourced lithic data is a promising means of conducting systematic archaeological meta-analyses, and that the compilation and examination of similar continental-scale datasets may be an important research goal in the future.Wir berichten über den 2. Workshop im Rahmen des CLIOARCH-Projekts, der darauf abzielte, auf eine neue Synthese technokultureller Langzeitentwicklungen an der Pleistozän/Holozän-Grenze in Europa hinzuarbeiten. Wir reagieren damit auf den wachsenden Bedarf nach einem metaanalytischen Fundament für den Vergleich und die eventuelle Integration von heterogenen regionalen Datensätzen in der Archäologie des Spätpaläolithikums und frühesten Mesolithikums und betonen insbesondere die reichhaltigen Möglichkeiten, die kooperative Ansätze hierbei bieten. Wir schlagen vor, dass das Expert-Sourcing von vorgefilterten lithischen Informationen eine vielversprechende Grundlage zur Durchführung systematischer archäologischer MetaAnalysen ist und dass die Zusammenstellung, Untersuchung und Konservierung ähnlicher großräumiger Datensammlungen ein wichtiges Forschungsziel für die Zukunft sein könnte.CLIOARCH is an ERC Consolidator Grant project and has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No. 817564)

Arrhythmogenic Convulsive Syncope in Neurological Practice: A Case Report

This case report presents a 24-year-old man with a long history of arrhythmogenic convulsive syncope, which was managed as a cryptogenic generalized PRE. During complex examination of the patient within the framework of preoperative screening for the purpose of neurosurgical treatment of PRE, an idiopathic SSS was diagnosed. The clinical diagnosis was changed. The patient underwent emergency surgery at the center for cardiac surgery. ECP was implanted, the seizures stopped, resulting in dramatically improved quality of life

Efficiency of Direct Transcutaneous Electroneurostimulation of the Median Nerve in the Regression of Residual Neurological Symptoms after Carpal Tunnel Decompression Surgery

Carpal tunnel syndrome (CTS) is the most frequent entrapment neuropathy. CTS therapy includes wrist immobilization, kinesiotherapy, non-steroidal anti-inflammatory drugs, carpal tunnel steroid injection, acupuncture, and physical therapy. Carpal tunnel decompression surgery (CTDS) is recommended after failure of conservative therapy. In many cases, neurological disorders continue despite CTDS. The aim of this study was to investigate the efficiency of direct transcutaneous electroneurostimulation (TENS) of the median nerve in the regression of residual neurological symptoms after CTDS. Material and Methods: 60 patients aged 28–62 years with persisting sensory and motor disorders after CTDS were studied; 15 patients received sham stimulation with a duration 30 min.; 15 patients received high-frequency low-amplitude TENS (HF TENS) with a duration 30 min; 15 patients received low-frequency high-amplitude TENS (LF TENS) with a duration 30 min; and 15 patients received a co-administration of HF TENS (with a duration of15 min) and LF TENS (with a duration of 15 min). Results: Our research showed that TENS significantly decreased the pain syndrome, sensory disorders, and motor deficits in the patients after CTDS. Predominantly, negative and positive sensory symptoms and the pain syndrome improved after the HF TENS course. Motor deficits, reduction of fine motor skill performance, electromyography changes, and affective responses to chronic pain syndrome regressed significantly after the LF TENS course. Co-administration of HF TENS and LF TENS was significantly more effective than use of sham stimulation, HF TENS, or LF TENS in patients with residual neurological symptoms after CTDS

Efficiency of Direct Transcutaneous Electroneurostimulation of the Median Nerve in the Regression of Residual Neurological Symptoms after Carpal Tunnel Decompression Surgery

Carpal tunnel syndrome (CTS) is the most frequent entrapment neuropathy. CTS therapy includes wrist immobilization, kinesiotherapy, non-steroidal anti-inflammatory drugs, carpal tunnel steroid injection, acupuncture, and physical therapy. Carpal tunnel decompression surgery (CTDS) is recommended after failure of conservative therapy. In many cases, neurological disorders continue despite CTDS. The aim of this study was to investigate the efficiency of direct transcutaneous electroneurostimulation (TENS) of the median nerve in the regression of residual neurological symptoms after CTDS. Material and Methods: 60 patients aged 28–62 years with persisting sensory and motor disorders after CTDS were studied; 15 patients received sham stimulation with a duration 30 min.; 15 patients received high-frequency low-amplitude TENS (HF TENS) with a duration 30 min; 15 patients received low-frequency high-amplitude TENS (LF TENS) with a duration 30 min; and 15 patients received a co-administration of HF TENS (with a duration of15 min) and LF TENS (with a duration of 15 min). Results: Our research showed that TENS significantly decreased the pain syndrome, sensory disorders, and motor deficits in the patients after CTDS. Predominantly, negative and positive sensory symptoms and the pain syndrome improved after the HF TENS course. Motor deficits, reduction of fine motor skill performance, electromyography changes, and affective responses to chronic pain syndrome regressed significantly after the LF TENS course. Co-administration of HF TENS and LF TENS was significantly more effective than use of sham stimulation, HF TENS, or LF TENS in patients with residual neurological symptoms after CTDS