How Generating PICO and Clinical Questions from PubMed Abstracts Challenges Instruction of PubMed Search Strategies to First-Year Dental Students

Objective To provide continuity in an evidence-based dental course the librarian led students to convert the course director’s PICO (Population, Intervention, Comparison, Outcome) and Clinical Question examples derived from PubMed abstracts to viable PubMed search strategies. Methods With student participation, a new course director diagrammed PICO elements from eight PubMed abstracts with different research methodologies to construct Clinical Questions. During the next class, the librarian led students to build a search strategies from six Clinical Question examples with Medical Subject Headings (MeSH) and keywords. Students viewed the accuracy and reliability of PubMed’s Automatic Term Mapping in Search Details, how to apply Boolean operators from the Search History, how to find the most appropriate MeSH in the MeSH Database and the MeSH Browser, and finding full-text documents. Students located MeSH listed in MEDLINE records and how to leverage Similar Articles and Cited By features. Students learned how to stratify the concepts in the Clinical Question by importance. Results Deriving PICO from PubMed abstracts and building a Clinical Question is a practical method to generate PICO and Clinical Question experience in novice evidence-based medicine students without clinical experience. Students could see real-world examples of some concepts neatly mapping to MeSH and keyword synonyms while some other concepts require more investigation to convert to MeSH and keywords. Conclusions The librarian appreciated the simplicity of building PICO and Clinical Questions from PubMed abstract text and more examples could be presented to students than in previous years. Students had to push beyond blind trust in Automatic Term Mapping to create better search strategies. The ranking of concepts allow novice learners to construct search strategies that overcome incorrect assignment of concepts to inappropriate PICO elements

Quiver grassmannians, quiver varieties and the preprojective algebra

Quivers play an important role in the representation theory of algebras, with a key ingredient being the path algebra and the preprojective algebra. Quiver grassmannians are varieties of submodules of a fixed module of the path or preprojective algebra. In the current paper, we study these objects in detail. We show that the quiver grassmannians corresponding to submodules of certain injective modules are homeomorphic to the lagrangian quiver varieties of Nakajima which have been well studied in the context of geometric representation theory. We then refine this result by finding quiver grassmannians which are homeomorphic to the Demazure quiver varieties introduced by the first author, and others which are homeomorphic to the graded/cyclic quiver varieties defined by Nakajima. The Demazure quiver grassmannians allow us to describe injective objects in the category of locally nilpotent modules of the preprojective algebra. We conclude by relating our construction to a similar one of Lusztig using projectives in place of injectives.Comment: 30 pages. v2: minor corrections and notation changes, some proofs simplified. v3: Some statements and their proofs corrected. This version incorporates an erratum to the published version. See Appendix B for detail

Analysis of Complex Valve and Feed Systems

A numerical framework for analysis of complex valve systems supports testing of propulsive systems by simulating key valve and control system components in the test loop. In particular, it is designed to enhance the analysis capability in terms of identifying system transients and quantifying the valve response to these transients. This system has analysis capability for simulating valve motion in complex systems operating in diverse flow regimes ranging from compressible gases to cryogenic liquids. A key feature is the hybrid, unstructured framework with sub-models for grid movement and phase change including cryogenic cavitations. The multi-element unstructured framework offers improved predictions of valve performance characteristics under steady conditions for structurally complex valves such as pressure regulator valve. Unsteady simulations of valve motion using this computational approach have been carried out for various valves in operation at Stennis Space Center such as the split-body valve and the 10-in. (approx.25.4-cm) LOX (liquid oxygen) valve and the 4-in. (approx.10 cm) Y-pattern valve (liquid nitrogen). Such simulations make use of variable grid topologies, thereby permitting solution accuracy and resolving important flow physics in the seat region of the moving valve. An advantage to this software includes possible reduction in testing costs incurred due to disruptions relating to unexpected flow transients or functioning of valve/flow control systems. Prediction of the flow anomalies leading to system vibrations, flow resonance, and valve stall can help in valve scheduling and significantly reduce the need for activation tests. This framework has been evaluated for its ability to predict performance metrics like flow coefficient for cavitating venturis and valve coefficient curves, and could be a valuable tool in predicting and understanding anomalous behavior of system components at rocket propulsion testing and design sites

Confronting Inequity: Social Justice Dialogue in a Health Science Library

Objective: To demonstrate how a departmental social justice discussion group was successful in achieving its purpose in introducing and discussing health-related social justice narratives and perspectives with personal meaning to each department member. Methods: In the aftermath George Floyd’s death, the Assistant Director of Research and Education Services at a health sciences library proposed devoting a portion of staff meetings to discuss issues in social justice and anti-racism. Each department member would generate a topic and organize readings or links to media in an internal LibGuide. Initially, there was a total of seven discussions, each lasting an average of twenty minutes. Each staff member described their motivation in selecting their topic and accompanying resources and led the subsequent discussion. Results: Discussion topics included white fragility, racial disparities surrounding leg amputations of Black diabetes patients in Mississippi, transracial adoption, local food deserts, white privilege in medical school education, black transgender violence and discrimination, and pipeline institutional racism. The readings and discussions revealed marginalized group perceptions and reality are not necessarily willingly acknowledged or addressed by the privileged group. The topic of food deserts was identified for follow-up action because of the need in the residential area adjacent to the health sciences campus. Conclusions: Participants felt the topics were timely, thought-provoking and useful in understanding current imbalances in social equity in health-related areas. Each department member could identify and share a social justice area of concern. Many of the topics are addressed in critical librarianship scholarship, and lessons from the discussions could be applied to increased understanding of, and service to, marginalized users of their library’s community. Team members agreed to continue the discussions at staff meetings once per month on broader diversity and social justice topics

Simulations of Instabilities in Complex Valve and Feed Systems

CFD analyses are playing an increasingly important role in identifying and characterizing flow induced instabilities in rocket engine test facilities and flight systems. In this paper, we analyze instability mechanisms that range from turbulent pressure fluctuations due to vortex shedding in structurally complex valve systems to flow resonance in plug cavities to large scale pressure fluctuations due to collapse of cavitation induced vapor clouds. Furthermore, we discuss simulations of transient behavior related to valve motion that can serve as guidelines for valve scheduling. Such predictions of valve response to varying flow conditions is of crucial importance to engine operation and testing

Symptoms and quality of life in late stage Parkinson syndromes: a longitudinal community study of predictive factors

BACKGROUND Palliative care is increasingly offered earlier in the cancer trajectory but rarely in Idiopathic Parkinson's Disease(IPD), Progressive Supranuclear Palsy(PSP) or Multiple System Atrophy(MSA). There is little longitudinal data of people with late stage disease to understand levels of need. We aimed to determine how symptoms and quality of life of these patients change over time; and what demographic and clinical factors predicted changes. METHODS We recruited 82 patients into a longitudinal study, consenting patients with a diagnosis of IPD, MSA or PSP, stages 3-5 Hoehn and Yahr(H&Y). At baseline and then on up to 3 occasions over one year, we collected self-reported demographic, clinical, symptom, palliative and quality of life data, using Parkinson's specific and generic validated scales, including the Palliative care Outcome Scale (POS). We tested for predictors using multivariable analysis, adjusting for confounders. FINDINGS Over two thirds of patients had severe disability, over one third being wheelchair-bound/bedridden. Symptoms were highly prevalent in all conditions - mean (SD) of 10.6(4.0) symptoms. More than 50% of the MSA and PSP patients died over the year. Over the year, half of the patients showed either an upward (worsening, 24/60) or fluctuant (8/60) trajectory for POS and symptoms. The strongest predictors of higher levels of symptoms at the end of follow-up were initial scores on POS (AOR 1.30; 95%CI:1.05-1.60) and being male (AOR 5.18; 95% CI 1.17 to 22.92), both were more predictive than initial H&Y scores. INTERPRETATION The findings point to profound and complex mix of non-motor and motor symptoms in patients with late stage IPD, MSA and PSP. Symptoms are not resolved and half of the patients deteriorate. Palliative problems are predictive of future symptoms, suggesting that an early palliative assessment might help screen for those in need of earlier intervention

Governing urban vacancy in post-crash Dublin: contested property and alternative social projects

© 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group. The scale and severity of property crashes following the global financial crisis has made vacancy a more visible and politically significant feature of cities. Although research has focused on urban experiments in vacant spaces, there has been less emphasis on how the contested property relations around vacancy remake urban governance. In this paper, we argue that debates about vacancy have been a central concern in post-crisis urban governance. In the first part of the paper we draw two conceptual approaches into a dialogue and apply them to an analysis of vacant space: that of Nicholas Blomley on property and Elizabeth Povinelli on “alternative social projects”. In the second part of the paper, we critically analyse how three groups discursively construct the need to “activate” and “re-use” vacant spaces in Dublin: grassroots groups, urban policy-makers, and financial actors. We argue that governing vacancy will be a key feature of post-crisis urbanisation

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin