DesignGPT: Multi-Agent Collaboration in Design

Generative AI faces many challenges when entering the product design workflow, such as interface usability and interaction patterns. Therefore, based on design thinking and design process, we developed the DesignGPT multi-agent collaboration framework, which uses artificial intelligence agents to simulate the roles of different positions in the design company and allows human designers to collaborate with them in natural language. Experimental results show that compared with separate AI tools, DesignGPT improves the performance of designers, highlighting the potential of applying multi-agent systems that integrate design domain knowledge to product scheme design

Federated Learning in Intelligent Transportation Systems: Recent Applications and Open Problems

Intelligent transportation systems (ITSs) have been fueled by the rapid development of communication technologies, sensor technologies, and the Internet of Things (IoT). Nonetheless, due to the dynamic characteristics of the vehicle networks, it is rather challenging to make timely and accurate decisions of vehicle behaviors. Moreover, in the presence of mobile wireless communications, the privacy and security of vehicle information are at constant risk. In this context, a new paradigm is urgently needed for various applications in dynamic vehicle environments. As a distributed machine learning technology, federated learning (FL) has received extensive attention due to its outstanding privacy protection properties and easy scalability. We conduct a comprehensive survey of the latest developments in FL for ITS. Specifically, we initially research the prevalent challenges in ITS and elucidate the motivations for applying FL from various perspectives. Subsequently, we review existing deployments of FL in ITS across various scenarios, and discuss specific potential issues in object recognition, traffic management, and service providing scenarios. Furthermore, we conduct a further analysis of the new challenges introduced by FL deployment and the inherent limitations that FL alone cannot fully address, including uneven data distribution, limited storage and computing power, and potential privacy and security concerns. We then examine the existing collaborative technologies that can help mitigate these challenges. Lastly, we discuss the open challenges that remain to be addressed in applying FL in ITS and propose several future research directions

Developing and validating a nomogram for cognitive impairment in the older people based on the NHANES

ObjectiveTo use the United States National Health and Nutrition Examination Study (NHANES) to develop and validate a risk-prediction nomogram for cognitive impairment in people aged over 60 years.MethodsA total of 2,802 participants (aged ≥ 60 years) from NHANES were analyzed. The least absolute shrinkage and selection operator (LASSO) regression model and multivariable logistic regression analysis were used for variable selection and model development. ROC-AUC, calibration curve, and decision curve analysis (DCA) were used to evaluate the nomogram’s performance.ResultsThe nomogram included five predictors, namely sex, moderate activity, taste problem, age, and education. It demonstrated satisfying discrimination with a AUC of 0.744 (95% confidence interval, 0.696–0.791). The nomogram was well-calibrated according to the calibration curve. The DCA demonstrated that the nomogram was clinically useful.ConclusionThe risk-prediction nomogram for cognitive impairment in people aged over 60 years was effective. All predictors included in this nomogram can be easily accessed from its’ user

Resident Immune Cells of the Liver in the Tumor Microenvironment

The liver is a central immunomodulator that ensures a homeostatic balance between protection and immunotolerance. A hallmark of hepatocellular carcinoma (HCC) is the deregulation of this tightly controlled immunological network. Immune response in the liver involves a complex interplay between resident innate, innate, and adaptive immune cells. The immune response in the liver is modulated by its continuous exposure to toxic molecules and microorganisms that requires a degree of immune tolerance to protect normal tissue from damage. In HCC pathogenesis, immune cells must balance a dual role that includes the elimination of malignant cells, as well as the repair of damaged liver tissue to maintain homeostasis. Immune response in the innate and adaptive immune systems extends to the cross-talk and interaction involving immune-regulating non-hematopoietic cells, myeloid immune cells, and lymphoid immune cells. In this review, we discuss the different immune responses of resident immune cells in the tumor microenvironment. Current FDA-approved targeted therapies, including immunotherapy options, have produced modest results to date for the treatment of advanced HCC. Although immunotherapy therapy to date has demonstrated its potential efficacy, immune cell pathways need to be better understood. In this review article, we summarize the roles of specific resident immune cell subsets and their cross-talk subversion in HCC pathogenesis, with a view to identifying potential new biomarkers and therapy options

MiR-770-5p inhibits cisplatin chemoresistance in human ovarian cancer by targeting ERCC2

In this study, we examined the role of the miRNA miR-770-5p in cisplatin chemotherapy resistance in ovarian cancer (OVC) patients. miR-770-5p expression was reduced in platinum-resistant patients. Using a 6.128-fold in expression as the cutoff value, miR-770-5p expression served as a prognostic biomarker and predicted the response to cisplatin treatment and survival among OVC patients. Overexpression of miR-770-5p in vitro reduced survival in chemoresistant cell lines after cisplatin treatment. ERCC2, a target gene of miR-770-5p that participates in the NER system, was negatively regulated by miR-770-5p. siRNA-mediated silencing of ERCC2 reversed the inhibition of apoptosis resulting from miR-770-5p downreglation in A2780S cells. A comet assay confirmed that this restoration of cisplatin chemosensitivity was due to the inhibition of DNA repair. These findings suggest that endogenous miR-770-5p may function as an anti-oncogene and promote chemosensitivity in OVC, at least in part by downregulating ERCC2. miR-770-5p may therefore be a useful biomarker for predicting chemosensitivity to cisplatin in OVC patients and improve the selection of effective, more personalized, treatment strategies

Older people´s experience of falls : A descriptive review

Background：As the population ages, so does the frequency of falls among the olderpeople. Falling is very common among the older people and can cause physical,psychological and social impacts on the older people. However, repeated falls can notonly limit the older people physically, but also make them psychologically anxious.Understanding how they feel after a fall can help us improve the quality of our lives.Aim：The aim of the study was to describe older people’s experiences of falls andprevention programs.Methods：A descriptive review including 13 articles with a qualitative approach, all ofwhich were retrieved from PubMed and Cinahl and published within ten years.Results：The resulted in older adults have different views of falls themselves andpreventive measures，Falling into one's own perspective, including self-conceit,fearand depression,neglect of hazard,isolation,avoid the fact of falling,lucky,be calm aboutthe fact that you fell,accept the impact of falls on your life; Opinions on preventivemeasures include embarrassment and shame, lake of objectiveness, lake of motivationand effectiveness.Conclusions：In the face of falls, older people have both fear and self-conceit, and inthe face of preventive measures, they may consider them effective. Therefore, healtheducation, increased attention to the older people, and changes in the familyenvironment can all help prevent falls to a certain extent.Keywords：Experience, fall, older peopl

Older people´s experience of falls : A descriptive review

Background：As the population ages, so does the frequency of falls among the olderpeople. Falling is very common among the older people and can cause physical,psychological and social impacts on the older people. However, repeated falls can notonly limit the older people physically, but also make them psychologically anxious.Understanding how they feel after a fall can help us improve the quality of our lives.Aim：The aim of the study was to describe older people’s experiences of falls andprevention programs.Methods：A descriptive review including 13 articles with a qualitative approach, all ofwhich were retrieved from PubMed and Cinahl and published within ten years.Results：The resulted in older adults have different views of falls themselves andpreventive measures，Falling into one's own perspective, including self-conceit,fearand depression,neglect of hazard,isolation,avoid the fact of falling,lucky,be calm aboutthe fact that you fell,accept the impact of falls on your life; Opinions on preventivemeasures include embarrassment and shame, lake of objectiveness, lake of motivationand effectiveness.Conclusions：In the face of falls, older people have both fear and self-conceit, and inthe face of preventive measures, they may consider them effective. Therefore, healtheducation, increased attention to the older people, and changes in the familyenvironment can all help prevent falls to a certain extent.Keywords：Experience, fall, older peopl

Research on the Status of European and Chinese Trade Competition in the Third Party Market

China’s increasingly important role in the global economy has changed the nature of global competition and reshaped international trade. At the same time, the EU has long been the most important force in global trade and continues to maintain a very large trade surplus. We discussed whether China is an increasingly important competitor of Europe in third-party markets, especially Latin America. More specifically, we have empirically estimated the elasticity of substitution between European exports and Chinese exports to Latin American economies (i.e. Their response to Latin American exports to changes in relative export prices). The results of this article show that over time, the competition between China and the EU in Latin America has increased. Before 2007, the competition between China and the EU was relatively high. Less, this reflects to a certain extent the fact that China mainly exports inferior products. However, since 2007, the substitution elasticity has increased, reflecting China ’s rise in the value chain upstream. We also studied China and the EU’s. The competition between the key industries of the EU exported by the Americas. We found that the competition between China and Europe in the field of motors and road vehicles is more intense. This should be sought Global level to maintain the competitiveness of European sounded the alarm