Experimental research and the numerical simulation of the non-standard pump for the flow-circulation type reactor

The paper shows the results of the experimental measurements and the numerical simulation of the flow-circulation type reactor pump main characteristics. The mathematical model based on Navier-Stokes equations and standard k-epsilon turbulence model was used for the pump CFD simulation. The pump power consumption was calculated by the proposed CFD post-processing method. It is found that the simulation error of the proposed method is not more than 2.9%. The obtained results include the regression equations of the pump full pressure, the pump feed and the power consumption at the pump cross-points. © 2019 IOP Publishing Ltd. All rights reserved

Landscape-Epidemiological Zoning of the Krasnodar Territory and the Republic of Adygea by Tularemia

Objective of the study was epizootic-epidemiological zoning of the area of Krasnodar Territory and the Republic of Adygea by manifestations of tularemia to determine the level of epidemic hazard of each zone.Materials and methods. Utilized were archival data of the Black Sea Plague Control station over the period of 1946–2017 and plague Control Center of the Rospotrebnadzor. With the help of GIS software packages, MapINFO 10.5 and ArcGIS 10.2, the data bases containing the point-like layers of the sites of infection with tularemia (49), isolation of tularemia agent (195), and the layer of landscape-geographical regions in the Krasnodar Territory and the Republic of Adygea were created.Results and discussion. Usage of the geo-information technologies allowed for detailed consideration of tularemia manifestations in different parts of the region. The prospects of applying Arc GIS and MapINFO for geoencoding, processing and creation of geo-information pool of tularemia manifestations over a long period was shown. Vector data of landscapes and sites of epidemics and epizootic manifestations of tularemia on different species of mammals and ticks were generated. The conversion of the database to Microsoft Excel made it possible to make full use of statistical capabilities for epidemiological analysis. The work on epidemiological zoning carried out in the Krasnodar region and the Republic of Adygea starkly illustrated the feasibility of using GIS technologies for those purposes. The results of the analysis allowed for optimization of the mode of epizootiological survey in different parts of the studied region. Advisability of epizootiological inspection and monitoring of the territories with identification of geographical coordinates for epizootic manifestation sites was proved

RESEARCH OF THE HYDRODYNAMIC OPERATION MODES OF A HIGH-SPEED SEDIMENTATION CENTRIFUGE

Two hydrodynamic regimes of high-speed sedimentation centrifuge were found. Laminar one is characterized by sedimentation of a solid phase and a liquid phase infinite mixing path. Turbulent is characterized by axial and radial pulsations of a liquid phase and decreasing of sedimentation efficiency

Edoxaban versus warfarin for the treatment of symptomatic venous thromboembolism.

BACKGROUND: Whether the oral factor Xa inhibitor edoxaban can be an alternative to warfarin in patients with venous thromboembolism is unclear. METHODS: In a randomized, double-blind, noninferiority study, we randomly assigned patients with acute venous thromboembolism, who had initially received heparin, to receive edoxaban at a dose of 60 mg once daily, or 30 mg once daily (e.g., in the case of patients with creatinine clearance of 30 to 50 ml per minute or a body weight below 60 kg), or to receive warfarin. Patients received the study drug for 3 to 12 months. The primary efficacy outcome was recurrent symptomatic venous thromboembolism. The principal safety outcome was major or clinically relevant nonmajor bleeding. RESULTS: A total of 4921 patients presented with deep-vein thrombosis, and 3319 with a pulmonary embolism. Among patients receiving warfarin, the time in the therapeutic range was 63.5%. Edoxaban was noninferior to warfarin with respect to the primary efficacy outcome, which occurred in 130 patients in the edoxaban group (3.2%) and 146 patients in the warfarin group (3.5%) (hazard ratio, 0.89; 95% confidence interval [CI], 0.70 to 1.13; P<0.001 for noninferiority). The safety outcome occurred in 349 patients (8.5%) in the edoxaban group and 423 patients (10.3%) in the warfarin group (hazard ratio, 0.81; 95% CI, 0.71 to 0.94; P=0.004 for superiority). The rates of other adverse events were similar in the two groups. A total of 938 patients with pulmonary embolism had right ventricular dysfunction, as assessed by measurement of N-terminal pro-brain natriuretic peptide levels; the rate of recurrent venous thromboembolism in this subgroup was 3.3% in the edoxaban group and 6.2% in the warfarin group (hazard ratio, 0.52; 95% CI, 0.28 to 0.98). CONCLUSIONS: Edoxaban administered once daily after initial treatment with heparin was noninferior to high-quality standard therapy and caused significantly less bleeding in a broad spectrum of patients with venous thromboembolism, including those with severe pulmonary embolism. (Funded by Daiichi-Sankyo; Hokusai-VTE ClinicalTrials.gov number, NCT00986154.)